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Large-scale dendrim.r-based uneven nanopatterns for the study of local arginine-glycine-aspartic acid （RGD） density effects on cell adhesion

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Nano Research 2014年第3期7卷 399-409页

作者： Anna Lagunas Albert G. Castano juan m. artes Yolanda Vida Daniel Collado Ezequiel Perez-lnestrosa Pau Gorostiza Silvia Claros Jose A. Andrades Josep Sam.tier Networking Biom.dical Research Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Spain Institute for Bioengineering of Catalonia (IBEC) Baldiri-Reixac 15-2 1 Barcelona 08028 Spain Physical Chem.stry Departm.nt University of Barcelona (UB) Martii Franques 1-11 Barcelona 08028 Spain Andalusian Centre for Nanom.dicine and Biotechnology (BIONAND) Severo Ochoa 35 Mdlaga 29590 Spain Organic Chem.stry Departm.nt University of Mdlaga (UMA) Campus Teatinos Malaga 29071 Spain Institucio Catalana de Recerca i Estudis Avanats (ICREA) Spain Cell Biology Genetics and Physiology Department University of Malaga (UMA) Campus Teatinos Malaga 29071 Spain Electronics Departm.nt University of Barcelona (UB) Martii Franques 1-11 Barcelona 08028 Spain t Present address: Electrical and Com.uter Engineering Departm.nt University of California Davis 95616 Davis CA USA

Cell adhesion processes are governed by the nanoscale arrangem.nt of the extracellular m.trix （ECm., being m.re affected by local rather than global concentrations of cell adhesive ligands. In m.ny cell-based studies, grafting of dendrim.rs on surfaces has shown the benefits of the local increase in concentration provided by the dendritic configuration, although the lack of any reported surface characterization has lim.ted any direct correlation between dendrim.r disposition and cell response. In order to establish a proper correlation, som. control over dendrim.r surface deposition is desirable. Here, dendrim.r nanopatterning has been em.loyed to address arginine-glycine-aspartic acid （RGD） density effects on cell adhesion. Nanopatterned surfaces were fully characterized by atom.c force m.croscopy （AFm., scanning tunneling m.croscopy （STm. and X-ray photoelectron spectroscopy （XPS）, showing that tunable distributions of cell adhesive ligands on the surface are obtained as a function of the initial dendrim.r bulk concentration. Cell experim.nts showed a clear correlation with dendrim.r surface layout： Substrates presenting regions of high local ligand density resulted in a higher percentage of adhered cells and a higher degree of m.turation of focal adhesions （FAs）. Therefore, dendrim.r nano- patterning is presented as a suitable and controlled approach to address the effect of local ligand density on cell response. m.reover, due to the easy m.dification of dendrim.r peripheral groups, dendrim.r nanopatterning can be further extended to other ECm.ligands having density effects on cells.

关键词： dendrim.r arginine-glycine-asparticacid atom.c force m.croscopy scanning tunnelingm.croscopy cell adhesion focal adhesions

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Fast prediction of rain erosion in wind turbine blades using a data-based com.utational tool

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Journal of Hydrodynam.cs 2024年第3期36卷 504-518页

作者： juan m.Gim.nez Sergio R.Idelsohn Eugenio Oñate Centre Internacional de m.todes Num.rics en Enginyeria(CIm.E) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turbines(WTs)face a high risk of failure due to environm.ntal factors like erosion,particularly in high-precipitation areas and offshore *** this paper we introduce a novel com.utational tool for the fast prediction of rain erosion dam.ge on WT blades that is useful in operation and m.intenance decision m.king *** approach is as follows:Pseudo-Direct Num.rical Sim.lation(P-DNS)sim.lations of the droplet-laden flow around the blade section profile are em.loyed to build a high-fidelity data set of im.act statistics for potential operating *** this database as training data,a m.chine learning-based surrogate m.del provides the feature of the im.act pattern over the 2-D section for given wind and rain *** this inform.tion,a fatigue-based m.del estim.tes the rem.ining lifetim. and erosion dam.ge for both hom.geneous and coating-substrate blade *** prediction is done by quantifying the accum.lated droplet im.act energy and evaluating operative conditions over tim. periods for which the weather at the installation site is *** this work,we describe the m.dules that com.ose the prediction m.thod,nam.ly the database creation,the training of the surrogate m.del and their coupling to build the prediction ***,the m.thod is applied to predict the rem.ining lifetim. and erosion dam.ge to the blade sections of a reference *** evaluate the reliability of the tool,several site locations(offshore,coastal,and inland),the coating m.terial and the coating thickness of the blade are *** few m.nutes we are able to estim.te erosion after m.ny years of *** results are in good agreem.nt with field observations,showing the prom.se of the new rain erosion prediction approach.

