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Outcomes following liver transplantation in intensive care unit patients

World Journal of Hepatology 2013年第1期5卷 26-32页

作者： Lena Sibulesky Michael G Heckman C Burcin Taner juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser david J Kramer Justin H Nguyen Department of Transplantation Mayo ClinicJacksonvilleFL 32225United States Biostatistics Unit Mayo ClinicJacksonvilleFL 32225United States Departments of Transplantation and Critical Care Medicine Mayo ClinicJacksonvilleFL 32225United States Department of Critical Care Medicine and Internal Medicine Aurora Health CareMilwaukeeWI 53204United States

AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient ***:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December ***:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and *** ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to ***-five ICU patients (64%) required dialysis *** 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU *** survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU *** formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable *** findings were consistent in multivariable *** not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (

关键词： Donor pool Donor outcomes Onor after cardiac death grafts Liver graft survival Patient survival

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Experimental culture of non-indigenous Juncus bufonius from King George Island, South Shetland Island, Antarctica

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Advances in Polar Science 2015年第1期26卷 24-29页

作者： Marely Cuba-Díaz Eduardo fuentes Mauricio Rondanelli-Reyes ángela Machuca Departamento Ciencias y Tecnología Vegetal Escuela Ciencias.y Tecnología Universidad de Concepción Campus Los ángeles Juan Antonio Coloma 0201Los ángeles Chile

Juncus bufonius L. （Juncaceae） is recognized by the US Department of Agriculture as a weed or invasive plant. Recently, we reported on 3i bufonius L. var. bufonius associated with the native vascular plants Deschampsia antarctica and Colobanthus quitensis in the environs of the Polish Arctowski Station, King George Island, in the Maritime Antarctica. In this study, we evaluated the developmental stages and morphological characteristics of J. bufonius plants cultivated in controlled conditions beginning with seeds obtained from plants of the Antarctic population. Germination occurred at 3 weeks and the germination percentage was low （22.5%）. The average time between the anthesis and seed formation was 7 weeks, similar to that reported for other species in the Juncaceae. According to data reported in the literature, Antarctic individuals were significantly smaller than their relatives growing in other conditions, except for the number of inflorescences. The morphological characteristics of a species vary according to its distribution and the edaphoclimatic environment where it occur; cosmopolitan plants shuch as J. bufonius also have reduced stature in cold environments. The low percentage germination may have been due to water availability in the plant chamber in which the study was conducted. J. bufonius is intolerant of dry environments, and once it suffers hydric stress its recovery is very low; thus, a moister environment could be beneficial. J. bufonius has become established amongst native vegetation near Arctowski Station and without careful control or eradication; it may have the potential to spread far beyond the site, as has happened with the alien grass Poa annua as human disturbance and climate warming increase.

关键词： Antarctica invasive plants Juncus bufonius (toad rush) non-native species regional warming

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LP-SVR Model Selection Using an Inexact Globalized Quasi-Newton Strategy

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Journal of Intelligent Learning Systems and Applications 2013年第1期5卷 19-28页

作者： Pablo Rivas-Perea juan Cota-Ruiz J. A. Perez Venzor david garcia Chaparro Jose-Gerardo Rosiles Department of Computer Science Baylor University Waco TX USA Department of Electrical and Computer Engineering Auto- nomous University of Ciudad Juarez Ciudad Juárez Mexico Science Applications International Corporation El Paso TX USA.

In this paper we study the problem of model selection for a linear programming-based support vector machine for regression. We propose generalized method that is based on a quasi-Newton method that uses a globalization strategy and an inexact computation of first order information. We explore the case of two-class, multi-class, and regression problems. Simulation results among standard datasets suggest that the algorithm achieves insignificant variability when measuring residual statistical properties.

