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Fibrinogen-thrombin collagen patch reinforcement of highrisk colonic anastomoses in rats

World Journal of Gastrointestinal Surgery 2016年第9期8卷 627-633页

作者： juan Manuel Suárez-Grau Carlos Bernardos García Carmen Cepeda franco Cristina Mendez García Salud García Ruiz Fernando Docobo Durantez Salvador Morales-Conde Javier Padillo Ruiz Department of General and Digestive Surgery Riotinto Hospital 21660 Huelva Spain Division of General and Laparoscopic Surgery Clinic Quiron Sagrado Corazón 41013 Seville Spain Institute of Biomedicine of Seville Research center University Hospital Virgen del Rocio 41013 Seville Spain Division of General Surgery Hospital of San Juan de Dios 41930 Bormujos Spain Department of General and Digestive Surgery University Hospital Virgen del Rocio 41013 Seville Spain Department of General surgery Hospital of Jerez 11407 Jerez de la Frontera Cadiz Spain Division of Surgery Clinic Quiron Donostia 20012 Donostia Spain Clinic Quiron Sagrado Corazón 41013 Seville Spain

AIMTo evaluate the effectiveness of human fibrinogen-thrombin collagen patch (TachoSil®) in the reinforcement of high-risk colon *** quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group (24 rats) and treatment group (24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil® (a piece of TachoSil® was applied over this high-risk anastomosis, covering the gap). Leak incidence, overall survival, intra-abdominal adhesions, and histologic healing of anastomoses were analyzed. Survivors were divided into two subgroups and euthanized at 15 and 30 d after intervention in order to analyze the adhesions and histologic *** survival was 71.4% and 57.14% in the TachoSil® group and control group, respectively (P = 0.29); four rats died from other causes and six rats in the treatment group and 10 in the control group experienced colonic leakage (P > 0.05). The intra-abdominal adhesion score was similar in both groups, with no differences between subgroups. We found non-significant differences in the healing process according to the histologic score used in both groups (P = 0.066).CONCLUSIONIn our study, the use of TachoSil® was associated with a non-statistically significant reduction in the rate of leakage in high-risk anastomoses. TachoSil® has been shown to be a safe product because it does not affect the histologic healing process or increase intra-abdominal adhesions.

关键词： Colon Rats Anastomosis Leak TachoSil® Surgery

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Using a GIS Tool to Map the Spatial Distribution ofPopulation for 2010 in the State of Mexico, Mexico

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Journal of Geographic Information System 2012年第1期4卷 1-11页

作者： Roberto franco-Plata L. Ricardo Manzano-Solís Miguel A. Gómez-Albores José I. juan-Pérez Noel B. Pineda-Jaimes Araceli Martínez-Carrillo 不详

The present document describes the experience of using a Geography Information System (GIS) tool to map the spatial distribution of the population of the State of Mexico, Mexico, for 2010. Prior to the development of the experience, dif- ferent projects, tools and products, which offered cartographic representations of the population, were presented, se- lecting one that was developed to function in Idrisi Taiga GIS. Likewise, the GIS tool and the process followed to apply it to a case study in the State of Mexico are described. The result is a raster image that shows the distribution of the population on the analyzed state, offering the possibility to identify the zones where the population concentrates and disperses and to produce an opinion from a geographic point of view on what the origin of these distribution patterns is. Among the conclusions from the analysis of results, distinguishable are the applications that the obtained image can have;for instance, the population can be estimated by basins or risk zones by only adding the values of the cells inside these zones. It is also concluded that the degree of detail expressed by the spatial distribution image of the population will depend on several factors, among them the scale and resolution of the input information and the resolution fixed for the output information.

