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Journal of Geriatric Cardiology 2012年第2期9卷 172-179页

作者： Xue-Hui Wang Xiao-Zhen Zhuo Ya-juan ni Min Gong Ting-Zhong Wang Qun Lu Ai-Qun Ma Department of Cardiovascular Medicine the First Affiliated Hospital of Medical SchoolXi'an Jiaotong UniversityNo.277 West Yanta RoadXi'an 710061 Shaanxi ProvinceChina Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Cardiovascular Medicine First Hospital of 33nxiang Medical College33nxiang 453000Henan ProvinceChina

ObjectiveWe 用 Neuregulin-1β 执行了实验；(NRG-1β；) 决定为保护的角色的机制由在 .MethodsRat HF 建模的心失败(HF ) 期间改变差距连接(GJ ) 源于它的有益的效果的处理被 aortocaval 建立管。48 只老鼠随机被划分成 H... 详细信息

ObjectiveWe 用 Neuregulin-1β 执行了实验；(NRG-1β；) 决定为保护的角色的机制由在 .MethodsRat HF 建模的心失败(HF ) 期间改变差距连接(GJ ) 源于它的有益的效果的处理被 aortocaval 建立管。48 只老鼠随机被划分成 HF (HF， n = 16 ) ， NRG-1β；处理(NRG， n = 16 ) ，并且假冒的操作(S， n = 16 ) 组。在 NRG 组的老鼠是管理 NRG-1β；(10 µ； g/kg 每天) 为经由尾巴静脉的 7 天，而另外的组与一样的剂量被注射盐。在操作以后的 12 个星期，在从左室获得的单个 myocytes 的 Connexin 43 (Cx43 ) 表示被 immunocytochemistry 决定。全部的蛋白质为 immunoblotting 试金从冻结的左室的纸巾被提取，并且 myocytes 的超微结构被传播电子 *** 与 HF 组，一起观察在 NRG 组的老鼠的心脏的功能显著地被改进的、不规则的分发和死亡 Cx43 表示被减轻。myocytes 的超微结构严重在 HF 老鼠，和 NRG-1β 被损坏；减少了这些病理学的 *** 术语 NRG-1β；在体积的试验性的模型的处理罐头营救泵失败导致超载的 HF，它与 GJ 结构和 Cx43 的改进的恢复有关表示。

关键词：大鼠模型心脏功能调节蛋白缝隙连接超负荷衰竭神经电子显微镜观察

Clinical Study of Acute Vasoreactivity Testing in Patients with Chronic Thromboembolic Pulmonary Hypertension

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Chinese Medical Journal 2017年第4期130卷 382-391页

作者： Qi-Xia Xu Yuan-Hua Yang Jie Geng Zhen-Guo Zhai juan-ni Gong Ji-Feng Li Xiao Tang Chen Wang Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Respiratory Medicine Capital Medical University Beijing 100069 China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui 233004 China Department of Respiratory and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China National Clinical Research Center for Respiratory Diseases Beijing 100730 China

Background： The clinical significance of acute vasoreactivity testing （AVT） in patients with chronic thromboembolic pulmonary hypertension （CTEPH） remains unclear. We analyzed changes in hemodynamics and oxygenation dynamics indices after AVT in patients with CTEPH using patients with pulmonary arterial hypertension （PAH） as controls. Methods： We analyzed retrospectively the results of AVT in 80 patients with PAH and 175 patients with CTEPH registered in the research database of Beijing Chao-Yang Hospital between October 2005 and August 2014. Demographic variables, cardiopulmonary indicators, and laboratory findings were compared in these two subgroups. A long-term follow-up was conducted in patients with CTEPH. Between-group comparisons were performed using the independent-sample t-test or the rank sum test, within-group comparisons were conducted using the paired t-test or the Wilcoxon signed-rank test, and count data were analyzed using the Chi-squared test. Survival was estimated using the Kaplan-Meier method and log-rank test. Results： The rates of positive response to AVT were similar in the CTEPH （25/175, 14.3%） and PAH （9/80, 11.3%） groups （P 〉 0.05）. Factors significantly associated a positive response to AVT in the CTEPH group were level of N-terminal pro-brain natriuretic peptide （〈1131.000 ng/L）, mean pulmonary arterial pressure （mPAE ≤44.500 mmHg）, pulmonary vascular resistance （PVR, 〈846.500 dyn＇s-1·m-5）, cardiac output （CO,≥3.475 L/rain）, and mixed venous oxygen partial pressure （PvO2, ≥35.150 mmHg）. Inhalation of iloprost resulted in similar changes in mean blood pressure, mPAE PVR, systemic vascular resistance, CO, arterial oxygen saturation （SaO2）, mixed venous oxygen saturation, partial pressure of oxygen in arterial blood （PaO2）, PvO2, and intrapulmonary shunt （Qs/Qt） in the PAH and CTEPH groups （all P 〉 0.05）. The survival time in patients with CTEPH with a negative response to AVT was somewhat shorter than that in AVT-responders although the di