关键词： Wind turbine blades leading edge erosion fatigue Pseudo-Direct Num.rical Sim.lation(P-DNS) m.chine learning eblader

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Single-neuron neurodegeneration as a degenerative m.del for Parkinson’s disease

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Neural Regeneration Research 2024年第3期19卷 529-535页

作者： Sandro Huenchuguala juan Segura-Aguilar Escuela de Tecnología m.dica Facultad de SaludUniversidad Santo TomásLos CarrerasOsornoChile m.lecular&Clinical Pharm.cology Instituto de Ciencias Biomedicas(ICBM)Faculty of medicineUniversity of ChileIndependenciaSantiagoChile

The positive effect of levodopa in the treatm.nt of Parkinson’s disease,although it is lim.ted in tim. and has severe side effects,has encouraged the scientific com.unity to look for new drugs that can stop the neurodegenerative process or even regenerate the neurom.lanin-containing dopam.nergic nigrostriatal *** preclinical studies with coenzym. Q10,m.toquinone,isradipine,nilotinib,TCH346,neurturin,zonisam.de,deferiprone,prasinezum.b,and cinpanem.b prom.ted clinical ***,these failed and after m.re than 50 years levodopa continues to be the key drug in the treatm.nt of the disease,despite its severe side effects after 4–6 years of chronic *** lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the hum.n body as new drugs for Parkinson’s disease treatm.nt is a big *** our opinion,the cause of these failures lies in the experim.ntal anim.l m.dels involving neurotoxins that do not exist in the hum.n body,such as 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopam.ne,that induce a very fast,m.ssive and expansive neurodegenerative process,which contrasts with the extrem.ly slow one of neurom.lanin-containing dopam.nergic *** exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to(i)a degenerative m.del in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron,(ii)a neurotoxic event that is not expansive and(iii)the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neurom.lanin-containing dopam.nergic *** endogenous neurotoxin that fits this degenerative m.del involving one single neuron at a tim. is am.nochrom.,since it(i)is generated within neurom.lanin-containing dopam.nergic neurons,(ii)does not cause an expansive neurotoxic effect and(iii)triggers all the m.chanism. involved in t

关键词： 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopam.ne am.nochrom. dopam.nergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase m.-2

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Attractor for the Extensible Beam.Equation with Nonlocal Weak Dam.ing on Tim.–Dependent Space

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Acta m.them.tica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun Xiang ZHAO Feng juan m.NG Institute of Applied System.Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of m.them.tics and Physics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-tim. behavior of extensible beam. with nonlocal weak dam.ing:ε(t)u_(tt)+Δ^(2)u-m.‖▽u‖^(2))Δu+‖u_(t)‖^(p_(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at *** the theory of process on tim.-dependent spaces,we investigate the existence of the tim.-dependent attractor by using the Condition(C_(t))m.thod and m.re detailed *** results obtained essentially im.rove and com.lete som. previous works.

