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Effects of organic chromium supplementation to finishing lambs diet on growth performance, carcass characteristics and meat quality

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Journal of Integrative Agriculture 2015年第3期14卷 567-574页

作者： Laura moreno-Camarena Ignacio Domínguez-Vara José Bórquez-Gastelum juan Sánchez-Torres juan Pinos-Rodríguez Antonia mariezcurrena-Berasain Ernesto morales-Almaráz Abdelfattah z m Salem Faculty of Veterinary medicine and Animal Science Autonomous University of the State of Mexico Center of Biosciences University Autonomous of San Luis PotosiPalma of the Cruz Soledad of Graciano Sánchez 78321Mexico

The objective of this study was to evaluate supplemental organic chromium（Cr） to finishing lambs on growth performance, carcass characteristics, and meat quality. Eighteen Suffolk lambs（age（4.5±0.2） mon;（25.8±3.6） kg body weight（BW）） were randomly assigned to three levels of supplemental organic Cr（0.0, 0.2 and 0.4 mg kg^–1 dry matter（Dm）） in a complete random design. Growth performance was evaluated for 70 d, and then lambs were slaughtered to study carcass characteristics and chemical composition of meat. Orthogonal contrasts were performed（contrast one-average level 0.2 ppm Cr vs. average level 0.4 ppm Cr; contrast two-level 0 vs. average levels（0.2＋0.4） ppm Cr）. Orthogonal polynomials were used to estimate the linear and quadratic effects of Cr concentrations. Growth and carcass performance were not affected by supplemental organic Cr. muscle conformation and leg perimeter linearly increased（P〈0.05） as organic Cr level increased in the diet. Kidney fat decreased linearly（P〈0.05） as supplemental Cr increased. In Longissimus dorsi（LD）, the ash content decreased linearly, and shear force（kg cm^–2） increased（P〈0.05） as organic Cr level increased in the diet. It is concluded that organic Cr did not affect growth performance, but it improved positively the muscle conformation, reduced kidney fat, whereas in LD there was an increment in shear force in finishing carcass lambs.

关键词： carcass finishing lambs Longissimus dorsi organic chromium

Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants

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Journal of Integrative Agriculture 2015年第3期14卷 526-533页

作者： mona m Y Elghandour Abdelfattah z m Salem Jose S martínez Castaeda Luis m Camacho Ahmed E Kholif juan C Vázquez Chagoyán Faculty of Veterinary medicine and Animal Science Autonomous University of the State of Mexico Faculty of Veterinary medicine and Animal Science Autonomous University of Guerrero Dairy Science Department National Research Centre

For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial（DFm） can be the most suitable solutions. microorganisms that are commonly used in DFm for ruminants may be classified mainly as lactic acid producing bacteria（LAB）, lactic acid utilizing bacteria（LUB）, or other microorganism＇s species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFm has not been established; although a variety of mechanisms have been suggested. Bacterial DFm potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFm may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFm may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFm administration. However, the response to DFm is not constant; depending on dosages, feeding times and frequencies, and strains of DFm. Nonetheless, recent studies have supported the positive effects of DFm on ruminant performance.

关键词： direct-fed microbial(DFm) mode of action ruminants

Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate

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Journal of Integrative Agriculture 2015年第1期14卷 131-139页

作者： Abdelfattah z m Salem German Buendía-Rodríguez mona m m Elghandour maría A mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego juan C V Chagoyán maría A Cerrillo miguel A Rodríguez Faculty of Veterinary medicine and Animal Science Autonomous University of the State of Mexico National Center of Disciplinary Research in Animal Physiology and Improvement INIFAP Ajuchitlán Institute of Agricultural Sciences Autonomous University of HidalgoEx-Hda. of Aquetzalpa Faculty of Veterinary medicine and Animal Science Juárez University of the Durango State

