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Characterization by EBSD of Antimony-calcium Rich Phases Formed during Purification of Aluminum Scrap

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Journal of Wuhan University of Technology(Materials Science) 2013年第4期28卷 647-649页

作者： MUIZ Rodrigo FLORES Alfredo ortiz juan RODRíGUEZ Nelly MARTíNEZ Fernando LUNA Jesús OROZCO Pilar Faculty of Engineering Autonomous University of Coahuila Camporedondo Unit CINVESTAV Saltillo Unit Department of Metal Mechanics Technological Institute of Saltillo Faculty of Engineering Autonomous University of Zacatecas

We studied the influence of antimony on the modification rate of the silicon eutectic with sodium and/or strontium for castiig of A1-Si alloys, and introduced controlled Ca and Sb to the system and studied the resulting compounds, which were determined to be CazSb and A1Sb. Scanning electron microscopy together with the complementary technique of electron backscatter diffraction （EBSD） were used to characterize the materials. The experimental results provided the basis for us to establish that antimony removal from AI occurs mainly through the reaction （Sb）A1 ＋ 2Ca = Ca^Sb ＋ A1.

关键词： aluminum alloys antimony contamination modification

Revision anterior cruciate ligament reconstruction:Return to sports at a minimum 5-year follow-up

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World Journal of Orthopedics 2022年第9期13卷 812-824页

作者： Ezequiel ortiz juan Pablo Zicaro Ignacio Garcia Mansilla Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresCiudad Autónoma 1181Buenos AiresArgentina

BACKGROUND Between 43%and 75%of patients who undergo primary anterior cruciate ligament(ACL)surgery return to sport ***,after a revision ACL reconstruction(ACLR)the rate of return to sports is variable.A few publications have reported returns to sports incidence between 56%to 100%after revision *** To determine return to sports and functional outcomes after a single-stage revision ACLR with a 5-year minimum follow-up at a single *** All patients operated between 2010 and 2016 with a minimum 5 years of followup were *** of sport,intensity,frequency,expectation,time to return to sport and failure rate were ***,Tegner and International Knee Documentation Committee forms were evaluated prior to the first ACLR surgery,at 6 mo after primary surgery and after revision ACLR at 5 years minimum of *** stability was tested with the knee arthrometer test(KT-1000 knee arthrometer,Medmetric Corp).RESULTS A total of 41 patients who underwent revision ACLR during that period of time were contacted and available for *** patient age at time of revision was 29 years old[interquartile range(IQR):24.0-36.0],and 39(95.0%)were *** median time from revision procedure to follow-up was 70 mo(IQR:58.0-81.0).Regarding return to sports,16(39.0%)were at the same level compared to preinjury period,and 25 patients(61.0%)returned at a lower ***-three percent categorized the sport as very important and 37.0%as *** patient(2.4%)failed with a recurrent ACL *** preoperative Lysholm and(SD)16]and 50(SD 11),*** follow-up,mean Lysholm and subjective International Knee Documentation Committee scores were 89(SD 8)and 82(SD 9)(P=0.0001).Mean Tegner score prior to primary ACLR was 6.7(SD 1.3),5.1(1.5 SD)prior to revision ACLR and 5.6(1.6 SD)at follow-up(P=0.0002).Overall,knee arthrometer test measurement showed an average of 6 mm(IQR:4.0-6.0)side-to-side difference of displacement pri

关键词： Return to sport Revision anterior cruciate ligament Arthroscopy Knee Functional outcome

Efficacy of Oncoxin-Viusid on the Reduction of Adverse Reactions to Chemotherapy and Radiotherapy in Patients Diagnosed with Cervical Cancer and Endometrial Adenocarcinoma

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Journal of Cancer Therapy 2020年第5期11卷 276-295页

作者： Raiza Ruiz Lorente Daysi Hernández Durán Jessica García Viamontes juan Lence Anta Rosa ortiz Reyes Eduardo sanz Navares Hospital “Ramón González Coro” Havana Cuba National Institute of Oncology and Radiobiology of Cuba Havana Cuba Laboratorios Catalysis S.L. Madrid Spain

