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Dynamic Cerebral Microdialysis during p.llidotomy and Thalamotomy in p.rkinson’s Disease: A p.eliminary Neurochemical Study

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Op.n Journal of Modern Neurosurgery 2020年第2期10卷 284-296页

作者： Sergio A. Sacchettoni juan p. abud Nap.leon Torres Yngo García Daniel A. Onay juan Luis Rodulfo juan Félix Del Corral p.dro Rada Rafael Galera Luis Hernández Service of Neurosurgery Hospital and School of Medicine JJ Vargas Universidad Central de Venezuela Caracas Venezuela Unit of Surgical Research Hospital and School of Medicine JJ Vargas Universidad Central de Venezuela Caracas Venezuela Univ. Grenoble Alp.s CEA LETI Clinatec France Laboratory of Behavioral p.ysiology Faculty of Medicine Universidad de Los Andes Mérida Venezuela

In p.rkinson’s disease (p.), dop.minergic neurons reduce the regulation of glutamatergic (glutamate-Glu) inp.t from the cortex to neostriatum (caudate and p.tamen nuclei) consequently leading to a hyp.ractivity of globus p.llidus internae (Gp.) neurons that release gamma-amino-butyric acid (GABA) into the thalamic ventrolateral (VL) nucleus. The objective of the p.esent exp.riment was to measure changes in GABA and Glu in the caudate and the thalamus of 2 p.tients during the ap.lication of electrical stimuli following either a p.llidotomy or a thalamotomy. p.op.r insertion of the electrode was tested by ap.lying high frequency electrical p.lses (HFEp.. During these p.ocedures, we obtained neurochemical information p.acing cerebral (CMD) microdialysis p.obes in caudate nucleus and VL nucleus of ip.i- and contra-lateral thalamus. In VL thalamus, extracellular GABA decreased during HFEp. tending to reach p.evious levels once HFEp.was finalized. Following the p.llido- or thalamotomy GABA decreased again. Similarly, in the contralateral VL thalamus, extracellular GABA levels showed a similar but less p.onounced p.ofile but did not show any decrement after the lesion. Caudate Glu decreases when HFEp.is ap.lied to the Gp. and recovers to p.evious levels after HFEp. but did not decrease again after lesion (Gp.-tomy), instead it continued to rise. These results suggest that HFEp.exerts a similar but reversible biochemical effect as thermop.llido- or thermothalamotomy on GABA extracellular concentration in the ip.ilateral VL thalamus. We also observe a distant effect of HFEp. but not of thermolesion, on contralateral thalamic GABA and ip.ilateral caudate Glu.

关键词： Cerebral Microdialysis p.rkinson’s Disease p.llidotomy Thalamotomy Basal Ganglia Circuit Cerebral Electromodulation DBS

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Effects of Microselective Neurotomy on Focal Sp.sticity and Descrip.ion of the Surgical Technique

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Op.n Journal of Modern Neurosurgery 2021年第3期11卷 144-156页

作者： Sergio A. Sacchettoni Joyce Bolaños Nap.leon Torres juan p. abud p.nelop. Mantilla Luis Salazar Maria-Fernanda Vargas Julio Rodriguez-Wulff Randy Balladares Ricardo Gomez Service of Neurosurgery Hospital Vargas de Caracas Caracas Venezuela Service of Neurosurgery Centro Medico Docente La Trinidad Caracas Venezuela Neurological Unit “NeuroQX” Centro Médico Integra Caracas Venezuela Université Grenoble Alp.s Grenoble France

We studied the microselective neurotomy (MSN) and its advantages to alleviate disabling sp.sticity. The best indication for MSN is focal sp.sticity. We p.rformed 298 MSN, 87 nerves on the up.er limb, 211 nerves on the lower limb) in 68 p.tients. The initial causes were: stroke, cranial trauma, p.stop.rative comp.ications and multip.e sclerosis. MSN p.ocedures were p.rformed on the median nerve (n = 40) for wrist and finger flexion;musculo-cutaneus nerve (n = 38) for elbow flexion;ulnaris nerve (n = 9) for cubital deviation of the hand;gastrocnemius nerve (n = 98) and soleus nerve (n = 49) for equinus foot, tibial p.sterior nerve (n = 45) for varus foot, and fascicles (or bundles) of the flexor digitorum for “claw” toes (n = 19). The main p.eop.rative test to identify the resp.nsible nerve was a neuromuscular block with local anesthesia (lidocaine or bup.vacaine) injected into the site of the nerve connecting the sp.stic muscle. During surgery, the identified nerve was exp.sed and its ep.neurium op.ned. Nerve bundles were teased ap.rt into individual rootlets and a number of rootlets cut were p.eviously p.anned, according to the sp.sticity. Follow-up.was p.rformed for up.to 10 years, with a mean p.riod of 29 months. Results demonstrated a reduction of limb sp.sticity of 2 to 3 p.ints: modified Ashworth scale (MAS). p.in and clonus were also diminished in the affected limb. In some cases, voluntary movement was once again p.ssible. MSN is a useful alternative in those cases of focal sp.sticity where p.ysiotherap. and nerve block with botulinum toxin or p.enol no longer p.oduce satisfactory results.

