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Fixed Dose combination of Magaldrate Plus Domperidone Is More Effective than Domperidone Alone in the Treatment of Patients with Gastroesophageal Reflux Symptoms: A Randomized Double-Blind Study

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Pharmacology & Pharmacy 2014年第2期5卷 216-223页

作者： Shendel nyx rodríguez-Sánchez Héctor Isaac Rocha-González cecilia Fernández del Valle-Laisequilla juan rodríguez-Silverio Francisco Javier Flores-Murrieta juan Gerardo Reyes-García Productos Medix S.A. de C.V. México City Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina del Instituto Politécnico Nacional Mexico City Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina del Instituto Politécnico Nacional Mexico City Mexico Instituto nacional de Enfermedades Respiratorias Secretaría de Salud Mexico City Mexico

Gastroeophageal reflux is a condition in which the acidified liquid content of the stomach backs up into the esophagus. The antiacid magaldrate and prokinetic domperidone are two drugs clinically used for the treatment of gastroesophageal reflux symptoms. However, the evidence of a superior effectiveness of this combination in comparison with individual drugs is lacking. A double-blind, randomized and comparative clinical trial study was designed to characterize the efficacy and safety of a fixed dose combination of magaldrate (800 mg)/domperidone (10 mg) against domperidone alone (10 mg), in patients with gastroesophageal reflux symptoms. One hundred patients with gastroesophageal reflux diagnosed by carlsson scale were randomized to receive a chewable tablet of a fixed dose of magaldrate/domperidone combination or domperidone alone four times each day during a month. Magaldrate/domperidone combination showed a superior efficacy to decrease global esophageal (pyrosis, regurgitation, dysphagia, hiccup, gastroparesis, sialorrhea, globus pharyngeus and nausea) and extraesophageal (chronic cough, hoarseness, asthmatiform syndrome, laryngitis, pharyngitis, halitosis and chest pain) reflux symptoms than domperidone alone. In addition, magaldrate/domperidone combination improved in a statistically manner the quality of life of patients with gastroesophageal reflux respect to monotherapy, and more patients perceived the combination as a better treatment. Both treatments were well tolerated. Data suggest that oral magaldrate/domperidone mixture could be a better option in the treatment of gastroesophageal reflux symptoms than only domperidone.

关键词： Antiacid Domperidone Gastroesophageal Reflux Magaldrate Prokinetic

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cOMPLEX SYSTEMS In SPORTS:InTRODUcTIOn TO THE SPEcIAL ISSUE

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Journal of Systems Science & complexity 2013年第1期26卷 1-3页

作者： MERELO juan Julin MORA Antonio M cOTTA carlos Depto.ATc CITICUniversidad de Granada Depto.Lcc Universidad de Malaga

1 complex Systems in Sports Sport is one of the most important activities of *** relevance goes beyond the physical/psychological benefits that their practicing provides(an aspect that justifies in itself its importance in our current society).In fact,be it as actually playing some sport or just watching some games,it provides a huge means for socialization and *** to say,the economical viewpoint is also enormously relevant:events such as the Olympic Games。

关键词：复杂系统运动教育手段社会化

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Flexible foraging decisions made by workers of the social wasp Vespula germanica (Hymenoptera: Vespidae) in response to different resources: influence of ontogenetic shifts and colony feedback

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Insect Science 2022年第2期29卷 581-594页

作者： Analía Mattiacci MaitéMasciocchi juan c.corley Grupo de Ecología de Poblaciones de Insectos IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ecología Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina

Decisions made by foraging animals conform a complex process based on the integration of information from multiple external environmental stimuli and internal physiological signals,which in turn are modulated by individual experience and a detection threshold of each *** social insects in which foraging is limited to given age subcastes,individual foraging decisions may also be affected by ontogenetic shifts and colony *** studied the short-term changes in foraging preferences of the generalist wasp Vespula germanica,focusing on whether the individual response to different resources could be influenced by the ontogenetic shifts and/or by social interaction with *** carried both laboratory and field experiments to confront worker wasps to a short-term resource switch between either protein or carbohydrate-based *** tested the response of(1)Preforager workers(no foraging experience nor interaction with other wasps),(2)Forager workers(experience in foraging and no colony feedback),and(3)Wild forager workers(foraging naturally and exposed to free interactions with nestmates).We evaluated the maxilla-labium extension response(MaLER)for laboratory assays or the landing response for field *** observed that for wasps deprived of colony feedback(either preforagers or foragers),the protein-rich foods acceptance threshold increased(and thus a lower level of foraging on that item was observed)if they had foraged on carbohydrates previously,whereas carbohydrates were accepted in all ***,wasps immersed in a natural foraging context did accept protein foods regardless of their first foraging experience and reduced the carbohydrates collected when trained on protein *** provide evidence that short-term changes in foraging preferences depend on the type of resource foraged and on the social interactions,but not on ontogenetic shifts.

