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Serum Bilirubin and 6-min Walk Distance as Prognostic Predictors for Inoperable Chronic Thromboembolic Pulmonary Hypertension： A Prospective Cohort Study

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Chinese Medical Journal 2015年第23期128卷 3125-3131页

作者： juan-Ni Gong Zhen-Guo Zhai Yuan-Hua Yang Yan Liu Song Gu Tu-Guang Kuang Wan-Mu Xie Ran Miao chen wang Department of Pulmonary and Critical Care Medicine Beijing Institute of Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Respiratory Medicine and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China Department of Respiratory Medicine Capital Medical University Beijing 100069 China Department of Cardiovascular Surgery Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Clinical Laboratory Beijing Instituteof Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing 100020 China China-Japan Friendship Hospital National Clinical Research Center of Respiratory Medicine Beijing 100029 China

Background： Inoperable chronic thromboembolic pulmonary hypertension （CTEPH） is a severe clinical syndrome characterized by right cardiac failure and possibly subsequent liver dysfunction. However, whether serum markers of liver dysfunction can predict prognosis in inoperable CTEPH patients has not been determined. Our study aimed to evaluate the potential role of liver function markers （such as serum levels of transaminase, bilirubin, and gamma-glutamyl transpeptidase [GGT]） combined with 6-min walk test in the prediction of prognosis in patients with inoperable CTEPH. Methods： From June 2005 to May 2013, 77 consecutive patients with inoperable CTEPH without confounding co-morbidities were recruited for this prospective cohort study. Baseline clinical characteristics and 6-min walk distance （6MWD） results were collected. Serum biomarkers of liver function, including levels of aspartate aminotransferase, alanine aminotransferase, GGT, uric acid, and serum bilirubin, were also determined at enrollment. All-cause mortality was recorded during the follow-up period. Results： During the follow-up, 22 patients （29%） died. Cox regression analyses demonstrated that increased serum concentration of total bilirubin （hazard ratio [HR] = 7.755, P 〈 0.001）, elevated N-terminal of the prohormone brain natriuretic peptide （HR = 1.001, P = 0.001）, decreased 6MWD （HR = 0.990, P 〈 0.001）, increased central venous pressure （HR = 1.074, P = 0.040）, and higher pulmonary vascular resistance （HR = 1.001, P = 0.018） were associated with an increased risk of mortality. Serum concentrations of total bilirubin （HR = 4.755, P = 0.007） and 6MWD （HR = 0.994, P = 0.017） were independent prognostic predictors for CTEPH patients. Patients with hyperbilirubinemia （≥23.7 μmol/L） had markedly worse survival than those with normobilirubinemia. Conclusion： Elevated serum bilirubin and decreased 6MWD are potential predictors for poor prognosis in inoperable CTEPH.

关键词： Chronic Thromboembolic Pulmonary Hypertension Heart Failure Liver Function Prognosis

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Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation

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Neural Regeneration Research 2021年第6期16卷 1011-1016页

作者： Hui-Ling wang Fei-Lai Liu Rui-Qing Li Ming-Yue Wan Jie-Ying Li Jing Shi Ming-Li Wu Jun-Hua chen Wei-juan Sun Hong-Xia Feng Wei Zhao Jin Huang Ren-Chao Liu Wen-Xue Hao Xiao-Dong Feng Rehabilitation Center the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhouHenan ProvinceChina Department of Rehabilitation Medicine Fujian University of Chinese MedicineFuzhouFujian ProvinceChina Department of Rehabilitation Medicine Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia,but the underlying mechanism has not yet been fully *** have shown that autophagy plays an important role in the formation and development of cognitive impairment,and the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway plays an important role in autophagy *** investigate the role played by the PI3K/Akt signaling pathway in the electroacupuncture treatment of cerebral ischemia/reperfusion rat models,we first established a rat model of cerebral ischemia/reperfusion through the occlusion of the middle cerebral artery using the suture *** at 2 hours after modeling,electroacupuncture was delivered at the Shenting(GV24)and Baihui(GV20)acupoints,with a dilatational wave(1-20 Hz frequency,2 mA intensity,6 V peak voltage),for 30 minutes/day over 8 consecutive *** results showed that electroacupuncture reduced the infarct volume in a rat model of cerebral ischemia/reperfusion injury,increased the mRNA expression levels of the PI3K/Akt signaling pathwayrelated factors Beclin-1,mammalian target of rapamycin(mTOR),and PI3K,increased the protein expression levels of phosphorylated Akt,Beclin-1,PI3K,and mTOR in the ischemic cerebral cortex,and simultaneously reduced p53 mRNA and protein expression *** the Morris water maze test,the latency to find the hidden platform was significantly shortened among rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** the spatial probe test,the number of times that a rat crossed the target quadrant was increased in rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** stimulation applied to the Shenting(GV24)and Baihui(GV20)acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory *** study was approved by the Animal Ethics Committee