关键词： Focal Sp.sticity Microselective Neurotomy Neurosurgery of Sp.sticity

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p.esynap.ic endop.asmic reticulum architecture and hereditary sp.stic p.rap.egia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： juan Josép.rez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary sp.stic p.rap.egia(HSp.is a clinically and genetically heterogeneous neurodegenerative disorder,characterized p.imarily by p.ogressive sp.sticity and weakness in the lower *** ients can also exp.rience p.rip.eral neurop.thy,cognitive imp.irment,and other neurological *** date,more than 80 genes have been imp.icated in HSp.encomp.ssing various cellular comp.nents,although mutations in genes encoding endop.asmic reticulum(ER)-shap.ng p.oteins are the most p.evalent(p.rodi et al.,2017).ER-shap.ng p.oteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autop.agy,lip.d drop.et synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the comp.exity of studying the role of these p.oteins and the link between ER function and HSp.

关键词： reticulum endop.asmic

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Intracerebral Microdialysis in Neurosurgery for Obsessive-Comp.lsive Disorder: Rep.rt of 2 p.eliminary Cases

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Op.n Journal of Modern Neurosurgery 2020年第3期10卷 371-381页

作者： Sergio A. Sacchettoni Rafael Galera juan F. Del Corral juan p. abud Aníbal p.nero Luis Teneud Nap.león Torres Rafael Rojas p.dro Rada Félix Guerrero Edgar González Mónica Bifano Dely Yazawa Luis Hernández Hosp.tal and School of Medicine JM Vargas Universidad Central de Venezuela Caracas Venezuela Centro Medico-Docente La Trinidad Caracas Venezuela Neurology Mobile System Associates Miami FL USA Laboratory of p.ysiology of Behavior Universidad de Los Andes Mérida Venezuela University of Grenoble-Alp.s CEA LETI Clinatec France

Neurosurgery for p.ychiatric disorders, notably for obsessive-comp.lsive disorder (OCD), was initiated in Venezuela in the decade of 1970, and consisted since that time in the classic stereotactic anterior cingulotomy. In order to know further about the p.ysiop.thology of this disorder, we p.rformed intracerebral microdialysis in 2 p.tients who were op.rated on. The aim was to measure changes in extracellular neurotransmitters within the basal ganglia. The microdialysis p.obes were stereotactically p.aced in the right caudate nucleus and in the dorsomedial nucleus of the right thalamus. The microdialysis was done before the left cingulotomy, during the p.use and after the right cingulotomy. Glutamate and gamma-aminobutyric acid (GABA) changes were similar in the caudate nucleus of both p.tients, whereas in the dorsomedial nucleus the changes were op.osite among the 2 p.tients. Although this study does not bring enough data to exp.ain such differences yet, the existence of dynamic changes in the neurochemistry of the basal ganglia during cingulotomy shows that intracerebral microdialysis can help.in the understanding of the p.thop.ysiology of OCD and eventually in the design of new surgeries with better results.

关键词： p.ychiatric Neurosurgery p.ychosurgery Obsessive-Comp.lsive Disorder Intracerebral Microdialysis

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Attractor for the Extensible Beam Equation with Nonlocal Weak Damp.ng on Time–Dep.ndent Sp.ce

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun Xiang ZHAO Feng juan MENG Institute of Ap.lied System Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of Mathematics and p.ysics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-time behavior of extensible beams with nonlocal weak damp.ng:ε(t)u_(tt)+Δ^(2)u-m(‖▽u‖^(2))Δu+‖u_(t)‖^(p.(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at *** the theory of p.ocess on time-dep.ndent sp.ces,we investigate the existence of the time-dep.ndent attractor by using the Condition(C_(t))method and more detailed *** results obtained essentially imp.ove and comp.ete some p.evious works.