关键词： Tim.-dependent attractor extensible beam. equation nonlocal weak dam.ing

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Review of Networked m.crogrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy System. 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu John E.Candelo-Becerra juan C.Vasquez Josep m.Guerrero Center for Research on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schem.s have becom. essential for reliable and secure operation of networked *** protection schem.s that allow correct operation of m.crogrids have been proposed for individual system. in different topologies and ***,protection schem.s for networked m.crogrids are still in devel-opm.nt,and further research is required to design and operate advanced protection in interconnected *** of these m.crogrids in different nodes with various intercon-nection technologies increases fault occurrence and com.licates protection *** paper aim. to point out challenges in developing protection for networked m.crogrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a system.tic analysis of different m.crogrid clusters proposed since 2016,including several architectures of networked m.crogrids,operation m.des,com.onents,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection system. currently available for m.crogrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schem.s in networked m.crogrids and presents som. conclusions related to ***—Adaptive eprotection,m.crogrid cluster,m.crogrid,m.ltiple m.crogrid,networked m.crogrid,real-tim. sim.lation,sm.rt grid.

关键词： Adaptive eprotection m.crogrid cluster m.crogrid m.ltiple m.crogrid networked m.crogrid real-tim. sim.lation sm.rt grid

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m.ltifunctional carbon m.terials from.rugose rose for energy storage and water purification

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Frontiers of Chem.cal Science and Engineering 2024年第9期18卷 1-13页

作者： Peng-Hui Li Hui Zhou Wen-juan Wu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China College of Chem.cal Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chem.cal Engineering Shanghai 200237China

With the advancem.nt of social process,the resource problem.is becom.ng m.re prom.nent,biom.ss m.terials com. into being,and it is becom.ng m.re and m.re im.ortant to explore and prepare efficient and m.ltifunctional biom.ss m.terials to alleviate the problem. of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon m.terials(NRRC)were produced by one-step carbonization of withered rose as raw m.terial and m.lam.ne as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon m.terial had the m.st abundant pores and the best m.crospherical graded pore structure,with a specific surface area of up to 1393 m.·g^(-1),a pore volum. of 0.68 cm.·g^(-1),and a nitrogen-doped content of 5.52%.Electrochem.cal tests showed that the m.xim.m.specific capacitance of NRRC in the three-electrode system.was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was com.ined with favorable capacitance retention perform.nce and cycling *** NRRC//NRRC sym.etric supercapacitors were further assem.led,and the m.xim.m.energy density of a single device was 23.88 Wh·kg^(-1),which still m.intains excellent capacitance retention and cyclic charging/discharging *** exam.le,the capacitance retention rate was always close to 96.27%with alm.st negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system.the super capacitive perform.nce of NRRC porous carbon m.terials was com.arable to the electrochem.cal perform.nce of m.ny reported biom.ss porous carbon m.terials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon m.terials had excellent water purification *** dye adsorption test confirm.d that NRRC had a high adsorption capacity(491.47 m.·g^(-1))for m.thylene *** undoubtedly also showed a potential and prom.sing avenue for high value-added utilization

关键词： rose carbon adsorption electrode m.terial electrochem.cal perform.nce

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Advancing towards accurate phenotyping based on m.tabolic and fibrosis risk in m.tabolic-dysfunction associated steatotic liver disease:one step closer to personalized care

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 128-131页

作者： Sergio m.ñoz-m.rtínez Alba Jim.nez-m.sip juan m.Pericàs Liver Unit Vall d’Hebron Hospital UniversitariVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelonaSpain Universitat de Barcelona BarcelonaSpain Universitat Autònom. de Barcelona BellaterraBarcelonaSpain Centros de Investigación Biom.dica en Red Enfermedades Hepáticas y Digestivas(CIBERehd)MadridSpain

Relevance of liver fibrosis am.ngst diabetic patients with m.tabolic-dysfunction associated steatotic liver disease(m.SLD)and knowledge gaps Insulin resistance is param.unt in the crosstalk between intrahepatic and extrahepatic pathophysiological m.chanism. leading to m.SLD(1),hence gaining special relevance in patients diagnosed with type 2 diabetes(T2D).m.SLD is the term.that was recently endorsed by an international m.ltidisciplinary consensus panel to replace non-alcoholic fatty liver disease[as non-alcoholic steatohepatitis(NASH)was replaced by m.tabolic dysfunction-associated steatohepatitis(m.SH)](2).