关键词： Hyper-Parameter Estimation Support Vector Regression Machine Learning Data Mining

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网络药理学联合分子对接技术分析高良姜治疗抑郁症的可能机制

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广东医科大学学报 2024年第1期42卷 25-33页

作者：彭素娟冯真英陈丹王建文周中流广东医科大学附属第二医院广东湛江524001 岭南师范学院广东湛江524048

目的借助网络药理学联合分子对接技术探讨高良姜治疗抑郁症的作用机制。方法通过TCMSP数据库检索高良姜有效成分及靶点,使用GeneCards数据库获取抑郁症疾病靶点基因,利用STRING数据库和Cytoscape 3.9.1软件构建PPI网络图并获取蛋白互作... 详细信息

目的借助网络药理学联合分子对接技术探讨高良姜治疗抑郁症的作用机制。方法通过TCMSP数据库检索高良姜有效成分及靶点,使用GeneCards数据库获取抑郁症疾病靶点基因,利用STRING数据库和Cytoscape 3.9.1软件构建PPI网络图并获取蛋白互作关系,筛选出高良姜治疗抑郁症的核心靶点;借助david数据库对相交靶点进行GO功能分析以及KEGG通路富集分析,得到高良姜治疗抑郁症的潜在作用通路。结果筛选出高良姜13种活性成分和169个高良姜治疗抑郁症的潜在作用靶点,包括JUN、MAPK1、AKT1、RELA、ESR1、IL6、MAPK14、MAPK8、RXRA等核心靶点;GO功能解析得到654个生物相关过程、85个细胞组分及147个分子功能;KEGG富集解析获得171条相关通路,分子对接验证了核心靶点与高良姜主要成分具有较强结合力。结论高良姜可通过多个靶点、多条通路治疗抑郁症。

关键词：高良姜网络药理学分子对接抑郁症

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Heavy Metals Concentration in Sediments of South Brittany Waters, France: An Ecological Risk Assessment Approach

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Open Journal of Marine Science 2021年第1期11卷 55-68页

作者： Meng Chuan Ong Hui-juan Pan Noor Azhar Mohamed Shazili david Menier Virginie Dupont Sidonie Révillon Alexandra Connell Faculty of Science and Marine Environment Universiti Malaysia Terengganu Kuala Nerus Terengganu Malaysia Institute of Oceanography and Environment Universiti Malaysia Terengganu Kuala Nerus Terengganu Malaysia Ocean Pollution and Ecotoxicology (OPEC) Research Group Universiti Malaysia Terengganu Kuala Nerus Terengganu Malaysia Institute of Earth Sciences College of Ocean Science and Resource National Taiwan Ocean University Chinese Taipei Center of Excellence for Ocean Engineering College of Engineering National Taiwan Ocean University Chinese Taipei Laboratoire Géosciences Océan (LGO) Université Bretagne Sud Vannes France Département Sciences de la Matière et de la Vie Université Bretagne Sud Vannes France UMR 6538 Laboratoire Géosciences Océan Institut Universitaire Européen de la Mer Place Nicolas Copernic Plouzané France SEDISOR Institut Universitaire Européen de la Mer Place Nicolas Copernic Plouzané France Université de Bordeaux—UMR CNRS 5805 EPOC Pessac France

Distribution patterns of selected heavy metals content in sediments from the Bay of Quiberon and Gulf of Morbihan were studied to understand the current heavy metals contamination due to urbanization and mariculture activities in the coastal area. Therefore, a survey was conducted and 196 sediments collected were characterized for heavy metals content using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) after mix acid digestion process. The distribution maps of the concentrations of the heavy metals studied were produced as an isopleth map based on data interpolation by the ArcGIS software application. The association with the adverse effects on aquatic organisms was determined by the classification of the sediment according to the sediment quality guidelines. Therefore, two approaches were employed namely: direct comparison with Sediment Quality Guidelines (SQGs) by USEPA (United States Environmental Protection Agency) and comparison with other numerical SQGs, threshold effect level/probable effect level, and effect range low/effect range medium. In order to estimate the effect of multiple contaminations of heavy metals, the mean-ERM-quotient was calculated at each sampling point.

关键词： Heavy Metals Bay of Quiberon Gulf of Morbihan Sediment Sediment Quality Guidelines

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低磷酸盐血症的原因和后果

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国际外科学杂志 1982年第3期09卷 137-140页

作者： david juan 李玉珠

30年代后期,曾有报告低磷酸盐血症性维生素D 耐药的软骨病。1945年 Franks 等强调了磷在糖尿病性酮症酸中毒替代治疗中的重要性。1968年 Lotz 等命名了缺磷综合征,其特征有低磷酸盐血症、骨痛和肌肉软弱无力,由于大量摄入氢氧化铝所致。... 详细信息