Introduction: Oncoxin-Viusid (OV) has shown antioxidant, immunomodulatory and anti-tumour capabilities in experimental studies on humans and animal subjects. Acute toxicity of Radiation Therapy (RT) and Chemotherapy (CT) in patients with cervical cancer and endometrial adenocarcinoma impact quality of life and, therefore, outcomes of these therapies. Objective: To identify Oncoxin-Viusid’s efficacy in reducing acute toxicity produced by onco-specific treatments in patients with cervical cancer and endometrial adenocarcinoma. Materials and Methods: A controlled, randomised double-blind phase II clinical trial was performed with a sample size of 63 patients distributed into 2 groups: one receiving the standard treatment plus the Oncoxin-Viusid nutritional supplement (OV group) and another receiving the standard treatment and placebo (P group). The primary efficacy variable is the proportion of secondary disruptions to acute adverse reactions produced by RT and CT. Results: The number of patients suffering adverse events from chemotherapy was 20.6% less in the OV group (70.0%) than in the placebo group (90.6%) (p = 0.04). We recorded consistently normal values of haemoglobin (-6.2 OV group vs -8.3 P group, p = 0.009), platelet count (-17.4 OV group vs -27.6 P group, p = 0.009) and leukocytes (-31.8 OV group vs -41.4 P group, p = 0.025) in the OV group, tolerating 4 more cytostatic doses on average than the placebo group. Significant increase in quality of life (QLQ-30) was registered in the OV group with a large effect size on such issues as emotional and social function (Cohen’s d = 0.9), as well as in the reduction of symptoms like dyspnea 60%, insomnia 15% and anorexia 30% (item CX-2), (Cohen’s d = 0.98), which were higher than the placebo group. Conclusions: OV administration reduces onco-specific adverse events and improves quality of life in patients diagnosed with cervical cancer and endometrial adenocarcinoma undergoing radiation therapy and chemotherapy.

关键词： Cervical Cancer Endometrial Adenocarcinoma Oncoxin-Viusid Radiotherapy Chemotherapy Adverse Effects

Effect of pesticides on phosphorylation of tau protein,and its influence on Alzheimer’s disease

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World Journal of Clinical Cases 2023年第24期11卷 5628-5642页

作者： Erandis D Torres-Sánchez Genaro G ortiz Emmanuel Reyes-Uribe juan H Torres-Jasso Joel Salazar-Flores Department of Medical and Life Sciences University Center of la CienegaUniversity of GuadalajaraOcotlan 47820JaliscoMexico Department of Philosophical and Methodological Disciplines and Service of Molecular Biology in Medicine Hospital Civil University of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biological Sciences CUCOSTAUniversity of GuadalajaraPuerto Vallarta 48280JaliscoMexico

Alzheimer’s disease(AD)is a progressive and neurodegenerative illness which results in alterations in cognitive *** is characterized by loss/dysfunction of cholinergic neurons,and formation of amyloid plaques,and formation of neurofibrillary tangles,among other changes,due to hyperphosphorylation of *** to pesticides in humans occurs frequently due to contact with contaminated food,water,or ***,organophosphates,carbamates,pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive *** aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein,and its cognitive implications in the development of *** was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198,Ser199,Ser202,Thr205,Ser396 and *** with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta,and protein ***,it altered the expression of the microtubule associated protein tau gene,and changed levels of intracellular *** changes affected tau protein phosphorylation and neuroinflammation,and also increased oxidative *** addition,the exposed subjects had poor level of performance in tests that involved evaluation of novelty,as test on verbal,non-verbal,spatial memory,attention,and problem-solving skills.

