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Genome-Wide Survey and Evolutionary Analysis of Trypsin Proteases in Apicomplexan Parasites

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Genomics, Proteomics & Bioinformatics 2010年第2期8卷 103-112页

作者： Aylan Farid Arenas juan Felipe Osorio-méndez Andres Julian gutierrez Jorge E. Gomez-marin Grupo de Parasitología molecular (GEPAmOL) Centro de Investigaciones BiomédicasUniversidad del QuindíoArmeniaColombia

Apicomplexa are an extremely diverse group of unicellular organisms that infect humans and other animals. Despite the great advances in combating infectious diseases over the past century, these parasites still have a tremendous social and economic burden on human societies, particularly in tropical and subtropical regions of the world. Proteases from apicomplexa have been characterized at the molecular and cellular levels, and central roles have been proposed for proteases in diverse processes. In this work, 16 new genes encoding for trypsin proteases are identified in 8 apicomplexan genomes by a genome-wide survey. Phylogenetic analysis suggests that these genes were gained through both intracellutar gene transfer and vertical gene transfer. Identification, characterization and understanding of the evolutionary origin of protease-mediated processes are crucial to increase the knowledge and improve the strategies for the development of novel chemotherapeutic agents and vaccines.

关键词： Apicomplexa trypsin endosymbiotic gene transfer

meteorological indicators of dengue epidemics in non-endemic Northwest Argentina

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Infectious Disease modelling 2022年第4期7卷 823-834页

作者： Javier Armando gutierrez Karina Laneri juan Pablo Aparicio Gustavo Javier Sibona Departamento de Física-FCE-Universidad Nacional de Salta SaltaArgentina Grupo de Física Estadística e Interdisciplinaria CONICETCentro Atòmico Bariloche-CNEASan Carlos de BarilocheRío NegroArgentina Instituto de Investigaciones en Energía no Convencional(INENCO)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional de Salta Av.Bolivia 51004400SaltaArgentina Simon A.Levin mathematical Computational and Modeling Sciences Center Arizona State UniversityPO Box 871904TempeAZ85287-1904USA IFEG-CONICET and Fa.m.A.F.-Universidad Nacional de Cordoba CordobaArgentina

In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin *** the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller *** pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic *** develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic *** variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological *** mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole *** tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to *** assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic *** found that the number of vectors per host and the effective reproductive number are proxies for large *** proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.

关键词： mathematical modelling Dengue Outbreak mosquitoes population

Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： Javier Arredondo montero monica Bronte Anaut Sara Hernandez-martin juan Carlos Lopez-gutierrez Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Pediatric Surgery Department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the *** ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with *** treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

A Transactive Energy model for Smart metering Systems Using Blockchain

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CSEE Journal of Power and Energy Systems 2021年第5期7卷 943-953页

作者： juan C.Olivares-Rojas Enrique Reyes-Archundia Jose A.gutierrez-Gnecchi Ismael molina-moreno Jaime Cerda-Jacobo Arturo mendez-Patino National Technological Institute of mexico/Technological Institute of morelia-Division of Graduate Studies and Research MoreliaMichoacan 58120Mexico. School of Electrical Engineering Michoacan University of San Nicolas de HidalgoMorelia 58030.Mexico

The lowering cost of electricity generation technologies by renewable means has caused the role of end-users to change from being a simple consumer to a producer of their *** new role has been called a prosumer and has contributed to modifying electricity markets,by allowing prosumers to merchandize the energy surplus to electricity companies and other *** fundamental key to any economic transaction is trust between the ***,new technologies,such as blockchain,are transforming transaction security,and allowing decentralization of the smart power *** study presents the development of a transactional model of electrical energy using the infrastructure of smart metering and blockchain systems to allow the commercialization of electrical energy by *** results show that for the mexican electricity market,they can he good alternatives hy reducing subsidies and being more profitable than current rates.