An in vitro gas production （GP） technique was used to investigate the effects of combining different doses of Salix babylonica extract （SB） with exogenous fibrolytic enzymes （Ez） based on xylanase （X） and cellulase （C）, or their mixture （XC; 1：1 v/v） on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture （50：50, w/w） as substrate. Four levels of SB （0, 0.6, 1.2 and 1.8 mL g-1 dry matter （Dm）） and four supplemental styles of Ez （1 μL g-1 Dm; control （no enzymes）, X, C and XC （1：1, v/v） were used in a 4×4 factorial arrangement. In vitro GP （mL g-1 Dm） were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant pH was determined, and then filtered to determine dry matter degradability （DmD）. Fermentation parameters, such as the 24 h gas yield （GY24）, in vitro organic matter digestibility （OmD）, metabolizable energy （mE）, short chain fatty acid concentrations （SCFA）, and microbial crude protein production （mCP） were also estimated. Results indicated that there was a SBxEz interaction （P〈0.0001） for the asymptotic gas production （b）, the rate of gas production （c）, GP from 6 to 72 h, GP2 （P=0.0095）, and GP4 （P=0.02）. The SB and different combination of enzymes supplementation influenced （P〈0.001） in vitro GP parameters after 12 h of incubation; the highest doses of SB （i.e., 1.8 mL g-1 Dm）, in the absence of any Ez, quadratically increased （P〈0.05） the initial delay before GP begins （L） and GP at different incubation times, with lowering b （quadratic effect, P〈0.0001 ） and c （quadratic effect, P〈0.0001 ; linear effect, P=0.0018）. The GP was the lowest （P〈0.05） when the highest SB level was combined with cellulose. There were SBxEz interactions （P〈0.001） for OmD, mE, the partitioning factor at 72 h of incubation （PF72）, GY24, SCFA, mCP （P=0.0143）, and pH （P=0.0008）. The OmD, mE, GY24 and SCFA with supplementation of SB extract at 1.8 mL g-1 Dm were h

关键词： cellulase degradability gas production Salix babylonica xylanase

A Note on Extreme Points in Dual Spaces

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Acta mathematica Sinica,English Series 2013年第3期29卷 471-476页

作者： juan Francisco mENA-JURADO juan Carlos NAVARRO-PASCUAL Departamento de Análisis matemático Facultad de Ciencias Universidad de Granada Departamento de lgebra y Análisis matemático Universidad de Almería

Given a normed space X it can be easily proven that every extreme point in Bx＊, the unit ball of X＊, is the restriction of an extreme point in Bx Our purpose is to study when the restrictions of extreme points in B... 详细信息

关键词： Extreme point Ll-predual m-ideal

Post-acute pancreatitis diabetes:A complication waiting for more recognition and understanding

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World Journal of Gastroenterology 2023年第28期29卷 4405-4415页

作者： Diego García-Compeán Alan R Jiménez-Rodríguez juan m muñoz-Ayala José A González-González Héctor J maldonado-Garza Jesús z Villarreal-Pérez Department of Gastroenterology Autonomous University of Nuevo LeónMonterrey 64700Nuevo LeónMexico Department of Endocrinology Autonomous University of Nuevo LeónMonterrey 64700Nuevo LeónMexico

Post-acute pancreatitis diabetes(PAPD)is the second most common type of diabetes below type 2 diabetes *** to the boom in research on this entity carried out during the last decade,its recognition has ***,much of the medical community still does not recognize it as a medium and long-term complication of acute pancreatitis(AP).Recent prospective cohort studies show that its incidence is about 23%globally and 34.5%in patients with severe *** the overall increase in the incidence of AP this complication will be certainly seen more *** to its high morbidity,mortality and difficult control,early detection and treatment are ***,its risk factors and pathophysiological mechanisms are not clearly *** diagnosis should be made excluding pre-existing diabetes and applying the criteria of the American Diabetes Association after 90 d of resolution of one or more AP *** review will show the evidence published so far on the incidence and prevalence,risk factors,possible pathophysiological mechanisms,clinical outcomes,clinical characteristics and preventive and corrective management of *** important gaps needing to be clarified in forthcoming studies will also be discussed.