关键词： Organochlorines Organophosphates Carbamates Pyrethroids Neonicotinoids Tau protein

Microstructural Feature of As-cast A-356 Alloy Modifiers with the Addition of SrO

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Journal of Wuhan University of Technology(Materials Science) 2014年第3期29卷 617-619页

作者： MU?IZ Rodrigo FLORES Alfredo ortiz juan RODRíGUEZ Nelly MARTíNEZ Fernando OROZCO Pilar LUNA Jesús Equihua Fabián García Adrián Faculty of Engineering Autonomous University of Coahuila Camporedondo UnitSaltillo Coahuila México CINVESTAV Saltillo Unit Department of Metal Mechanics Technological Institute of Saltillo Faculty of Engineering Autonomous University of Zacatecas FIME Autonomous University of Coahuila Unit

To explore the effect of strontium on the structure of as-cast A356 alloy, the strontium was incorporated to the alloy by metallothermic reduction of SrO where the mineral was added to the melt through the submerged powders injection technique. The evaluation of the modification of the eutectie silicon and the chemical analysis of samples were done using optical microscopy （OP） and inductively coupled plasma （ICP）, respectively, while microstructural analyses by scanning electron microscopy （SEM）, and the injection time was variable. Magnesium was added to the melt to increase the reactivity and reduce the surface tension of the molten aluminum. It was possible to increase the strontium content from 0 to 0.027% after 20 minutes treatment. This concentration was sufficient to bring about full modification structure of eutectic silicon of as cast alloy A 356 and the acceptable quality metallurgical of alloy.

关键词： modification microstmcture strontium eutectic silicon submerged powder injection

Paclitaxel-loaded hollow-poly（4-vinylpyridine） nano- particles enhance drug chemotherapeutic efficacy in lung and breast cancer cell lines

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Nano Research 2017年第3期10卷 856-875页

作者： Rafael Contreras-Caceres Maria C. Leiva Raul ortiz Amelia Diaz Gloria Perazzoli Miguel A.Casado-Rodriguez Consolacion Melguizo Jose M. Baeyens juan M. Lopez-Romero Jose Prados Department of Organic Chemistry Faculty of Science University of Mdlaga 29071 Malaga Spain Institute of Biopathology and Regenerative Medicine (IBIMER) Center of Biomedical Research (CIBM) University of Granada 18100 Granada Spain Department of Anatomy and Embryology Faculty of Medicine University of Granada 18071 Granada Spain Biosanitary Institute of Granada (IBS. GRANADA) SAS-Universidad de Granada 18014 Granada Spain Department of Health Science University of Jaen 23071 Jadn Spain Department of Pharmacology Institute of Neuroscience Biomedical Research Center (CIBM) University of Granada 18100 Granada Spain

Paclitaxel （PTX）, one of the most effective cytotoxins for the treatment of breast and lung cancer, is limited by its severe side effects and low tumor selectivity. In this work hollow-poly（4-vinylpyridine）（hollow-p4VP） nanoparticles （NPs） have been used for the first time to generate PTX@p4VP NPs, employing a novel technique in which a gold core in the center of the NP is further oxidized to produce the hollow structure into which PTX molecules can be incorporated. The hollow-p4VP NPs exhibit good physicochemical properties and displayed excellent biocompatibility when tested on blood （no hemolysis） and cell cultures （no cytotoxicity）. Interestingly, PTX@p4VP NPs significantly increased PTX cytotoxicity in human lung （A-549） and breast （MCF-7） cancer cells with a significant reduction of PTX ICs0 （from 5.9 to 3.6 nM in A-549 and from 13.75 to 4.71 nM in MCF-7）. In addition, PTX@p4VP caused a decrease in volume of A-549 and MCF-7 multicellular tumor spheroids （MTS）, an in vitro system that mimics in vivo tumors, in comparison to free PTX. This increased antitumoral activity is accompanied by efficient cell internalization and increased apoptosis, especially in lung cancer MTS. Our results offer the first evidence that hollow- p4VP NPs can improve the antitumoral activity of PTX. This system can be used as a new nanoplatform to overcome the limitations of current breast and lung cancer treatments.

