检索结果-南通市图书馆

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-ramírez Mónica G Mendoza-rodríguez Omar r Alemán Fernando A Candanedo-gonzález Miriam rodríguez-Sosa juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CrC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(Dr)that has been inversely associated with poor prognosis;less Dr is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CrC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CrC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

risk of fracture in celiac disease:Gender,dietary compliance,or both?

引用

World Journal of Gastroenterology 2011年第25期17卷 3035-3042页

作者： María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea gonzález roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli juan Andrés de Paula juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai Small Bowel Section Department of Medicine"Dr.C.Bonorino Udaondo" Gastroenterology Hospital Department of Gastroenterology German Hospital Nutritional Support Unit and Malabsortion "San Martin" HIGA1900 La PlataArgentina Department of Gastroenterology Italian Hospital

AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture ***:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal *** were collected through in-person interviews with an *** overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).rESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (Hr):1.78,95% CI:1.23-2.56,P r:2.67,95% CI:1.37-5.22,P racture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P riod after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (Hr:1.08,95% CI:0.55-2.10 for women;Hr:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before *** is associated with male sex and classic clinical *** fracture risk was reduced after the treatment.

关键词： Celiac disease Fracture risk Peripheralfractures Gluten-free diet Sex difference

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Failure to rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution Located in a Middle-Income Country

引用

Congenital Heart Disease 2024年第2期19卷 207-218页

作者： Gustavo Cruz Santiago Pedroza juan F.Vélez Jessica Largo juan F.Tejada Jorge H.Mejía-Mantilla Departamento de Anestesiología Fundación Valle del LiliCali760032Colombia Centro de Investigaciones Clínicas Fundación Valle del LiliCali760032Colombia Departamento de Cardiología Pediátrica Fundación Valle del LiliCali760032Colombia Facultad de Medicina Universidad IcesiCali760031Colombia Unidad de Cuidado Intensivo Fundación Valle del LiliCali760032Colombia

Background:Failure to rescue has been an effective quality metric in congenital heart ***,mor-bidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality *** aim to measure the complications,mortality,and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar ***:A retrospective observational study was conducted in a high-complexity service provider institution,in Cali,*** pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were *** main outcomes evaluated in the study were complication,mortality,and failure to rescue *** and multivariate logistic regression analysis was performed with mortality as the outcome ***:We evaluated 308 congenital heart *** the outcomes,201(65%)complications occurred,23(7.5%)patients died,and the FTr of the entire cohort was 11.4%.The presence of a postoperative complication(Or 14.88,CI 3.06–268.37,p=0.009),age(Or 0.79,CI 0.57–0.96,p=0.068),and urgent/emergent surgery(Or 8.14,CI 2.97–28.66,pre the most significant variables in predicting ***:Failure to rescue is an effective and comparable quality measure in healthcare institutions and is the major contributor to postoperative mortality in congenital heart *** our higher mortality and complication rate,we obtained a comparable failure to rescue rate to high-income countries’health institutions.

关键词： Congenital heart surgery complication mortality failure to rescue quality metric

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blood Flow Simulation in the Femoral Artery

引用

Journal of Electronic Science and Technology 2018年第3期16卷 269-279页

作者： Camilo A.Naranjo Andrés F.Villa juan C.Vélez ricardo A.Prato Alberto J.Cadena juan P.Tello IPATEC Institute CONICETBariloche R8400 Integra IT Bogotá 602 the Electronic and Electric Engineering Department Universidad del NorteBarranquilla 1569 the Institute of Mathematics Universidad de AntioquiaMedellin 050010 the Cardiology Department Clínica de la CostaBarranquilla 080020

This paper presents the development of the blood flow simulation in two dimensions over the real geometry of the femoral artery. The Navier-Stokes equations are solved using the finite element method, to obtain the distributions of the blood pressure and flow velocity in multiple instants of time and different places of the femoral artery and thus determine the current condition of the blood vessels. The velocity field shows a laminar behavior,where, the velocity is higher in the center of the artery and decreases as the blood flow approaches artery walls. In spite of all artery and blood flow properties not being considered, the values of pressure and velocity obtained are within the normal ranges. Finally the model is used to verify if there exist irregularities in the blood flow in both healthy subjects and sick patients.

