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Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis

World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第3期1卷 75-80页

作者： Javier Escobar Javier Pereda Alessandro Arduini juan Sastre juan sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater Department of Physiology University of Valencia 46100 Burjasot (Valencia) Spain Department of Biochemistry & Molecular Biology University of Valencia 46100 Burjasot (Valencia) Spain Laboratory of Pancreatic Function University Clinic Hospital 46010 Valencia Spain Department of Surgery University Clinic Hospital 46010 Valencia Spain

Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed.

关键词： Dual specificity protein phosphatases Acute pancreatitis Phosphodiesterase inhibitors Cytokines Histone acetylation Pentoxifylline PP2A Serine/threonine protein phosphatases

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Unusual clinical presentation of oral pyogenic granuloma with severe alveolar bone loss:A case report and review of literature

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World Journal of Clinical Cases 2023年第16期11卷 3907-3914页

作者： Sarah Monserrat LomelíMartínez Dennisse Bocanegra Morando Ana Esther Mercado González juan Ramón Gómez sandoval Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludGuadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray Antonio Alcalde” Guadalajara 44280Mexico Research Institute of Dentistry Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico

BACKGROUND Pyogenic granuloma(PG)is a localized,reddish and vascularized hyperplastic lesion of the connective tissue which occurs in the oral *** most cases,the presence of this lesion does not show alveolar bone *** pathology is diagnosed clinically with some ***,the diagnosis and treatment are usually corroborated with histopathological *** SUMMARY Three clinical cases of PG associated with bone loss were described in this *** three patients presented tumor-like growth which bled on touch,and were associated with local irritant *** showed bone *** cases were treated with conservative surgical *** scarring was satisfactory,and there was no case of *** diagnoses were based on clinical findings,and were confirmed *** The occurrence of oral PG with bone loss is ***,clinical and radiographic evaluations are important for the diagnosis.

关键词： Hyperplastic lesion Pyogenic granuloma Alveolar bone loss Case report

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(4 + 4)-Dimensional Space-Time as a Dual Scenario for Quantum Gravity and Dark Matter

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Journal of Applied Mathematics and Physics 2022年第3期10卷 688-702页

作者： Brandon Mariano Martínez-Olivas juan Antonio Nieto Andrés sandoval-Rodríguez Facultad de Ciencias Fsico-Matemáticas de la Universidad Autónoma Culiacán Sinaloa México

In this work, we make a number of proposals to explain how a world of (4 + 4)-dimensions can be useful for a better understanding of both dark matter and quantum gravity. The key idea is to look for some advantage of considering self-dual invariants in (4 + 4)-dimensions rather than in a separate context of (1 + 3)-dimensions or (3 + 1)-dimensions. In fact, we show that by considering the duality concept in (4 + 4)-dimensions we may provide an alternative meaning of a framework for loop quantum gravity. Moreover, considering the Dirac equation in (4 + 4)-dimensions for a particle without electric charge and mass, we show that when it is projected into the (1 + 3) and (3 + 1)-worlds may describe a system with electric charge and mass. We also discuss the relation between the three physical scenarios;(4 + 4)-world, black-holes and dark matter.

关键词： (4 + 4)-Dimensions Dark Matter Quantum Gravity

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Increased DNA binding activity of NF-κB,STAT-3,SMAD3 and AP-1 in acutely damaged liver

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World Journal of Gastroenterology 2006年第37期12卷 5995-6001页

作者： Adriana Salazar-Montes Luis Ruiz-Corro Ana sandoval-Rodriguez Alberto Lopez-Reyes juan Armendariz-Borunda Institute of Molecular Biology in Medicine and Gene Therapy CUCS University of Guadalajara Apdo. Postal 2-123 Guadalajara 44281 Jal Mexico Institute of Molecular Biology in Medicine and Gene Therapy CUCS University of Guadalajara Apdo.Postal 2-123 Guadalajara 44281 Jal Mexico OPD Hospital Civil de Guadalajara Guadalajara Jal Mexico