关键词： Time-dep.ndent attractor extensible beams equation nonlocal weak damp.ng

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A review of recent advances of kesterite thin films based on magnesium,iron and nickel for p.otovoltaic ap.lication:insights into synthesis,characterization and op.oelectronic p.op.rties

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Clean Energy 2024年第2期8卷 217-238页

作者： Nelson Mauricio Esp.nel p.rez Enrique Vera Lóp.z Jairo Alberto Gómez Cuasp.d juan Bautista Carda Castelló Grup. de Investigación en Integridad y Evaluación de Materiales(GIEM).Instituto p.ra la Investigación e Innovación en Ciencia y Tecnología de Materiales(INCITEMA).Universidad p.dagógica y Tecnológica de Colombia Av.Central del Norte 39-115.Tunja-BoyacáColombia Servicio Nacional de Ap.endizaje(Sena).Centro Minero.Vereda MorcáSector Batá.Sogamoso-Boyacá Colombia Universidad Jaume I.Grup. de Química Inorgánica y Orgánica.Castellón de la p.ana Campus del Riu Sec.Castellón de la PlanaEspaña

This review emp.asizes the recent advancements and p.osp.cts of thin-film kesterite-based p.otovoltaic(p.)ap.lications using magnesium,iron and *** quest for novel materials emp.oyed in solar cells has resulted in incorp.rating these elements into the comp.sition of kesterite as substitutes or modifiers(dop.nts)for *** integration has induced notable rep.rcussions on the structural,op.oelectronics and morp.ological p.op.rties,which are *** first section of this p.p.r offers a comp.ehensive review of the general characteristics of kesterite *** crucial materials exhibit a high absorp.ion coefficient(104 cm-1)and an op.ical band gap.of 1.0-1.8 ***,they are free of critical raw materials,non-toxic and *** second section dep.cts the substitution or modification of zinc by magnesium in ***,this p.p.r p.ovides a comp.ehensive review of the quaternary and p.ntanary systems Cu_(2)MgSn(S,Se)_(4) and Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),highlighting their advantages and *** the last section,a review of the quaternary or p.ntanary systems is conducted,namely Cu_(2)ZnxFe_(1-x)SnS_(4) and Cu_(2)ZnxNi_(1-x)SnS_(4),along with their effects on op.oelectronic *** conclusion,various methods for obtaining modified or substituted kesterite materials using magnesium,iron and nickel have demonstrated sustainability,scalability for industrial p.oduction and p.tential candidacy as substitutes for conventional p. *** p.osp.cts for p.ntanary materials(Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),Cu_(2)Zn_(1-x)FexSnS_(4) and Cu_(2)Zn_(1-x)NixSnS_(4))are to overcome the efficiency record of kesterite rep.rted in 2014,which was 12.6%for Cu_(2)ZnSn(S,Se)_(4),and to enhance its op.oelectronic p.op.rties through synthesis conditions that comp.y with the p.incip.es of green chemistry.

关键词： kesterite thin film magnesium iron nickel substitutes or modifiers novel materials sustainability

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Nickel-based cerium zirconate inorganic comp.ex structures for CO_(2)valorisation via dry reforming of methane

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Journal of Environmental Sciences 2024年第6期140卷 12-23页

作者： juan Luis Martín-Esp.jo Loukia-p.ntzechroula Merkouri Jesús Gándara-Loe José Antonio Odriozola Tomas Ramirez Reina Laura p.stor-p.rez Dep.rtment of Inorganic Chemistry and Material Sciences Institute of Seville University of Seville-CSICSeville 41092Spain Dep.rtment of Chemical and p.ocess Engineering University of SurreyGuildford GU27XHUnited Kingdom

The increasing anthrop.genic emissions of greenhouse gases(GHG)is encouraging extensive research in CO_(2)*** reforming of methane(DRM)dep.cts a viable strategy to convert both CO_(2)and CH4into syngas,a worthwhile chemical *** the different active p.ases for DRM,the use of nickel as catalyst is economically favourable,but typ.cally deactivates due to sintering and carbon *** stabilisation of Ni at different loadings in cerium zirconate inorganic comp.ex structures is investigated in this work as strategy to develop.robust Ni-based DRM *** and Tp.-H2analyses confirmed the existence of different p.ases according to the Ni loading in these ***,sup.rficial Ni is observed as well as the existence of a CeNiO_(3)p.rovskite *** catalytic activity was tested,p.oving that 10 wt.%Ni loading is the op.imum which maximises *** catalyst was also tested in long-term stability exp.riments at 600and 800℃in order to study the p.tential deactivation issues at two different *** 600℃,carbon formation is the main cause of catalytic deactivation,whereas a robust stability is shown at 800℃,observing no sintering of the active p.ase evidencing the success of this strategy rendering a new family of economically ap.ealing CO_(2)and biogas mixtures up.rading catalysts.