关键词： Blood flow femoral artery finite elements Navier-Stokes pressure velocity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Proposal to Disseminate the Knowledge of Tsunamis in the Caribbean Coast of Costa rica, Central America

引用

World Journal of Engineering and Technology 2014年第3期2卷 85-90页

作者： Mario Fernández Arce Daniel Solís juan Luis Porras Gino gonzález 不详

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

引用

Neural regeneration research 2022年第1期17卷 31-37页

作者： Mercedes A.Hernández-Sapiéns Edwin E.reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu ricardo r.Cevallos juan C.Mateos-Díaz Víctor J.Sánchez-gonzález Alejandro A.Canales-Aguirre Unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de Neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and Molecular Genetics Department University of AlabamaBirminghamAlabama Unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,Notch-1,N-and E-cadherin,LrP,Syndecan,Delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSEN1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSEN1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatoprotective effect of silymarin

引用

World Journal of Hepatology 2014年第3期6卷 144-149页

作者： Nancy Vargas-Mendoza Eduardo Madrigal-Santillán ngel Morales-gonzález Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel García-Luna y gonzález-rubio juan A Gayosso-de-Lucio José A Morales-gonzález Institute of Health Sciences Autonomous University of Hidalgo State Laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico NacionalAv.Juan de Dios Bátiz s/n esquina Miguel Othón de MendizabalUnidad Profesional Adolfo López Mateos Faculty of Dentistry UNAM

The use of medicinal plants in treating illnesses has been reported since ancestral *** the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic *** is a natural compound derived from the species Silybum marianum,which is commonly known as Milk *** plant contains at least seven flavoligands and the flavonoid *** hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon *** generation of free radicals is known to damage cellular membranes and cause *** enhances hepatic glutathione and may contribute to the antioxidant defense of the *** has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating rNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.

关键词： Silybum marianum Hepatoprotector Lipoperoxidation Silymarin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Air Quality Trends in Metropolitan Zones in Veracruz, México

引用

Open Journal of Air Pollution 2016年第2期5卷 64-94页

作者： Sergio Natan gonzález rocha juan Cervantes Pérez José M. Baldasano recio Facultad Ciencias Químicas Universidad Veracruzana Veracruz Mexico Earth Sciences Department Barcelona Supercomputing Center (BSC-CNS) Barcelona Spain Centro de Ciencias de la Tierra Universidad Veracruzana Veracruz Mexico Universitat Politecnica de Catalunya Barcelona Spain

Mexico and currently in Veracruz state, there are metropolitan zones (MZ) growing. Therefore, main objective in this paper is to analyze new data and AQ trends during 01.09.2013 to 30.06.2015 of two new AQ monitoring stations installed in Xalapa and Minatitlan MZ in 2013-year. The methodology applied used quality criteria to the datasets, followed by data validation and statistics for further analysis to determine the hourly, weekly and yearly trends of NO2, O3, SO2, PM10 and PM2.5. Indicators were compared with Mexican standards, CAI-LAC report, WHO guidelines, EU and USA standards to evaluate the AQ in both sites. We observed AQ trends from moderate to bad in Xalapa and Minatitlan MZ where the PM10 and PM2.5 surpassed the WHO guidelines and Mexican standards. O3 and SO2 in Xalapa presented a quality from good to moderate and in Minatitlan sometimes were from moderate to bad. NO2 did not exceed the value limits of Mexican standards, only Xalapa has exceeded the WHO guidelines. In Minatitlan, the Mexican limits were not exceeded. Concluding, PM10 and PM2.5 concentrations were the main problem. Others pollutants that influenced the AQ were O3, NO2 and SO2 in Minatitlan MZ due probably to meteorology, site conditions, location and oil and petrochemical industries. In Xalapa, MZ NO2 and SO2 are attributed mainly to road transport.

