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Serum Glypican 4 Levels Are Associated with Metabolic Syndrome in a Han Population from Guizhou Province, China

Biomedical and Environmental Sciences 2019年第5期32卷 383-388页

作者： NING Dong Ping XU Ke ZHU Hui juan SHAN Guang Liang WANG ding Ming PING Bo YU Yang Wen PAN Hui GONG Feng ying Key Laboratory of Endocrinology of National Health Commission Dept. of EndocrinologyPeking Union Medical College HospitalTranslation Medicine CentreCAMS & PUMCBeijing 100730China Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Linfen Central Hospital Linfen 041000ShanxiChina Dept. of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityZhejiang Provincial First Hospital of WenzhouWenzhou 325000ZhejiangChina Dept. of Epidemiology and Health Statistics Institute of Basic Medical SciencesCAMS & PUMCBeijing 100005China Guizhou Provincial Center for Disease Control and Prevention Guiyang 550004GuizhouChina Longli Center for Disease Control and Prevention Longli 551200GuizhouChina

Metabolic syndrome (MetS) is the presence of a battery of cardiovascular risk factors including abdominal obesity, hypertension, dyslipidemia, and disturbed carbohydrate metabolism[1]. MetS affects 20% of adults in the Western world and 33% of adults in China[2] and has become a serious public health problem worldwide. However, the mechanism underlying the occurrence and progression of MetS is still largely unclear. It is now well established that excess fat deposition leads to abdominal obesity, which plays a vital role in the underlying mechanism. Adipose tissue can function as an endocrine organ that secretes various adipokines. The dysregulated expression of adipokines caused by excess adiposity and adipocyte dysfunction, has been linked to the pathogenesis of MetS[3]. Some serum adipokines such as leptin, adiponectin, interleukin 6 (IL-6), and tumour necrosis factor-α(TNF-α), might be potential markers for MetS development.

关键词： Serum Glypican 4 Levels Metabolic Syndrome

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Controlled Synthesis of NaV_6O_(15) Nanorods with High Reversible Capacity and Excellent Cycling Stability

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Journal of Materials Science & Technology 2017年第3期33卷 271-275页

作者： Taotao ding juan Xu Cheng Chen Zhongwei Luo Jiangnan Dai Yu Tian Changqing Chen Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology School of Physics and Information Engineering Jianghan University

In this work, we demonstrate an effective method to improve capacitive performance of NaV6O（15） intrinsically by annealing. NaV6O（15） nanorods（NRs） prepared by a simple annealing treatment exhibit significantly improved electrochemical performance compared with the untreated NaV6O（15） electrode, and yield a high specific capacitance（402.8 F/g at 300 mA/g）. Furthermore, the annealing treated nanorods show excellent rate capability and cycling stability（ca. 80% capacitance retention after 1000 cycles at a scan rate of100 mV/s）. Our results have confirmed that the annealing treatment has great influence on the capacitive performance of NaV6O（15）, which may be attributed to the intrinsic three dimensional（3D） tunneled structures of NaV6O（15）, and NR morphology. These findings may further broaden the application of NaV6O（15）-based materials for high performance supercapacitors（SCs）, aqueous rechargeable lithium batteries and Li-ion capacitors.

关键词： NaV6O(15) Nanobelt Nanorod Supercapacitor

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Advance of swainsonine biosynthesis

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Chinese Chemical Letters 2018年第3期29卷 417-422页

作者： Xiang-mei Tan Amanda juan Chen Bin WU Gui-Shan Zhang Gang ding Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China Key Laboratory of Microbial Resources Coltection and Preservation Ministry of Agriculture Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China

Swainsonine （1） belongs to the family of indolizine alkaloid with strong neurologically toxic effects on herbivorous livestock. Recently, a great amount of evidence confirmed that this alkaloid displayed a wide range of bioactivities especially anti-cancer biological effects. The potential targets of swainsonine （1） were now revealed to be the mannosidase and Golgi mannosidase 1I. Its low yield in plants or fungi, and no economically total synthesis route in practice as the key bottleneck restricted its further structure- activities relationships （SAR） investigation in drug discovery. This mini-review highlighted the biosynthetic advance of swainsonine （1） from 1973 to 2017 based on the results of isotope-labelled experiments and the recent research of its biosynthetic gene cluster, which could provide some thoughts for further biosynthetic investigation and efficiently biomimetic synthesis of swainsonine （1） in order to increase its output in practice.

