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抗酸染色联合PAS染色和六胺银染色在感染性疾病病理学实验教学中的应用

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中国组织化学与细胞化学杂志 2024年第2期33卷 201-207,200页

作者：瞿智玲郭俊红王曦杨茹梦倪娟段亚琦华中科技大学基础医学国家级实验教学示范中心武汉430030 华中科技大学同济医学院基础医学院病理学系武汉430030 华中科技大学附属同济医院病理研究所武汉430030

为配合医学整合课程体系改革,结合临床病理诊断常用的感染性疾病的辅助诊断方法,将抗酸染色、高碘酸-Schiff(periodic acid-Schiff,PAS)染色和六胺银染色阳性病例切片引入病理学感染性疾病章节的实验教学,显示出病变组织致病微生物。通... 详细信息

为配合医学整合课程体系改革,结合临床病理诊断常用的感染性疾病的辅助诊断方法,将抗酸染色、高碘酸-Schiff(periodic acid-Schiff,PAS)染色和六胺银染色阳性病例切片引入病理学感染性疾病章节的实验教学,显示出病变组织致病微生物。通过对不同班级进行问卷调研,绝大多数同学认可特殊染色在感染性疾病章节中的应用,认为不仅丰富了课堂内容,学习了结核杆菌和真菌在病变组织中的形态学特征及其导致的组织病理变化,而且加深了对感染性疾病理论知识的理解,深刻认识到病理学研究内容除了疾病的病理变化之外,还要探讨疾病发生的病因以及好发部位。同时,这些增加的特殊染色切片改变了本章节实验教学切片普通光学显微镜下色彩的单调性——单一的“红-蓝”色调,丰富了镜下色彩,提高了学生的学习兴趣,活跃了课堂气氛。

关键词：感染性疾病实验教学抗酸染色 PAS染色六胺银染色

血液透析患者透析饮食健康信念的潜在剖面分析

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护理实践与研究 2024年第9期21卷 1295-1302页

作者：徐玉娇陈青李铃佳曾维轲倪娟吴秀丽湖南中医药大学第一附属医院(湖南省长沙市 410007) 湖南中医药大学(湖南省长沙市 410208) 长沙当代护士杂志社有限公司(湖南省长沙市 410008) 湖南中医药高等专科学校(湖南省株洲市 412012)

目的调查血液透析患者饮食健康信念潜在分类,并分析其影响因素。方法2023年4—5月选取湖南省某三级甲等医院血液净化中心收治的228例维持性血液透析患者作为调查对象,采取一般资料调查表、透析饮食健康信念量表(Dialysis Diet-Related H... 详细信息

目的调查血液透析患者饮食健康信念潜在分类,并分析其影响因素。方法2023年4—5月选取湖南省某三级甲等医院血液净化中心收治的228例维持性血液透析患者作为调查对象,采取一般资料调查表、透析饮食健康信念量表(Dialysis Diet-Related Health Belief Questionnaire,DDHBQ)对患者进行调查,采用Rstudio 4.1.0软件的tidyPA程序包进行潜在剖面分析调查血液透析患者透析饮食健康不同类别,并分析血液透析患者透析饮食健康信念的影响因素。结果共回收220份有效问卷,回收有效率96.49%。潜在剖面分析结果显示,血液透析患者透析饮食健康信念特征可分为4个潜在类别:“稳定型”“严重型”“障碍型”“行动型”。多因素Logistic回归分析结果显示,文化程度、职业、透析年龄、原发病、月收入状况是影响血液透析患者透析饮食健康信念的因素(P<0.05)。结论血液透析患者饮食健康信念有明显的分类特征,分为“稳定型”“严重型”“障碍型”“行动型”。医护人员应根据血液透析饮食健康信念影响因素对不同类别患者制订出具有针对性、人性化、更高效的饮食健康管理方案并进行积极的心理疏导,对患者进行系统化的健康教育,让患者更加了解疾病的治疗方案和相关诊疗知识,帮助患者进行科学饮食行为决策,以增强患者透析饮食健康信念,提高患者的生活质量。

关键词：血液透析饮食健康信念潜在剖面影响因素

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重组人生长激素治疗特发性矮小症患儿的疗效

中华妇幼临床医学杂志（电子版） 2024年第3期20卷 346-352页

作者：李倩刘倩朱海玲倪娟任宝芹刘长云潍坊医学院临床医学院儿科教研室潍坊261000 潍坊医学院附属医院查体中心潍坊261000 潍坊医学院附属医院儿科潍坊261000

目的探讨重组人生长激素(rhGH)治疗特发性矮小症(ISS)患儿的疗效。方法选择2020年10月至2022年12月于潍坊医学院附属医院儿科门诊就诊的84例ISS患儿为研究对象。首先根据是否采取rhGH治疗,将其分为治疗组(n=45,注射rhGH者)和对照组(n=39... 详细信息