关键词： Spatial Distribution of the Population Idrisi Taiga GIS Tool State of Mexico

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Response of rice cultivation to biofertilizers in Campeche, Mexico

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Agricultural Sciences 2013年第12期4卷 715-720页

作者： Fermín Orona-Castro Mónica Guadalupe Lozano-Contreras Martín Tucuch-Cauich Oscar A. Grageda-Cabrera juan Medina-Mendez Arturo Díaz-franco Esaú Ruiz-Sánchez Jesús Soto-Rocha Campo Experimental Bajío (INIFAP) Celaya México Campo Experimental Río Bravo (INIFAP) Rio Bravo México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias (INIFAP) Campo Experimental Edzna Campeche México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias (INIFAP) Campo Experimental Mococha Yucatán México Instituto Tecnológico de Conkal Conkal México

The activity of various biofertilizers on rice production (Sabanero A95) was evaluated in Palizada, Campeche, Mexico, in the wet season of 2009 (year one) and 2011 (year two). On year one, arbuscular mycorrhiza INIFAP? (Rhizophagus intraradices), Azospirillum brasilense plus arbuscular micorrhiza Rhizophagus sp., and chemical fertilizer (92, -92, -60 kg·ha-1) were evaluated, while on year two marine algae extracts, a consortium of growth promoting bacteria (Pseudomonas spp.) and a control (not fertilized) were evaluated. The results showed that there were no significant differences on grain yield among treatments during the year one. The average grain yield was 2,800 kg·ha-1. As for the year two, the highest grain yield was observed on plots fertilized with chemical fertilizer (3333 kg·ha-1), followed by plots treated with mycorrhiza INIFAP? (3000 kg·ha-1). The economic analysis for rice production in both years showed that the use of arbuscular mycorrhiza decreases the cost of production by 18.5% and 16.3%, which suggests that microbial inoculants might be good substitutes of chemical fertilizers in rice production.

关键词： Rice Wet Season Validation Biofertilizers

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Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt

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World Journal of Cardiology 2017年第4期9卷 355-362页

作者： Cecilia Cuevas Nicola Ryan Alicia Quirós juan Gustavo Del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned Cardiovascular Institute Hospital Clinico San Carlos28040 MadridSpain

AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) *** In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO.

关键词： Repeat percutaneous coronary intervention Chronic total occlusion

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cysA,cysP,and rpoS mutations increase the power density in *** microbial fuel cells:Performing enhancement based on metabolic flux analysis

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Advances in Bioscience and Biotechnology 2013年第1期4卷 103-111页

作者： juan Diego Mejia Cindy Stephany Rojas Laura Avellaneda franco David Alejandro Urbina Gomez Beatriz Helena Correa Arias Nubia Milena Velasco Rodriguez Maria Teresa Cortes Montanez Martha Josefina Vives-Florez Andres Fernando Gonzalez Barrios Grupo de Diseno de Productos y Procesos(GDPP) Departamento de Ingenieria QuimicaUniversidad de los AndesBogotaColombia Grupo de Investigacion en Produccion y Logistica(PYLO) Departamento de Ingenieria IndustrialUniversidad de los AndesBogotaColombia Laboratorio de Electroquimica y Materiales Polimericos Departamento de QuimicaUniversidad de los AndesBogotaColombia Centro de Investigaciones Microbiologicas(CIMIC) Departamento de Ciencias BiologicasUniversidad de los AndesBogotaColombia

This study presents the simulation of a MFC with Pseudomonas aeruginosa based on a metabolic flux analysis (MFA) which arises as a linear programming model that served as input for the fuel cell model. The linear model was implemented in Xpress MP? and the coupling model in Comsol Multiphysics?. The in silico model predicted maximum potentials of 0.135 V which were consistent with those obtained in the experimental cell. Afterwards, an optimization platform based on multiobjective optimization approach was implemented aimed to determine genes that increase the average cell power. cysA, cysP and rpoS mutants which were predicted to increase the power of the cell, were experimentally tested with an air cathode fuel cell finding an augment up to 35-fold in the average power density for the rpoS mutant. Power densities were obtained through experimentation in the range of [0.13 - 5] mW/m2. Electron shuttle rise was qualitative corroborated trough cyclic voltammetry tests, which allowed to visualize the augment of the peaks for rpoS mutation.

