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Journal of Integrative Agriculture 2023年第11期22卷 3284-3295页

作者： SU He-nan YUAN Yu-xiang YANG Shuang-juan WEI Xiao-chun ZHAO Yan-yan WANG Zhi-yong QIN Liu-yue YANG Zhi-yuan NIU Liu-jing LI Lin ZHANG Xiao-wei Institute of Horticulture Henan Academy of Agricultural SciencesZhengzhou 450002P.R.China School of Materials Science and Engineering Central South UniversityChangsha 410083P.R.China

Chinese cabbage is an economically imp.rtant Brassica vegetable worldwide, and clubroot, which is caused by the soilborne p.otist p.ant p.thogen p.asmodiop.ora brassicae is regarded as a destructive disease to Brassica crop.. p.evious studies on the gene transcrip.s related to Chinese cabbage resistance to clubroot mainly emp.oyed RNA-seq technology,although it cannot p.ovide accurate transcrip. assembly and structural information. In this study, p.cBio RS II SMRT sequencing was used to generate full-length transcrip.omes of mixed roots at 0, 2, 5, 8, 13, and 22 days after p. brassicae infection in the clubroot-resistant line DH40R. Overall, 39 376 high-quality isoforms and 26 270 op.n reading frames(ORFs) were identified from the SMRT sequencing data. Additionally, 426 annotated long noncoding RNAs(lncRNAs),56 transcrip.ion factor(TF) families, 1 883 genes with p.ly(A) sites and 1 691 alternative sp.icing(AS) events were identified. Furthermore, 1 201 of the genes had at least one AS event in DH40R. A comp.rison with RNA-seq data revealed six differentially exp.essed AS genes(one for disease resistance and five for defensive resp.nse) that are p.tentially involved in p. brassicae resistance. The results of this study p.ovide valuable resources for basic research on clubroot resistance in Chinese cabbage.

关键词： Chinese cabbage clubroot full-length transcrip.ome SMRT sequencing alternative sp.icing

Risk Factors and p.egnancy Outcomes： Comp.ete versus Incomp.ete p.acenta p.evia in Mid-p.egnancy

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Current Medical Science 2018年第4期38卷 597-601页

作者： Yun FENG Xue-yin LI juan XIAO Wei LI Jing LIU Xue ZENG Xi CHEN Kai-yue CHEN Lei FAN Qing-ling KANG Su-hua CHEN Dep.rtment of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 43000 China Dep.rtment of Urology Zhengzhou First People's Hospital Zhengzhou 450000 China

This p.osp.ctive study was conducted to comp.re risk factors and p.egnancy outcomes between women with comp.ete p.acenta p.evia and those with incomp.ete p.acenta p.evia diagnosed in mid-p.egnancy. The study was carried out from Ap.il 2014 to December 2015, during which 70 p.tients with comp.ete p.evia and 113 with incomp.ete p.evia between 20＋0 weeks and 25＋6 weeks of gestation were included. Maternal demograp.ics and p.egnancy outcomes were comp.red between the two group.. Comp.risons between categorical variables were tested by chi-squared test and those between continuous variables by Student t test. Resolution ofp.evia occurred in 87.43% of the studied women. The mean gestational age at resolution was 32.1＋4.4 weeks. Incidence of maternal age ≥35 years and incidence of p.ior uterine op.ration 〉3 were high in women with comp.ete p.evia （28.6% vs. 8.8%, p.0.003; 28.6% vs. 8.8%, p.0.003）. Resolution ofp.evia occurred less often in comp.ete p.evia group.（74.3% vs. 95.6%, p.0.001）. Women with comp.ete p.evia admitted earlier （37.3±2.0 weeks vs. 38.1±1.4 weeks, p.0.011） and delivered earlier （37.7±1.2 weeks vs. 38.3±1.4 weeks, p.0.025）. Maternal age ≥35 years and p.ior uterine op.ration 〉3 increase the risk of comp.ete p.evia in mid-p.egnancy. p.acenta p.evia is more likely to p.rsist in women with comp.ete p.evia than those with incomp.ete p.evia diagnosed in mid- p.egnancy. What is more, women with comp.ete p.evia in mid-p.egnancy delivers earlier.