目的探讨重组人生长激素(rhGH)治疗特发性矮小症(ISS)患儿的疗效。方法选择2020年10月至2022年12月于潍坊医学院附属医院儿科门诊就诊的84例ISS患儿为研究对象。首先根据是否采取rhGH治疗,将其分为治疗组(n=45,注射rhGH者)和对照组(n=39,未注射rhGH者)。其次,再根据患儿年龄,将治疗组分为治疗亚组1(n=21,年龄0.05)。②治疗2年后,治疗组和对照组患儿身高、GV、IGF-1和25(OH)D水平比较,差异均有统计学意义(t=3.80、17.27、6.34、2.34,P=0.006、0.008、0.05)。③治疗2年后,治疗亚组1、2患儿的身高和年GV分别优于对照1、2组,并且差异均有统计学意义(t=5.00、64.35,P=0.007、0.009)。此外,治疗亚组1患儿的年GV大于治疗亚组2,并且差异有统计学意义(t=35.60,P=0.006);而对照亚组1、2患儿的年GV比较,差异无统计学意义(P>0.05)。④治疗1年后,4个亚组患儿GV比较,治疗亚组2于治疗后7~12个月的GV明显高于0~6个月,组内比较,差异有统计学意义(t=0.37,P=0.049)。⑤研究组与对照组患儿治疗过程中出现关节疼痛、肝肾功能异常、甲状腺功能异常、FBG升高等总发生率比较,差异均无统计学意义(P>0.05)。结论rhGH治疗ISS患儿,可显著提高其身高和GV,尤其在<8岁儿童中效果更佳,并且治疗过程中未发现严重不良反应。

关键词：特发性矮小症重组人生长激素骨龄血糖药物相关性副作用和不良反应儿童

Synthesis of novel chiral N,P-containing multidentate ligands and their applications in asymmetric transfer hydrogenation

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Chinese Chemical Letters 2011年第11期22卷 1269-1272页

作者： Shen Luan Yu Yan Yun Li Zhen Rong Dong juan ni Zhang Qi Li Jing Xing Gao State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green ChemicalProductions of Alcohols-Ethers-Esters and Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral *** structures were fully characterized by IR,EI-MS and *** catalytic systems,prepared in situ from the multidentate ligands and iridium（I） complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee.

关键词： Chiral multidentate aminophosphine ligand Iridium complex Propiophenone Asymmetric transfer hydrogenation

Improvement of cardiac function and reversal of gap junction remodeling by Neuregulin-1β in volume-overloaded rats with heart failure

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Journal of Geriatric Cardiology 2012年第2期9卷 172-179页

作者： Xue-Hui Wang Xiao-Zhen Zhuo Ya-juan ni Min Gong Ting-Zhong Wang Qun Lu Ai-Qun Ma Department of Cardiovascular Medicine the First Affiliated Hospital of Medical SchoolXi'an Jiaotong UniversityNo.277 West Yanta RoadXi'an 710061 Shaanxi ProvinceChina Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Cardiovascular Medicine First Hospital of 33nxiang Medical College33nxiang 453000Henan ProvinceChina

Objective We performed experiments using Neuregulin-1β （NRG-1β） treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions （GJs） during heart failure （HF）. Methods Rat models of I-IF were established by aortocaval fistula. Forty-eight rats were divided randomly into the HF （HF, n = 16）, NRG-1β trealanent （NRG, n = 16）, and sham operation （S, n = 16） group. The rats in the NRG group were administered NRG-1β （10 μg/kg per day） for 7 days via the tail vein, whereas the other groups were injected with the same doses of saline, Twelve weeks after operation, Connexin 43 （Cx43） expression in single myocytes obtained from the left ventricle was determined by immunocytochemistry. Total protein was extracted from frozen left ventricular tissues for immunoblotting assay, and the ultrastmcture of myocytes was observed by transmission electron microscopy. Results Compared with the HF group, the cardiac fimction of rats in the NRG group was markedly improved, irregular distribution and deceased Cx43 expression were relieved. The ultrastmcture of myocytes was seriously damaged in HF rats, and NRG-1β reduced these pathological damages. Conclusions Short-term NRG-1β treatment can rescue pump failure in experimental models of volume overload-induced HF, which is related to the recovery of GJs structure and the improvement of Cx43 expression.

