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Proteomic analysis of F_(1)hybrids and intermediate variants in a Littorina saxatilis hybrid zone

Current Zoology 2022年第3期68卷 351-359页

作者： Angel P.DIZ Mónica R.ROMERO juan GALINDO María SAURA david O.F.SKIBINSKI Emilio ROLÁN-ALVAREZ Centro de Investigación Mariña(CIM-UVIGO) Universidade de VigoVigo 36310Spain Departamento de Mejora Genética Animal INIAMadrid 28040Spain Institute of Life Science Swansea University Medical SchoolSwansea SA28PPUK

Proteomic analysis was carried out on the Crab(upper-shore)and Wave(lower-shore)ecotypes of Littorina saxatilis from a hybrid zone at Silleiro Cape,*** profiles of individual snails were *** expression in F_(1)hybrid snails bred in the laboratory and snails with intermediate shell phenotypes collected from the mid-shore were compared with Crab and Wave ecotypes using analytical approaches used to study *** analysis over many protein spots showed that the F_(1)snails are distinct from both ecotypes but closer to the Wave *** intermediate snails are highly variable,some closer to the Crab and others to the Wave *** on a protein by protein basis,some proteins are significantly closer in expression to the Crab and others to the Wave ecotype for both F_(1)and intermediate ***,a significant majority of proteins were closer in expression to the Wave ecotype for the F_(1),consistent with the multivariate *** such significant majority toward either the Crab or Wave ecotype was observed for the intermediate *** closer similarity of F_(1)and Wave ecotype expression patterns could be the result of similar selective pressures in the similar mid-shore and low-shore *** a significantly larger number of proteins,intermediate snails were closer in expression to the ecotype having the lower expression,for both Crab and Wave *** is somewhat unexpected as lower expression might be expected to be an indication of impairment of function and lower *** analysis could be important for the identification of candidate proteins useful for gaining improved understanding of adaptation and barriers to gene flow in hybrid zones.

关键词： F_(1)hybrids gene expression marine invertebrates molecular phenotype reproductive isolation speciation

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Digestibility,Antioxidant and Anti-Inflammatory Activities of Pecan Nutshell(Carya illioinensis)Extracts

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Journal of Renewable Materials 2022年第10期10卷 2569-2580页

作者： María Janeth Rodríguez-Roque Carmen Lizette Del-Toro-Sánchez Janet Madeline Chávez-Ayala Ricardo Iván González-Vega Liliana Maribel Pérez-Pérez Esteban Sánchez-Chávez Nora AideéSalas-Salazar juan Manuel Soto-Parra Rey david Iturralde-garcía María Antonia Flores-Córdova Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Universidad de Sonora Rosales y Niños Héroes S/NHermosilloSonMéxico Centro de Investigación en Alimentación y Desarrollo A.C.Unidad DeliciasDeliciasChihuahuaMéxico

Phenolic compounds are related to high biological activity,avoiding oxidation in food and human *** are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be *** research aimed to evaluate the antioxidant(DPPH,ABTS,FRAP and hemolysis)and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic compounds,including *** showed that extracts from the crop production cycle 2018 obtained the highest yield,while those from 2019 contained the highest concentration of phenolic compounds,flavonoids and antioxidant capacity determined by DPPH(22.96 mmol ET),ABTS(91.55 mmol ET)and inhibition of hemolysis(92.12%).The anti-inflammatory activity exhibited an inhibition of the elastase enzyme up to 50 min and the bioaccessibility of phenolic compounds reached up to 32%.These results showed that pecan nutshell extracts are an important source of biologically active compounds,thus,they are suitable to be used as commodities in different fields such as agricultural,food and pharmaceutical *** studies must be carried out in order to elucidate the activity of nutshell extracts within in vivo systems.

关键词： Anti-inflammatory activity antioxidants digestibility shell phenolic compounds

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Facial Asymmetry Correction in Facial Palsy Patients with Silhouette Sutures

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International Journal of Clinical Medicine 2012年第1期3卷 55-59页

作者： María Luisa Navarrete Ricard Palao Lluisa Torrent juan Fernando fuentes Mireia González 不详

Introduction: over the last few decades several techniques static and dynamics, have been performed to improve facial asymmetry and functionality alter suffering facial paralysis. Methods: we present a pilot study to show and evaluate the benefits of a new form of facial suspension, with Silhouette sutures. We performed two patients with total and complete facial palsy due to otical tuberculosis in one case and to parotid carcinoma in the other. Results: one year after surgery, both patients have improved facial asymmetry, mastication and speech production which have lead to a higher self-esteem and major social interaction. Conclusions: static facial suspension with Silhouette sutures is a non invasive alternative to dynamic techniques in patients who don’t want or can’t undergo more complex surgeries.

