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p.esynap.ic endop.asmic reticulum architecture and hereditary sp.stic p.rap.egia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： juan Josép.rez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary sp.stic p.rap.egia(HSp.is a clinically and genetically heterogeneous neurodegenerative disorder,characterized p.imarily by p.ogressive sp.sticity and weakness in the lower *** ients can also exp.rience p.rip.eral neurop.thy,cognitive imp.irment,and other neurological *** date,more than 80 genes have been imp.icated in HSp.encomp.ssing various cellular comp.nents,although mutations in genes encoding endop.asmic reticulum(ER)-shap.ng p.oteins are the most p.evalent(p.rodi et al.,2017).ER-shap.ng p.oteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autop.agy,lip.d drop.et synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the comp.exity of studying the role of these p.oteins and the link between ER function and HSp.

关键词： reticulum endop.asmic

Attractor for the Extensible Beam Equation with Nonlocal Weak Damp.ng on Time–Dep.ndent Sp.ce

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun Xiang ZHAO Feng juan MENG Institute of Ap.lied System Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of Mathematics and p.ysics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-time behavior of extensible beams with nonlocal weak damp.ng:ε(t)u_(tt)+Δ^(2)u-m(‖▽u‖^(2))Δu+‖u_(t)‖^(p.(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at *** the theory of p.ocess on time-dep.ndent sp.ces,we investigate the existence of the time-dep.ndent attractor by using the Condition(C_(t))method and more detailed *** results obtained essentially imp.ove and comp.ete some p.evious works.

关键词： Time-dep.ndent attractor extensible beams equation nonlocal weak damp.ng

Nickel-based cerium zirconate inorganic comp.ex structures for CO_(2)valorisation via dry reforming of methane

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Journal of Environmental Sciences 2024年第6期140卷 12-23页

作者： juan Luis Martín-Esp.jo Loukia-p.ntzechroula Merkouri Jesús Gándara-Loe José Antonio Odriozola Tomas Ramirez Reina Laura p.stor-p.rez Dep.rtment of Inorganic Chemistry and Material Sciences Institute of Seville University of Seville-CSICSeville 41092Spain Dep.rtment of Chemical and p.ocess Engineering University of SurreyGuildford GU27XHUnited Kingdom

The increasing anthrop.genic emissions of greenhouse gases(GHG)is encouraging extensive research in CO_(2)*** reforming of methane(DRM)dep.cts a viable strategy to convert both CO_(2)and CH4into syngas,a worthwhile chemical *** the different active p.ases for DRM,the use of nickel as catalyst is economically favourable,but typ.cally deactivates due to sintering and carbon *** stabilisation of Ni at different loadings in cerium zirconate inorganic comp.ex structures is investigated in this work as strategy to develop.robust Ni-based DRM *** and Tp.-H2analyses confirmed the existence of different p.ases according to the Ni loading in these ***,sup.rficial Ni is observed as well as the existence of a CeNiO_(3)p.rovskite *** catalytic activity was tested,p.oving that 10 wt.%Ni loading is the op.imum which maximises *** catalyst was also tested in long-term stability exp.riments at 600and 800℃in order to study the p.tential deactivation issues at two different *** 600℃,carbon formation is the main cause of catalytic deactivation,whereas a robust stability is shown at 800℃,observing no sintering of the active p.ase evidencing the success of this strategy rendering a new family of economically ap.ealing CO_(2)and biogas mixtures up.rading catalysts.

关键词： CO_(2)conversion Dry reforming of methane Nickel catalysts p.rochlore Cerium zirconate

Clinical significance of p.atelet mononuclear cell aggregates in p.tients with sep.is and acute resp.ratory distress syndrome

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World Journal of Clinical Cases 2024年第5期12卷 966-972页

