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Journal of Modern Power systems and Clean Energy 2023年第1期11卷 191-200页

作者： Pedro P.Vergara juan s.giraldo Mauricio salazar Nanda K.Panda Phuong H.Nguyen Intelligent Electrical Power Grids(IEPG)Group Delft University of TechnologyDelft 2628CDThe Netherlands Energy Transition studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Electrical Energy systems(EEs)Group Eindhoven University of TechnologyEindhovenThe Netherlands IEEE

A photovoltaic(PV)-rich low-voltage(LV)distribution network poses a limit on the export power of PVs due to the voltage magnitude *** defining a customer export limit,switching off the PV inverters can be avoided,and thus reducing power *** on this,this paper proposes a mixed-integer nonlinear programming(MINLP)model to define such optimal customer *** MINLP model aims to minimize the total PV power curtailment while considering the technical operation of the distribution ***,a nonlinear mathematical formulation is ***,a new set of linearizations approximating the Euclidean norm is introduced to turn the MINLP model into an MILP formulation that can be solved with reasonable computational *** extension to consider multiple stochastic scenarios is also *** proposed model has been tested in a real LV distribution network using smart meter measurements and irradiance profiles from a case study in the *** assess the quality of the solution provided by the proposed MILP model,Monte Carlo simulations are executed in OpenDss,while an error assessment between the original MINLP and the approximated MILP model has been conducted.

关键词： Low-voltage distribution network photovoltaic(PV)curtailment optimal power flow Monte Carlo simulations

Estimating Risk-aware Flexibility Areas for Electric Vehicle Charging Pools via AC stochastic Optimal Power Flow

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Journal of Modern Power systems and Clean Energy 2023年第4期11卷 1247-1256页

作者： juan s.giraldo Nataly Bañol Arias Pedro P.Vergara Maria Vlasiou Gerwin Hoogsteen Johann L.Hurink Energy Transition studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Department of Electrical Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Electrical Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduces an AC stochastic optimal power flow(sOPF)for the flexibility management of electric vehicle(EV)charging pools in distribution networks under *** AC sOPF considers discrete utility functions from charging pools as a compensation mechanism for eventual energy not served to their charging *** application of the AC sOPF is described where a distribution system operator(DsO)requires flexibility to each charging pool in a day-ahead time frame,minimizing the cost for flexibility while guaranteeing technical *** areas are defined for each charging pool and calculated as a function of a risk parameter involving the uncertainty of the *** show that all players can benefit from this approach,i.e.,the DsO obtains a riskaware solution,while charging pools/tasks perceive a reduction in the total energy payment due to flexibility services.

关键词： Electric vehicle flexibility management stochastic optimal power flow(sOPF) risk awareness compensation mechanism

Consequences of early life stress on the structure and function of the adult mouse retina

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Neural Regeneration Research 2024年第1期19卷 150-151页

作者： juan s.Calanni Ruth E.Rosenstein Laboratory of Retinal Neurochemistry and Experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

Early-life stress(ELs)refers to a period of environmental/social deprivation,physica l,sexual or emotional abuse,neglect,severe and/or chronic trauma in the prenatal/early postnatal stage,which is closely related to many adverse psychiatric disorders later in life,such as depressive disorder,substance abuse,dysthymia,panic,anxiety,and suicidal behavior in adulthood(Waters and Gould,2022).

关键词： stress life Gould

The relationship between morphology and flight in Drosophila:a study of two pairs of sibling species from a natural population

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Insect science 2024年第3期31卷 885-900页

作者： Nicolás Flaibani Victoría Estefania Ortiz juan JoséFanara Valeria Paula Carreira Laboratorio de Evolucion Departamento de EcologiaGenética y Evolucion(DEGE)Facultad de Ciencias Exactas y Naturales(FCEN)Universidad de Buenos Aires(UBA)Instituto de GenéticaEcologia y Evolucion de Buenos Aires(IEGEBA)Consejo Nacional de Investigaciones Cientificasy Tecnicas(CONICET)-UBABuenos AiresArgentina