AIM: To investigate the role of genes and kinetics of specific transcription factors in liver regeneration, and to analyze the gene expression and the activity of some molecules crucially involved in hepatic regeneration. METHODS: USING gel-shift assay and RT-PCR, transcription factors, such as NF-κB, STAT-3, SMAD3 and AP-1, and gene expression of inducible nitric oxide synthase (iNOS), hepatocyte growth factor (HGF) and c-met were analyzed in an animal model of chemically induced hepatectomy. RESULTS: Gene expression of HGF and its receptor c-met peaked at 3 h and 24 h after acute CCl4 intoxi- cation. iNOS expression was only observed from 6 to 48 h. Transcriptional factor NF-κB had an early activation at 30 min after acute liver damage. STAT-3 peaked 3 h post- intoxication, while AP-1 displayed a peak of activation at 48 h. SMAD3 showed a high activity at all analyzed times. CONCLUSION: TNF-α and IL-6 play a central role in hepatic regeneration. These two molecules are responsible for triggering the cascade of events and switch-on of genes involved in cell proliferation, such as growth factors, kinases and cyclins which are direct participants of cell proliferation.

关键词： NF-κB STAT-3 SMAD3 AP-1 肝疾病基因表达病理机制

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Eucalyptus grandis plantations:effects of management on soil carbon,nutrient contents and yields

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Journal of Forestry Research 2020年第2期31卷 601-611页

作者： Diego Martin sandoval Lopez Marcelo Fabian Arturi juan Francisco Goya Carolina Alejandra Perez Jorge Luis Frangi Laboratorio de Investigacion de Sistemas Ecologicos y Ambientales(LISEA) Universidad Nacional de La PlataDiagonal 113 N°4691900 La PlataBuenos AiresArgentina

The expansion of fast-growing tree plantations is a worldwide process,with consequences on soil fertility and soil carbon *** results were found on the effects of afforestation with Eucalyptus on soil carbon and other nutrient *** discrepancies are usually caused by differences in climate,land use history,soil texture as well as by management related factors such as plantation age,number of rotations,method of establishment(plantation or coppice),harvest residue management and soil *** studied the effect of plantation age,number of rotations,and method of establishment on soils and plant nutrient concentrations in Eucalyptus grandis plantations in NE Argentina on different textured *** also determined if yields changed with nutrient variations in soils,and compared soils under plantations to soils under grasslands they ***-one *** stands of different ages,number of rotations and method of establishment were evaluated as well as eight grassland *** of carbon,nitrogen,phosphorus,potassium,calcium and magnesium were determined for soils and *** carbon and nitrogen decreased over the number of rotations and were more pronounced in soils with 50-60%sand than soils with>75%*** stands showed higher soil carbon and nitrogen levels than plantations,suggesting a negative effect of site preparation before planting on soil nutrient conservation,especially in fine-textured *** nutrient concentrations did not follow the trends observed for soil nutrients nor did they reflect nutrient *** was no evidence of decreased yields over successive *** carbon and nitrogen contents decrease when grasslands are replaced by *** plantations,and therefore a yield limitation may occur in a medium to long-term frame,especially in stands re-established for short-rotation *** residue management and site preparation must be specifically designed for improving so

关键词： Soil texture Grasslands Foliar nutrient concentrations Successive harvest Coppice Eucalyptus grandis

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Experimental determination and modeling of equilibrium moisture content from the sapwood of Mexican pine (Pinus pseudostrobus Lindl.)

