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Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

World Journal of Diabetes 2024年第4期15卷 758-768页

作者： Enriqueta Muñoz-Islas Edgar David Santiago-SanMartin Eduardo Mendoza-Sánchez Héctor Fabián Torres-Rodríguez Laura Yanneth Ramírez-Quintanilla Christopher Michael Peters juan mig.el jiménez-andrade Unidad Académica Multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDM)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vasculature in the pancreas from adult offspring born from mouse dams with *** GDM was induced by *** of streptozotocin(STZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDM were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control ***,the microvasculature in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDM compared to control *** GDM induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring

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Portal Venous Thrombosis and Splenic Hemangioma, Secondary to Acute Pancreatitis: Case Report

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Open Journal of Gastroenterology 2024年第1期14卷 11-17页

作者： Gustavo Adolfo Hernández Valdez Harvey Yair Zamora Veliz Estefany Gilberty Mendoza Verdin Quitzia Mayanim Rentería Fonseca Itzel Velázquez Viniegra Janette Alejandra Gamiño Gutierrez Diana Rita Velázquez jimenez Florencio Favian andrade Luis Fernando Baez Bustos Jorge Morales Rojas María Jacqueline Martínez Tejeda Graciela Gaddy Robles Martínez juan Antonio Contreras Escamilla Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic Nayarit México General Surgery Department ISSSTE Tepic General Hospital APP Tepic Nayarit México Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco México

We present an unusual case of portal vein thrombosis with a splanchnic hemangioma secondary to acute biliary pancreatitis. We report a 45-year-old patient, who has systemic arterial hypertension in treatment, was admitted for abdominal pain in the epigastrium, with irradiation to the right hypochondrium, accompanied by nausea and vomiting of 10 occasions of bile content, physical examination with pain in the right hypochondrium, Murphy positive. We have laboratory studies with a lipase of 788, so a diagnosis of pancreatitis is made with an etiology to be determined. The laboratories suggestive of acute biliary pancreatitis (lipase 788.71);an imaging study was subsequently performed (ultrasonography) with the result of stone in the common bile duct. A laparoscopy was performed with relative improvement, so he was discharged and returned 20 days after surgery due to abdominal pain of the same intensity in the left hypochondrium. Ending his hospitalization with a splenectomy for splenic hemangioma with portal vein thrombosis.

关键词： Pancreatitis Esplenic Hemangioma Esplenectomy Portal Vein Thrombosis Surgery

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Quality assessment of Continuous Operating Reference Stations(CORS)-GPS stations in Mexico

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Geodesy and Geodynamics 2022年第3期13卷 275-287页

作者： Daniel Hernández-andrade Rosendo Romero-andrade Gopal Sharma Manuel E.Trejo-Soto juan L.Cabanillas-Zavala Faculty of Earth and Space Sciences Autonomous University of Sinaloa80013Culiacán RosalesSinaloaMexico North Eastern Space Applications Centre Umiam793103MeghalayaIndia

The present analysis provided the quality assessment of 65 Continuous Operating Reference Stations(CORS) situated in and around Mexico using the data of about ten years(January 2010 to January 2020).To accomplish the assessment,we considered 4 quality indexes for performing the quality check,incluing the multipath effect on L1 and L2 bands,signal-to-noise ratio in both bands,cycle slips,and ***,a new reference parameter named regio nal values for Mexico(RVM) was calculated for the stations situated in ***,an exhaustive analysis of the quality indicators in the worst and best cases was *** signal degradation was proved by a long-term time series and cru stal defo rmation analysis in GAMIT/GLOBK *** results showed a stro ng correlation between integrity,cycle slips and daily observations time,and the multipath effect is strong in the case of outdated *** study indicates that the estimated quality indexes and values could be the basis for establishing new CORS in Mexico,and the errors corrections which cannot be mitigated in the postprocessing stage would greatly help utilize the data for different scientific *** results were supported by deformation analysis in part of Baja California Peninsula in Mexico indicating northern and eastern velocity vector of -3.08±0.02 mm/yr,-7.85±0.02 mm/yr and-0.07±0.03 mm/yr,-9.33±0.02 mm/yr respectively at MPR1 and INEG stations.

关键词： Multipath effect Signal-to-Noise ratio Cycle slip Integrity Regional quality indicators IGS indicators

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The number of alignments between two DNA sequences

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International Journal of Biomathematics 2016年第4期9卷 75-80页

作者： Helena andrade juan J. Nieto Angela Torres Departamento de Andlisis Matemdtico Facultad de Matemdticas Universidad de Santiago de Compostela Spain Department of Mathematics Faculty of ScienceKing Abdulaziz University Jeddah 21589 Saudi Arabia Departamento de Psiquiatrla Radiologla y Salud Publica Facultad de Medicina Universidad de Santiago de Compostela Spain

We consider two DNA sequences and compare both sequences. One of the crucial issues in bioinformatics is to measure the similarity of two DNA sequences. To this purpose one has to consider different alignments between both sequences. The number of alignments grows very rapidly with the length of the sequences. In this paper we give exact, explicit and computable formulas for the number of different possible alignments and for some classes of reduced alignments. We provide a new insight into the theory of DNA sequence alignment.