关键词： Component Formatting Style Styling Insert

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Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques(Macaca mulatta)

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Animal Models and Experimental Medicine 2019年第4期2卷 326-333页

作者： Jose J.Rosado-franco Marcos J.Ramos-Benitez Laura M.Parodi Derick Rosario Nicole Compo Luis D.Giavedoni Ana M.Espino Department of Microbiology and Medical Zoology Medical Sciences CampusUniversity of Puerto RicoSan JuanPuerto Rico Southwest National Primate Research Center Texas Biomedical Research InstituteSan AntonioTXUSA Chemistry Department Rio Piedras CampusUniversity of Puerto RicoSan JuanPuerto Rico Medical Sciences Campus Caribbean Primate Research Center University of Puerto RicoToa BajaPuerto Rico

The aim of this study was to identify inflammation-associated markers during the early phase of sepsis in rhesus macaque. Four rhesus macaques were given an intravenous dose of 1010 CFU/kg of E. coli. Blood samples were collected before, or 30 minutes, 2, 4, 6 and 8 hours after E. coli infusion. Physiological parameters, bacteremia, endotoxemia, C-reactive protein(CRP), procalcitonin(PCT), and plasma cytokines/chemokines were determined for each animal. Bacteremia was present in all animals from 30 minutes to 3 hours after E. coli infusion whereas endotoxin was detected during the full-time course. CRP and PCT levels remained at detectable levels during the whole experimental window suggesting an ongoing inflammatory process. Signature cytokines and chemokines such as TNF-α, MIP-1α, and MIP-1β peaked about 2 hours after E. coli infusion and decreased thereafter. Plasma IL-6, IL-12 p40, IFN-γ, and IL-1 Ra, as well as I-TAC, MIG, IP-10 and MCP-1, remained at detectable levels after 4 hours of E. coli infusion. This nonhuman primate model could be useful for the assessment of new therapeutics aiming to suppress key inflammatory markers throughout sepsis early phases.

关键词： chemokines cytokines Macaca mulatta sepsis

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Post-Hospital Syndrome and Hyponatremia

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Health 2021年第8期13卷 846-856页

作者： José Bellod-Tonda Julio Blázquez-Encinar María Dolores Jover-Ríos Carmen Seguí-Pérez juan Méndez-Mora Francisco Caparrós-Hernández Álex Méndez-Jover Marc Seguí-Pérez David Baláž Leticia Espinosa del Barrio Jesús Corbacho-Redondo Carles García-Cervera juan Manuel Núñez-Cruz isidro Hernández-Isasi Javier Guzmán-Martínez Angie Gómez-Uranga Pedro Esteve-Atiénzar Jorge Peris-García Veronica Martínez-Sempere Eliana Damonte-White Óscar Hernando Ruiz-Ariza juan Carlos López-Corbalán Lourdes Lajara-Villar Andrea Riaño-Pérez Paloma Chazarra-Pérez María Escamilla-Espínola Maria Luisa Asensio-Tomás Miguel Ángel Auladell-Alemany Laura Serna-Torres Asunción Pérez-Fullana Amparo Gómez-Siurana Sergio Menargues-Irles José Miguel Seguí-Ripoll Internal Medicine Department University Hospital of San Juan Alicante Spain Internal Medicine Department Torrevieja University Hospital Alicante Spain Internal Medicine Department Hospital La Vega Baja of Orihuela Alicante Spain CEU Cardinal Herrera University Veterinary Hospital Valencia Spain Secondary School Marist Brothers High School Alicante Spain Department of Clinical Medicine Miguel Hernández University Elche Spain Primary Care Medicine Benilloba Spain Sub-Delegation of the Government Alicante Spain Chemical Engineering Department University of Alicante Alicante Spain