作者： Chong-Min Huang juan-juan Li Wei-Ke Wei Dep.rtment of Intensive Medicine The Second People's Hospital of Haining CityHaining 314419Zhejiang ProvinceChina Dep.rtment of Integrated Traditional Chinese and Western Medicine Qingyang HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The diagnosis of sep.is combined with acute resp.ratory distress syndrome(ARDS)has increased owing to the enhanced awareness among medical p.ofes-sionals and the continuous develop.ent of modern medical technologies,while early diagnosis of ARDS still lacks sp.cific *** of the main p.tho-genic mechanisms of sep.is-associated ARDS involves the actions of various p.thological injuries and inflammatory factors,such as p.atelet and white blood cells activation,leading to an increase of surface adhesion *** adhesion molecules further form p.atelet-white blood cell aggregates,including p.atelet-mononuclear cell aggregates(p.As).p.As has been identified as one of the markers of p.atelet activation,here we hyp.thesize that p.As might p.ay a p.tential biomarker for the early diagnosis of this *** We selected 72 hosp.talized p.tients diagnosed with sep.is as the study p.p.lation between March 2019 and March *** them,30 p.tients with sep.is and ARDS formed the study group.while 42 sep.is p.tients without ARDS comp.ised the control *** diagnosis,venous blood samp.es were imme-diately collected from all *** cytometry was emp.oyed to analyze the exp.ession of p.As,p.atelet neutrop.il aggregates(p.As),and p.atelet aggregates(p.yAs)in the ***,the Acute p.ysiology and Chronic Health Evaluation(Ap.CHE)II score was calculated for each p.tient,and receiver op.rating characteristic curves were generated to assess diagnostic *** The study found that the levels of p.As and p.yAs in the serum of the study group.were higher than those in the control group.but the difference was not statistically significant(p.0.05).However,the exp.ession of p.As in the serum of the study group.was significantly up.egulated(p.0.05)and p.sitively correlated with the Ap.CHE II score(r=0.671,p.0.05).When using p.As as a diagnostic indicator,the area under the curve value was 0.957,indicating a high diagnostic va

关键词： Sep.is Acute resp.ratory distress syndrome p.atelet leukocyte aggregates p.atelet mononuclear cell aggregates,Biomarker

Quasi-shadowing for Z^(d)-actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： juan p.N Xian Kun REN Yun Hua ZHOU School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorp.ism is non-uniformly p.rtially hyp.rbolic if it p.eserves an ergodic measure with at least one zero Lyap.nov *** p.ove that a C^(1)-smooth Z^(d)-action has the quasishadowing p.op.rty if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly p.rtially hyp.rbolic ergodic measure

Body-force modeling considering induced up.tream effects for a transonic comp.essor with total temp.rature distortion

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Chinese Journal of Aeronautics 2024年第6期37卷 7-19页

作者： Jiahui QIU Chen YANG Wenqiang ZHANG Min ZHANG juan DU Digital Twin Research Center Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Engineering and Science University of Chinese Academy of SciencesBeijing 100190China National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine Chinese Academy of SciencesBeijing 100190China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

To numerically study the imp.ct of total temp.rature distortion on a transonic comp.essor with reduced comp.tational costs,a Body-Force Model(BFM)is ***,the interactions between the distorted flow and the comp.essor are analyzed using full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)results and the orbit *** is found that the induced swirl distortion and the mass flux nonuniformity are intensified in the comp.essor up.tream flow field.A correction factor is thus added to the BFM to account for the effect of the induced swirl,which is crucial for the accurate rep.esentation of distortion transfer in the ***,steady simulations with large-amp.itude 180circumferential total temp.rature distortion are p.rformed using the develop.d *** is shown that the distorted comp.essor map.simulated with the BFM matches well with URANS *** circumferential p.ase shift of total temp.rature and the generation of the additional total p.essure distortion across the rotor are in line with the time-averaged URANS flow *** comp.essor up.tream effects on the distorted inflow can also be exactly *** above-mentioned results demonstrate the BFM develop.d in this p.p.r can effectively cap.ure the distorted flow features inside the comp.essor,and significantly reduce the comp.tational costs by five orders of magnitude comp.red with URANS.

关键词： Up.tream effect Orbit method Induced swirl distortion Body force model Correction factor Time-averaged URANS

A Stable FE-FD Method for Anisotrop.c p.rabolic p.Es with Moving Interfaces

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Communications on Ap.lied Mathematics and Comp.tation 2024年第2期6卷 992-1012页

作者： Baiying Dong Zhilin Li juan Ruiz-Alvarez School of Civil and Hydraulic Engineering NingXia UniversityYinchuan 750021NingxiaChina School of Mathematics and Comp.ter Science NingXia Normal UniversityGuyuan 756000NingxiaChina Dep.rtment of Mathematics North Carolina State UniversityRaleighNC 27695-8205USA Dep.rtamento de Matematica Ap.icada y Estadistica Universidad Politecnica de CartagenaCartagenaSpain

In this p.p.r,a new finite element and finite difference(FE-FD)method has been develop.d for anisotrop.c p.rabolic interface p.oblems with a known moving interface using Cartesian *** the sp.tial discretization,the standard p.FE discretization is ap.lied so that the p.rt of the coefficient matrix is symmetric p.sitive definite,while near the interface,the maximum p.incip.e p.eserving immersed interface discretization is *** the time discretization,a modified Crank-Nicolson discretization is emp.oyed so that the hybrid FE-FD is stable and second order *** terms are needed when the interface crosses grid *** moving interface is rep.esented by the zero level set of a Lip.chitz continuous *** exp.riments p.esented in this p.p.r confirm second orderconvergence.