关键词： German wasp invasive species plastic insect behavior response thresholds modulation social insect yellowjackets

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Suitability of open-field autorefractors as pupillometers and instrument design effects

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 567-572页

作者： carles Otero Mikel Aldaba Oriol Ferrer Andrea Gascón juan c Ondategui-Parra Jaume Pujol Davalor Research center Technical University of Catalonia

AIM：To determine the agreement and repeatability of the pupil measurement obtained with VIP-200（neuroptics）,Power Ref II（Plusoptix）,WAM-5500（Grand Seiko） and study the effects of instrument design on ***：Forty patients were measured twice in low,mid and high *** was analyzed with the within-subject standard deviation（Sw） and paired *** was studied with Bland-Altman plots and repeated measures *** design analysis consisted on measuring pupil size with Power Ref II simulating monocular and binocular conditions as well as with proximity cues and without proximity ***：The mean difference（±standard deviation） between test-retest for low,mid and high mesopic conditions were,respectively：-0.09（±0.16）,-0.05（±0.18） and-0.08（±0.23） mm for neuroptics,-0.05（±0.17）,-0.12（±0.23） and-0.17（±0.34） mm for WAM-5500,-0.04（±0.27）,-0.13（±0.37） and-0.11（±0.28） mm for Power Ref *** agreement with neuroptics,the mean difference for low,mid and high mesopic conditions were,respectively：-0.48（±0.35）,-0.83（±0.52） and-0.38（±0.56） mm for WAM-5500,-0.28（±0.56）,-0.70（±0.55） and-0.61（±0.54） mm for Power Ref *** mean difference of binocular minus monocular pupil measurements was：-0.83（±0.87） mm;and with proximity cues minus without proximity cues was：-0.30（±0.77） ***：All the instruments show similar *** all illumination conditions,agreement of neuroptics with WAM-5500 and Power Ref II is not good enough,which can be partially induced due to their open field design.

关键词： pupil repeatability agreement open-field

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大中小学思政课区域一体化的价值意蕴、驱动要素与推进策略

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东北师大学报（哲学社会科学版） 2025年第1期 10-18页

作者：李爱琴师海娟东北林业大学马克思主义学院黑龙江哈尔滨150040

大中小学思政课区域一体化是大中小学思政课一体化的重要组成部分和重点建设方向,其核心要义在于区域教育主体突破学段和校际壁垒,以共同体成员的协作互动促进思想政治教育资源在区域间的有序流动和优化配置,实现大中小学思政课区域一... 详细信息

大中小学思政课区域一体化是大中小学思政课一体化的重要组成部分和重点建设方向,其核心要义在于区域教育主体突破学段和校际壁垒,以共同体成员的协作互动促进思想政治教育资源在区域间的有序流动和优化配置,实现大中小学思政课区域一体化的整体内涵式发展。新时代持续推进大中小学思政课区域一体化走深走实,可广泛凝聚区域多主体人才协同共培的价值共识,形成多模态纵横连贯式的区域教育网络生态系统,全面提升大中小学思想政治教育区域一体化的建设质量。学校思想政治教育政策要求、新时代思政课改革创新发展诉求和学生个人成长发展需求对大中小学思政课区域一体化具有正向驱动作用,牵动着大中小学思政课区域一体化建设的“时”和“序”、“质”和“量”、“道”和“术”。深化大中小学思政课区域一体化建设,要健全常态长效运行机制,畅通区域管理行动经络;补足协同推进短板弱项,统筹区域格局协调发展;建立多元主题合作网络,深化区域合作互联互通;优化教育资源服务供给,实现区域资源无界共享。

关键词：大中小学思政课区域一体化立德树人思想政治教育

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Specific cD8^+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis

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World Journal of Gastroenterology 2016年第28期22卷 6469-6483页

作者： Elia Moreno-cubero juan-Ramón Larrubia Translational Hepatology Unit Guadalajara University Hospital University of Alcalá Department of Biology of Systems University of Alcalá Department of Medicine and Medical Specialties University of Alcalá

