检索结果-南通市图书馆

Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo juan CRama Merchán Catia Costa juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in sierra-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in sierra-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial

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World Journal of Gastroenterology 2015年第23期21卷 7305-7312页

作者： Francisco Hernández-Bernal Georgina Castellanos-sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García juan E Domínguez-Suárez Pedro A López-Saura 无 Clinical Research Direction Center for Genetic Engineering and Biotechnology juan B.Zayas Hospital Ernesto Guevara Hospital Celia Sánchez Hospital Manzanillo Gustavo Aldereguía Hospital THERESA-4(Treatment of HEmorrhoids with REcombinant Streptokinase Application)Group of Investigators

AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal ***: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also ***: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and he

关键词： Streptokinase Suppository Hydrocortisoneacetate Thrombolysis Hemorrhoids Randomizedclinical trial

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XRF Standardless Comparison of Mining Head and Tail Grades to Screen and Display Ore Processing Recoveries

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American Journal of Analytical Chemistry 2016年第11期7卷 785-796页

作者： Nicholas E. Pingitore Jr juan W. Clague Daniel Gorski Department of Geological Sciences The University of Texas at El Paso El Paso Texas USA Environmental Engineering & Public Health LLC El Paso Texas USA Texas Mineral Resources Corporation Sierra Blanca Texas USA

Separation of target elements or minerals from their host rock or ore is essential to successful mining operation. The inevitable loss of a portion of the desired material that accompanies each step in the extraction process must be documented to develop the operational protocol. Superposition of the characteristic X-ray fluorescence spectra of head (crushed rock ore particles, pre-processing) and tail (post-processing particles) samples provides a direct visual comparison of relative peak sizes, and thereby the relative concentrations, of elements of interest. If the head and tail peaks are identical, none of the element was recovered in the extraction process. At the other extreme if the tail peak “flat lines”, i.e., there is no peak, there was 100% recovery of that element. Standardless visual comparison is valid if the same mass of identical starting material is incorporated into the head and tail sample analysis pucks, and XRF analytical conditions are identical. The considerable time and expense of acquiring and calibrating the standards associated with XRF analysis of 75 or more elements are avoided, a significant advantage during initial broad screening of an experimental extraction procedure. Full quantitation by XRF or an alternate technique can proceed at a later project stage, if desired. The approach retains and presents all features of the original data, thus eliminating questions about data quality, standards and their calibration, and data manipulation in processing from raw counts to concentrations in printout tables. This form of display is ideal for both the mining professional and such less technical groups as corporate staff, investors, regulators, and the public. Examples presented herein are for heap leaching;the protocol can be applied as well to any of the other traditional ore processing and beneficiation procedures, e.g., gravity concentration, magnetic and electrical separation, froth flotation, and ore sorting.

关键词： XRF (X-Ray Fluorescence) Ore Processing Heap Leach Standardless Analysis Round Top Mountain Rare Earth Elements

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Remarkably Consistent Rare Earth Element Grades at Round Top Yttrofluorite Deposit

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Advances in Materials Physics and Chemistry 2018年第1期8卷 1-14页

作者： Nicholas E. Pingitore Jr. juan W. Clague Daniel Gorski Department of Geological Sciences The University of Texas at El Paso El Paso TX USA Environmental Engineering & Public Health LLC El Paso TX USA Texas Mineral Resources Corporation Sierra Blanca TX USA