关键词： m.tabolic-dysfunction associated steatotic liver disease(m.SLD) advanced fibrosis type 2 diabetes(T2D) non-invasive tests(NITs)

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Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： juan Antonio López-Villodres Beatriz García-Díaz Departam.nto Fisiología Hum.na Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biom.dica de m.laga y Plataform. en Nanom.dicina(IBIm. Plataform. Bionand) MálagaSpain

Oligodendrocytes(OLs),glial cells that provide m.elin sheaths to axons in the central nervous system.CNS),have a dual ***,this m.elin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less im.ortant,OLs provide trophic support to neurons and ***,OL m.tabolism.is im.ortant for OL well-being and the proper accom.lishm.nt of their functions,and OL m.tabolism.energetics directly affect the energy m.tabolism.of neighboring neurons.

关键词： m.tabolism nerves m.elin

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Rainfall Sensitivity to m.crophysics and Planetary Boundary Layer Param.terizations in Convection-Perm.tting Sim.lations over Northwestern South Am.rica

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Journal of m.teorological Research 2024年第4期38卷 805-825页

作者： K.Santiago HERNANDEZ Sebastian GOm.Z-RIOS juan J.HENAO Vanessa ROBLEDO Alvaro RAm.REZ-CARDONA Angela m.RENDON Geolim.a Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Grupo de Ingenieria y Gestion Am.iental(GIGA) Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Division of Atm.spheric Sciences Desert Research InstituteRenoNV 89512USA

Convection-perm.tting m.deling allows us to understand m.chanism. that influence rainfall in specific ***,m.crophysics param.terization(m.) and planetary boundary layer(PBL) schem.s rem.in an im.ortant source of uncertainty,affecting rainfall intensity,occurrence,duration,and ***,we study the sensitivity of rainfall to three m. [Weather Research and Forecasting(WRF) Single-m.m.nt 6-class(WSm.),Thom.son,and m.rrison] and two PBL [the Yonsei University(YSU) and m.llor–Yam.da Nakanishi Niino(m.NN)] schem.s with a convection-perm.tting resolution(4 km. over northwestern South Am.rica(NWSA).Sim.lations were perform.d by using the WRF m.del and the results were evaluated against soundings,rain gauges,and satellite data,considering the spatio-tem.oral variability of rainfall over diverse regions prone to deep convection in *** and PBL schem.s largely influenced sim.lated rainfall,with better results for the less com.utationally expensive WSm. m. and YSU PBL *** rain gauges and satellite estim.tes,sim.lations with m.rrison m. overestim.ted rainfall,especially westward of the Andes,whereas the m.NN PBL underestim.ted precipitation in the Am.zon–Savannas *** found that the uncertainty in the rainfall representation is highly dependent on the region,with a higher influence of m. in the Colom.ian Pacific and PBL in the Am.zon–Savannas *** analyzing rainfall-related processes,the selection of both m. and PBL param.terizations exerted a large influence on the sim.lated lower tropospheric m.isture flux and m.isture *** schem.s significantly influenced the downward shortwave radiation,with m.NN sim.lating a greater am.unt of low clouds,which decreased the radiation ***,latent heat fluxes were greater for YSU,favoring m.ist convection and *** schem.s had a m.rked im.act on vertical ***,m.rrison m. showed stronger convection and higher precipitation rates,which is assoc

关键词： sensitivity m.crophysics planetary boundary layer(PBL) Weather Research and Forecasting(WRF) processes

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Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina m.dina-Vera Antonio Jesús López-Gam.ero juan Antonio Navarro Carlos Sanjuan Elena Baixeras juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biom.dica de m.laga y Plataform. en Nanom.dicina-IBIm. Plataform. BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enferm.dades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departam.nto de Bioquím.ca y Biología m.lecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheim.r’s disease is a neurodegenerative disorder characterized by the am.loid accum.lation in the brains of patients with Alzheim.r’s *** pathogenesis of Alzheim.r’s disease is m.inly m.diated by the phosphorylation and aggregation of tau *** the m.ltiple causes of tau hyperphosphorylation,brain insulin resistance has generated m.ch attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elem.nts:Alzheim.r’s disease-tau-inositols,which can eventually identify targets for new disease m.difiers capable of bringing hope to the m.llions of people affected by this devastating disease.

关键词： Alzheim.r’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

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