Hepatocellular carcinoma (Hcc), chronic hepatitis B (cHB) and chronic hepatitis c (cHc) are characterized by exhaustion of the specific cD8+ T cell response. This process involves enhancement of negative co-stimulatory molecules, such as programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen-4 (cTLA-4), 2B4, Tim-3, cD160 and LAG-3, which is linked to intrahepatic overexpression of some of the cognate ligands, such as PD-L1, on antigen presenting cells and thereby favouring a tolerogenic environment. Therapies that disrupt these negative signalling mechanisms represent promising therapeutic tools with the potential to restore reactivity of the specific cD8+ T cell response. In this review we discuss the impressive in vitro and in vivo results that have been recently achieved in Hcc, cHB and cHc by blocking these negative receptors with monoclonal antibodies against these immune checkpoint modulators. The article mainly focuses on the role of cTLA-4 and PD-1 blocking monoclonal antibodies, the first ones to have reached clinical practice. The humanized monoclonal antibodies against cTLA-4 (tremelimumab and ipilimumab) and PD-1 (nivolumab and pembrolizumab) have yielded good results in testing of Hcc and chronic viral hepatitis patients. Trelimumab, in particular, has shown a significant increase in the time to progression in Hcc, while nivolumab has shown a remarkable effect on hepatitis c viral load reduction. The research on the role of ipilimumab, nivolumab and pembrolizumab on Hcc is currently underway.

关键词： Hepatocellular carcinoma cD8+ T cells Immune checkpoint modulation chronic viral hepatitis cytotoxic T-lymphocyte antigen-4 Programmed cell death protein-1

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Latest developments in early diagnosis and specific treatment of severe influenza infection

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Journal of Intensive Medicine 2024年第2期4卷 160-174页

作者： Francisco Valenzuela-Sánchez Blanca Valenzuela-Méndez juan Francisco rodríguez-Gutiérrez Ángel Estella Intensive care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain centro de Investigación Biomédica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncological Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biomédica de cádiz(InIBicA) Avenida Ana de Viya 21CádizSpain

Influenza pandemics are unpredictable recurrent events with global health,economic,and social *** objective of this review is to provide an update on the latest developments in early diagnosis and specific treatment of the disease and its complications,particularly with regard to respiratory organ *** advances in treatment,the rate of mortality in the intensive care unit remains approximately 30%.Therefore,early identification of potentially severe viral pneumonia is extremely important to optimize treatment in these *** pathogenesis of influenza virus infection depends on viral virulence and host ***,in some patients,it is associated with an excessive systemic response mediated by an authentic cytokine *** process leads to severe primary pneumonia and acute respiratory distress *** prognostication in the emergency department based on comorbidities,vital signs,and biomarkers(e.g.,procalcitonin,ferritin,human leukocyte antigen-DR,mid-regional proadrenomedullin,and lactate)is *** of these biomarkers on admission may facilitate clinical decision-making to determine early admission to the hospital or the intensive care *** decisions are reached considering pathophysiological circumstances that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflammation,immune paralysis,severe endothelial damage,organ dysfunction,and septic shock).Moreover,early implementation is important to increase treatment *** on a limited level of evidence,all current guidelines recommend using oseltamivir in this *** possibility of drug resistance should also be *** options include other antiviral drugs and combination therapies with monoclonal ***,it is not recommended to use corticosteroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pandemic Respiratory failure Acute respiratory distress syndrome Intensive care unit admission

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Molecular epidemiology and putative origin of hepatitis c virus in random volunteers from Argentina

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World Journal of Gastroenterology 2013年第35期19卷 5813-5827页

作者： noemí del Pino José Raúl Oubia Francisco rodríguez-Frías juan Ignacio Esteban María Buti Teresa Otero Josep Gregori Damir García-cehic Silvia camos María cubero Rosario casillas Jaume Guàrdia Rafael Esteban Josep Quer Apunlab Laboratories Institute of Medical Microbiology and Parasitology (IMPAM) UBA-cOnIcET Department of MicrobiologyParasitology and Immunology Faculty of Medicine University of Buenos Aires cIBER de Enfermedades Hepáticas y Digestivas (cIBERehd) del Instituto de Salud carlos Ⅲ and Biochemistry Department Hospital Universitari Vall d’Hebrón (HUVH) cIBERehd del Instituto de Salud carlos Ⅲ Autonomous University of Barcelona and Liver Unit Internal Medicine Lab. Malalties Hepatiques Vall d’Hebron Institut de Recerca (VHIR) Hospital Universitari Vall d’Hebrón (HUVH) Unitat de Diagnostic Molecular HUVH Liver Unit Internal Medicine Lab Malalties Hepatiques VHIR-HUVH Roche Diagnostics SL cIBERehd del Instituto de Salud carlos Ⅲ Liver Unit Internal Medicine Lab MalaltiesHepatiques VHIR-HUVH Liver Unit and Biochemistry Department HUVH