The peraluminous rhyolite that forms Round Top Mountain (approximately 375 m high × nearly 2 km in diameter), near sierra Blanca, Hudspeth County, west Texas, USA, is enriched in yttrium and heavy rare earth elements (YHREEs), as well as Li, Be, U, Th, Sn, F, Rb, Cs, Nb, and Ta. Texas Mineral Resources Corp. (USA) proposes to release the YHREEs from their unique yttrofluorite host via heap leaching with dilute sulfuric acid. The inexpensive process also releases portions of valuable byproduct Be, Li, and U from accessory minerals amid the insoluble feldspars and quartz that comprise 90% - 95% of the surface-exposed rhyolite mountain. The objective of this study is to determine the consistency of mineralization grade, an important consideration in mine planning and preliminary economic analysis. The method is to plot elemental analyses of Y, Dy, Ho, Tm, Yb, Ce, Pr, Nd, Eu, Gd, Tb, U, and Nb from more than 1400 reverse circulation cuttings taken from 64 exploration drill holes against sample depth. The result of inspection of the plots reveals a remarkably homogeneous distribution of minor and trace elements throughout the sampled portion of the massive, 1.6-billion-tonne laccolith. The plots drive the conclusion that Round Top mine feedstock should remain constant for the life of the mine (multiple decades). Thus mining mechanics could be optimized at the start of operations and not require expensive later changes. The physical and chemical design of the heap leach and recovery and purification of target elements from pregnant leach solution also could be perfected during early development.

关键词： Heavy Rare Earth Elements Deposit Grade Round Top Mountain Heap Leach Mineral Processing

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下一代图书馆服务平台sierra和Alma的比较研究——基于Marshall Breeding 2016年调查数据

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现代情报 2017年第6期37卷 113-118页

作者：李娟张雪蕾魏青山西安交通大学图书馆陕西西安710049

本文首先概括了图书馆服务平台的技术和功能特征,并介绍了目前主流的图书馆服务平台,重点基于Marshall Breeding 2013-2016年相关调研用户反馈结果和统计数据,从用户对系统满意度、系统功能性、印刷型馆藏管理功能、电子资源管理功能、... 详细信息

本文首先概括了图书馆服务平台的技术和功能特征,并介绍了目前主流的图书馆服务平台,重点基于Marshall Breeding 2013-2016年相关调研用户反馈结果和统计数据,从用户对系统满意度、系统功能性、印刷型馆藏管理功能、电子资源管理功能、公司满意度、支持满意度、支持改进、公司忠诚度和开源兴趣等9个方面对Alma和sierra两项产品进行多维分析与比较,期望为国内图书馆评估和选择LSP产品时提供参考与借鉴。

关键词：图书馆服务平台图书馆集成系统 Alma sierra

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军队传染病医院执行重大疫情防控任务物资筹措实践与启示

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解放军医院管理杂志 2015年第2期22卷 115-116页

作者：张凯博段惠娟解放军第302医院北京100039

结合本院援塞医疗队赴塞拉利昂执行埃博拉出血热疫情防控任务的实践,探讨军队医院执行处置重大疫情任务中物资筹措的主要做法,并就卫生物资应急筹措提出几点建议。

关键词：重大疫情物资筹措物资保障

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西非埃博拉病毒病治疗现状

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传染病信息 2015年第3期28卷 129-132页

作者：吉英杰段学章段惠娟解放军第三〇二医院干部医疗保健中心北京100039 解放军第三〇二医院肿瘤放射治疗中心北京100039 解放军第三〇二医院北京100039

埃博拉病毒病传染性强,病死率高,目前尚无疫苗和特异性药物。现将解放军援塞医疗队塞拉利昂埃博拉留观治疗中心的治疗经验进行总结,并结合文献报道,对一些试验性药物的使用情况及临床试验开展情况进行综述,以期为今后应对该疾病提供依据。

关键词：埃博拉病毒属流行病学治疗学

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解放军援塞拉利昂医疗队抗埃博拉病毒治疗药品保障与管理

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中国药学杂志 2015年第20期50卷 1833-1835页

作者：夏晖刘峰群秦立孙志强赵庆国韩晋段惠娟解放军第302医院北京100039

目的对解放军援塞医疗队赴塞拉利昂执行抗击埃博拉病毒病任务中药品保障与管理的经验教训进行总结和分析。方法对2014年9月16日至2015年3月21日执行任务期间的药品准备、运输、储存、管理等工作进行总结,分析各个环节中的经验和教训。... 详细信息