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Forestry Studies in China 2011年第4期13卷 285-289页

作者： juan RODRIGUEZ-RAMIREZ Sadoth sandoval-TORRES Lilia MENDEZ-LAGUNAS Artemio Carrillo PARRA Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR) Oaxaca Instituto Politécnico Nacional Oaxaca 71230 Mexico Facultad de Ciencias Forestales Universidad Autónoma de Nuevo León Linares Nuevo León 67700 Mexico

A desorption isotherm is a very important basis in the understanding of drying process. In this study, the desorption isotherms from the sapwood of Mexican pine （Pinus pseudostrobus Lindl.） were determined by the gravimetric method （discontinuous control of sample weight） at 30℃ and 50℃. The salt method was used in the range of water activities from 0.11 to 0.89. The results show that the desorption ability of Mexican pine sapwood increased with temperature at a given relative humidity. The experimental data was further simulated with the models, i.e., BET, GAB, Oswin and Henderson models. The GAB, Oswin and Henderson models allow the representation of the entire desorption isotherms. The BET model showed a better fit for water activity lower than 0.35, with a mean relative deviation of 0.0286 at 30℃ and 0.0167 at 50℃. Simultaneously, the BET model gave a better representation of moisture content in the monolayer saturation region. Overall, the GAB model ensured the best simulation of the entire isotherm, while the Henderson model displayed the worst simulation.

关键词： modeling isotherms Mexican pine sapwood

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Diversity of Saxicolous Lichens along an Aridity Gradient in Central México

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Phyton-International Journal of Experimental Botany 2022年第4期91卷 827-840页

作者： JoséCarmen Soto-Correa Abraham Saldaña-Vega Víctor Hugo Cambrón-sandoval Laura Concostrina-Zubiri Mariela Gómez-Romero Facultad de Ciencias Naturales Universidad Autónoma de QuerétaroQuerétaro73230México Departamento de Biología y Geología Física y Química Inorgánica Tulipán s/nUniversidad Rey Juan CarlosMóstolesMadrid28933España Cátedra CONACYT–Facultad de Biología Universidad Michoacana de San Nicolás de HidalgoMoreliaMichoacán58030México

Lichens are symbiotic organisms that comprise a fungus and a photosynthetic partner wich are recognized as a good indicator of climate ***,our understanding of how aridity affects the diversity of saxicolous lichens in drylands is still *** evaluate the relationship between saxicolous lichen diversity and aridity in a central México dryland,a geographical transect was established of 100 km to build an aridity gradient in the semiarid zone of the State of Querétaro,Mexico,comprising ten sampling sites with a 10 km *** richness,abundance and diversity of soil lichen species were recorded using two sampling methods:the quadrat-intercept and the line-intercept method,to compare their performance in assessing soil lichen diversity in *** number of species and Shannon diversity of saxicolous lichens were higher at intermediate values of the aridity index(AI=0.10-0.34).Quadrat intercept and point intercept methods gave quite similar results,which means that the selected method does not influence the results in a significant *** study confirms the role of saxicolous lichens as climate change indicators and reveals the importance of the sampling method selection in the evaluation of different parameters of soil lichen diversity in drylands.

关键词： Climate change drylands ecological indicators environmental stress precipitation temperature

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Spatial patterns of distribution and abundance of Harrisia portoricensis,an endangered Caribbean cactus

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Journal of Plant Ecology 2013年第6期6卷 489-498页

作者： Julissa Rojas-sandoval Elvia J.Meléndez-Ackerman Department of Biology University of Puerto RicoRío Piedras CampusPO Box 23360San JuanPuerto Rico 00931-3360USA Center for Applied Tropical Ecology and Conservation University of Puerto RicoPO Box 70377San JuanPuerto Rico 00936-8377USA Department of Environmental Sciences College of Natural SciencesUniversity of Puerto RicoPO Box 70377San JuanPuerto Rico 00936-8377USA

Aims The spatial distribution of biotic and abiotic factors may play a dominant role in determining the distribution and abundance of plants in arid and semiarid *** this study,we evaluated how spatial patterns of microhabitat variables and the degree of spatial dependence of these variables influence the distribution and abundance of the endangered cactus Harrisia *** We used geostatistical analyses of five microhabitat variables(*** cover,soil cover and light incidence)and recorded the abundance of *** in 50 permanent plots established across Mona Island,Puerto Rico,by the United States Department of Agriculture Forest Service as part of the Forest Inventory and Analysis(USDA–FIA).We also used partial Mantel tests to evaluate the relationships between microhabitat variables and abundance of ***,controlling for spatial *** findings Abundance of *** showed strong affinities with microhabitat variables related to canopy structure,soil cover and light *** distribution of this cactus species throughout the island was consistent with the spatial variation patterns of these *** general,landscape-level analyses suggested a predictive value of microhabitat traits for the distribution and abundance of this endangered *** sensitive cacti species,wherein abundance may be influenced by similar variables,these types of analyses may be helpful in developing management plans and identifying critical habitats for conservation.