30年代后期,曾有报告低磷酸盐血症性维生素D 耐药的软骨病。1945年 Franks 等强调了磷在糖尿病性酮症酸中毒替代治疗中的重要性。1968年 Lotz 等命名了缺磷综合征,其特征有低磷酸盐血症、骨痛和肌肉软弱无力,由于大量摄入氢氧化铝所致。Gilbert

关键词：低磷酸盐血缺磷维生素糖尿病性细胞内甲状旁腺机能亢进甲旁亢甲状旁腺疾病血清磷

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Evaluation of Two Highly Porous Microcrystalline Biphasic Calcium Phosphate-Based Bone Grafts for Bone Regeneration: An Experimental Study in Rabbits

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Journal of Materials Science and Chemical Engineering 2020年第6期8卷 8-30页

作者： Miguel Ángel garcés-Villalá Sergio david Rico Sergio Gustavo Nazar Mariano Escudero-Pinel Víctor Galván-Josa José Luis Calvo-Guirado Department of Implant and Biomaterial Research Fundación Corazón de Jesús San Juan Argentina Facultad de Matemática Astronomía y Física Universidad Nacional de Córdoba Córdoba Argentina Department of Oral Surgery and Implant Dentistry Faculty of Health Sciences Universidad Católica San Antonio de Murcia Murcia Spain

A biphasic bone grafting biomaterial based on a mixture of calcium phosphates and beta-tricalcium phosphate (β-TCP) phases with high nanoporosity was synthesized. The synthesis route was based on calcium phosphate composition and the incorporation of glycolic acid as a pore former, giving a material composed of 97% β-TCP and 3% calcium orthophosphates (CaPO4). An in vitro study of the purity, microstructure, crystalline domain, and pores size for the material obtained was performed by SEM analysis as well as full structural characterization. The region of interest related to the surface was determined by the specific surface area measured with the BET method. In vivo evaluation of bone response was performed by implanting the new low-cost biphasic manufacturing material synthesized in this work, which was compared with a biphasic material of similar chemical and microstructural composition existing in the commercial market and with higher cost called Synergy Odontit® β-TCP. The materials were implanted separately into 5 mm diameter defects in the tibias of New Zealand White rabbits at 30, 60, and 90 days. The results obtained showed that the host tissue well accepted the new biphasic material;the presence of new bone formation was observed. A more complete resorption was observed for the new microcrystalline biphasic material compared to for a commercial β-TCP material.

关键词： Microcrystalline Beta-Tricalcium Phosphate Ceramic Bone Graft Glycolic Acid

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飞行物体对微波链路遮挡效应的角谱法分析(邀请)

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光学技术 2019年第1期45卷 1-5页

作者：黄德丰匡瑛刘娟 Department of Electrical Electronic and Computer Engineering The University of Western Australia 北京理工大学光电学院北京100081

利用包括低轨卫星星座及同步轨道卫星等无线通信空中平台所发出的微波信号,提出一种基于飞行物体对微波的遮挡效应进行飞行物体监测的方法。如何定量分析遮挡效应是这种新方法需要解决的一个关键问题。由于微波衍射和光衍射本质上是相同... 详细信息

利用包括低轨卫星星座及同步轨道卫星等无线通信空中平台所发出的微波信号,提出一种基于飞行物体对微波的遮挡效应进行飞行物体监测的方法。如何定量分析遮挡效应是这种新方法需要解决的一个关键问题。由于微波衍射和光衍射本质上是相同的,提出利用光学分析的方法来解决这一问题。通过将整个微波链路系统用一个简化的光学系统来描述,用角谱法计算并分析了飞行物体相对于微波传播路线的移动速度、飞行物体高度等参数对接收机接收的微波强度的影响,为进一步研究这种新的监测方法奠定了基础。

关键词：角谱法低轨卫星通信衍射地球同步轨道卫星飞行物体的检测、识别和跟踪

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基于网络药理学、分子对接和实验验证探讨加味活络效灵丹干预结直肠癌的作用机制

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中国中药杂志 2024年第13期49卷 3657-3667页

作者：江威赵秋萍黄琳姜家旺李明莉陈小春徐燕王国娟邓兰张磊昌李志明江西中医药大学临床医学院江西南昌330004 江西中医药大学附属医院江西南昌330019 上海中医药大学附属龙华医院上海200032