Introduction: Post-hospital syndrome (PHS) is defined as a period of vulnerability during the first 30 days after a patient is discharged from hospital, in which multiple factors come into play. Hyponatremia is the most frequent hydroelectrolytic disorder in hospitalized patients and may be related to the appearance of PHS. Objective: The objective is to estimate the prevalence of PHS that is assessed as the rate of readmissions in the first 30 days after discharge, in patients with hyponatremia. Material and Methods: It is a descriptive observational study of patients with hyponatremia who were discharged from 1 September 2010 to 2 February 2020 at the Internal Medicine Service of the Hospital University of San juan (Alicante, Spain). Results: Of the 25 included patients, 5 (20%) were readmitted within a month of discharge, after a mean of 11.4 days (standard deviation [SD] 5.1). The overall mortality of the study was 20% (n = 5), with one case of death in the first 30 days post-hospitalization (4%). In 12 patients (48%) the origin of the hyponatremia was undetermined. The most frequently recorded etiology for the condition was pharmacological (n = 7, 28%), and there was pronounced variability in its clinical and laboratory study. The most widely used corrective measure was drug withdrawal, in 16 patients (64%). Water intake restriction was the most common treatment after discharge (5 patients, 20%), followed by urea (2 patients, 8%), while tolvaptan was not used. Conclusion: Hyponatremia may be the cause of PHS, which could increase the rate of early readmission. Hyponatremia is an underdiagnosed and undertreated entity, so it is necessary to apply an appropriate system to optimize its management and, in future studies, to assess its impact on PHS.

关键词： Hospitalization Hyponatremia Patient Readmission Inappropriate ADH Syndrome

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无阿片类药物应用时手术中输注艾司洛尔可以减少门诊腹腔镜胆囊切除术后芬太尼的用量

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麻醉与镇痛 2008年第6期4卷 52-59页

作者： Vincent Collard,MD Giovanni Mistraletti, MD Ali Taqi, MD juan Francisco Asenjo,MD Liane S. Feldman, MD Gerald M. Fried, MD franco Carli, MD, Mphil 颜学滔宋学敏(译) 王焱林(校) Department of Anesthesia and Surgery Steinberg-Bernstein Centre for Minimally Invasive Surgery McGill University Health Centre Montreal Quebec Canada 不详

背景门诊手术患者使用阿片类药物可以延迟出院时间或导致意外入院。对手术中持续输注艾司洛尔替代阿片类药物能否减少手术后阿片类药物用量效应的报道结论不一。本研究比较了手术中持续输注艾司洛尔、间断输注芬太尼或连续输注瑞芬太尼... 详细信息

背景门诊手术患者使用阿片类药物可以延迟出院时间或导致意外入院。对手术中持续输注艾司洛尔替代阿片类药物能否减少手术后阿片类药物用量效应的报道结论不一。本研究比较了手术中持续输注艾司洛尔、间断输注芬太尼或连续输注瑞芬太尼的手术后阿片类药物的用量、副作用及患者的出院时间。方法90例患者分3组，进行前瞻性、随机双盲研究。对照组（n=30），手术中间断输注芬太尼；艾司洛尔组（聍=30），手术中持续输注艾司洛尔（5～15μg·kg～min^-1），不补充阿片类药物；瑞芬太尼组（n=30），持续输注瑞芬太尼（0．1-0．5μg·kg^-1·min^-1）。标准化全身麻醉，辅助药物包括：对乙酰氨基酚、酮洛酸、切皮时使用局麻药、地塞米松和氟哌利多。手术后使用芬太尼镇痛。结果手术后在麻醉恢复室，艾司洛尔组与其他2组相比，芬太尼的用量明显减少，为91．5±42．7μg；瑞芬太尼组为237．8±54．7μg，对照组为168．1±96．8μg（P〈0．0001）。与艾司洛尔组（30％）相比，瑞芬太尼组（67．9％）和对照组（66．7％）手术后恶心的发生率更高（P〈0．01）。手术后White-Song评分，艾司洛尔组到达12～14的速度比瑞芬太尼组更快（P〈0．01），出院时间早45-60分钟（P〈0．004）。结论手术中持续输注艾司洛尔能显著减少手术后芬太尼和昂丹司琼的用量，有利于患者及早出院。

关键词：阿片类药物门诊手术患者瑞芬太尼艾司洛尔腹腔镜胆囊切除术后术中输注用量药物应用

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Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： Xun Chen Chang Bo Fu Javier Galan Karl Giboni franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC Micromegas

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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