关键词： abundance Caribbean cactus geostatistics Harrisia portoricensis Mona Island spatial correlation spatial distribution

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Photodegradation and Removal of Diclofenac by the Green Alga Nannochloropsis oculata

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1519-1533页

作者： Danaé Samara Sánchez-sandoval Omar González-Ortega Mara Fernanda Navarro-Martínez juan Marcos Castro-Tapia Ramón Fernando García de la Cruz Ruth Elena Soria-Guerra Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México

The emerging contaminants(ECs)are organic compounds including *** products are consumed in large quantities,favoring their continuous entrance to the environment and affecting the health of living *** is a non-steroidal anti-inflammatory drug with analgesic properties of prolonged *** is the commonest postoperative analgesic,and it is highly consumed without *** recent years,the capability of microalgae to remove pharmaceuticals in water has been tested as a promising *** this work,the removal efficiency of diclofenac(16µg/mL)by the microalga Nannochloropsis oculata CCAP 186/7 was *** major nutrient concentrations in Bold’s Basal Medium were modified(nitrogen and carbon:50 and 100%of their original concentration)to know their effect in the removal of *** degradation by light was also *** maximum removal capacity of diclofenac in the medium was 68.8%.The percentage of diclofenac adsorbed on the cell wall was between 6 and 12.7%.Around 23.6%of diclofenac was degraded by light after 18 *** did not show growth inhibition due to the presence of *** results obtained point to the promissory application of *** as a bioremediation system for diclofenac removal.

关键词： Adsorption emerging contaminants microalgae pharmaceuticals phycoremediation photodegradation

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“Quito municipal schools” cohort study: Baseline results

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Open Journal of Epidemiology 2012年第3期2卷 70-74页

作者： Natalia Romero-sandoval Virginia Ruiz juan Quizanga Ricardo Recalde Efrén Anchali Jaime Falconí Oscar Flores Miguel Martín Instituto Superior de Postgrado Facultad de Ciencias Médicas Universidad Central del Ecuador Quito Ecuador Grupos de Investigación de América y Africa Latinas (GRAAL) Barcelona Espana and Quito Ecuador Consultora de UNICEF Quito Ecuador Municipio del Distrito Metropolitano de Quito Quito Ecuador Unidad de Bioestadística Facultad de Medicina Universidad Autónoma de Barcelona Cerdanyola del Vallès Spain

The lack of population-level data on growth and development of children and adolescents in Ecuador, and the existence of previous data suggesting an alarming increase in the numbers of children presenting overweight or obesity justifies the present cohort study which includes all pupils of municipal schools of Quito aged 9 to 17 years. Follow-up will continue for a minimum of 7 years. This will allow determining the evolution of prevalence of these phenomena and their trends as well as other indices, both physiological and family-related customs, in order to plan appropriate preventive interventions. The present cross-sectional study includes 21 municipal schools, grouped into four health zones, each of which depends on a health centre, also municipal, and which are responsible for the health of pupils in these schools. Of the 6964 pupils studied, 18.7% suffer overweight and 7.9% obesity: 19.3% and 9.7% respectively in boys, compared to 18.2% and 5.4% in girls. The study also assesses family characteristics, degree of sedentarism and nutritional habits: 62.3% declared living in a nuclear family, and 60.5% declared their families to be in the “adolescent” life-cycle stage;91.9% of pupils were sedentary while 5.4% (CI95% 4.87 - 5.94) reported not eating breakfast every day.

关键词： Overweight and Obesity Equatorian School Children Sedentarism Type of Family

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