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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： juan Luis Santiago Eva Maria Galan-Moya jose Ramon Munoz-Rodriguez Miguel Angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias jose Manuel Perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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Home range variability and philopatry in Cinereous vultures(Aegypius monachus)breeding in Iberia

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Avian Research 2023年第4期14卷 586-592页

作者： Jorge García-Mací Ernesto Alvarez Manuel Galan juan jose Iglesias-Lebrija Marc Galvez Gerard Plana Núria Vallverdú Vicente Urios Grupo de Investigacion Zoología de Vertebrados Universidad de AlicanteApdo.99E-03080AlicanteSpain GREFA(Grupo de Rehabilitacion de la Fauna Autoctonay su Habitat) C/Monte del Pilar S/NE-28220MajadahondaSpain Cos d’Agents Rurals de la Generalitat de Catalunya Spain Associacio Trenca LleidaSpain

Large scavengers are strongly dependent on environmental conditions and carrion distribution and abundance,so season and breeding-related factors may influence the spatial ecology of species such as the Cinereous Vulture(Aegypius monachus),the largest European *** holds one of the biggest populations worldwide,but some aspects of the spatial ecology of the species in this region remain *** this study,17 adult Cinereous Vultures were GPS-tracked in order to study their spatial ecology during the adult *** average monthly home ranges(95%Kernel Density Estimation,KDE)and core areas(50%KDE)were 6543±19,935 km^(2)and 1174±4004 km^(2),*** average monthly home range fidelity ranged between 50 and 73%.Differences in movement-related variables between the seasonal periods(incubation,chick-rearing and non-breeding)were *** the chick-rearing period,the monthly accumulated distance was higher than during the other periods:3316±1108(chick-rearing)vs.1621±622(incubation)vs.1726±1159 km per month(nonbreeding).Additionally,large home range sizes were more frequent during the chick-rearing *** are two likely causes for these seasonal ***,chick-rearing entails a higher energetic expenditure by the parental individuals in foraging activities,so larger movements and foraging areas are expected during this ***,the flight is favoured during spring and summer due to environmental *** chick-rearing and warm months is a great evolutionary advantage for soaring-gliding raptors,as it allows them to cover larger areas with low energy ***,six individuals tagged as nestlings highlight the philopatric behaviour of the species:vultures settle their breeding areas 54±51 km from their natal nest(range=9–138 km).

关键词： Bird of prey Movement ecology Philopatry Raptor Scavenger

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Electronic structure, optical properties, and lattice dynamics in atomically thin indium selenide flakes

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Nano Research 2014年第10期7卷 1556-1568页

作者： juan F. Sanchez-Royo Suillermo Munoz-Matutano Mauro Brotons-Gisbert juan P. Martinez-Pastor Alfredo Segura Andres Cantarero Rafael Mata josep Canet-Ferrer Gerard Tobias Enric Canadell jose Marques-Hueso Brian D. Gerardot ICMUV Instituto de Oencia de Materiales Universidad de Valencia P.O. Box 22085 46071 Valencia Spain MALTA-Consolider Team Institut de Ciencia dels Materials-Dpto. de Fisica Apficada Universitat de Valencia E-46100 Burjassot (Valencia) Spain Institut de Ciencia de Materials de Barcelona (ICMAB-CSIC) Campus de la UAB 08193 Bellaterra Barcelona Spain Institute of Photonics and Quantum Science SUPA Hefiot-Watt University Edinburgh EH14 4AS UK

The progressive stacking of chalcogenide single layers gives rise to two- dimensional semiconducting materials with tunable properties that can be exploited for new field-effect transistors and photonic devices. Yet the properties of some members of the chalcogenide family remain unexplored. Indium selenide （InSe） is attractive for applications due to its direct bandgap in the near infrared, controllable p- and n-type doping and high chemical stability. Here, we reveal the lattice dynamics, optical and electronic properties of atomically thin InSe flakes prepared by micromechanical cleavage. Raman active modes stiffen or soften in the flakes depending on which electronic bonds are excited. A progressive blue-shift of the photoluminescence peaks is observed for decreasing flake thickness （as large as 0.2 eV for three single layers）. First-principles calculations predict an even larger increase in the bandgap, 0.40 eV, for three single layers, and as much as 1.1 eV for a single layer. These results are promising from the point of view of the versatility of this material for optoelectronic applications at the nanometer scale and compatible with Si and III-V technologies.