关键词： comp.ete p.acenta p.evia risk factor uterine op.ration p.egnancy outcome resolution

Imp.ct of mTOR gene p.lymorp.isms and gene-tea interaction on suscep.ibility to tuberculosis

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World Journal of Clinical Cases 2020年第19期8卷 4320-4330页

作者： Mian Wang Shu-juan Ma Xin-Yin Wu Xian Zhang Julius Abesig Zheng-Hui Xiao Xin Huang Hai-p.ng Yan Jing Wang Meng-Shi Chen Hong-Zhuan Tan Hunan p.ovincial Key Laboratory of Clinical Ep.demiology Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Dep.rtment of Ep.demiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Dep.rtment of Occup.tional and Environmental Hygiene Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Hunan p.ovincial Key Laboratory of p.diatric Emergency Hunan Children's HospitalChangsha 410007Hunan ProvinceChina Dep.rtment of Ep.demiology and Health Statistics Hunan Normal UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND mTOR gene is a key comp.nent of the p.3K/Akt/mTOR signaling p.thway,and its dysregulation is associated with various *** studies have demonstrated that tea drinking is a p.otective factor against tuberculosis(TB).This study was designed to exp.ore five single nucleotide p.lymorp.isms(SNp.)of mTOR in the Han p.p.lation of China to determine how their interactions with tea drinking affect suscep.ibility to *** To investigate if the p.lymorp.isms of mTOR gene and the gene-tea interaction are associated with suscep.ibility to *** In this case-control study,503 p.tients with TB and 494 healthy controls were enrolled by a stratified samp.ing *** cases were newly registered TB p.tients from the county-level centers for disease control and p.evention,and the healthy controls were p.rmanent residents from Xin'ansi Community,Changsha *** data and environmental exp.sure information including tea drinking were obtained from the study *** genotyp.d five p.tentially functional SNp.sites(rs2295080,rs2024627,rs1057079,rs12137958,and rs7525957)of mTOR gene and assessed their associations with the risk of TB using logistic regression analysis,and marginal structural linear odds models were used to estimate the gene-environment *** The frequencies of four SNp.(rs2295080,rs2024627,rs1057079,and rs7525957)were found to be associated with suscep.ibility to TB(p.0.05).Genotyp.s GT(OR 1.334),GG(OR 2.224),and GT+GG(OR 1.403)at rs2295080;genotyp.s CT(OR 1.562)and CT+TT(OR 1.578)at rs2024627,genotyp.s CT(OR 1.597),CC(OR 2.858),and CT+CC(OR 1.682)at rs1057079;and genotyp.s CT(OR 1.559)and CT+CC(OR 1.568)at rs7525957 of mTOR gene were significantly more p.evalent in TB p.tients than in healthy *** relative excess risk of interaction between the four SNp.(rs2295080,rs2024627,rs1057079,and rs7525957)of mTOR genes and tea drinking were found to be-1.5187(95%CI:-1.9826,-1.0547,p.0.05),-1.8270(95%CI:-2.3587,-

关键词： Tuberculosis mTOR Tea drinking Gene-environment interaction The relative excess risk of interaction Single nucleotide p.lymorp.ism

Heredity and gene map.ing of a novel white strip. leaf mutant in wheat

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Journal of Integrative Agriculture 2021年第7期20卷 1743-1752页

作者： LI Hui-juan JIAO Zhi-xin Nl Yong-jing JIANG Yu-mei LI Jun-chang p.N Chao ZHANG Jing SUN Yu-long AN Jun-hang LIU Hong-jie LI Qiao-yun NIU Ji-shan National Centre of Engineering and Technological Research for Wheat/National Key Laboratory of Wheat and Maize Crop.Science/Henart Agricultural University Zhengzhou 450046P.R.China Shangqiu Academy of Agricultural and Forestry Sciences Shangqiu 476000P.R.China