关键词： Acute Vasoreactivity Testing Calcium ChannelBlocker Treatment Chronic Thromboembolic PulmonaryHypertension Iloprost

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教育风险治理的“嫁接模式”

高教发展与评估 2022年第6期38卷 1-8,I0002页

作者：丁奕然倪娟东北师范大学教育学部吉林长春130024 江苏省教育科学研究院基础教育研究所江苏南京210013

教育风险治理作为我国新时代防范、化解重大风险攻坚战的重要组成部分,对于教育系统的稳定运行和优质发展至关重要。教育风险大多并非首发性风险,因而可以通过采用教育风险治理的“嫁接模式”实现高效和精准治理。借助植物嫁接过程的隐... 详细信息

教育风险治理作为我国新时代防范、化解重大风险攻坚战的重要组成部分,对于教育系统的稳定运行和优质发展至关重要。教育风险大多并非首发性风险,因而可以通过采用教育风险治理的“嫁接模式”实现高效和精准治理。借助植物嫁接过程的隐喻,阐释教育风险治理的“嫁接模式”,包括三个环节:探寻备用的风险治理经验,研判风险生成本质的相似性,进行面向本土实际问题的变式应用。“嫁接模式”可应用于治理非首发性教育风险,应通过搭建风险案例的汇总平台、寻求信息挖掘的技术支撑与建立鉴别转化的专家智库等保障方式提升教育风险治理的有效性。

关键词：教育风险大学治理教育安全教育改革风险

Effects of Aphidius gifuensis on the feeding behavior and potato virus Y transmission ability of Myzus persicae

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Insect Science 2018年第6期25卷 1025-1034页

作者： Ying-Qin He Yong-Qiang Zhang juan-ni Chen Wen-Long Chen Xian-Yi Zeng Hai-Tao Chen Wei Ding College of Plant Protection Southwest UniversityChongqingChina Guizhou Key Laboratory of Plant Disease and Pest Management for Mountain Agriculture Institute of EntomologyGuizhou UniversityGuiyangChina Chongqing Institute of Tobacco Science ChongqingChina

The stylet penetration behavior of aphids when feeding on plants is associated with virus acquisition and *** gifuensis (Ashmead)is a primary endoparasitoid of Myzuspersicae (Sulzer)which is the most efficient vector of plant viruses. Information about the effects ofparasitoid on aphid and virus transmission can provide an essential foundation for designing effective biological control *** study aimed to investigate the effects *** on the feeding behavior and potato virus Y (PVY) transmission ability of *** results showed that after *** was para-sitized by ***,the duration of the first probe significantly ***, *** exerted remarkable effects on aphid feeding in phloem *** contribution of the E1 waveform to the phloem phase was significantly higher in all parasitized aphids than in the control *** the time of infestation increased for parasitized aphids,the total duration of phloem sap ingestion ***,the percentage of time *** spent in the xylem and phloem phases only changed significantly on day *** percent transmission of PVY by the aphids parasitized on day 5 was lower than that in the control,but no significant differences were *** significance of this work is the demonstration that *** can impede the feeding behavior of ***,which sheds light on the biological basis *** as a natural enemy, but unfortunately does not provide an immediate solution for disrupting the transmission of PVY.