关键词： DNA序列比对生物信息学相似性路线

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Epistatic interactions between pterin and carotenoid genes modulate intra-morph color variation in a lizard

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Integrative Zoology 2022年第1期17卷 44-53页

作者： Prem AGUILAR Pedro andrade Guillem PÉREZ I DE LANUZA CIBIO/InBIO Centro de Investigação em Biodiversidade e Recursos Genéticos da Universidade do PortoPortoPortugal Ethology Lab Institut Cavanilles de Biodiversitat i Biologia EvolutivaUniversitat de ValènciaValènciaSpain

Color polymorphisms have become a major topic in evolutionary biology and substantial efforts have been devoted to the understanding of the mechanisms responsible for originating such colorful ***-morph continuous variation,on the other hand,has been neglected in most of the ***,we combine spectrophotometric/visual modeling and genetic data to study the mechanisms promoting continuous variation within categorical color morphs of Podarcis *** results suggest that intra-morph variability in the pterin-based orange morph is greater compared to white and yellow *** also show that continuous variation within the orange morph is partially discriminable by *** results indicate that allelic variants at the BCO2 locus(responsible for deposition of yellow carotenoids)contribute to generate continuous variation in orange ***,other intrinsic and/or extrinsic mechanisms,such as body size,might be involved,opening a new avenue for future research on the drivers of continuous variation within-morphs.

关键词： BCO2 color polymorphism continuous variation lizard Podarcis muralis

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Bacterial extracts and bioformulates as a promising control of fruit body rot and root rot in avocado cv. Hass

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Journal of Integrative Agriculture 2020年第3期19卷 748-758页

作者： David GRANADA Lorena LÓPEZ-LUJAN Sara RAMIREZ-RESTREPO juan MORALES Carlos PelÁEZ-JARAMILLO Galdino andrade juan Carlos BEDOYA-PEREZ Phytosanitary and Biological Control Unit Corporation for Biological ResearchMedellin 050034Colombia Faculty of Health Sciences Institution University Colegio Mayor de AntioquiaMedellin 050034Colombia Department of Agronomic Sciences National University of ColombiaMedellin 050034Colombia Faculty of Exact Sciences University of AntioquiaMedellin 050010Colombia Department of Microbiology Londrina State UniversityLondrina 86051-990Brazil

At least 20-40% of annual losses of avocado crops are caused by pathogenic *** chemical treatments of these diseases are inefficient,cause environmental pollution and are increasingly restricted by international *** work aimed to assess the biocontrol capacity of a bacterial extract to protect avocado fruits and plants from pathogen *** from the bacterial isolate Serratia ***5.1 were obtained from liquid fermentations in a biorreactor.A body rot postharvest infection model with Colletotrichum gloeosporioides on fruits was ***,packaging conditions were simulated using the bacterial extract and the commercial fungicide prochloraz as a positive ***,seedlings infections with Phytophthora cinnamomi were performed on two types of avocado(West Indian race and ***).The Area Under Disease Progress Curve(AUDPC) was recorded using the bacterial extract and a commercial product with fosetyl-aluminium as *** bacterial extract significantly reduced infections by *** on injured avocado fruits at 31.1 μg mL^-*** fruits were also protected against body rot infections at the same concentration and showed no significant differences with the commercial *** the other hand,AUDPC in the seedlings was significantly reduced with the extract treatment at 3 μg mL^-1 compared to the ***,a possible phytotoxicity effect of the extract was evidenced in the seedlings and confirmed by pathogen recovery and tests on Raphanus sativus ***,formulations of the extracts(emulsion and emulsifiable concentrate) were prepared,and bioactive stability was assessed for 8 *** emulsion formulates demonstrated very stable bioactivity against *** extract and the emulsion formulate showed promising results for the control of avocado *** bioproducts based on this type of active principles could be developed for the benefit of avocado industry.

关键词： Colletotrichum gloeosporioides Phytophthora cinnamomi Serratia sp. antagonistic microbes secondary metabolites biofungicide

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Effects of drying process on total phenolics,antioxidant activity and flavonoid contents of common Mediterranean herbs

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International Journal of Agricultural and Biological Engineering 2015年第2期8卷 145-150页

作者： Taha M.Rababah Muhammad Al-u'datt Mohammad Alhamad Majdi Al-Mahasneh Khalil Ereifej juan andrade Bayan Altarifi Ali Almajwal Wade Yang Faculty of Agriculture Jordan University of Science and TechnologyIrbid 22110Jordan Faculty of Engineering Jordan University of Science and TechnologyIrbid 22110Jordan Department of Food Science and Human Nutrition University of Illinois at Urbana-ChampaignUrbana Illinois 61801USA Department of Community Health Sciences College of Applied Medical SciencesKing Saud UniversityRiyadh 11451Saudi Arabia Department of Food Science and Human Nutrition University of FloridaGainesville Florida 32611USA

