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treatment strategies for patients with HER2-positive gastric cancer

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Cancer Biology & Medicine 2023年第12期20卷 934-941页

作者： Feixue Wang Yi ba Department of Medical Oncology Department of Cancer CenterPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100032China Department of GI Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Gastric cancer (GC) is a major health concern globally,ranking fifth in frequency and fourth in cancer-associated *** China,an estimated 396,500 new cases are diagnosed each year,and late-stage disease comprises more than 80%of *** of late diagnosis and heterogeneous characteristics,the prognosis of GC remains *** patients with advanced disease,traditional chemotherapy has been the mainstay of treatment,but its clinical outcomes are far from satisfactory,with a 5-year survival rate below 10%.

关键词： patients cancer Gastric

Regularity of Structural Superplasticity of Hypoeutectoid Steel

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Journal of Iron and Steel Research International 2005年第4期12卷 60-62页

作者： YANGYun-lin WENJiu-ba HenanUniversityofScienceandTechnology Henan471003China

The curve of the relation between fracture elongation and temperature for unltrafine grained low alloy hypoeutectoid steels generally shows that three peaks occur at temperatures just below A_ c1, between A_ c1 and A_ c3, and just above A_ c3, When these steels are subjected to superplastic tensile test at different temperatures, the value of the last one is the lowest and the other two peaks are different one from another depending on components, microstructures and deformation conditions of the steels.

关键词： hypoeutectoid steel structural superplasticity superplastic temperature

On the Space bv_p(F) of Sequences of p-bounded Variation of Fuzzy Numbers

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1205-1212页

作者： zer TALO Feyzi ba■AR Fatih niversitesi Fen-Edebiyat FakltesiMatematik BlmBykekmece Kamps 34500-stanbulTrkiye

Recently, the space bvp of real or complex numbers consisting of all sequences whose differences are in the space lp has been studied by basar, Altay [Ukrainian Math. J. 55（1）（2003）, 136-147], where 1 ≤ p ≤ ∞. The main purpose of the present paper is to introduce the space bvp（F） of sequences of p-bounded variation of fuzzy numbers. Moreover, it is proved that the space bvp（F） includes the space lp（F） and also shown that the spaces bvp（F） and lp（F） axe isomorphic for 1 ≤ p ≤∞. Furthermore, some inclusion relations have been given.

关键词： sequence of fuzzy numbers space of difference sequences isomorphic spaces and inclusion relations

Characterization and antifouling activity analysis of extracellular polymeric substances produced by an epibiotic bacterial strain Kocuria flava associated with the green macroalga Ulva lactuca

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Acta Oceanologica Sinica 2021年第4期40卷 107-115页

作者： Mohammad Abdulaziz ba-akdah Sathianeson Satheesh Department of Marine Biology Faculty of Marine SciencesKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Extracellular polymeric substances(EPS)are present externally to the microorganisms and play an important role in attachment and biofilm *** polymers possess antibacterial and antifouling *** this study,the antifouling activity of EPS produced by an epibiotic bacterium associated with macroalga Ulva lactuca was assessed against fouling bacteria and barnacle *** indicate that the EPS isolated from the epibiotic bacterium inhibits the biofilm formation of the bacteria without much antibacterial ***,the EPS reduced the settlement of barnacle larvae on the hard substrate under laboratory *** epibiotic bacterium was identified as Kocuria flava based on 16 S rRNA gene *** EPS was further analysed using Fourier transform infrared(FT-IR),nuclear magnetic resonance(NMR)and X-ray diffraction(XRD)to understand the biochemical *** analysis revealed the presence of polysaccharides,proteins,acetyl amine and succinyl *** electron microscope analysis indicated that the EPS consisted of aggregated and irregular sphere-shaped particles.

关键词： biofouling antifouling Kocuria flava exopolymers antibiofilm activity Red Sea

High-Efficiency DC-DC Converter for Large Input-Voltage Fluctuations in Solar Applications

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Chinese Journal of Electronics 2015年第3期24卷 502-507页

作者： AGUILLON-GARCIA Jacobo baNUELOS-SANCHEZ Pedro SIST Sun Yat-sen University

In the solar energy systems the solar irradiance variation is partially engaged, limiting the converter’s transformation rate for a certain input amount and leaving the rest of energy unconverted. In order to utilize at its maximum the energy provided from a Photovoltaic(PVP) system, this manuscript proposed a topology that can cope with marginal input voltage variations from 60V(DC) up to 1050V(DC) for a steady output voltage of 700V(DC). This output voltage value is suitable for any interlink post-regulation architecture. based on previous observations, this paper presents a wide-input voltage high-efficiency non-isolated single-control topology. Analysis, operating stages, simulations and experimental results for a 3k W prototype are presented.