关键词： paclitaxel poly(4-vinylpyridine)(p4VP) nanoparticles lung cancer breast cancer cytotoxicity multicellular tumorspheroids

Ocular Toxoplasmosis: A Case Report

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International Journal of Clinical Medicine 2013年第1期4卷 1-4页

作者： Sara ortiz Raul Martin Victoria de juan Optometry Research Group IOBA-Eye Institute University of Valladolid Valladolid Spain

Report a case of a male patient with a macular scar compatible with ocular toxoplasmosis (OT) in right eye (RE) and review the relevant literature on this disease. A patient, who attended for a routine contact lens follow up, presented with amblyopic exotropia without any ocular disease. Best-corrected visual acuity of the affected eye was 20/40 with constant and mono-fixation exotropia. Ophthalmoscopic assessment revealed a macular scar compatible with OT. OT is the leading cause of infection in the posterior segment. Inactive cases could be asymptomatic and diagnosis requires a complete eye examination, providing a correct diagnosis and patient management.

关键词： Toxoplasmosis Retinochoroiditis Ophthalmoscopy Posterior Uveitis

Contrasting levels of genotype by environment interaction for life history and morphological traits in invasive populations of Zaprionus indianus(Diptera:Drosophilidae)

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Insect Science 2020年第5期27卷 1090-1100页

作者： Nicolas J.Lavagnino Marcos Imberti Victoria E.ortizj Nicolas Flaibani juan Jose Fanara Laboratorio de Evolucion Departamento de EcologiaGenetica y EvolucidnFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina IEGEBA-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

It has been demonstrated that phenotypic plasticity and genotype by envi-ronment interaction are important for coping with new and heterogeneous environments during *** indianus Gupta(Diptera:Drosophilidae)is an Afrotropical invasive fly species introduced to the South American continent in *** species is generalist and polyphagous,since it develops and feeds in several different fruit *** characteristics of *** suggest that phenotypic plasticity and genotype by environment interaction may be important in this species invasion *** this sense,our aim was to investigate the role of genetic variation for phenotypic plasticity(geno-type by environment interaction)in *** invasion of the South American ***,we quantified quantitative genetic variation and genotype by environment in-teractions of morphological and life history traits in different developmental environments,that is,host *** was done in different populations in the invasive range of ***-anus in *** showed that *** populations have considerable amounts of quantitative genetic ***,genotype by environment interactions was detected for the different traits analyzed in response to the different developmental ***,the amounts and patterns of these parameters differed between *** interpreled these results as the existence of diferences in evolutionary potential be-tween populations that have an important role in the short-and long-term success of the *** invasion process.

关键词： biological invasion genotype by env ironment interaction invaded range life history traits morphological traits Zaprionus indianus

Alpha-Dihydroergocryptine vs. Pramipexole as Adjunct Symptomatic Treatment of Idiopathic Parkinson’s

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Advances in Parkinson's Disease 2015年第1期4卷 1-8页

作者： Ulises Rodríguez ortiz Daniel San- juan Francesco Scarci Movement Disorders Clinic and Neurophysiology Department Instituto Nacional de Neurología y Neurocirugía Mexico City Mexico Scientific Department Polichem S.A. Lugano Switzerland

A randomized, double blind, and active reference-controlled study was carried out among 116 patients suffering from idiopathic Parkinson’s disease (PD). The aim of the study was to compare the safety and efficacy of alpha-dihydroergocryptine (DHEC) vs. pramipexole (PRAM) as an adjunct symptomatic therapy to levodopa in PD patients. The motor symptoms, assessed by the Unified Parkinson’s Disease Rating Scale (UPDRS) III subscale, was identified as efficacy target. Fifty-six patients were randomized to DHEC and 60 to PRAM. Patients included were under constant levodopa dose for at least 3 months before entering the study, with baseline UPDRS III ≥14. They underwent a 16-week treatment. Out of the 116 included patients, 85 (39 in DHEC group and 46 in PRAM group, respectively) completed the study protocol. In DHEC group, UPDRS III decreased by 24.2% from baseline at week 10 and by 28.1% at week 16. In PRAM group, UPDRS III decreased by 27.1% from baseline at week 10 and by 29.2% at week 16. The data were highly significant

关键词： Adjunct Symptomatic Therapy Alpha-Dihydroergocryptine Pramipexole Idiopathic Parkinson’s Disease Motor Complications UPDRS