关键词： acupuncture brain central nervous system factor neurological function pathways protein stroke

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标准—检测—认证体系支撑防汛抗旱产品行业高质量发展的思考

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中国防汛抗旱 2024年第9期34卷 96-100页

作者：吕娟张大伟刘行刚盖红星王帆刘鑫鑫中国水利水电科学研究院北京100038 水利部防洪抗旱减灾工程技术研究中心北京100038 北京中水润科认证有限责任公司北京100048

标准、检验检测和认证作为国家质量基础设施的重要组成,对产业升级、技术创新和质量提升有重要作用,已经在我国消防和环保等诸多行业发挥了重要作用。但是防汛抗旱产品领域尚未建立起成熟的标准—检测—认证体系。我国防汛抗旱产品具有... 详细信息

标准、检验检测和认证作为国家质量基础设施的重要组成,对产业升级、技术创新和质量提升有重要作用,已经在我国消防和环保等诸多行业发挥了重要作用。但是防汛抗旱产品领域尚未建立起成熟的标准—检测—认证体系。我国防汛抗旱产品具有种类多、类型杂、涉及行业广的特点,为规范防汛抗旱产品市场,促进防汛抗旱产品行业高质量发展,在简要分析国内外防汛抗旱领域标准—检测—认证制度基础上,针对我国防汛抗旱产品行业发展现状,提出了在防汛抗旱产品领域建设标准—检测—认证体系的相关建议。

关键词：标准检验检测产品认证防汛抗旱质量管理

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Cooperative Quantum Cutting in Er^(3+)/Yb^(3+)Codoped Oxyfluoride Glass Ceramics

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Chinese Physics Letters 2011年第3期28卷 97-99页

作者： LUO Shi-Qiang ZHAO Li-juan HU Nan ZHANG Ming ZHANG Pan wang Ya-Zhou YU Hua Key Laboratory for Weak Light Nonlinear Photonics(Ministry of Education) Nankai UniversityTianjin 300457 College of Physics Nankai UniversityTianjin 300071

Oxvfluoride glass ceramic doped with doped with Er^(3+)/Yb^(3+)was *** earth ions are doped into fluoride nanocrystals according to x-ray diffractive *** enhanced red emission of Er^(3+)/Yb^(3+)in the fluoride nanocrystals,excited by xenon lamp ta 449nm,is investigated and analyzed by cooperative quantum cutting *** cross relaxation appears from^(4)F_(5/2)→^(4)F_(9/2)to^(4)I_(15/2)→^(4)I_(13/2)because of the nearer distance of rare earth ions and the larger absorption section of^(4)F_(5/2)→^(4)I_(13/2)in the quantum *** results in two emissions of^(4)F_(9/2)→^(4)I_(15/2)and^(4)I_(13/2)→^(4)I_(15/2).This implies that a 449nm photon could dissolve into two emiswith wavelength 665nm and *** could be an effective way to obtain 1530nm emission for optical communication.