关键词： Air Pollution Air Quality Management Air Quality Trends NO2 O3 PM10 PM2.5 SO2 Veracruz

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environmental Deterioration of the Tecomate Coastal Lagoon, in the Guerrero State, Mexico

引用

International Journal of Geosciences 2016年第1期7卷 1-10页

作者： Salvador Villerías-Salinas juan Violante-gonzález Neftalí García-Castro Lorena Alonzo-Guzmán Centro de Estudios y Posgrado en Estudios Socioterritoriales Universidad Autónoma de Guerrero Chilpancingo México Unidad Académica de Ecología Marina Universidad Autónoma de Guerrero Acapulco México Unidad Académica de Ingeniería Universidad Autónoma de Guerrero Chilpancingo México

An exhaustive field study was undertaken between November 2011 and August 2012, with the aim to know the causes of the environmental deterioration of the Tecomate Lagoon, in the Guerrero state, Mexico. Data of temperature, dissolved oxygen, salinity parameters and depth of the lagoon were interpolated using the Kriging geostatistical method to generate a prediction surface. The lagoon registered a great variation in its saline concentration, which ranged from 8.0 to 65.0 ppt, with the lowest values in November 2011 and the highest at May 2012. The great variability in the salinity throughout the year contributed in significant form to the lagoon’s instability. An average water temperature of 32?C and dissolved oxygen levels of 4.49 to 7.44 mg/L were recorded. The low depth registered in the lagoon (mean = 1 m), is related to fluvial and marine processes, both of which modify depth through the transport of sediment to its interior. Currently, fishing is scarce, with the mangrove forest in some areas in a process of deterioration due to a lack of moisture. The lagoon system is undergoing a process of environmental deterioration, with an advanced ecological succession and non-aquatic vegetable species colonizing the area surrounding the lagoon.

关键词： Tecomate Lagoon Environmental Parameters Habitat Deterioration Aquatic Ecosystem

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Taphonomic characterisation of tooth marks of extinct Eurasian carnivores through geometric morphometrics

引用

Science Bulletin 2022年第16期67卷 1644-1648,M0003,M0004页

作者： José Yravedra Lloyd Austin Courtenay Darío Herranz-rodrigo gonzalo Linares-Matás juan Josérodríguez-Alba Verónica Estaca-Gómez Carmen Luzón Alexia Serrano-ramos MiguelÁngel Maté-gonzález JoséAntonio Solano Diego gonzález-Aguilera juan Manuel Jiménez-Arenas Department of Prehistory Ancient History and ArchaeologyComplutense University of MadridMadrid 28040Spain C.A.I.Archaeometry and Archaeological Analysis Complutense UniversityMadrid 28040Spain Grupo de Investigación Ecosistemas Cuaternarios Complutense UniversityMadrid 28040Spain Grupo de Investigación Arqueología Prehistórica Complutense UniversityMadrid 28040Spain Museo Primeros Pobladores de Europa‘Josep Gibert’ Orce 18858Spain Department of Cartographic and Land Engineering Higher Polytechnic School of AvilaUniversity of SalamancaAvila 05003Spain School of Archaeology St.Hugh’s CollegeUniversity of OxfordOxford 01865United Kingdom History and Arts Doctoral Program University of GranadaGranada 18071Spain Escuela Técnica Superior de Ingenieros en Topografía Geodesia y Cartografía.Universidad Politécnica de MadridMadrid 28031Spain Department of Prehistory and Archaeology University of GranadaGranada 18071Spain

Determining the cause and nature of the postmortem processes that living organisms experience is one of the main common issues faced by forensic experts,zooarchaeologists,palaeontologists,and other *** are among the most destructive agents that can interact with a corpse,since their feeding behaviour can lead to very extensive alterations,complicating the diagnostic identification of which carnivore species was responsible for the death of an individual,a livestock unit,or the formation of a fossil *** though some currently available techniques enable forensic experts to undertake a differential diagnosis of carnivore agency from corpse examination.

关键词：几何形态测量学埋藏特征有蹄类动物齿痕几何形态学机器学习分类预测多变量分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：