关键词： Facial Paralysis Suture Suspension Static Technique Silhouette Sutures

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Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

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World Journal of Stem Cells 2017年第3期9卷 45-67页

作者： Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa juan M Rodriguez Fernanda Elías juan Fló Ricardo A López Norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul Franco Alejandro D Montaner david L Horn Immunotech S.A. Ciudad de Buenos Aires C1440FFXArgentina Infectious Disease Division Memorial Hospital of Rhode Island and Alpert Medical SchoolProvidenceRI 02905United States Fundación Pablo Cassara Ciudad Autonoma de Buenos Aires C1440FFXArgentina Instituto de Biología y Medicina Experimental(IBYME-CONICET) Ciudad Autónoma de Buenos Aires C1428ADNArgentina Instituto de Ciencia y Tecnolog'DR.Cesar Milstein” Fundación Pablo CassaráCiudad Autonoma de Buenos Aires C1440FFXArgentina david Horn LLC DoylestownPA 18902United States

The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy.

关键词： Immunohomeostasis Immunoprotection Immunoregeneration Inflammation Mesenchymal stem cells IMT504

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Canola and Oat Forage Potential Evaluation in Four Early Planting Dates

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Phyton-International Journal of Experimental Botany 2019年第4期88卷 435-448页

作者： juan Isidro Sánchez-Duarte david Guadalupe Reta-Sánchez JoséAntonio Cueto-Wong Arturo Reyes-González Esmeralda Ochoa-Martínez Campo Experimental La Laguna Instituto Nacional de Investigaciones ForestalesAgrícolas y Pecuarias(INIFAP).Blvd.JoséSantos Valdez 1200 Pte.Col.CentroMatamorosCoahuilaCP 27440México

Canola and oat forage potential may be affected by climatic conditions when sown *** objective of this study was to evaluate the forage canola and oat potential in four early sowing dates(September 11 and 25;October 9 and 23)during the 2012-2013 and 2013-2014 cycles in Matamoros,Coahuila,*** cycle duration,chemical composition,dry matter(DM),crude protein(CP),and net energy for lactation(NEL)yields were *** temperatures and long photoperiods affected crops seeded on September 11,accelerating growth and reducing canola(26.6%-31.7%)and oat(15.8%)DM *** of September 25,canola cv IMC 205 reached DM yields(7746 kg ha^(-1)-9276 kg ha^(-1))similar to those obtained by oat(8115 kg ha^(-1)-9507 kg ha^(-1)),while canola cv Hyola 401 obtained such yields only until October *** chemical composition was better than that found in oat,with higher CP,but lower acid detergent fiber(ADF)and neutral detergent fiber(NDF)*** equaled oat CP yields(972 kg ha^(-1)-1215 kg ha^(-1))in the first sowing date,while in the other three other canola sowings reached higher yields(1193 kg ha^(-1)-1889 kg ha^(-1)).As for NEL yields,no difference was observed between both *** best sowing date for canola is from September 25 on,with CP production advantages over oat.

关键词： Avena sativa L. Brassica napus L.var.oleifera chemical composition dry matter yield nutrients

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Current and emerging therapies for alcohol-associated hepatitis

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Liver Research 2023年第1期7卷 35-46页

作者： Francisco Idalsoaga Gustavo Ayares Luis Antonio Díaz Jorge Arnold María Ayala-Valverde david Hudson Marco Arrese juan Pablo Arab Department of Gastroenterology School of MedicinePontificia Universidad Catolica de ChileSantiagoChile Internal Medicine Service Hospital El PinoCritical Patient UnitClinica DavilaSantiagoChile Division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonOntarioCanada Department of Epidemiology and Biostatistics Schulich School of MedicineWestern UniversityLondonOntarioCanada Alimentiv LondonOntarioCanada