Insect flight is a complex trait involved in different behaviors,from the search for sexual partners,food,or breeding *** studies have postulated the adaptive advantages of certain morphological traits in relation to increased flight capacity,such as low values of wing loading or high values of wing:thorax ratio and wing-aspect ***,few studies have evaluated the relationship between variables related to flight and morphological traits in *** work aimed to study morphological traits in males and females of two pairs of sibling species:Drosophila buzzati Patterson and Wheeler-Drosophila koeferae Fontdevila and Wasserman,and Drosophila melanogaster Meigen-Drosophila simulans sturtevant,and to analyze its relationship with *** detected the highest proportion of flight time in *** and *** compared to *** and ***,*** results also revealed sexual dimorphism,with males exhibiting a higher proportion of flight time than ***,we did not find a general pattern to explain the relationship between morphology and the proportion of flight time because associations varied depending upon the analyses(considering all groups together or each sex-species combination separately).Moreover,these associations explained a low percentage of variation,suggesting that other nonmorphological components related to flight,such as physiological variables,should be taken into *** work allowed us to show the variability and complexity of an aspect of flight,suggesting that the adaptive role of the morphological traits studied might have been overestimated.

关键词： morphological traits time in flight wing loading wing:thorax ratio wingaspect ratio wing second moment of area

Porphyrinic Acceptors forFullerene-Free MolecularPhotovoltaics

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CCs Chemistry 2024年第2期6卷 276-296页

作者： Jorge Labella juan Laforga-Martin Tomás Torres Department of Organic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanced Research in Chemical sciences Universidad Aut´onoma de MadridMadrid IMDEA—Nanociencia 28049 Madrid

Over the past few years,the development of nonfullerene acceptors(NFAs)has become a prominent focus in both organic and perovskite solar cell(OsCs and PsCs,respectively)research *** this context,porphyrinoids,compounds structurally related to porphyrins,have emerged as promising solar cell *** contrast to the widely used fullerene acceptors,porphyrinoids exhibit strong,broad absorption properties across the UV–vis/NIR spectrum,which can be easily tuned through chemical ***,they can be prepared and derivatized using cost-effective and straightforward methodologies,allowing for convenient adjustments in thin-film morphology,processability,supramolecular organization,and energy ***,these compounds offer higher thermal and photochemical stability,resulting in longer device lifetimes compared to their fullerene-based *** this review,we outline the utilization of porphyrinoids as NFAs in OsCs and PsCs,discussing essential aspects such as design guidelines,molecular properties,and device *** goal is to inspire and further promote the development of n-type porphyrinoids,which have not yet fully unleashed their potential.

关键词： fullerene-free molecular photovoltaics nonfullerene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovskite solar cells

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jesús López-Gambero juan Antonio Navarro Carlos sanjuan Elena Baixeras juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra s.L.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Quality assessment of the Topo-Iberia CGPs stations and data quality's effects on postfit ionosphere-free phase residuals

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Geodesy and Geodynamics 2024年第2期15卷 189-199页

作者： juan A.García-Armenteros Center for Advanced studies in Earth sciences Energy and Environment(CEACTEMA)University of Jaén23071 JaenSpain

This paper analyzed GPs data from the Topo-Iberia network spanning almost 12 years(2008-2020).The data quality information for all 26 Topo-Iberia stations is provided for the first time,complementing the spanish Geological survey’s storage *** analyses based on quality indicators obtained using TEQC have been carried *** guidelines and data quality information from the IGs stations have been considered as the quality references,with the stations ALJI,EPCU,and TIOU standing out as the worst stations,while on the contrary,FUEN,PALM,PILA,and TRIA meet the quality requirements to become an IGs *** relationship between the GPs data quality and their GAMIT-and Gipsy X-derived postfit ionosphere-free phase residuals has also been investigated,and the results reveal an inversely proportional *** has been found that the stations showing an increase in elevation of the horizon line,also show an increase in cycle slips and multipath,are among the poorest quality stations,and among those with the highest postfit RMs of phase ***,the evolution of the vegetation around the antenna should be considered as it could cause a progressive loss of quality,which is not complying with the IGs *** quality assessment shows that the Topo-Iberia stations are appropriate for geodetic purposes,but permanent monitoring would be necessary to avoid the least possible loss of data and *** addition,a method to characterize the GNss data quality is proposed.