关键词： indium selenide two-dimensional flakes micro-Raman spectroscopy micro-photoluminescence electronic structure

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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo juan CRama Merchán Catia Costa juan Sanchis Renato Fernandes Alberto Rodrigues jose M Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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磺酸多相催化剂用于二甲基亚砜中C_6-单糖脱水制5-羟甲基糠醛(英)

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催化学报 2014年第5期35卷 644-655页

作者： Gabriel Morales juan A.Melero Marta Paniagua jose Iglesias Blanca Hernandez Maria Sanz Department of Chemical and Environmental Technology Universidad Rey Juan Carlos. C/Tulipan s/n. Mostoles. E28933Madrid Spain Department of Chemical and Energy Technology Universidad Rey Juan Carlos. C/Tulipan s/n. Mostoles. E28933 Madrid Spain

Sulfonic acid-functionalized heterogeneous catalysts have been evaluated in the catalytic dehydration of C(,monosaccharides into 5-hydroxymethylfurfural(HMF) using dimethyl sulfoxide(DMSO)as *** commercial resin Amberlyst-70 was the most active catalyst,which was ascribed to its higher concentration of sulfonic acid sites as compared with the other catalysts,and it gave 93 mol%yield of HMF from fructose in 1 *** glucose as the starting material,which is a much more difficult reaction,the reaction conditions(time,temperature,and catalyst loading) were optimized for Amberlyst-70 by a response surface methodology,which gave a maximum HMF yield of 33 mol%at 147 °C with 23 wt%catalyst loading based on glucose and 24 h reaction *** promotes the dehydration of glucose into anhydroglucose,which acts as a reservoir of the substrate to facilitate the production of HMF by reducing side *** reuse without a regeneration treatment showed a gradual but not very significant decay in catalytic activity.

关键词：非均相催化剂羟甲基糠醛二甲基亚砜磺酸脱水单糖响应面分析法 DMSO

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Site Characterization Index for Continuous Power Quality Monitoring Based on Higher-order Statistics

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 222-231页

作者： Olivia Florencias-Oliveros juan-José González-de-la-Rosa jose-María Sierra-Fernández Agustín Agüera-Pérez Manuel-Jesús Espinosa-Gavira José-Carlos Palomares-Salas Department of Automation Engineering ElectronicsArchitecture and Computers NetworksResearch Group TIC168Higher Polytechnic SchoolUniversity of CádizAlgeciras 11202Spain

The high penetration of distributed generation(DG)has set up a challenge for energy management and consequently for the monitoring and assessment of power quality(PQ).Besides,there are new types of disturbances owing to the uncontrolled connections of non-linear *** stochastic behaviour triggers the need for new holistic indicators which also deal with big data of PQ in terms of compression and scalability so as to extract the useful information regarding different network states and the prevailing PQ disturbances for future risk assessment and energy management *** and continuous monitoring would guarantee the report to claim for damages and to assess the risk of PQ *** this context,we propose a measurement method that postulates the use of two-dimensional(2D)diagrams based on higher-order statistics(HOSs)and a previous voltage quality index that assesses the voltage supply waveform in a continous monitoring *** suitable for both PQ and reliability applications,the results conclude that the inclusion of HOS measurements in the industrial metrological reports helps characterize the deviations of the voltage supply waveform,extracting the individual customers’pattern fingerprint,and compressing the data from both time and spatial *** method allows a continuous and robust performance needed in the SG ***,the method can be used by an average consumer as a probabilistic method to assess the risk of PQ deviations in site characterization.

关键词： Continuous statistical monitoring big data data compression higher-order statistics(HOSs) power quality(PQ)

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Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

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Light(Science & Applications) 2020年第1期9卷 1418-1429页

作者： Yuzhi Shi Tongtong Zhu Tianhang Zhang Alfredo Mazzulla Din Ping Tsai Weiqiang Ding Ai Qun Liu Gabriella Cipparrone juan jose Saenz Cheng-Wei Qiu School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China School of Physics Harbin Institute of TechnologyHarbin 150001China CNR-NANOTEC LiCryL and Centre of Excellence CEMIF.CALPonte P.BucciCubo 33B87036 Rende(CS)Italy Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Physics University of CalabriaPonte P.BucciCubo 33B87036 Rende(CS)Italy Donostia International Physics Center 20018 Donostia-San SebastianSpain

Lateral optical forces induced by linearly polarized laser beams have been predicted to deflect dipolar particles with opposite chiralities toward opposite transversal ***“chirality-dependent”forces can offer new possibilities for passive all-optical enantioselective sorting of chiral particles,which is essential to the nanoscience and drug ***,previous chiral sorting experiments focused on large particles with diameters in the geometrical-optics ***,we demonstrate,for the first time,the robust sorting of Mie(size~wavelength)chiral particles with different handedness at an air–water interface using optical lateral forces induced by a single linearly polarized laser *** nontrivial physical interactions underlying these chirality-dependent forces distinctly differ from those predicted for dipolar or geometrical-optics *** lateral forces emerge from a complex interplay between the light polarization,lateral momentum enhancement,and out-of-plane light refraction at the particle-water *** sign of the lateral force could be reversed by changing the particle size,incident angle,and polarization of the obliquely incident light.