Alcohol-related liver disease(ALD)encompasses a spectrum of diseases caused by excessive alcohol *** includes hepatic steatosis,steatohepatitis,variable degrees of fibrosis,cirrhosis,and alcohol-associated hepatitis(AH),the latter being the most severe acute form of the *** AH is associated with high mortality(reaching up to 30%e50%)at 90 *** cornerstone of ALD,and particularly AH,treatment continues to be abstinence,accompanied by support measures such as nutritional supplementation and management of alcohol withdrawal syndrome(AWS).In severe AH with model for end-stage liver disease(MELD)score21,corticosteroids can be used,especially MELD score between 25 and 39,where the highest benefit is *** key aspects of treatment include the early identification of infections and their associated management and the proper identification of potential candidates for liver *** development of new therapies based on the pathophysiology and mechanisms of liver injury are *** includes the modulation and management of the innate immune response,gut dysbiosis,bacterial translocation,and bacteria-derived products from the *** hold promise for the future of AH treatment.

关键词： Alcohol-associated hepatitis(AH) Alcohol-related liver disease(ALD) Alcohol use disorder(AUD) AUD treatment Nutritional therapy Steroids therapy Cirrhosis Fibrosis

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历经磨难奋发向上——大卫·科波菲尔的形象

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白城师范学院学报 2024年第4期38卷 42-45页

作者：郭鸣鹃游瑞娇漳州卫生职业学院通识教育学院福建漳州363005

大卫·科波菲尔是19世纪英国批判现实主义文学家狄更斯带有自传性质的长篇小说《大卫·科波菲尔》的主人公,小说描写了大卫苦难的童年生活,刻画了他善良正直乐于助人的性格特征,突显了他刻苦努力、拼搏进取、奋斗成才的可贵品质,描绘了... 详细信息

大卫·科波菲尔是19世纪英国批判现实主义文学家狄更斯带有自传性质的长篇小说《大卫·科波菲尔》的主人公,小说描写了大卫苦难的童年生活,刻画了他善良正直乐于助人的性格特征,突显了他刻苦努力、拼搏进取、奋斗成才的可贵品质,描绘了当时英国社会的现状,批判了金钱对婚姻、家庭和社会的腐蚀作用。大卫的形象堪称世界艺术宝库中的珍品,蕴含着深刻的审美价值和思想意义,揭示了有奋斗才会获得成功的人生哲理。

关键词：大卫·科波菲尔狄更斯人物形象

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Real World Evidence (RWE, Real World Data), of the Effectiveness of Amoxicillin-Clavulanate in the Treatment of Children with Upper Respiratory Tract Infections (Tonsillitis, Otitis, Sinusitis)

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Open Journal of Respiratory Diseases 2024年第3期14卷 77-89页

作者： Maria Gonzalez Yibirin juan Chirinos david Alberto Rincón Matute Trinidad Coll Miriam Rosales Yuliana Guevara Kuanlin Doried Guitens Pérez Mauribel Figueroa Rosalía Romero Jurgensen Andrea Rojas Gabriel Jesús Arismendi González Milagros Salcedo Marife Martina Marin Marcano Carolina Mendoza Marycarmen Anuel Maria Morao Raymond Aguilera Diego Ríos Maryenis Rodríguez Loren Sánchez Jennyfer Fernández Rafael González Zaidith Zerpa Nelson Rodríguez Mirluis Rojas Sixtaime Quijada Mariangel Moya Diego Orsini Chris Gómez Hector Gamero José Rodríguez Laboratorios LETI S.A.V. Guarenas Venezuela Ambulatorio Rural tipo II CPT3 Pampatar Venezuela Ambulatorio Los Robles CPT Dr. Luis Rosas Bravo Los Robles Venezuela Clnica Prevaler Pampatar Venezuela Hospital tipo 1 Dr. David Espinoza Rojas en Salamanca Salamanca Venezuela Centro Mdico Rotary El Valle Venezuela Ambulatorio Rural Tipo II CPT3 Dr. Enrique Albornoz Lares La Asuncin Venezuela

Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting from routine healthcare delivery. This study evaluates the clinical efficacy of amoxicillin + clavulanic acid in children with pharyngitis, acute otitis, or acute rhinosinusitis with suspected bacterial origin under normal office and home conditions. Methods: This was a real-life, prospective, observational, pharmacovigilance study. It included children of both sexes between 2 and 12 years old, with a diagnosis of Rhinopharyngitis (tonsillitis), Acute Otitis Media and Rhinosinusitis. The main effectiveness variable evaluated was reduction and time to resolution of symptoms. All patients received Amoxicillin/Clavulanic Acid suspension 600 mg/42.9 mg/5 mL at a dose of 90 mg/Kg/day in two doses, every 12 hours for 7 days. The evaluations were carried out at the beginning, at 72 hours (3rd day) and at 7 days. All patients underwent culture and antibiogram. Results: The majority of cultures were negative for pathogenic germs, suspecting unidentifiable germs, or viral etiology despite the rigorous selection of subjects following validated scores. The most frequently isolated germ was Staphylococcus aureus;growth of gram-negative bacteria was reported in 33.33% of the cultures. There was a significant improvement in symptoms in children with tonsillitis and rhinosinusitis from the first 72 hours of treatment, persisting until the 7 days. In the otitis media group, returning to normal by the tenth day. During the conduction of this investigation, no adverse effects associated with the prescribed therapy were reported.

关键词： Amoxicillin Clavulanic Acid Tonsillitis Otitis Sinusitis

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Functional divergence of oligoadenylate synthetase 1(OAS1)proteins in Tetrapods

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Science China(Life Sciences) 2022年第7期65卷 1395-1412页

作者： Xiaoxue Wang Jiaxiang Hu Linfei Song Enguang Rong Chenghuai Yang Xiaoyun Chen juan Pu Honglei Sun Chuze Gao david WBurt Jinhua Liu Ning Li Yinhua Huang State Key Laboratory for Agrobiotechnology College of Biology SciencesChina Agricultural UniversityBeijing 100193China China Institute of Veterinary Drug Control Beijing 100081China Key Laboratory of Animal Epidemiology and Zoonosis Ministry of AgricultureCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100083China University of Queensland St.LuciaBrisbaneQLD 4072Australia

OASs play critical roles in immune response against virus infection by polymerizing ATP into 2-5 As,which initiate the classical OAS/RNase L pathway and induce degradation of viral *** members are functionally diverged in four known innate immune pathways(OAS/RNase L,OASL/IRF7,OASL/RIG-I,and OASL/cGAS),but how they functionally diverged is ***,we focus on evolutionary patterns and explore the link between evolutionary processes and functional divergence of Tetrapod *** show that Palaeognathae and Primate OAS1 genes are conserved in genomic and protein structures but differ in *** former(i.e.,ostrich)efficiently synthesized long 2-5 A and activated RNase L,while the latter(i.e.,human)synthesized short 2-5 A and did not activate RNase *** predicted and verified that two in-frame indels and one positively selected site in the active site pocket contributed to the functional divergence of Palaeognathae and Primate ***,we discovered and validated that an in-frame indel in the C-terminus of Palaeognathae OAS1 affected the binding affinity of ds RNA and enzymatic activity,and contributed to the functional divergence of Palaeognathae OAS1 *** findings unravel the molecular mechanism for functional divergence and give insights into the emergence of novel functions in Tetrapod OAS1.

关键词： functional divergence OAS1 molecular evolution primate palaeognathae

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Intraoperative intracardiac thrombosis in a liver transplant patient

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World Journal of Hepatology 2010年第5期2卷 198-200页

作者： Lena Sibulesky Prith Peiris C Burcin Taner david J Kramer juan M Canabal Justin H Nguyen Department of Transplantation Division of Transplant SurgeryMayo ClinicJacksonvilleFL 32224United States Department of Anesthesiology Mayo ClinicJacksonvilleFL 32224United States Departments of Trans-plantation and Critical Care Mayo ClinicJacksonvilleFL32224United States

A 66-year-old female with cryptogenic cirrhosis complicated by ascites,hepatic encephalopathy,variceal bleeding and malnutrition with MELD of 34 underwent orthotopic deceased donor liver transplantation performed with piggyback *** eversion thromboendovenectomy was performed for a portal vein thrombus which resulted in an excellent portal vein *** liver graft was recirculated without any hemodynamic ***,the patient became hypotensive progressing to *** was resuscitated and a transesophageal probe was inserted which revealed a mobile right atrial thrombus and an underfilled poorly contractile right *** patient was noted to be coagulopathic at the *** became progressively more stable with a TEE showing complete resolution of the intracardiac thrombus.

关键词： Liver transplantation Cardiac thrombus Reperfusion injury Coagulopathy Transesophageal echocardiogram

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