关键词： GPs dataquality's effects IGs quality standard Postfit LC phase residual Qualityassessment Topo-Iberia CGPs network

single-neuron neurodegeneration as a degenerative model for Parkinson’s disease

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Neural Regeneration Research 2024年第3期19卷 529-535页

作者： sandro Huenchuguala juan segura-Aguilar Escuela de Tecnología Médica Facultad de SaludUniversidad Santo TomásLos CarrerasOsornoChile Molecular&Clinical Pharmacology Instituto de Ciencias Biomedicas(ICBM)Faculty of medicineUniversity of ChileIndependenciaSantiagoChile

The positive effect of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effects,has encouraged the scientific community to look for new drugs that can stop the neurodegenerative process or even regenerate the neuromelanin-containing dopaminergic nigrostriatal *** preclinical studies with coenzyme Q10,mitoquinone,isradipine,nilotinib,TCH346,neurturin,zonisamide,deferiprone,prasinezumab,and cinpanemab prompted clinical ***,these failed and after more than 50 years levodopa continues to be the key drug in the treatment of the disease,despite its severe side effects after 4–6 years of chronic *** lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the human body as new drugs for Parkinson’s disease treatment is a big *** our opinion,the cause of these failures lies in the experimental animal models involving neurotoxins that do not exist in the human body,such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine,that induce a very fast,massive and expansive neurodegenerative process,which contrasts with the extremely slow one of neuromelanin-containing dopaminergic *** exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to(i)a degenerative model in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron,(ii)a neurotoxic event that is not expansive and(iii)the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neuromelanin-containing dopaminergic *** endogenous neurotoxin that fits this degenerative model involving one single neuron at a time is aminochrome,since it(i)is generated within neuromelanin-containing dopaminergic neurons,(ii)does not cause an expansive neurotoxic effect and(iii)triggers all the mechanisms involved in t

关键词： 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine aminochrome dopaminergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase M2-2

Temporal stability and directional change in a color cline of a marine snail from NW spain

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Current Zoology 2024年第2期70卷 163-173页

作者： juan Gefaell Ramon Vigo A.Honorato Gonzalez-Vazquez juan Galindo Emilio Rolan-Alvarez Centro de Investigacion Marina Universidade de VigoDepartamento de BioquimicaGenetica e Inmunologia36310 VigoSpain

The evolution and maintenance of color clines is a classic topic of research in evolutionary ***,studies analyzing the temporal dynamics of such clines are much less frequent,due to the difficulty of obtaining reliable data about past color distributions along environmen-tal *** this article,we describe a case of decades-long temporal stability and directional change in a color cline of the marine snail Littorina saxatilis along the coastal inlet of the Ria de Vigo(NW spain).*** from this area shows a clear color cline with 3 distinct areas from the innermost to the more wave-exposed localities of the Ria:the inner,protected localities show an abundance of fawn-like individuals;the intermediate localities show a high diversity of colors;and the outer,wave-exposed localities show populations with a high frequency of a black and lineated *** compare data from the 1970s and 2022 in the same localities,showing that the cline has kept relatively stable for at least over half a century,except for some directional change and local variability in the frequency of certain *** regression analyses and biodiversity measures are presented to provide clues into the selective pressures that might be involved in the maintenance of this color *** research avenues to properly test the explanatory power of these selective agents as well as the possible origins of the cline are discussed.

关键词： clinal variation color polymorphism ecological gradient Littorina saxatilis natural selection wave exposure.

Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： juan Jose Urquijo-Ponce Carlos Alventosa-Mateu Mercedes Latorre-sánchez Inmaculada Castelló-Miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(sT),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel sT in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of sT in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of sT in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant systemic therapy