关键词： ceramic fluoride earth

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数智转型背景下智慧教学模式探究——以“计算方法”为例

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曲阜师范大学学报（自然科学版） 2024年第2期50卷 120-124页

作者：闫晓辉郭双建谢进赵娟邵桂伟王丽丽合肥大学人工智能与大数据学院安徽省合肥市230601 贵州财经大学数学与统计学院贵州省贵阳市550025

结合现代信息化教育技术,以“计算方法”课程为例探究数智转型背景下的有效课堂智慧教学策略,充分利用“云+端”的智慧教学辅助平台,构建“分阶段、全过程、立体式”的线上线下混合式(“双线”)智慧教学模式.以“曲线拟合的最小二乘法... 详细信息

结合现代信息化教育技术,以“计算方法”课程为例探究数智转型背景下的有效课堂智慧教学策略,充分利用“云+端”的智慧教学辅助平台,构建“分阶段、全过程、立体式”的线上线下混合式(“双线”)智慧教学模式.以“曲线拟合的最小二乘法”课题为例,分析智慧教学设计实施过程,“双线”智慧教学贯穿于“课前—课中—课后”,实现教学决策数据化、评价反馈即时化、交流互动立体化、资源推送智能化.

关键词：智慧教学线上线下混合式过程评价计算方法

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铁路快递物品目的地市内配送派单的优化算法

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铁道学报 2008年第2期30卷 17-22页

作者：黄由衡王娟中南大学交通运输工程学院湖南长沙410075

铁路快递物品到达目的地城市配送中心后,须由当地配送中心首先编制各批物品的车辆装载配送交货计划即派单,而如何优化派单是一个NP-Hard问题。以出车总数少并保证特殊物品和时限物品的优先配送和充分利用车辆的载货能力为目标,按各批次... 详细信息

铁路快递物品到达目的地城市配送中心后,须由当地配送中心首先编制各批物品的车辆装载配送交货计划即派单,而如何优化派单是一个NP-Hard问题。以出车总数少并保证特殊物品和时限物品的优先配送和充分利用车辆的载货能力为目标,按各批次物品的类别及应送货时间将其分为不同的优先等级并赋以相应的权重值,将出车总数与装载物品的总权重之比值最小为评价解的优劣程度的目标函数,在运送车辆类型及其载重容量、物品配送次序、可出车总数和出车车辆最低载货量等有关约束条件和基本假设的前提下,建立派单的0-1规划模型,并提出相应的两阶段启发式算法进行计算。以中铁快运在某市某时段的数据为例模拟派单,得到满意结果。

关键词：铁路快递配送派单启发式算法区域

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硅溶胶在纸张涂布与施胶中的应用研究

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中国造纸 2006年第5期25卷 24-25页

作者：陈影韩卿王亚娟陕西科技大学陕西咸阳712081

通过测定施胶和涂布后纸张的表面强度、油墨吸收性及接触角,分析了硅溶胶对施胶和涂布纸张表面强度、油墨吸收性和抗水性的影响。结果表明,随着硅溶胶用量的增加,施胶和涂布纸张的表面强度均先上升,达到最高点后下降;而油墨吸收性和抗... 详细信息

通过测定施胶和涂布后纸张的表面强度、油墨吸收性及接触角,分析了硅溶胶对施胶和涂布纸张表面强度、油墨吸收性和抗水性的影响。结果表明,随着硅溶胶用量的增加,施胶和涂布纸张的表面强度均先上升,达到最高点后下降;而油墨吸收性和抗水性均随着硅溶胶用量的增加而下降。

关键词：硅溶胶施胶涂布油墨吸收性表面强度

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Genome-wide scan for selection signatures based on whole-genome re-sequencing in Landrace and Yorkshire pigs

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Journal of Integrative Agriculture 2021年第7期20卷 1898-1906页

作者： wang Kai WU Ping-xian chen De-juan ZHOU Jie YANG Xi-di JIANG An-an MA Ji-deng TANG Qian-zi XIAO Wei-hang JIANG Yan-zhi ZHU Li QIU Xiao-tian LI Ming-zhou LI Xue-wei TANG Guo-qing Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China College of Life Science Sichuan Agricultural UniversityYa'an 625014.P.R.China National Animal Husbandry Service Beijing 100125P.R.China