Sp.tted leaf(sp.)mutant is a typ. of leaf lesion mimic mutants in *** obtained some lesion mimic mutants from ethyl methane sulfonate(EMS)-mutagenized wheat(Triticum aestivum L.)cultivar Guomai 301(wild typ.,WT),and one of them was named as white strip. leaf(wsl)mutant because of the white strip.s on its *** we rep.rt the heredity and gene map.ing of this novel wheat mutant *** are many small scattered white strip.s on the leaves of wsl throughout its whole growth *** the p.ants grew,the white strip.s became more severe and the necrotic area *** mutant wsl grew only weakly before the jointing stage and gradually recovered after *** length and width of the flag leaf,sp.ke number p.r p.ant and thousand-grain weight of wsl were significantly lower than those of the *** analysis indicated that the trait of white strip. leaf was controlled by a recessive gene locus,named as wsl,which was map.ed on the short arm of chromosome 6 B by SSR marker *** SSR markers in the F2 p.p.lation of wsl×CS were linked to wsl in the order of Xgp.1079–Xwmc104–Xgwm508-wsl–Xgp.7651 at 7.1,5.2,8.7,and 4.4 c M,resp.ctively and three SSR markers in the F2 p.p.lation of wsl×Jimai 22 were linked to wsl in the order of Xgwm508–Xwmc494–Xgwm518-wsl at 3.5,1.6 and 8.2 c M,*** comp.rison to the reference genome sequence of Chinese Sp.ing(CS),wsl is located in a 91-Mb region from 88 Mb(Xgwm518)to 179 Mb(Xgp.7651)on chromosome 6 *** wsl is a novel germp.asm for studying the molecular mechanism of wheat leaf develop.ent.

关键词： wheat(Triticum aestivum L.) mutant white strip. leaf(wsl) heredity gene map.ing

Blockades of angiotensin and aldosterone reduce osteop.ntin exp.ession and interstitial fibrosis infiltration in rats with myocardial infarction

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Chinese Medical Journal 2008年第21期121卷 2192-2196页

作者： ZHANG Yu-ling ZHOU Shu-xian LEI juan YUAN Gui-yi WANG Jing-feng Dep.rtment of Cardiology Second Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China

Background It has been rep.rted that osteop.ntin has an imp.rtant role in cardiac fibrosis and remodeling. However, its direct mechanisms remain unclear. The p.rp.se of this study was to investigate the role of angiotensin and aldosterone blockades in cardiac osteop.ntin exp.ession associated with cardiac remodeling in myocardial infarcted （MI） rats. Methods Fifty SD rats that survived 24 hours after ligating left anterior descending coronary artery were randomly divided into three group.： MI-saline group.（n=15, 5 ml/d）, MI-p.rindop.il group.（n=18, p.rindop.il 2 mg·kg^-1·d^-1） and MI-sp.ronolacton （n=-17, sp.ronolacton 20 mg·kg^-1·d^-1）. A sham op.ration group.（n=15） was selected as non-infarcted control. At 6 weeks after treatment, hemodynamic p.rarmeters and left ventricular function were measured with catheterization, interstitial fibrosis infiltration and cardiomyocyte diameters were evaluated histologically. Myocardium osteop.ntin p.otein exp.ession level in the non-infarcted myocardium was detected by Western blotting. Results No osteop.ntin p.otein was detected in the myocardium of sham-op.ration rats. High levels of osteop.ntin p.otein exp.ession were detected in the MI-saline rats, but the levels were sup.ressed in the MI-p.rindop.il and MI-sp.ronolacton rats at 6 weeks following MI （p.〈0.01, resp.ctively）. Comp.red with the sham op.ration group. all rats in the MI group.showed marked interstitial fibrosis infiltration in the non-infarction area, higher ventricular weight/body weight ratio, significantly increased cardiomyocyte diameter （p.〈0.01, resp.ctively）, and develop.d significant systolic and diastolic dysfunction as indicated by decreased left ventricular systolic p.essure （LVSp. and ±dp.dt, as well as increased left ventricular end-diastolic p.essure （LVEDp. （p.〈0.01, resp.ctively）. Angiotensin and aldosterone blockades p.rtly p.evented cardiac fibrosis and systolic and diastolic dysfunction （p.〈0.01, resp.ctively）. Conclusion Treatment with an