关键词： DC-DC power converters Energy conversion Photovoltaic system Power conditioning Solar generation

A Unified trajectory Optimization Approach for Long-Term and Reactive Motion Planning of Legged Locomotion

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Journal of Bionic Engineering 2023年第5期20卷 2108-2122页

作者： Yapeng Shi Bin Yu Kaixian ba Mantian Li School of Mechanical Engineering Yanshan UniversityNo.438 West Hebei AvenueQinhuangdao066004HebeiPeople’s Republic of China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin150001People’s Republic of China

This paper proposes a unified trajectory optimization approach that simultaneously optimizes the trajectory of the center of mass and footholds for legged *** on a generic point-mass model,the approach is formulated as a nonlinear optimization problem,incorporating constraints such as robot kinematics,dynamics,ground reaction forces,obstacles,and target *** unified optimization approach can be applied to both long-term motion planning and the reactive online planning through the use of model predictive control,and it incorporates vector field guidance to converge to the long-term planned *** effectiveness of the approach is demonstrated through simulations and physical experiments,showing its ability to generate a variety of walking and jumping gaits,as well as transitions between them,and to perform reactive walking in obstructed environments.

关键词： Legged locomotion Motion planning trajectory optimization Bionic robot

An end-to-end 3D seismic simulation of underground structures due to point dislocation source by using an FK-FEM hybrid approach

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1515-1529页

作者： Zhenning ba Jisai FU Zhihui ZHU Hao ZHONG State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300350China National Engineering Research Center of High Speed Railway Construction Technology Central South UniversityChangsha 410075China School of Civil Engineering Central South UniversityChangsha 410075China

based on the domain reduction idea and artificial boundary substructure method,this paper proposes an FK-FEM hybrid approach by integrating the advantages of FK and FEM(i.e.,FK can efficiently generate high-frequency three translational motion,while FEM has rich elements types and constitutive models).An advantage of this approach is that it realizes the entire process simulation from point dislocation source to underground *** with the plane wave field input method,the FK-FEM hybrid approach can reflect the spatial variability of seismic motion and the influence of source and propagation *** approach can provide an effective solution for seismic analysis of underground structures under scenario of earthquake in regions where strong earthquakes may occur but are not recorded,especially when active faults,crustal,and soil parameters are *** Daikai subway station as an example,the seismic response of the underground structure is simulated after verifying the correctness of the approach and the effects of crustal velocity structure and source parameters on the seismic response of Daikai station are *** this example,the influence of velocity structure on the maximum interlayer displacement angle of underground structure is 96.5%and the change of source parameters can lead to the change of structural failure direction.

关键词： source-to-structure simulation FK-FEM hybrid approach underground structures point dislocation source

Investigation of physicochemical,microbiological and sensorial properties for organic and conventional retail chicken meat

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Food Science and Human Wellness 2021年第2期10卷 183-190页

作者： Berna Capan Aytunga bağdatli Manisa Celal bayar University Faculty of EngineeringDepartment of Food EngineeringYunusemre45140 ManisaTurkey

In this study,the commercially available chicken thigh and breast meat produced by organic and conventional methods were investigated in terms of physicochemical,microbiological and sensorial *** organic chicken breasts had higher fat content than the conventional chicken *** protein content of organic thighs was higher than conventional *** chicken meat contains more mineral substances than conventional chicken meat and has higher pH value,cooking loss and water holding ***-linoleic acid,docosahexaenoic acid was found to be higher in organic chicken *** *** detected in all conventional chicken and 66.66%of organic chicken.

关键词： Organic chicken Conventional chicken Chicken breast Chicken thigh Chicken meat quality Fatty acid composition

Sharkskin-Inspired Magnetoactive Reconfigurable Acoustic Metamaterials

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Research 2020年第1期2020卷 799-811页

作者： Kyung Hoon Lee Kunhao Yu Hasan Al ba’ba’a An Xin Zhangzhengrong Feng Qiming Wang Sonny Astani Department of Civil and Environmental Engineering University of Southern CaliforniaLos AngelesCA 90089USA

Most of the existing acoustic metamaterials rely on architected structures with fixed configurations,and thus,their properties cannot be modulated once the structures are *** active acoustic metamaterials highlight a promising opportunity to on-demand switch property states;however,they typically require tethered loads,such as mechanical compression or pneumatic *** untethered physical stimuli to actively switch property states of acoustic metamaterials remains largely ***,inspired by the sharkskin denticles,we present a class of active acoustic metamaterials whose configurations can be on-demand switched via untethered magnetic fields,thus enabling active switching of acoustic transmission,wave guiding,logic operation,and *** key mechanism relies on magnetically deformable Mie resonator pillar(MRP)arrays that can be tuned between vertical and bent states corresponding to the acoustic forbidding and conducting,*** MRPs are made of a magnetoactive elastomer and feature wavy air channels to enable an artificial Mie resonance within a designed frequency *** Mie resonance induces an acoustic bandgap,which is closed when pillars are selectively bent by a sufficiently large magnetic *** magnetoactive MRPs are further harnessed to design stimuli-controlled reconfigurable acoustic switches,logic gates,and *** of creating the first generation of untethered-stimuli-induced active acoustic metadevices,the present paradigm may find broad engineering applications,ranging from noise control and audio modulation to sonic camouflage.

关键词： typically conducting artificial