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Genes & Diseases 2022年第6期9卷 1419-1422页

作者： francisco Gallardo-Chamizo Nieves Lara-Urena juan F.Correa-Vazquez Jose C.Reyes Benoit R.Gauthier Mario Garcia-Dominguez Cell Dynamics and Signaling Department CABIMERCSICUniversidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Genome Biology Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Cell Therapy and Regeneration Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabo´licas Asociadas(CIBERDEM) Madrid 28029Spain

To the Editor,Constricted oxygen and glucose supplies are common conditions that healthy cells following a stress such an ischemic insult as well as cancer cells within a solid tumor need to overcome in order to *** conditions are a serious challenge for cells,which accurately measure the impact to make a life or death *** cancer cells,aberrant gene expression and/or protein regulation,frequently linked to appearing mutations,may confer selective advantages to survive under these adverse *** the past years,cumulative evidence indicates that protein modification by covalent attachment of the Small Ubiquitin-like MOdifier(SUMO)plays a role in cell survival after oxygen and glucose deprivation(OGD).

关键词： cancer deprivation colon

Design and Development of Impeller Synergic Systems of Electromagnetic Type to Levitation/Suspension Flight of Symmetrical Bodies

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Journal of Electromagnetic Analysis and Applications 2012年第1期4卷 42-52页

作者： francisco Bulnes juan Carlos Maya Isaías Martínez 不详

Using certain models of twistor surfaces for fields of force and the mathematical relationships that lie among fields, lines, surfaces and flows of energy, it has been designed and developed a flight electromagnetic type system based on the synergic study of their electromagnetic field geodesics to generate vehicle levitation, suspension and movement without being in contact with the surface. The idea of such work is to obtain a new flight and impulse patent of an electromagnetic vehicle by principles of super-conduction and some laws of the current like Eddy currents and principles which are very similar to mechanics of sidereal objects like galaxies or stars under models of twistor surfaces. This vehicle will be controlled by one microchip that will be programmed by conscience operators algebra of electromagnetic type that leads to the flow of Eddy currents, the iso-rotations and suspension of the special geometrical characteristics vehicle, generating also on the vehicle structure certain “magnetic conscience” that provokes all movements like succeeding to the sidereal objects in the universe.

关键词： Electromagnetic Levitation Twistor Surfaces of Impulse Symmetrical Space of Iso-Rotations Superconductive Quantum Algebra Magnetic Conscience Operators

A Comparative Analysis of Vessels Detained under the PSC Agreements of Paris, Tokyo and Vina del Mar

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Journal of Shipping and Ocean Engineering 2014年第11期4卷 291-306页

作者： francisco Piniella Emilio Rodriguez-Diaz juan Ignacio Alcaide Department of Maritime Studies University of C6diz Puerto Real E-11510 Spain

Twenty years ago, in 1992, the International Maritime Organization set the objective of extending the regional Port State Control agreements to the world scale. This would be achieved, it was hoped, by ＂exporting＂ the model of the Paris MoU （Memorandum of Understanding） agreement of 1982 to other regional areas. Now would seem to be a good time to consider the prospects for a future scenario where all the countries involved form a truly global network with uniform procedures. The authors of this article put forward an earlier objective that could be the beginning of that global policy, fi＇om a detailed look at the three most important regional agreements （Paris, Tokyo and Vifia del Mar） that encompass geographically the following areas, respectively： Europe plus Canada, the Asia-Pacific, and South America. To this end, we first make a theoretical comparison based on the legal standards of application, and then present a study made of all the vessels detained under the three agreements, with a view to determining whether or not there are different kinds of behaviours, with regard to the flags and ＂recognised organizations＂ used by the vessels to certify their levels of safety. The numerical variables we have taken as basic with respect to compliance with the international standards are： the date that the vessel＇s keel was laid （age of the vessel） and as significant categorical variables, the type of vessel, the flag, the typology of that flag, the corresponding classification society, and whether or not that society is a member of the IACS （International Association of Classification Societies）. The results show a similar trend between the Paris and Tokyo agreements, but in the case of Vifia del Mar, the level of efficacy in the control appears to be insufficient in comparison with the standard of the other two.

关键词： Port state control flags of convenience maritime safety globalization.