关键词： Swainsonine Indolizine Biosynthesis Isotope-labeled Gene Cluster

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Missense mutation in DYNC1H1 gene caused psychomotor developmental delay and muscle weakness:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9302-9309页

作者： Feng-juan ding Gui-Zhen Lyu Victor Wei Zhang Hua Jin Prenatal Diagnosis Center Jinan Maternal and Child Health HospitalJinan 250001Shandong ProvinceChina AmCare Genomics lab(Guangzhou) Guangzhou 510300Guangdong ProvinceChina Department of Human and Molecular Genetics Baylor College of MedicineHoustonTX 77001United States

BACKGROUND The DYNC1H1 gene encodes a part of the dynamic protein,and the protein mutations may further affect the growth and development of neurons,resulting in degeneration of anterior horn cells of the spinal cord,and a variety of clinical phenotypes finally resulting in axonal Charcot-Marie-Tooth disease type 20(CMT20),mental retardation 13(MRD13)and spinal muscular atrophy with lower extremity predominant 1(SMA-LED).The incidence of the disease is low,and it is difficult to diagnose,especially in ***,we report a case of DYNC1H1 gene mutation and review the related literature to improve the pediatrician’s understanding of DYNC1H1 gene-related disease to make an early correct diagnosis and provide better services for *** SUMMARY A 4-mo-old Chinese female child with adducted thumbs,high arch feet,and epileptic seizure presented slow response,delayed development,and low limb muscle *** showed abnormal waves,a large number of multifocal sharp waves,sharp slow waves,and multiple spasms with a series of ***-throughput sequencing and Sanger sequencing identified a heterozygous mutation,c.5885 G>A(p.R1962H),in the DYNC1H1 gene(NM 001376)of the proband,which was not identified in her *** with the clinical manifestations and pedigree of this family,this mutation is likely pathogenic based on the American Academy of Medical Genetics and Genomics *** child was followed when she was 1 year and 2 mo *** magnetic resonance imaging result was consistent with the findings of white matter myelinated dysplasia and congenital giant *** extensive neurogenic damage to the extremities was considered,as the results of electromyography showed that the motor conduction velocity and sensory conduction of the nerves of the extremities were not abnormal,and the degree of fit of the children with severe contraction was *** present,the child is 80 cm in length and 9 kg in weight,with slender limbs and

关键词： DYNC1H1 Mental retardation Muscle weakness Medical exome sequencing Case report

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High-performance polarization-sensitive photodetector based on a few-layered PdSe2 nanosheet

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Nano Research 2020年第6期13卷 1780-1786页

作者： Jiahong Zhong juan Yu Lingkai Cao Cheng Zeng Junnan ding Chunxiao Cong Zongwen Liu Yanping Liu School of Physics and Electronics Hunan Key Laboratory for Super-microstructure and Ultrafast ProcessCentral South UniversityChangsha410083China School of Electronics and Information Hangzhou Dianzi UniversityHangzhou310018China School of Information Science and Technology Fudan UniversityShanghai200433China School of Chemical and Biomolecular Engineering The University of SydneySydneyNSW2006Australia Shenzhen Research Institute of Central South University Shenzhen518057China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha410083China

The extraordinary optical and electronic properties of anisotropic two-dimensional materials,such as black phosphorus,ReS2,and GeSe,enable them a promising component of polarization-sensitive ***,these applications are significantly limited by the challenges of air-stability,response time,and linearly dichroic ***,palladium diselenide(PdSe2)with high air stability is an emerging material that has robust in-plane anisotropy induced by its asymmetric pentagonal lattice *** have successfully prepared a few-layer PdSe2 using micromechanical exfoliation,and here we demonstrate the strong linear dichroism behavior of PdSe2 by polarization-resolved absorption spectra *** unique linear dichroism,endows the PdSe2 photodetector powerful ability to detect polarized *** photodetector based on 5L PdSe2,as tested with polarization-dependent photocurrent mapping,exhibited competitive capability to detect polarized light,achieving a significant photocurrent on/off ratio(>10^2),the quite fast response time(<11 ms)and robust linearly dichroic ratios(/max//min≈1.9 at 532 nm).These results are essential advance in the development of polarization-sensitive photodetector,a crucial step towards opening up a new avenue for the application of 2D optoelectronic devices.