目的对解放军援塞医疗队赴塞拉利昂执行抗击埃博拉病毒病任务中药品保障与管理的经验教训进行总结和分析。方法对2014年9月16日至2015年3月21日执行任务期间的药品准备、运输、储存、管理等工作进行总结,分析各个环节中的经验和教训。结果解放军援塞医疗队药品保障组结合此次埃博拉爆发的疾病特征、疫情动态变化趋势及当地医疗卫生状况,做出了及时、全面的药品准备工作;通过冷链运输等手段保证了药品运输安全;药品分类储存科学合理,确保了药品质量安全;药品管理工作认真细致,确保了药品合理使用。结论解放军援塞医疗队药品保障与管理措施科学有效,为今后我军执行类似海外重大医疗援助行动的药品保障和管理提供可借鉴的经验。

关键词：药品保障埃博拉病毒病医疗救援塞拉利昂

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塞拉利昂马邦托地区铁矿地质特征及找矿预测

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矿产勘查 2019年第3期10卷 668-674页

作者：郝玉军尹展吴碧娟卜鹏徐思超有色金属矿产地质调查中心北京100012

马邦托地区位于塞拉利昂北方省,苏拉山—坎格瑞丘陵弧形构造带由北北东向北北西的转折部位、新太古代绿岩带内,铁矿、金矿资源丰富,成矿地质条件优越。文章在论述巴伐亚铁矿床地质特征的基础上分析了区域铁矿成矿规律,总结了铁矿控矿因... 详细信息

马邦托地区位于塞拉利昂北方省,苏拉山—坎格瑞丘陵弧形构造带由北北东向北北西的转折部位、新太古代绿岩带内,铁矿、金矿资源丰富,成矿地质条件优越。文章在论述巴伐亚铁矿床地质特征的基础上分析了区域铁矿成矿规律,总结了铁矿控矿因素,建立了区域沉积变质型铁矿成矿模式和预测模型。结合马邦托地区1:5万航磁异常特征,进行了矿产预测,指明了找矿方向,总结了找矿标志。结果表明:马邦托地区铁矿找矿潜力仍然巨大,Y2异常区为寻找富铁矿的有利地段。

关键词：塞拉利昂沉积变质型铁矿预测模型航磁异常找矿方向

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解放军援非医疗队对塞拉利昂医务人员实施埃博拉防护技能培训的效果

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中华现代护理杂志 2015年第5期21卷 562-565页

作者：王新华秦玉玲贾红军孙娟张洁利闫涛解放军第三〇二医院妇产中心北京100039 解放军第三〇二医院门诊部急诊科北京100039 解放军第三〇二医院医务部感染控制科北京100039 解放军第三〇二医院肝病生物治疗与研究中心北京100039 解放军第三〇二医院国际肝病科北京100039

目的：探讨解放军援非医疗队对塞拉利昂医务人员实施埃博拉防护技能培训的方法及效果。方法由医疗队成员对塞方47名护理人员及40名保洁人员分别实施埃博拉防护技能培训,培训分两批次进行,历时10d。培训内容包括讲解埃博拉相关知识、心... 详细信息

目的：探讨解放军援非医疗队对塞拉利昂医务人员实施埃博拉防护技能培训的方法及效果。方法由医疗队成员对塞方47名护理人员及40名保洁人员分别实施埃博拉防护技能培训,培训分两批次进行,历时10d。培训内容包括讲解埃博拉相关知识、心理疏导及防护知识与技能培训、集中考核。培训前采用自行设计的调查问卷调查塞方医务人员的防护知识现状。结果培训前,塞方医务人员74.71%缺乏埃博拉相关知识,85.06%缺乏传染病防护知识,88.50%未参加过防护技能培训。塞方87名医务人员全部参加培训及考核,其中护理人员考核得分为（94.93±4.69）分,保洁人员考核得分为（91.18±5.37）分,考核未合格3人经再培训,补考后全部合格。结论在建立良好沟通的基础上,通过多种方法对当地医务人员实施埃博拉防护技能培训并取得了良好效果,为其他援非医疗队提供了一定借鉴。

关键词：埃博拉病毒医务人员防护培训

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