Outcomes of abdominal surgery in patients with liver cirrhosis

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World Journal of Gastroenterology 2016年第9期22卷 2657-2667页

作者： juan C Lopez-Delgado Josep Ballus francisco Esteve Nelson L Betancur-Zambrano Vicente Corral-Velez Rafael Manez Antoni J Betbese Joan A Roncal Casimiro Javierre Hospital Universitari de Bellvitge Intensive Care Department L'Hospitalet de Llobregat 08907 Barcelona Spain IDIBELL (Institut d'Investigacio Biomedica Bellvitge Biomedical Investigation Institute of Bellvitge) Research Team of Area of Innate Immunity and Pathology of the Critical Patient L'Hospitalet de Llobregat 08908 Barcelona Spain Hospital de la Santa Creu i Sant Pau Intensive Care Department 08041 Barcelona Spain Physiological Sciences II Department Universitat de Barcelona Campus Bellvitge 08907 Barcelona Spain

Patients suffering from liver cirrhosis(LC) frequently require non-hepatic abdominal surgery,even before liver *** is an important risk factor itself for surgery,due to the higher than average associated morbidity and *** high surgical risk occurs because of the pathophysiology of liver disease itself and to the presence of contributing factors,such as coagulopathy,poor nutritional status,adaptive immune dysfunction,cirrhotic cardiomyopathy,and renal and pulmonary dysfunction,which all lead to poor *** evaluation of these factors and the degree of liver disease can help to reduce the development of complications both during and after abdominal *** the emergency setting,with the presence of decompensated LC,alcoholic hepatitis,severe/advanced LC,and significant extrahepatic organ dysfunction conservative management is preferred.A multidisciplinary,individualized,and specialized approach can improve outcomes;preoperative optimization after risk stratification and careful management are mandatory before *** techniques can also improve *** review the impact of LC on surgical outcome in non-hepatic abdominal surgeries required in this cirrhotic population before,during,and after surgery.

关键词： Liver cirrhosis Outcomes Coagulopathy Nutritional status Abdominal surgery Adaptive immune dysfunction Cirrhotic cardiomyopathy

Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

Capsule endoscopy in patients refusing conventional endoscopy

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World Journal of Gastroenterology 2014年第23期20卷 7424-7433页

作者： Javier Romero-Vázquez Federico Argüelles-Arias Josefa Maria García-Montes ángel Caunedo-álvarez francisco Javier Pellicer-Bautista juan Manuel Herrerías-Gutiérrez Gastroenterology Service Virgen Macarena University Hospital41071 SevilleSpain

Capsule endoscopy is nowadays the diagnostic technique of choice in the study of small bowel pathologies,allowing the non-invasive study of the entire *** has led,together with new technical advances,to the creation of two new models(PillCam ESO and PillCam Colon)for the study of esophageal and colonic *** two new capsules offer an interesting alternative to conventional endoscopy in the study of the upper and lower digestive tracts,because traditional endoscopy is often unpleasant and uncomfortable for the patient,can be painful,often requires moderate or deep sedation and is not without complications(hemorrhage,perforation,etc.).PillCam Colon is particularly important for its usefulness in the diagnosis of colonic polyps,and is a potentially useful tool in cases of incomplete colonoscopy or in colorectal cancer screening,even more when most patients are reluctant to undergo screening programs due to the said disadvantages of conventional *** article discusses the advantages of capsule endoscopy over conventional endoscopy,its current application possibilities and indications in routine clinical *** the various sections of the work,we assess the application of endoscopic capsule in different sections of the digestive tract(esophagus,stomach,and colon)and finally the potential role of panendoscopy with PillCam Colon.

关键词： Conventional endoscopy Capsule endoscopy Esophageal capsule endoscopy Colon capsule endoscopy Panendoscopy

Measuring frailty in patients with severe aortic stenosis:a comparison of the edmonton frail scale with modified fried frailty assessment in patients undergoing transcatheter aortic valve replacement

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Journal of Geriatric Cardiology 2020年第7期17卷 441-446页

作者： francisco J Romeo Maximiliano Smietniansky Mariela Cal Cristian Garmendia juan M Valle Raleigh Ignacio MSeropian Mariano Falconi Pablo Oberti Vadim Kotowicz Carla RAgatiello Daniel H Berroca Division of Interventional Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Internal Medicine and Geriatrics Hospital Italiano de Buenos AiresBuenos AiresArgentina Division Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Cardiovascular Surgery Hospital Italiano de Buenos AiresBuenos AiresArgentina

Frailty is generally defined as a clinical syndrome of decreased physiologic reserve which drives to increased vulnerability and susceptibility to different stressors together with poor recovery to homeostasis.[1]The relevance of frailty status in a wide range of prospective cohorts is mostly related to an increasing burden in both mortality,hospital readmissions,disability,and falls.