借助网络药理学和分子对接预测加味活络效灵丹抗结直肠癌(colorectal cancer,CRC)可能的作用靶点及相关信号通路,并通过实验验证。采用中药系统药理学数据库与分析平台(TCMSP)获取加味活络效灵丹的活性成分及靶点,利用GeneCards、DrugB... 详细信息

借助网络药理学和分子对接预测加味活络效灵丹抗结直肠癌(colorectal cancer,CRC)可能的作用靶点及相关信号通路,并通过实验验证。采用中药系统药理学数据库与分析平台(TCMSP)获取加味活络效灵丹的活性成分及靶点,利用GeneCards、DrugBank、OMIM、TTD数据库获取CRC的相关靶点,Cytoscape软件构建药物-活性成分-靶点网络,STRING数据库构建蛋白-蛋白互作(PPI)网络,david平台对靶点进行基因本体论(Gene Ontology,GO)功能和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,AutoDock Vina进行分子对接。设置不同浓度加味活络效灵丹含药血清组分别处理HCT 116细胞,利用cell counting kit-8(CCK-8)检测各组HCT 116细胞增殖抑制情况,Transwell检测HCT 116细胞侵袭能力,蛋白免疫印迹法(Western blot)检测β-连环蛋白(β-catenin)、细胞周期蛋白D1(cyclinD1)、V-Myc骨髓细胞瘤病毒癌基因同源物(c-Myc),以及上皮间质转化(EMT)标志蛋白E-钙黏蛋白(E-cadherin)、N-钙黏蛋白(N-cadherin)、波形蛋白(vimentin)、基质金属蛋白酶2(MMP2)、基质金属蛋白酶7(MMP7)、基质金属蛋白酶9(MMP9)、转录因子TWIST的表达水平。网络药理学分析,得到加味活络效灵丹活性成分242个,CRC靶点1844个,CRC与加味活络效灵丹交集靶点127个,与CRC相关的信号通路涉及PI3K-Akt、TNF、HIF-1、IL-17、Wnt等。分子对接显示,主要活性成分与核心蛋白有较稳定的结合构象。CCK-8检测显示,加味活络效灵丹能显著抑制HCT 116细胞的增殖;Transwell检测显示,随着加味活络效灵丹含药血清浓度的增加,抑制HCT 116细胞的侵袭能力越明显;经含药血清处理后,β-catenin、cyclinD1、c-Myc、N-cadherin、vimentin、MMP2、MMP7、MMP9和TWIST蛋白表达受抑制,E-cadherin表达上调。结果表明,加味活络效灵丹通过多成分、多靶点、多途径抑制结直肠癌细胞的增殖、侵袭和转移,其机制可能与抑制Wnt/β-catenin信号通路激活,从而影响EMT的发生有关。

关键词：加味活络效灵丹结直肠癌网络药理学分子对接细胞实验上皮间质转化

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International Journal of Clinical Medicine 2013年第12期4卷 1-4页

作者： david Saez Martinez Felipe Lopez Oliva Maria Jesus Fernandez Acenero Elena Fontoira Moyer juan Luis Arranz Cozar Ortrhopedic Surgery Department Fundacion Jimenez DiazMadridSpain Pathology Department Fundacion Jimenez DiazMad-ridSpain Radiology Department Fundacion Jimenez DiazMadridSpain Oncology Department Fundacion Jimenez DiazMad-ridSpain

Background: IgG4-related disease is a systemic lymphoproliferative syndrome that shows IgG4-producing plasma cell expansion in affected organs with fibrotic or sclerotic changes. The lacrimal glands, salivary glands and pancreas are typically affected. We report a case of IgG4-related disease presenting a soft tissue tumor affecting skeletal muscle. Case Report: A 32-year-old man presented a soft tissue mass in his left arm. Magnetic resonance imaging revealed a spindle like, peripheral mass, in the lateral head of the triceps of his left arm. Tru-Cut Biopsy provided the diagnosis of IgG4-related disease affecting skeletal muscle. Glucocorticoid treatment was effective. Conclusion: To our knowledge, this is the first reported case of IgG4-related disease affecting skeletal muscle and presenting a soft tissue mass.

关键词： IgG4-Related Disease Soft Tissue Mass Skeletal Muscle

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