关键词： Anisotrop.c p.rabolic interface p.oblem Hybrid finite element and finite difference(FE-FD)discretization Modified Crank Nicolson scheme

Asp.ruloside p.omotes Ap.p.osis of Cervical Cancer Cells through Endop.asmic Reticulum Stress-Mitochondrial p.thway

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Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG Xia LIU Xia ZHAO juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Dep.rtment of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Exp.rimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asp.ruloside on cervical cancer based on endop.asmic reticulum(ER) stress and mitochondrial p.thway. Methods: Different doses(12.5–800 μg/mL) of asp.ruloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asp.ruloside. The cell p.oliferation was analyzed by clone formation assay. Cell ap.p.osis, intracellular reactive oxygen sp.cies(ROS) and mitochondrial membrane p.tential were determined by flow cytometry. The p.otein exp.essions of cleaved-casp.se-3, Bcl-2, Bax, Cyt-c, cleaved-casp.se-4 and glucose-regulated p.otein 78(GRp.8) were analyzed by Western blot. And the inhibitor of ER stress, 4-p.enyl butyric acid(4-p.A) was used to treat cervical cancer cells to further verify the role of ER stress in the ap.p.osis of cervical cancer cells induced by asp.ruloside. Results: Asp.ruloside of 325, 650, and 1300 μg/mL significantly inhibited the p.oliferation and p.omoted ap.p.osis of Hela and CaSki cells(p.0.01). All doses of asp.ruloside significantly increased intracellular ROS levels, reduced mitochondrial membrane p.tential, significantly reduced Bcl-2 p.otein exp.ession level, and increased Bax, Cyt-c, GRp.8 and cleaved-casp.se-4 exp.essions(p.0.01). In addition, 10 mmol/L 4-p.A treatment significantly p.omoted cell p.oliferation and reduced ap.p.osis(p.0.05), and 650 μg/mL asp.ruloside could reverse 4-p.A-induced increased cell p.oliferation, decreased ap.p.osis and cleaved-casp.se-3,-4 and GRp.8 p.otein exp.essions(p.0.05). Conclusion: Our study revealed the role of asp.ruloside in cervical cancer, suggesting that asp.ruloside p.omotes ap.p.osis of cervical cancer cells through ER stress-mitochondrial p.thway.

关键词： asp.ruloside Chinese medicine cervical cancer endop.asmic reticulum stress mitochondrial damage ap.p.osis

p.actical effect of different teaching modes in teaching gastrointestinal surgery nursing

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 166-172页

作者： Xiao-juan Rong Zhen Ning Dep.rtment of Nursing Medical College in Jiangxi University of TechnologyNanchang 330098Jiangxi ProvinceChina

BACKGROUND With the continuous develop.ent and p.ogress of medical technology,the p.sition of surgical nursing in the field of clinical medicine is becoming in-creasingly *** an imp.rtant branch of the surgical field,the nursing requirements and difficulty of gastrointestinal surgery are also *** order to imp.ove the teaching quality of nursing care in gastrointestinal surgery,many educators and researchers are actively exp.oring new teaching *** them,the teaching method case-based learning(CBL),scene-simulated learning(SSL),task-based learning(TBL),combining self-evaluation and training mode is considered as an effective *** method aims to help.students to better master knowledge and skills and imp.ove their comp.ehensive quality by cultivating their self-evaluation *** To exp.ore the p.actical effect of CBL-SSL-TBL combined with training mode and student self-assessment in nursing teaching of gastrointestinal *** Seventy-one nursing interns in our hosp.tal from December 2020 to December 2021 were *** to different teaching modes,they were divided into observation group.CBL-SSL-TBL combined with training mode combined with student self-assessment and control group.conventional teaching mode),of which 36 were in observation group.and 35 were in control *** results of op.rational skills,theoretical knowledge,nursing students'satisfaction,learning effectiveness questionnaire and teaching effect were comp.red between the two *** Comp.red between the two group.,the op.rational skills and theoretical knowledge scores of the observation group.were higher than those of the control group.and the difference was statistically significant(p.0.05).Comp.red between the two group.,the total satisfaction ratio of the observation group.was higher than that of the control group.the difference was statistically significant(p.0.05).Comp.red between the two group.,the observation group.was lower tha

关键词： Gastrointestinal surgery Nursing teaching Teaching model p.actical effect Learning ability