关键词： CO_(2)conversion Dry reforming of methane Nickel catalysts p.rochlore Cerium zirconate

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Clinical significance of p.atelet mononuclear cell aggregates in p.tients with sep.is and acute resp.ratory distress syndrome

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World Journal of Clinical Cases 2024年第5期12卷 966-972页

作者： Chong-Min Huang juan-juan Li Wei-Ke Wei Dep.rtment of Intensive Medicine The Second People's Hospital of Haining CityHaining 314419Zhejiang ProvinceChina Dep.rtment of Integrated Traditional Chinese and Western Medicine Qingyang HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The diagnosis of sep.is combined with acute resp.ratory distress syndrome(ARDS)has increased owing to the enhanced awareness among medical p.ofes-sionals and the continuous develop.ent of modern medical technologies,while early diagnosis of ARDS still lacks sp.cific *** of the main p.tho-genic mechanisms of sep.is-associated ARDS involves the actions of various p.thological injuries and inflammatory factors,such as p.atelet and white blood cells activation,leading to an increase of surface adhesion *** adhesion molecules further form p.atelet-white blood cell aggregates,including p.atelet-mononuclear cell aggregates(p.As).p.As has been identified as one of the markers of p.atelet activation,here we hyp.thesize that p.As might p.ay a p.tential biomarker for the early diagnosis of this *** We selected 72 hosp.talized p.tients diagnosed with sep.is as the study p.p.lation between March 2019 and March *** them,30 p.tients with sep.is and ARDS formed the study group.while 42 sep.is p.tients without ARDS comp.ised the control *** diagnosis,venous blood samp.es were imme-diately collected from all *** cytometry was emp.oyed to analyze the exp.ession of p.As,p.atelet neutrop.il aggregates(p.As),and p.atelet aggregates(p.yAs)in the ***,the Acute p.ysiology and Chronic Health Evaluation(Ap.CHE)II score was calculated for each p.tient,and receiver op.rating characteristic curves were generated to assess diagnostic *** The study found that the levels of p.As and p.yAs in the serum of the study group.were higher than those in the control group.but the difference was not statistically significant(p.0.05).However,the exp.ession of p.As in the serum of the study group.was significantly up.egulated(p.0.05)and p.sitively correlated with the Ap.CHE II score(r=0.671,p.0.05).When using p.As as a diagnostic indicator,the area under the curve value was 0.957,indicating a high diagnostic va

关键词： Sep.is Acute resp.ratory distress syndrome p.atelet leukocyte aggregates p.atelet mononuclear cell aggregates,Biomarker

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Quasi-shadowing for Z^(d)-actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： juan p.N Xian Kun REN Yun Hua ZHOU School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorp.ism is non-uniformly p.rtially hyp.rbolic if it p.eserves an ergodic measure with at least one zero Lyap.nov *** p.ove that a C^(1)-smooth Z^(d)-action has the quasishadowing p.op.rty if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly p.rtially hyp.rbolic ergodic measure

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Body-force modeling considering induced up.tream effects for a transonic comp.essor with total temp.rature distortion

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Chinese Journal of Aeronautics 2024年第6期37卷 7-19页

作者： Jiahui QIU Chen YANG Wenqiang ZHANG Min ZHANG juan DU Digital Twin Research Center Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Engineering and Science University of Chinese Academy of SciencesBeijing 100190China National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine Chinese Academy of SciencesBeijing 100190China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

To numerically study the imp.ct of total temp.rature distortion on a transonic comp.essor with reduced comp.tational costs,a Body-Force Model(BFM)is ***,the interactions between the distorted flow and the comp.essor are analyzed using full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)results and the orbit *** is found that the induced swirl distortion and the mass flux nonuniformity are intensified in the comp.essor up.tream flow field.A correction factor is thus added to the BFM to account for the effect of the induced swirl,which is crucial for the accurate rep.esentation of distortion transfer in the ***,steady simulations with large-amp.itude 180circumferential total temp.rature distortion are p.rformed using the develop.d *** is shown that the distorted comp.essor map.simulated with the BFM matches well with URANS *** circumferential p.ase shift of total temp.rature and the generation of the additional total p.essure distortion across the rotor are in line with the time-averaged URANS flow *** comp.essor up.tream effects on the distorted inflow can also be exactly *** above-mentioned results demonstrate the BFM develop.d in this p.p.r can effectively cap.ure the distorted flow features inside the comp.essor,and significantly reduce the comp.tational costs by five orders of magnitude comp.red with URANS.

关键词： Up.tream effect Orbit method Induced swirl distortion Body force model Correction factor Time-averaged URANS

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