We performed a genome-wide scan to detect selection signatures that showed evidence of positive selection in the domestication process by re-sequencing the whole genomes of Landrace and Yorkshire *** annotated elements with 13 associated genes were identified using the Z-transformed FST(Z(FST))method,and 208 annotated elements with 140 associated genes were identified using the Z-transformed heterozygosity(ZHp)*** functional analysis and the results of previous studies showed that most of the candidate genes were associated with basic metabolism,disease resistance,cellular processes,and biochemical signals,and several were related to body morphology and *** included PPP3CA,which plays an essential role in the transduction of intracellular Ca2+-mediated signals,and WWTR1,which plays a pivotal role in organ size control and tumor *** results suggest that genes associated with body morphology were subject to selection pressure during domestication,whereas genes involved in basic metabolism and disease resistance were subject to selection during artificial *** findings provide new insights into the potential genetic variation of phenotypic diversity in different pig breeds and will help to better understand the selection effects of modern breeding in Landrace and Yorkshire pigs.

关键词： pig variation whole-genome sequence selection signature phenotypic trait

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Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids

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General Psychiatry 2020年第4期33卷 194-200页

作者： Sidi He Wen juan Yu Xiaoliang wang Lei Zhang Nan Zhao Guanjun Li Yi Feng Shen Huafang Li Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Pudong New Area Mental Health Center ShanghaiChina Clinical Research Center Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina

Background Hyperprolactinemia is a common adverse reaction in patients with schizophrenia who take antipsychotic drugs;it often leads to treatment noncompliance in patients and has an adverse effect on their *** This study aimed to explore the risk factors of elevated prolactin(PRL)caused by risperidone(RIS)and olanzapine(OLZ)and the relationship between PRL and fasting plasma glucose and *** Patients with schizophrenia were divided into two groups:264 patients who were taking RIS and 175 patients who were taking *** two groups were further divided according to serum PRL levels:an elevated PRL group(>30ng/mL)and a normal PRL group(PRL<30ng/mL).The demographics,medication dosage,fasting plasma glucose,total cholesterol and triglycerides were compared in the two *** regression analysis was performed to explore the risk factors of elevated PRL *** Compared with the OLZ group,the RIS group had a greater number of patients with elevated PRL(155/264 vs 58/175).Either the RIS or the OLZ group,the proportion of elevated PRL was greater in female patients(RIS:x^2=6.76,p=0.009;OLZ:x^2=12.98,p<0.001)and with higher doses of the related drugs(RIS:U=-3.73,p<0.001;OLZ:U=-2.31,p=0.021).In patients taking RIS,the elevated PRL subgroup took the drug for a longer period(U=-2.76,p=0.006)and had lower triglyceride levels(U=2.76,p=0.006).In patients taking OLZ,the elevated PRL subgroup had lower fasting plasma glucose levels(U=2.29,p=0.022).Logistic regression analysis showed that gender,dose and fasting glucose levels were significantly associated with elevated PRL levels(RIS:p=0.001,OLZ:p<0.001;RIS:p<0.001;OLZ:p=0.003;RIS:p=0.020,OLZ:p=0.001,respectively).Conclusion Compared with OLZ,RIS had a greater effect on PRL in patients with schizophrenia,and in patients with schizophrenia taking RIS or OLZ,gender and dose were significantly correlated with the PRL ***,the plasma glucose level of the group with elevated PRL was lower

关键词： elevated drugs dosage

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严译《天演论》对社会主义思想在中国早期传播的四大贡献及其影响

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理论学刊 2022年第6期 82-90页

作者：王宪明陈娟清华大学马克思主义学院北京100084

严复所译《天演论》,至少从确立“物竞”观念、阐明“民惟安生乐业乃有以自奋于学问思索之中”的“唯物”思想、创译“乌托邦”和创译“事各视其所胜,养各给其所欲”等四个方面,为社会主义思想在中国的早期传播作了观念上的铺垫,在当时... 详细信息

严复所译《天演论》,至少从确立“物竞”观念、阐明“民惟安生乐业乃有以自奋于学问思索之中”的“唯物”思想、创译“乌托邦”和创译“事各视其所胜,养各给其所欲”等四个方面,为社会主义思想在中国的早期传播作了观念上的铺垫,在当时的中国思想界产生了广泛影响,也为近代中国先进分子接受社会主义和马克思主义作了思想理论上的准备。

关键词：《天演论》 “物竞” “唯物” “乌托邦” “各尽所能,各取所需”

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