关键词： Aortic stenosis Frailty Transcatheter aortic valve replacement

Opposing roles of plant laticifer cells in the resistance to insect herbivores and fungal pathogens

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Plant Communications 2021年第3期2卷 93-104页

作者： Lourdes Castelblanque Javier García-Andrade Clara Martínez-Arias juan J.Rodríguez francisco J.Escaray Ernestina Aguilar-Fenollosa Josep A.Jaques Pablo Vera Instituto de Biología Moleculary Celular de Plantas Universitat Politécnica de Valéncia-C.S.I.CCiudad Politécnica de la InnovaciònEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain Universitat Jaume I Departament de Ciéncies Agráries i del Medi NaturalCampus del Riu Sec12003 Castellòde la PlanaSpain

More than 12,000 plant species(ca.10%of flowering plants)exude latex when their tissues are *** is produced and stored in specialized cells named“laticifers”.Laticifers form a tubing system composed of rows of elongated cells that branch and create an internal network encompassing the entire *** constitute a recent evolutionary achievement in ecophysiological adaptation to specific natural environments;however,their fitness benefit to the plant still remains to be *** identification of Euphorbia lathyris mutants(pil mutants)deficient in laticifer cells or latex metabolism,and therefore compromised in latex production,allowed us to test the importance of laticifers in pest *** provided genetic evidence indicating that laticifers represent a cellular adaptation for an essential defense strategy to fend off arthropod herbivores with different feeding habits,such as Spodoptera exigua and Tetranychus *** marked contrast,we also discovered that a lack of laticifer cells causes complete resistance to the fungal pathogen Botrytis ***,a latex-derived factor required for conidia germination on the leaf surface was *** factor promoted disease susceptibility enhancement even in the non-latex-bearing plant *** speculate on the role of laticifers in the coevolutionary arms race between plants and their enemies.

关键词： latex Euphorbia lathyris disease resistance disease susceptibility plant defense

Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

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Journal of Geriatric Cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez juan Luis Bonilla-Palomas María Anguita-Gámez María García JoséLuis Bernal Náyade Del Prado Cristina Fernández-Pérez Julián Pérez-Villacastin juan JoséGómez-Doblas francisco Javier Elola Cardiology Department Hospital Universitario Severo OchoaMadridSpain Cardiology Department Hospital Universitario Reina SofíaCórdobaSpain Cardiology Department Hospital San Juan de la CruzÚbedaSpain Cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management Control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain Cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BACKGROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older ***,there are little data on in-hospital mortality in patients with HF≥75 years in *** A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and *** was performed using the International Classification of Diseases,10th ***≥75 years with HF as the principal diagnosis were *** calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(ICCU)in the *** We included 354,792 HF episodes of patients over 75 *** mean age was 85.2±5.5 years,and 59.2%of patients were *** most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%CI:1.07–1.07,P<0.001]and was lower in women(OR=0.96,95%CI:0.92–0.97,P<0.001).The main predictors of mortality were the presence of cardiogenic shock(OR=19.5,95%CI:16.8–22.7,P<0.001),stroke(OR=3.5,95%CI:3.0–4.0,P<0.001)and advanced cancer(OR=2.6,95%CI:2.5–2.8,P<0.001).In hospitals with ICCU,the in-hospital risk-adjusted mortality tended to be lower(OR=0.85,95%CI:0.72–1.00,P=0.053).CONCLUSIONS In-hospital mortality in patients with HF≥75 years between 2016 and 2019 was 12.7%,higher in males and elderly *** main predictors of mortality were cardiogenic shock,stroke,and advanced *** was a trend toward lower mortality in centers with an ICCU.

关键词： patients mortality diagnosis

Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells

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World Journal of Stem Cells 2015年第3期7卷 605-617页

作者： Amparo Beltran-Povea Estefania Caballano-Infantes Carmen Salguero-Aranda Franz Martín Bernat Soria francisco J Bedoya juan R Tejedo Gladys M Cahuana Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide CIBERDEM RED-TERCEL 41092 Seville Spain Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) -Fundación Progreso y Salud CIBERDEM RED-TERCEL 41092 Seville Spain

Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide(NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness.

关键词： Pluripotency Differentiation Nitric oxide Metabolism Hypoxia Stem cell