关键词： momentum chiral optics

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Situation of Biofungicides Reconnaissance, a Case of Anthracnose Disease of Cowpea

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American Journal of Plant Sciences 2014年第9期5卷 1202-1211页

作者： Vitus Ikechukwu Obi juan jose Barriuso-Vargas Department of Agricultural Science and Natural environment University of Zaragoza Zaragoza Spain

Plant extracts have long been used in commercial agriculture as anti-microbial tools in food safety applications. These offer growers and agrobiologists many unique benefits which include their eco-friendliness. This work reviews the situation of Biofungicides reconnaissance in reference to fungal disease of cowpea. Twenty different pathogens were associated with various fungal diseases of cowpea and, only the species of Colletotrichum was found to have the virulence and propensity of afflicting a 100% infection on a single susceptible cowpea crop. Plant families under the affliction of Colletotrichum were analyzed. The different forms of botanicals so far availed for use as potential biofungicidal were identified. Eighteen plant families were found to represent the entire plants and plant materials agrobiologically screened within a range of thirteen years and found to habour large spectra of species containing substances of biofungicidal potentials. Current position in the use of Botanicals to combat agricultural pests and disease is 7% of the total cowpea disease management options.

关键词： Anthracnose Biofungicides Biopesticides Colletotrichum destructivum Cowpea.

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Characterization of Driving Style and the Influence of Distraction Based on Non-intrusive Driving Parameters

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Journal of Mechanics Engineering and Automation 2011年第6期1卷 413-419页

作者： Felipe Jimenez juan jose Sanchez Oscar Gomez University Institute for Automobile Research Technical University of Madrid Madrid 28031 Spain

It is difficult to model human behavior because of the variability in driving styles and driving skills. However, for some driver assistance systems, it is necessary to have knowledge of that behavior to discriminate potentially hazardous situations, such as distraction, fatigue or drowsiness. Many of the systems that look for driver distraction or drowsiness are based on intrusive means （analysis of the electroencephalogram--EEG） or highly sensitive to operating conditions and expensive equipment （eye movements analysis through artificial vision）. A solution that seeks to avoid the above drawbacks is the use of driving parameters This article presents the conclusions obtained after a set of driving simulator tests with professional drivers with two main objectives using driving variables such as speed profile, steering wheel angle, transversal position on the lane, safety distance, etc., that are available in a non-intrusive way：（1） To analyze the differences between the driving patterns of individual drivers; and （2） To analyze the effect of distraction and drowsiness on these parameters. Different scenarios have been designed, including sequences with distractions and situations that cause fatigue. The analysis of the results is carried out in time and frequency domains in order to identify situations of loss of attention and to study whether the evolution of the analyzed variables along the time could be considered independent of the driver.

关键词： ADAS (advanced driver assistance systems) driver behavior distraction driving simulator professional driver.

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Foliar persistence and residual activity of methoxyfenozide against beet armyworm （Lepidoptera： Noctuidae）

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Insect Science 2013年第6期20卷 734-742页

作者： Omar-Ulises Aguirre Ana-Mabel Martinez Jesus Campos-Garcia Luis-Antonio Hernaindez jose-Isaac Figueroa Philippe Lobit Elisa Vinuela juan-Manuel Chavarrieta Guy Smagghe Samuel Pineda Instituto de Investigaciones Agropecuarias y Forestales Universidad Michoacana de San Nicolas de Hidalgo Michoacan Instituto de Investigaciones Quimico Biologicas Universidad Michoacana de San Nicolas de Hidalgo Edif. B-3 Ciudad Universitaria CP 58030 Morelia Michoacan Mexico Proteccion de Cultivos Escuela Tecnica Superior de Ingenieros Agronomos Madrid E-28040 Spain Department of Crop Protection Faculty of Bioscience Engineering Ghent University Ghent B-9000 Belgium

A greenhouse study was conducted to investigate the persistence of methoxyfenozide in pepper （Capsicum annuum L.） foliage. An aqueous suspension of methoxyfenozide was sprayed on pepper plants at concentrations of 72 and 144 mg of active ingredient （a.i.）/L. Foliage was collected at different intervals of time （0, 3, 5, 10, 20, 30, 40, and 50 days） after the treatment, and the methoxyfenozide residue was measured by high-performance liquid chromatography. The foliage was also used in bioas- says to determine the residual toxicity on and the consumption rate of the third-instar larvae of the beet armyworm, Spodoptera exigua （Htibner）（Lepidoptera： Noctuidae）. The methoxyfenozide concentrations observed after 50 days had decreased to 19 and 69μg/g per sample, corresponding to a loss of 61% and 28% from the application concentrations of 72 and 144 mg a.i./L, respectively. When fitting a first-order kinetics degradation model, the half-life （DT50） of this compound was 76 days. Both application concentrations of methoxyfenozide caused a high mortality rate （〉97%） when the larvae were fed the pepper foliage collected at all of the time intervals. Lastly, at all of the time points, the consumption rate by the larvae was reduced to between 57% and 92% for both concentrations that were bioassayed. Our results indicate that, under the present greenhouse conditions, the degradation of methoxyfenozide was slower than that reported by other authors and that its residues were highly toxic to S. exigua larvae. The implications of these results for the management programs of this pest are discussed.

关键词： consumption rate foliar persistence methoxyfenozide residue residualactivity Spodoptera exigua

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