AIM:To study the subtype prevalence and the phylogenetic relatedness of hepatitis c virus(HcV)sequences obtained from the Argentine general population,a large cohort of individuals was ***:Healthy Argentinian volunteers(n=6251)from 12 provinces representing all geographical regions of the country were *** parents or legal guardians of individuals younger than 18 years provided informed written consent for *** corresponding written permission from all municipal authorities was obtained from each city or town where subjects were to be *** RnA reverse transcription-polymerase chain reaction products were sequenced and phylogenetically *** 5’untranslated region(5’UTR)was used for RnA detection and initial genotype *** nS5B polymerase region,encompassing nt 8262-8610,was used for ***:An unexpectedly low prevalence of HcV infection in the general population(0.32%)was *** data contrasted with previous studies that reported rates ranging from 1.5%to 2.5%,mainly performed in selected populations of blood donors or vulnerable *** latter values are in keeping with the prevalence reported by the 2007 Argentinian HcV consensus(approximately 2%).HcV subtypes weredistributed as follows:1a(25%),1b(25%),2c(25%),3a(5%),and 2j(5%).Two isolates ascribed either to genotype 1(5%)or to genotype 3(5%)by 5’UTR phylogenetic analysis could not be *** 1a sequences comprised a highly homogeneous population and clustered with United States ***1b sequences represented a heterogeneous population,suggesting that this genotype might have been introduced from different *** subtype 2c sequences clustered close to the 2c reported from Italy and Southern ***:HcV has a low prevalence of 0.32%in the studied general population of *** pattern of HcV introduction and transmission in Argentina appears to be a consequence of multiple events and different

关键词： Hepatitis c virus nS5B subtyping Molecular epidemiology Hepatitis c virus Argentina Hepatitis c virus 5’ untranslated region

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Hexavalent chromium Removal by citrus limonium Shell

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Open Journal of Inorganic non 2012年第3期2卷 19-24页

作者： juan Manuel Vargas-Morales Diana Bautista-Mata juan F. cárdenas-González Víctor Manuel Martínez-Juárez Ismael Acosta-rodríguez área Académica de Medicina Veterinaria y Zootecnia Instituto de Ciencias AgropecuariasUniversidad Autónoma del Estado de Hidalgo Tulancingo de Bravo México Laboratorio de Micología Experimental Centro de Investigación y de Estudios de Posgrado Facultad de Ciencias Químicas Universidad Autónoma de San Luis Potosí San Luis Potosí México

We studied the chromium(VI) removal capacity in aqueous solution by the lemon shell, using the diphenylcarbazide method to evaluate the metal concentration. So, the highest biosorption of the metal (50 mg/L) occurs within 100 minutes, at pH of 1.0, and 28°c. According to temperature, the highest removal was observed at 60°c, in 11 minutes, when the metal (1 g/L) is completely adsorbed. At the analyzed concentrations of cr(VI), lemon shell, showed excellent removal capacity, besides it removes efficiently the metal in situ (97.2% removal, 7 days of incubation, 5 g of biomass). After 1 hour of incubation the studied biomass reduces 1.0 g of cr(VI) with the simultaneous production of cr(III);so it can be used to eliminate it from industrial wastewater.

关键词： chromium(VI) Biosorption Remotion Biomass chromium(III)

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Feedback control for Ecosystem Management:The case of Wolf-Elk-Hunting Dynamics in the US Mountain West

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Journal of Mountain Science 2014年第4期11卷 850-865页

作者： Kevin MAcKSAMIE Jeffrey WAGnER juan c.cOcKBURn Black River Systems company Inc. 162 Genesee Street Utica New York 13507 USA Department of Economics Rochester Institute of Technology 92 Lomb Memorial Drive Rochester NY 14623 USA Department of computer Engineering Rochester Institute of Technology 83 Lomb Memorial Drive Rochester NY 14623USA

The purpose of this paper is to explore the promise of utilizing some relatively new feedback control techniques in ecosystem management. First, we set forth a basic ecological-economic model of a predator-prey-hunting system in which both the predator and prey have use(flow) and non-use(stock) value and when the predator can inflict transboundary damages. We then use new data from the US Mountain West to show how a particular feedback approach—linear parameter-varying(LPV) control—can be utilized in this context. Our LPV model is able to quantify the cost of managing disturbances that inevitably arise as a manager tries to keep the actual path of the system "close" to its optimum. The results suggest management strategies in mountain ecosystems that feature large, mammalian carnivores.

关键词： Feedback control Linear parameter Optimal vontrol Robust control Predator-prey Recreational hunting

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