关键词： Braconidae electrical penetration graphs feedingbehavior Myzuspersicae parasitoids virus transmission

“双一流”建设高校本科创新人才培养的风险预警与规避策略研究

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杭州师范大学学报（社会科学版） 2022年第4期44卷 79-86页

作者：侯浩翔倪娟江南大学教育学院江苏无锡214000 江苏省教育科学研究院江苏南京210013

创新人才培养是“双一流”建设高校本科教育教学的应尽职责,也是建设世界重要人才中心和创新高地的必由路径。以“卡脖子”“缺芯”等事件为标志,“双一流”建设高校的本科创新人才培养问题已经成为影响社会经济高质量发展的教育风险。... 详细信息

创新人才培养是“双一流”建设高校本科教育教学的应尽职责,也是建设世界重要人才中心和创新高地的必由路径。以“卡脖子”“缺芯”等事件为标志,“双一流”建设高校的本科创新人才培养问题已经成为影响社会经济高质量发展的教育风险。基于风险社会理论,从专家系统“人为性风险”增加、传统教学方式潜藏原发型教育风险、制度性风险演化为组织管理危机、工具理性异化诱发评价风险等角度出发,揭示“双一流”建设高校本科创新人才培养的课程知识建构、高阶思维培养、创新实践能力培育和创新精神品质激发四方面的风险预警。基于风险的可预测性和可控性提出四点策略:围绕自反性主体建构改进课程设置,聚焦学生创新知识建构;明确创新人才培养的因果链条,借助数字技术培养学生创新思维;建构人本主义制度关照下的纯粹关系,提升学生创新实践能力;破解功利化评价导向,建立发展性和过程化的创新品质评价机制。

关键词： “双一流”建设高校创新人才培养风险社会理论教育风险本科教育

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我国职业教育政策制定的基本逻辑、现实问题与对策建议

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西南大学学报（社会科学版） 2023年第3期49卷 167-177页

作者：崔志钰陈鹏倪娟陕西师范大学教育学部陕西西安710062 江苏省教育科学研究院江苏南京210013

职业教育政策制定作为职业教育政策过程的起点,是职业教育政策效能发挥的前提和基础。我国职业教育政策制定遵循鲜明的国家意志逻辑、典型的问题解决逻辑和严密的风险管控逻辑。当前,我国职业教育政策制定面临一些现实问题:从政策主体看... 详细信息

职业教育政策制定作为职业教育政策过程的起点,是职业教育政策效能发挥的前提和基础。我国职业教育政策制定遵循鲜明的国家意志逻辑、典型的问题解决逻辑和严密的风险管控逻辑。当前,我国职业教育政策制定面临一些现实问题:从政策主体看,政策制定带有行政主观性;从政策本身看,政策制定呈现孤立零散性;从政策环境看,政策制定缺乏差别适应性。优化的对策建议为:一是就政策主体而言,需要健全层级型职业教育政策制定体系,形成纵向政策链的政策制定架构;二是就政策本身而言,需要塑造组合型职业教育政策制定范式,形成横向政策组的政策制定样态;三是就政策环境而言,需要建立螺旋型职业教育政策制定机制,形成整体递进环的政策制定理路。以此为我国职业教育高质量发展提供更精准、更有效的政策供给。

关键词：职业教育政策制定政策体系政策链政策组

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Serum Bilirubin and 6-min Walk Distance as Prognostic Predictors for Inoperable Chronic Thromboembolic Pulmonary Hypertension： A Prospective Cohort Study

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Chinese Medical Journal 2015年第23期128卷 3125-3131页

作者： juan-ni Gong Zhen-Guo Zhai Yuan-Hua Yang Yan Liu Song Gu Tu-Guang Kuang Wan-Mu Xie Ran Miao Chen Wang Department of Pulmonary and Critical Care Medicine Beijing Institute of Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Respiratory Medicine and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China Department of Respiratory Medicine Capital Medical University Beijing 100069 China Department of Cardiovascular Surgery Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Clinical Laboratory Beijing Instituteof Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing 100020 China China-Japan Friendship Hospital National Clinical Research Center of Respiratory Medicine Beijing 100029 China