关键词： PdSe2 anisotropy polarization-sensitive linear dichroism

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Inhibition of corneal neovascularization by topical application of nintedanib in rabbit models

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1666-1673页

作者： juan Chen Xue ding Wei Du Xin Tang Wen-Zhen Yu Department of Ophthalmology Peking University People's HospitalEye Diseases and Optometry InstituteBeijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid DiseasesCollege of OptometryPeking University Health Science CenterBeijing 100044China Department of Ophthalmology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 402218China

AIM:To evaluate the potential efficacy and mechanisms of nintedanib in corneal neovascularization(NV)in rabbit ***:Corneal NV was induced using 1 mol/L Na ***(n=21)were randomized to 3 groups:Group 1 were treated with 0.9%NaCl,Group 2 with Avastin(5 mg/mL),and Group 3 with nintedanib(1 mg/mL).All treatments star ted 1 d af ter alkaline burns and were topically performed 3 times a day for 2 *** were taken on a slit lamp microscope on day 7 and *** NV area,the length of the vascularization and angiogenesis index(AI)were used to evaluate the corneal *** day 14,the immunohistochemical(IHC)studies of the cornea were *** blot was performed to test the expression levels of vascular endothelial growth factor(VEGF),Akt,p-Akt,P38,p-P38,MMP-2 and ***:The corneal NV area,vessel length and AI in Group 3 were significantly lower than Group 2,with both being lower than Group *** staining showed that VEGF was significantly overexpressed in the epithelium and stroma of cornea following alkaline *** contrast,the level of VEGF was significantly suppressed in both Group 2 and Group *** blot results further confirmed that,compared with Group 1,Group 3 had significantly reduced expressions of VEGF,Akt,p-Akt,p-P38,MMP-2,and MMP-9 in corneal *** of lower levels of MMP-2,AKT,and p-AKT in Group 3 than Group 2 were ***:Nintedanib and Avastin can effectively inhibit corneal NV,with P38 MAPK and AKT signaling pathways being possibly *** seems more effective than Avastin and has the potential to be a novel therapy for preventing corneal NV.

关键词： corneal neovascularization nintedanib vascular endothelial growth factor animal model

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Abietane Diterpernoids from the Roots of Euphorbia ebracteolata

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Natural Products and Bioprospecting 2018年第2期8卷 131-135页

作者： Yuan-Liang Ma Xiao-Han Tang Wen-juan Yuan Xiao ding ying-Tong Di Xiao-Jiang Hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Yunnan Institution for Food And Drug Control Kunming 650011People’s Republic of China

A new ent-abietane diterpernoid,named ebracteolata D(1),along with 11 known analogues,was isolated from the roots of Euphorbia ebracteolata *** structure of 1 was elucidated on the basis of spectroscopic analysis and molecular *** of compounds 1-12 was evaluated as well as the effect on the NF-κB *** them,compound 12,jolkinolide B,displayed broad inhibitory effects against proliferation of tumor cell *** studies indicated that the compound 12 can inhibit TNF-αinduced NF-κB activation,thereby inducing tumor cell apoptosis.

关键词： Euphorbiaceae Euphorbia ebracteolata Abietane diterpernoid Cytotoxic activity

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Comparative performance assessment of landslide susceptibility models with presence-only,presenceabsence,and pseudo-absence data

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Journal of Mountain Science 2020年第12期17卷 2961-2981页

作者： ZHAO Dong-mei JIAO Yuan-mei WANG Jin-liang ding Yin-ping LIU Zhi-lin LIU Cheng-jing QIU ying-mei ZHANG juan XU Qiu-e WU Chang-run School of Tourism and Geography Sciences Yunnan Normal UniversityNo.768 Juxian StreetChenggong DistrictKunming 650500China.