关键词： qeuregulin-1β Cardiac function Heart failure Connexin 43 Gap junction Remodeling

Robust structured total least squares algorithm for passive location

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Journal of Systems Science & Complexity 2015年第5期28卷 946-953页

作者： Hao Wu Shuxin Chen Yihang Zhang Hengyang Zhang juan ni Information and Navigation College Air Force Engineering University Unit 94303 of PLA

A new approach called the robust structured total least squares(RSTLS) algorithm is described for solving location inaccuracy caused by outliers in the single-observer passive location. It is built within the weighted structured total least squares(WSTLS)framework and improved based on the robust estimation ***, the improved Danish weight function is proposed according to the robust extremal function of the WSTLS, so that the new algorithm can detect outliers based on residuals and reduce the weights of outliers automatically. Finally, the inverse iteration method is discussed to deal with the RSTLS problem. Simulations show that when outliers appear, the result of the proposed algorithm is still accurate and robust, whereas that of the conventional algorithms is distorted seriously.

关键词： passive location structured total least squares robustestimation equivalent weight function.

"Light-on"Colorimetric Assay for Ascorbic Acid Detection via Boosting the Peroxidase-like Activity of Fe-MIL-88

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Journal of Analysis and Testing 2022年第1期6卷 67-75页

作者： Chuan-xia Chen Cheng-hui Zhang Peng-juan ni Yuan-yuan Jiang Bo Wang Yi-zhong Lu School of Materials Science and Engineering University of JinanJinan 250022China

A label-free"light-on"colorimetric assay for ascorbic acid(AA)determination is unprecedentedly devised by regulating the intrinsic peroxidase-mimetic activity of the *** can reduce Fe(Ⅲ)presented in Fe-MIL-88 to Fe(Ⅱ),which will dramatically promote the hydroxyl radicals(·OH)conversion efficiency of H_(2)O_(2)through a Fenton reaction,and effectually accelerate the Fe-MIL-88 catalyzed chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine(TMB)-H_(2)O_(2).Redox reaction between AA and H_(2)O_(2)also can produce·OH and promote this chromogenic ***,quantification of AA is real-ized via determining the enhanced colorimetric *** linear range is 0.5−40μM with a detection limit of 0.12μ***,the straightforward yet effective colorimetric strategy with the merits of simplicity,cost-effectiveness,high accuracy,specificity,and sensitivity is widely utilized to determine the concentrations of AA in serological tests.

关键词： Ascorbic acid Colorimetric Fe-MIL-88 Hydroxyl radicals Fenton reaction

Effects of Aphidius gifuensis on the feeding behavior and potato virus Y transmission ability of Myzus persicae

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Insect Science 2018年第6期25卷 1025-1034页

作者： Ying-Qin He Yong-Qiang Zhang juan-ni Chen Wen-Long Chen Xian-Yi Zeng Hai-Tao Chen Wei Ding College of Plant Protection Southwest UniversityChongqingChina Guizhou Key Laboratory of Plant Disease and Pest Management for Mountain Agriculture Institute of EntomologyGuizhou UniversityGuiyangChina Chongqing Institute of Tobacco Science ChongqingChina

The stylet penetration behavior of aphids when feeding on plants is associated with virus acquisition and *** gifuensis (Ashmead)is a primary endoparasitoid of Myzuspersicae (Sulzer)which is the most efficient vector of plant viruses. Information about the effects ofparasitoid on aphid and virus transmission can provide an essential foundation for designing effective biological control *** study aimed to investigate the effects *** on the feeding behavior and potato virus Y (PVY) transmission ability of *** results showed that after *** was para-sitized by ***,the duration of the first probe significantly ***, *** exerted remarkable effects on aphid feeding in phloem *** contribution of the E1 waveform to the phloem phase was significantly higher in all parasitized aphids than in the control *** the time of infestation increased for parasitized aphids,the total duration of phloem sap ingestion ***,the percentage of time *** spent in the xylem and phloem phases only changed significantly on day *** percent transmission of PVY by the aphids parasitized on day 5 was lower than that in the control,but no significant differences were *** significance of this work is the demonstration that *** can impede the feeding behavior of ***,which sheds light on the biological basis *** as a natural enemy, but unfortunately does not provide an immediate solution for disrupting the transmission of PVY.

关键词： Braconidae electrical penetration graphs feedingbehavior Myzuspersicae parasitoids virus transmission

Current Clinical Management Status of Pulmonary Embolism in China

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Chinese Medical Journal 2017年第4期130卷 379-381页

作者： juan-ni Gong Yuan-Hua Yang Department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing institute of Respiratory Medicine Beijing 100020 China

Pulmonary embolism （PE） is a potentially life-threatening disease with high morbidity and mortality all over the world. PE and deep vein thrombosis （DVT）, as two different forms of venous thromboembolism （VTE） on patients, cannot be separated apart in the management. After years of efforts, the management of PE has been comprehensively promoted in China. Medical authorities and staff have gained more awareness of the disease, standardized diagnosis and treatment has been extended, and varieties of clinical and basic researches have been conducted.

关键词： Deep Vein Thrombosis Disease Management Pulmonary Embolism