Background： Inoperable chronic thromboembolic pulmonary hypertension （CTEPH） is a severe clinical syndrome characterized by right cardiac failure and possibly subsequent liver dysfunction. However, whether serum markers of liver dysfunction can predict prognosis in inoperable CTEPH patients has not been determined. Our study aimed to evaluate the potential role of liver function markers （such as serum levels of transaminase, bilirubin, and gamma-glutamyl transpeptidase [GGT]） combined with 6-min walk test in the prediction of prognosis in patients with inoperable CTEPH. Methods： From June 2005 to May 2013, 77 consecutive patients with inoperable CTEPH without confounding co-morbidities were recruited for this prospective cohort study. Baseline clinical characteristics and 6-min walk distance （6MWD） results were collected. Serum biomarkers of liver function, including levels of aspartate aminotransferase, alanine aminotransferase, GGT, uric acid, and serum bilirubin, were also determined at enrollment. All-cause mortality was recorded during the follow-up period. Results： During the follow-up, 22 patients （29%） died. Cox regression analyses demonstrated that increased serum concentration of total bilirubin （hazard ratio [HR] = 7.755, P 〈 0.001）, elevated N-terminal of the prohormone brain natriuretic peptide （HR = 1.001, P = 0.001）, decreased 6MWD （HR = 0.990, P 〈 0.001）, increased central venous pressure （HR = 1.074, P = 0.040）, and higher pulmonary vascular resistance （HR = 1.001, P = 0.018） were associated with an increased risk of mortality. Serum concentrations of total bilirubin （HR = 4.755, P = 0.007） and 6MWD （HR = 0.994, P = 0.017） were independent prognostic predictors for CTEPH patients. Patients with hyperbilirubinemia （≥23.7 μmol/L） had markedly worse survival than those with normobilirubinemia. Conclusion： Elevated serum bilirubin and decreased 6MWD are potential predictors for poor prognosis in inoperable CTEPH.

关键词： Chronic Thromboembolic Pulmonary Hypertension Heart Failure Liver Function Prognosis

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui Liu juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

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校本课程研发的风险来源及其防范

课程．教材．教法 2022年第4期42卷 24-32页

作者：崔志钰陈鹏倪娟陕西师范大学教育学部西安710062 江苏省教育科学研究院南京210013

校本课程研发是教育高质量发展的重要抓手,其所带来的风险没有得到应有的关注。校本课程研发的风险主要源自研发主体课程素养的参差不齐、研发内容选择处理的主观率性、研发过程组织实施的缺标失范、研发质量评估保障的机制缺失。校本... 详细信息

校本课程研发是教育高质量发展的重要抓手,其所带来的风险没有得到应有的关注。校本课程研发的风险主要源自研发主体课程素养的参差不齐、研发内容选择处理的主观率性、研发过程组织实施的缺标失范、研发质量评估保障的机制缺失。校本课程研发风险的防范应从组建有资质的专业团队、选编基于课标的学科资源、遵循项目化的标准管理以及建立全周期的保障体系入手。防范并化解校本课程研发所带来的各类风险,为教育高质量发展提供重要的课程资源和环境。

关键词：校本课程研发风险来源风险防范

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动因·价值·遵循:“双减”政策的三维审思

现代教育管理 2022年第4期 30-39页

作者：赵亮倪娟代建军西北师范大学教育学院甘肃兰州730000 江苏师范大学基础教育研究所江苏徐州221116 江苏省教育科学研究院基础教育研究所江苏南京210000 江苏师范大学教育科学学院江苏徐州221116

“双减”政策是党中央通过“小切口”推动教育领域“大改革”的一次实践创新,其本质是对教育利益的再分配,追求的是社会公共利益的最大化,体现的是以人为本。“双减”政策的产生主要是受双动力因素的驱动,既为了解决现实中微观层面的内... 详细信息

“双减”政策是党中央通过“小切口”推动教育领域“大改革”的一次实践创新,其本质是对教育利益的再分配,追求的是社会公共利益的最大化,体现的是以人为本。“双减”政策的产生主要是受双动力因素的驱动,既为了解决现实中微观层面的内生问题、中观层面的关联问题以及宏观层面的诱发问题,也为了防范教育领域可能出现的风险。公共政策的双重价值属性决定了“双减”政策具有形式价值和实质价值,二者表现为手段与目的的关系,这为贯彻“双减”政策提供了方法论关照。落实“双减”政策,应注重教育政策之“志”“、制”和“治”三者的内在有机统一:在“志”的高度上坚守逻辑起点,在“制”的深度上坚持有序推进,在“治”的宽度上坚定实践创新。

关键词： “双减”政策教育改革教育政策教育利益政策价值