The quality of the data for statistical methods plays an important role in landslide susceptibility *** different data types influence the performance of landslide susceptibility maps is worth *** goal of this study was to explore the effects of different data types namely,presence-only(PO),presence-absence(PA),and pseudo-absence(PAs) data,on the predictive capability of landslide susceptibility *** was completed by conducting a case study in the landslide-prone Honghe County in the Yunnan Province of China.A total of 428 landslide PO data points were *** equivalent number of nonlandslide locations were generated as PA data by random sampling,and 10,000 sites were uniformly selected at random from each region as PAs *** landslide susceptibility models,namely the information value model(IVM),logistic regression(LR) model,and maximum entropy(MaxEnt) model,corresponding to the three data types were ***,the area under the receiver operating characteristic curves(ROC-AUC),seven statistical indices(***,sensibility,falsepositive rate,specificity,precision,Kappa,and Fmeasure),and a landslide density analysis were used to evaluate model performance regarding landslide susceptibility *** results indicated that the MaxEnt model using PAs data performed the best and had the highest fitness with the highest ROC-AUC values and statistical indices,followed by the IVM model with only landslide data(PO),and the LR model using PA *** PAs data avoided the inherent over-predictive shortcomings of PO data by limiting the predicted area of high-landslide ***,the random sampling design of landslide PA data increased the uncertainty of landslide susceptibility mapping and influenced the performance of the ***,our results suggested that the PAs data sampling provided a useful data type in the absence of high-quality ***,we summarized the principles,advantages,a

关键词： Landslide susceptibility mapping Presence-only data Presence-absence data Pseudoabsence data ROC-AUC

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Spatial prisoner’s dilemma games with increasing size of the interaction neighborhood on regular lattices

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Chinese Science Bulletin 2012年第7期57卷 724-728页

作者： Wang juan Xia ChengYi Wang YiLing ding Shuai Sun JunQing Tianjin Univ Technol Tianjin Key Lab Control Theory & Complicated Ind Tianjin 300384 Peoples R China Tianjin Univ Technol Minist Educ Key Lab Comp Vis & Syst Tianjin 300384 Peoples R China Shanxi Normal Univ Sch Life Sci Linfen 041000 Peoples R China Hefei Univ Technol Inst Comp Network Syst Hefei 230009 Peoples R China

We studied the evolution of cooperation in the prisoner's dilemma game on a square lattice where the size of the interaction neighborhood is considered. Firstly, the effects of noise and the cost-to-benefit ratio on the maintenance of cooperation were investigated. The results indicate that the cooperation frequency depends on the noise and cost-to-benefit ratio: cooperation reaches a climax as noise increases, but it monotonously decreases and even vanishes with the ratio increasing. Furthermore, we investigated how the size of the interaction neighborhood affects the emergence of cooperation in detail. Our study demonstrates that cooperation is remarkably enhanced by an increase in the size of the interaction neighborhood. However, cooperation died out when the size of the interaction neighborhood became too large since the system was similar to the mean-field system. On this basis, a cluster-forming mechanism acting among cooperators was also explored, and it showed that the moderate range of the neighborhood size is beneficial for forming larger cooperative clusters. Finally, large-scale Monte Carlo simulations were carried out to visualize and interpret these phenomena explicitly.

关键词：囚徒困境正方晶格相互作用合作伙伴游戏空间蒙特卡罗模拟成本效益

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Achieving long-cycling sodium-ion full cells in ether-based electrolyte with vinylene carbonate additive

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Journal of Energy Chemistry 2021年第6期30卷 650-655,I0016页

作者： juan Shi Lina ding Yanhua Wan Liwei Mi Linjie Chen Dan Yang Yuxiong Hu Weihua Chen Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001HenanChina Henan Key Laboratory of Functional Salt Materials Center of Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007HenanChina College of Pharmacy Zhengzhou UniversityZhengzhou 450001HenanChina

Application of sodium-ion batteries is suppressed due to the lack of appropriate electrolytes matching cathode and anode ***-based electrolytes,preference of anode materials,cannot match with high-potential cathodes failing to apply in full ***,vinylene carbonate(VC)as an additive into NaCF_(3) SO_(3)-Diglyme(DGM)could make sodium-ion full cells applicable without preactivation of cathode and *** assembled FeS@C||Na3 V2(PO_(4))_(3)@C full cell with this electrolyte exhibits long term cycling stability and high capacity *** deduced reason is additive VC,whose HOMO level value is close to that of DGM,not only change the solvent sheath structure of Na^(+),but also is synergistically oxidized with DGM to form integrity and consecutive cathode electrolyte interphase on Na3 V2(PO_(4))_(3)@C cathode,which could effectively improve the oxidative stability of electrolyte and prevent the electrolyte *** work displays a new way to optimize the sodium-ion full cell seasily with bright practical application potential.

关键词： Cathode electrolyte interphase Sodium-ion batteries Full cell Ether-based electrolyte Vinylene carbonate DFT calculation

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