关键词： Acute pancreatitis Diabetes mellitus Chronic pancreatitis Post-pancreatitis diabetes Pancreatogenic diabetes

Translating Solutions of the Nonparametric mean Curvature Flow with Nonzero Neumann Boundary Data in Product manifold m^(n)×R^(*)

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Chinese Annals of mathematics,Series B 2022年第4期43卷 601-620页

作者： Ya GAO Yi-juan GONG Jing mAO Faculty of mathematics and Statistics Key Laboratory of Applied Mathematics of Hubei ProvinceHubei UniversityWuhan 430062China

In this paper,the authors can prove the existence of translating solutions to the nonparametric mean curvature flow with nonzero Neumann boundary data in a prescribed product manifold m^(n)×R,where m^(n) is an n-dime... 详细信息

关键词： Translating solutions Singularity Nonparametric mean curvature flow Convexity Ricci curvature

Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： juan martínez-milla marcelino Cortés García Julia Anna Palfy mikel Taibo Urquía marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero monteagudo maría Luisa martín mariscal Inés Jiménez-Varas Sem Briongos Figuero juan Antonio Franco-Pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,andm L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;Pm L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,Pm L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFRm L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

Equitable Coloring of Three Classes of 1-planar Graphs

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Acta mathematicae Applicatae Sinica 2018年第2期34卷 362-372页

作者： Xin zHANG Hui-juan WANG Lan XU School of mathematics and Statistics Xidian University Xi'an 710071 China College of mathematics Qingdao University Qingdao 266071 China Department of mathematics Changji University Changji 831100 China

A graph is 1-planar if it can be drawn on a plane so that each edge is crossed by at most one other edge. A plane graph with near-independent crossings or independent crossings, say NIC-planar graph or IC-planar graph, is a 1-planar graph with the restriction that for any two crossings the four crossed edges are incident with at most one common vertex or no common vertices, respectively. In this paper, we prove that each 1-planar graph, NIC-planar graph or IC-planar graph with maximum degree A at least 15, 13 or 12 has an equitable △-coloring, respectively. This verifies the well-known Chen-Lih-Wu Conjecture for three classes of 1-planar graphs and improves some known results.

关键词： 1-planar graph equitable coloring independent crossing

Formulation of dried lignans nanosuspension with high redispersibility to enhance stability,dissolution,and oral bioavailability

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Chinese Journal of Natural medicines 2016年第10期14卷 757-768页

作者： SHEN Gang CHENG Ling WANG Li-Qiang zHANG Li-Hong SHEN Bao-De LIAO Wei-Bo LI juan-juan zHENG juan XU Rong YUAN Hai-Long Department of Pharmacy Air Force General Hospital of PLABeijing 100142China Pharmacy College Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Biomedical Sciences Huaqiao UniversityQuanzhou 362021China

Herpetospermum caudigerum lignans(HTL), one of the potential drugs with anti-hepatitis B virus and hepatoprotective effects, has limited clinical applications because of poor aqueous solubility and low bioavailability. Both herpetrione(HPE) and herpetin(HPN) are the most abundant ingredients in HTL and exhibit weak acidity. The purpose of the present study was to produce dried preparations of HTL(composed of HPE and HPN) nanosuspensions(HTL-NS) with high redispersibility using lyophilization technology. The HTL-NS was prepared by utilizing precipitation-combined homogenization technology based on acid-base neutralization reactions, and critical formulation and process parameters affecting the characteristics of HTL-NS were optimized. The resultant products were characterized by particle size analysis, SEm, XRD, stability, solubility, dissolution and in vivo bioavailability. HTL-NS showed near-spherical-shaped morphology and the size was 243 nm with a narrow PDI value of 0.187. The dried preparations with a relatively large particle size of 286 nm and a PDI of 0.215 were achieved by using 4%(W/V) mannitol as cryoprotectants, and had a better stability at 4 or 25 oC for 2 months, compared to HTL-NS. In the in vitro test, the dried preparations showed markedly increased solubility and dissolution velocity. Besides, in the in vivo evaluation, it exhibited significant increases in AUC0–t, C_(max), mRT and a decrease in T_(max), compared to the raw drug.. In conclusion, our results provide a basis for the development of a drug delivery system for poorly water-soluble ingredients with p H-dependent solubility.

关键词： Herpetospermum caudigerum lignans Nanosuspensions Acid-base neutralization Saturation solubility Dissolution Oral bioavailability