Four different fresh and dried herb species(sage,thyme,mint and lemonbalm)were evaluated to study the effect of drying process on the total phenolics,antioxidant activity,flavonoid contents and color *** mint had the highest contents of total phenolics(335.4 mg GAE/100 g),whereas lower levels were respectively found in sage(316.4 mg GAE/100 g)followed by lemonbalm(303.2 mg GAE/100 g)and thyme(299.2 mg GAE/100 g).Dry processing significantly decreased the phytochemical contents of all investigated *** to air drying,total phenolics,antioxidant activity and flavonoids content in herbs decreased apparently by oven *** mint had the highest antioxidant activity(87.46%)and flavonoids content(298.51 mg CE/100 g),while the fresh sage,thyme and lemonbalm were found to have antioxidant activity values of 86.81%,86.56% and 85.26%,*** showed that air drying herbs contained more total phenolics,antioxidant activity,and flavonoids than oven drying herbs.

关键词： Herbs drying process antioxidant activity flavonoids

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Effect of Dietary EGCG on Normal and Vitamin E and Selenium Deficient Rats

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Food and Nutrition Sciences 2013年第8期4卷 163-173页

作者： juan E. andrade John R. Burgess Department of Food Science and Human Nutrition University of Illinois Champaign-Urbana USA Department of Nutrition Sci- ence Purdue University West Lafayette USA.

The tea catechin EGCG has been postulated to provide health benefits in humans, to some extent, as an antioxidant. The dose-response effect of dietary EGCG (0, 30, 60, or 120 mg/kg diet) was tested in rats under high versus low oxidative stress conditions that were created by feeding diets adequate in vitamin E and Se (Lox), or deficient in both (Hox) for six weeks. Effects on growth, quinone reductase (NQO1) activity, F2-isoprostanes and nutrient antioxidant amounts in the liver were evaluated as markers of nutrient deficiency and oxidative status. Under Hox conditions consumption of EGCG only at the lowest dose was partially associated with a protection against oxidative stress, reflected by a delay in growth deceleration, but no protection against lipid oxidation. elevated liver NQO1 activity was observed in this group (>4-fold) increasing with the dose;but it was not associated with antioxidant protection. In contrast, under Lox conditions consumption of EGCG was associated with antioxidant activity reflected in a reduction (>30%) in F2-isoprostanes and protection of CoQ reduced status in the liver. Overall these results suggest that the antioxidant effect of EGCG in vivo depends on the level of oxidative stress and the presence of other nutrient antioxidants.

关键词： Vitamin E Deficiency Oxidative Stress EGCG Flavonoid Rat Antioxidant

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Opposing roles of plant laticifer cells in the resistance to insect herbivores and fungal pathogens

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Plant Communications 2021年第3期2卷 93-104页

作者： Lourdes Castelblanque Javier García-andrade Clara Martínez-Arias juan J.Rodríguez Francisco J.Escaray Ernestina Aguilar-Fenollosa Josep A.Jaques Pablo Vera Instituto de Biología Moleculary Celular de Plantas Universitat Politécnica de Valéncia-C.S.I.CCiudad Politécnica de la InnovaciònEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain Universitat Jaume I Departament de Ciéncies Agráries i del Medi NaturalCampus del Riu Sec12003 Castellòde la PlanaSpain

More than 12,000 plant species(ca.10%of flowering plants)exude latex when their tissues are *** is produced and stored in specialized cells named“laticifers”.Laticifers form a tubing system composed of rows of elongated cells that branch and create an internal network encompassing the entire *** constitute a recent evolutionary achievement in ecophysiological adaptation to specific natural environments;however,their fitness benefit to the plant still remains to be *** identification of Euphorbia lathyris mutants(pil mutants)deficient in laticifer cells or latex metabolism,and therefore compromised in latex production,allowed us to test the importance of laticifers in pest *** provided genetic evidence indicating that laticifers represent a cellular adaptation for an essential defense strategy to fend off arthropod herbivores with different feeding habits,such as Spodoptera exigua and Tetranychus *** marked contrast,we also discovered that a lack of laticifer cells causes complete resistance to the fungal pathogen Botrytis ***,a latex-derived factor required for conidia germination on the leaf surface was *** factor promoted disease susceptibility enhancement even in the non-latex-bearing plant *** speculate on the role of laticifers in the coevolutionary arms race between plants and their enemies.

关键词： latex Euphorbia lathyris disease resistance disease susceptibility plant defense

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卢卡诺伯爵

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丛书名：悦读经典

2008年

作者： Don juan Manuel原）（美） Marcel C. andrade改编）（孟宪臣译）

本书是《卢卡诺伯爵》的改编版，选入了《卢卡诺伯爵》中15个最受读者喜爱的故事，学习者可以充分感受到西班牙经典文学作品中的幽默、智慧以及哲理。

ISBN: (纸本)9787561920749

关键词：对照读物长篇小说西班牙语西班牙中世纪汉语

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