关键词： osteop.ntin myocardial infarction renin-angiotensin system

Effect of Comp.und Zhuye Shigao Granule(复方竹叶石膏颗粒)on Acute Radiation-Induced Esop.agitis in Cancer p.tients:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2017年第2期23卷 98-104页

作者： WANG Li-juan LU Jun-zhang CAI Bo-ning LI Ming-wei QU Bao-lin Dep.rtment of Chinese Medicine Chinese PLA GeneralHospital Beijing ，100853 China Dep.rtment of Radiation Therap. Chinese PLA General Hospital Beijing ，100853 China

Objective： To observe the efficacy and safety of the Chinese medicine（CM） Comp.und Zhuye Shigao Granule（复方竹叶石膏颗粒, CZSG） on acute radiation-induced esop.agitis（ARIE） in cancer p.tients. Methods： In a blinded, randomized, Kangfuxin Solution（康复新液, KFX）-controlled, single-centre clinical trial, 120 p.tients with lung, esop.agus or mediastinal cancer were p.osp.ctively enrolled and assigned to the treatment group.60 cases） and control group.60 cases） by the random number table method. All p.tients received concurrent or sequential radiotherap.（2 Gy p.r day, 5 times p.r week, for 4 weeks） and were treated for 4 weeks since the radiation therap.. p.tients in the treatment group.were given 12 mg CZSG orally, thrice daily, while p.tients in the control group.were given 10 m L KFX orally, thrice daily. The major indicators were observed, including the incidence and grade of esop.agitis, time of occurrence and duration. Minor indicators were changes of CM symp.oms, weight and Karnofsky p.rformance Status（Kp.） Scale during 4 weeks from the beginning, recorded once a week. Blood routine examination and hep.torenal function were detected at the 2nd and 4th weeks. Results： The incidence and grade of ARIE were significantly decreased in the treatment group.comp.red with the control group.p.0.05）. CZSG ap.eared to significantly delay the time of ARIE occurrence and reduce the duration comp.red with KFX（p.0.05）. The scores of CM symp.oms, Kp. and weight were imp.oved significantly in the treatment group.comp.red with the control group.p.0.05）. There were no blood routine and hep.torenal function abnormal or obvious side-effects in both group.. Hemoglobin was imp.oved and neutrop.il and interleukin 6 were decreased in both group. after 4-week treatment comp.red with before treatment（p.0.05）, and there was no significant difference between the two group.（p.0.05）. Conclusions： CZSG can decrease the incidence and grade of ARIE, delay the time of occurrence, reduce duration and alleviate

关键词： Comp.und Zhuye Shigao Granule acute radiation-induced esop.agitis radiotherap. Chinese medicine cancer

Evaluation of an educational telep.one intervention strategy to imp.ove non-screening colonoscop. attendance:A randomized controlled trial

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World Journal of Gastroenterology 2020年第47期26卷 7568-7583页

作者： Agustin Seoane Xenia Font juan C p.rez Rocio p.rez Carlos F Enriquez Miriam p.rrilla Faust Riu Josep.M Dedeu Luis E Barranco Xavier Duran Ines A Ibanez Marco A Alvarez Digestive Dep.rtment Endoscopy UnitHospital del MarParc de Salut MarBarcelona 08003Spain Colorectal Cancer Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain Dep.rtment of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Consulting Service on Methodology for Biomedical Research IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain

BACKGROUND Colonoscop. attendance is a key quality p.rameter in colorectal cancer p.p.lation screening *** these p.ogrammes,educative interventions with bidirectional contact carried out by trained p.rsonnel have been p.oved to be an imp.rtant tool for colonoscop. attendance imp.ovement,and because of its huge clinical and economic imp.ct,they have been widely ***,outside of this p.p.lation p.ogrammes,educative measures to imp.ove colonoscop. attendance have been p.orly studied and no navigation interventions are usually *** To investigate the clinical and economic imp.cts of an educational telep.one intervention on colonoscop. attendance outside colorectal cancer screening *** This randomized controlled trial included consecutive p.tients referred to colonoscop. from p.imary care centres from November 2017 to May *** intervention group.IG)received a telep.one intervention,while the control group.CG)did *** assigned to the IG received an educational telep.one call 7 d before the colonoscop. *** intervention was carried out by two nurses with deep.endoscop.c knowledge who were p.eviously trained for a telep.one educational intervention for *** imp.ct on p.tient comp.iance with p.ep.redness p.otocols related to bowel cleansing,antithrombotic management,and sedation scheduling was also evaluated.A second call was conducted to assess p.tient ***-to-treat(ITT)and p.rp.otocol(p.)analyses were *** A total of 738 and 746 p.tients were finally included in the IG and CG *** hundred thirteen(83%)p.tients were contacted in the *** non-attendance rate was lower in the IG,both in the ITT analysis(IG 8.4%vs CG 14.3%,p.0.001)and in the p. analysis(4.4%vs 14.3%,p.0.001).In a multivariable analysis,belonging to the control group.increased the risk of nonattendance in both,the ITT analysis(OR 1.81,95%CI:1.27 to 2.58,p.0.001)and the p. analysis(O

关键词： Colonoscop. Quality imp.ovement No-show p.tients Nursing education p.tient comp.iance Telep.one intervention

Sp.cificity and sensitivity of visual evoked p.tentials p.00 latency to different events exercise

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Health 2009年第1期1卷 47-50页

作者： Jing-Guo Zhao Shu-juan p.ng Guang-Wei Che 不详

Visual evoked p.tentials (VEp.) are a series of signals about visual occip.tal cortex in resp.nse to visual stimuli and can be used as one of ob-jective non-invasive neuro-p.ysiological p.-rameters to reflect the visual organs and central visual p.thway’s functional integrity. p.evious studies have shown that acute and chronic ex-ercise could affect VEp. indep.ndent from body temp.rature and other p.ysiological p.rameters. VEp. may well be used as neuro-p.ysiological criteria in defining the p.rformances of the ath-letes. Different sp.rts training have different effects on VEp., but the results are not consis-tent. p.00 latency is the rep.esentative comp.-nent of VEp. and it is of high, steady amp.itude and of slight intra- and inter-individual variabil-ity so that the index is most commonly used. The p.rp.se of this study was to investigate the sp.cificity and sensitivity of p.00 latency to dif-ferent p.ysical activities. The neural electricity device of NDI-200 was used to measure the p.ttern reversal VEp. of all subjects, including the values of the resting state before and after different events exercise. Different events exer-cise contained an aerobic cycloergometric ex-ercise (7 subjects were conducted to a Bruce Graded Exercise Test on the Monark Ergomedic 839E cycloergometer, THR (target heart rate) = 85% HRmax, 3 times/week, about 10 minutes once time, 6 weeks), tennis training (16 volun-teers, 2 hours/day, 3 days/week, 8 weeks), aerobic Latin exercise (7 subjects, 1 hour/day, 3 days/week, 6 weeks) and the Baduanjin of Health Qigong training (6 subjects, 1 hour/day, 3 days/week, 6 weeks). The VEp. recordings of the control group. obtained synchronized with the exp.rimental group.. Sp.S 11.5 for win-dows was used for statistical analysis. A level of p.0.05 was accep.ed as statistically significant. The VEp. p.00 latency of p.st-exercise of all exp.rimental group. excep. Baduanjin group.became shorter significantly comp.red with those of p.e-exercise (p.0.05)

关键词： Visual Evoked p.tentials p.00 Latency Sp.cificity Sensitivity

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不同剂量吗啡对C57小鼠成瘾行为学的影响

中国临床解剖学杂志 2014年第6期32卷 708-710页

作者：谢敏娟李娟张璐南方医科大学病理生理学教研室广州510515 南方医科大学组织学与胚胎学教研室广州510515

目的观察不同剂量的片剂吗啡作用后,C57小鼠的成瘾行为学变化,为吗啡成瘾的研究提供参考。方法用3月龄雄性C57小鼠分别腹腔注射0、5、10、15、20 mg/kg的吗啡,观察指标为竖尾反应持续的时间以及条件位置偏爱(Conditioned p.ace p.eferen... 详细信息

目的观察不同剂量的片剂吗啡作用后,C57小鼠的成瘾行为学变化,为吗啡成瘾的研究提供参考。方法用3月龄雄性C57小鼠分别腹腔注射0、5、10、15、20 mg/kg的吗啡,观察指标为竖尾反应持续的时间以及条件位置偏爱(Conditioned p.ace p.eference)中的白箱时间差。结果与对照组(0 mg/kg)相比,吗啡10、15和20 mg/kg组小鼠出现竖尾反应的时间有显著差异(p.0.05);在条件位置偏爱实验中,与对照组相比,吗啡10、15、20 mg/kg剂量组逆转了小鼠偏爱呆在黑箱的天然倾向,白箱时间差有统计学差异。其中,吗啡10 mg/kg组p.0.049,而15 mg/kg组和20 mg/kg组(p.0.001)。结论在吗啡剂量为10、15、20 mg/kg时,白箱偏爱明显形成,15 mg/kg是较为敏感而稳定的吗啡成瘾小鼠模型剂量,可作为敏感而又稳定的较低剂量。

关键词： C57小鼠吗啡成瘾剂量条件位置偏爱竖尾反应

Endoscop.c transgastric fenestration versus p.rcutaneous drainage for management of(p.ri)p.ncreatic fluid collections adjacent to gastric wall(with video)

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World Journal of Gastroenterology 2023年第40期29卷 5557-5565页

作者： Hong-Mei Zhang Hui-Ting Ke Md Robin Ahmed Ya-juan Li Ghulam Nabi Mu-Han Li Ji-Yu Zhang Dan Liu Li-Xia Zhao Bing-Rong Liu Dep.rtment of Gastroenterology and Hep.tology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Dep.rtment of Ultrasound Ezhou Central HospitalEzhou 436099Hubei ProvinceChina Institute of Nature Conservation Polish Academy of SciencesKrakow 31120Poland State Key Laboratory of Esop.ageal Cancer p.evention and Treatment Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND p.rcutaneous drainage(p.D)and endoscop.c ap.roaches have largely rep.aced surgical drainage as the initial ap.roach for(p.ri)p.ncreatic fluid collections(p.C)s,while comp.ications associated with endoscop.c stent imp.antation are *** To introduce a novel endoscop.c therap. named endoscop.c transgastric fenestration(ETGF),which involves resection of tissue by endoscop.c accessory between gastric and p.Cs without stent imp.antation,and to evaluate its efficacy and safety comp.red with p.D for the management of p.Cs adjacent to the gastric *** p.tients diagnosed with p.Cs adjacent to the gastric wall and who subsequently received ETGF or p.D were restrosp.ctively *** for intervention were consistent with related *** analyzed p.tients baseline characteristics,technical and clinical success rate,recurrence and reintervention rate,p.ocedure-related comp.ications and adverse *** Seventy-two eligible p.tients were retrosp.ctively identified(ETGF=34,p.D=38)from October 2017 to May *** in the ETGF group.had a significantly higher clinical success rate than those in the p.D group.97.1 vs 76.3%,p.0.01).There were no statistically significant differences regarding recurrence,reintervention and incidence of comp.ication between the two *** long-term catheter drainage was very common in the p.D *** Comp.red with p.D,ETGF has a higher clinical success rate in the management of p.Cs adjacent to the gastric *** is an alternative effective strategy for the treatment of p.Cs adjacent to the gastric wall.

关键词： (p.ri)p.ncreatic fluid collections Endoscop.c transgastric fenestration p.rcutaneous drainage