关键词： Data visualization fault diagnosis IoT network photovoltaic system wireless remote monitoring

Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy

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World Journal of Gastroenterology 2014年第43期20卷 15992-16013页

作者： maria Victoria Preciado Pamela Valva Alejandro Escobar-gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando martinez-Guarneros juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado mayra Cruz-Rivera Laboratorio de Biología molecular División PatologíaHospital de Ni?os "Ricardo Gutiérrez"Buenos Aires C1425EFDArgentina Instituto de Diagnóstico y Referencia Epidemiológicos Mexico 01480Mexico Department of Biology Institute of BioscienceLanguage and Exact ScienceS?o Paulo State UniversityS?o José do Rio PretoSP 13560-970Brazil Laboratorio de Inmunobiología de Enfermedades Infecciosas Unidad de Investigación MultidisciplinariaFacultad de Estudios Superiores CuautitlánUniversidad Nacional Autónoma de MéxicoCuautitlán IzcalliEstado de México 54714Mexico Departmento de microbiología y Parasitología Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico City 04510Mexico

Hepatitis C virus(HCV)infection represents an important public health problem *** of HCV morbidity and mortality is a current challenge owned to several viral and host *** molecular evolution plays an important role in HCV transmission,disease progression and therapy *** high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and *** evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging *** advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against *** a result,superior sustained viral responses have been *** rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era.

关键词： Hepatitis C virus Evolution Phylogenetics Drug resistance Clinical outcome

Granulomatous mastitis: Incidence and Experience in a mexican Institute

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Journal of Biosciences and medicines 2019年第6期7卷 24-32页

作者： Arnoldo Topete Olin Carrasco Gabriel Barrera juan Garzón Eduardo gutierrez Cuahutémoc márquez Rodrigo Dávila marco Cuervo maría Irene Rivera Department of Plastic and Reconstructive Surgery Pemex Hospital Mexico City Mexico Department of Pathological Anatomy Pemex Hospital Mexico City Mexico

The significance of this work is that chronic granulomatous disease can mimic two common breast diseases;breast cancer and breast abscess;so it is mandatory that the diagnosis is made in order to avoid mistaken carcinoma diagnosis. On the other hand, the current treatment of this particular disease still remains controversial. Objectives: The aim of this study is to expose and describe the chronicity and the impact in a patient’s quality of life with Granulomatous mastitis diagnosis. We describe the evolution of the disease and the treatment of the disease in a mexican Institution. material and methods: In a descriptive retrospective study we identified 9 patients with idiopathic granulomatous mastitis (ImG), all of them were diagnosed with histopathological findings. Results: In a period of time between January 2005 and December 2017, we included a total of 9 female patients. All of them have had histopathological findings consistent with granulomatous mastitis. The age range was 25 - 83 years old (mean 50.8 yrs). In 4 patients (44.4%) had the right side affected, three patients (33.3%) had the left side affected and 2 patients (22.2%) had a bilateral presentation. In 3 patients (33.3%) we observed more than one affected quadrant and 4 patients (44.4%) had a diffuse presentation on image. The most common symptom was breast pain in 9 patients (100%) and the most common sign was the presence of a nodule, 8 patients (88.8%). We observed erythema in 7 cases (77.7%) followed by abscess, edema and pus secretion in 6 patients (66.6%). The most frequent treatment was the use of a combination of NAIDs and antibiotic in 8 patients (88.8%). Six patients were incised with scalp and drained. Six patients underwent mastectomy.

关键词： Idiopathic Granulomatous mastitis Incidence and Experience Descriptive Retrospective Study

Influence of occult hepatitis B virus infection in chronic hepatitis C outcomes

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World Journal of Gastroenterology 2011年第12期17卷 1558-1562页

作者： Conrado m Fernandez-Rodriguez maria Luisa gutierrez JoséLuis Lledó maria Luisa Casas Service of Gastroenterology Hospital Universitario Fundación AlcorcónUniversity King Juan CarlosAv Budapest-128922 AlcorcónMadridSpain Service of Biochemestry Hospital Universitario Fundación AlcorcónUniversity King Juan CarlosAv Budapest-128922 AlcorcónMadridSpain

Persistence of hepatitis B virus-DNA in the sera,peripheral blood mononuclear cells or in the liver of hepatitis B surface antigen(HBsAg) -negative patients with or without serological markers of previous exposure(antibodies to HBsAg and/or to HB-core antigen) defines the entity called occult hepatitis B infection(OBI).Co-infection with hepatitis B and hepatitis C viruses is frequent in highly endemic *** this co-infection increases the risk of liver disease progression,development of cirrhosis and hepatocellular carcinoma and also increases the rate of therapeutic failure to interferon-based treatments than either virus alone,a potentially negative effect of OBI on clinical outcomes and of therapeutic response to current antiviral regimes of patients with chronic hepatitis C remains inconclusive.

关键词： Occult hepatitis B infection Chronic hepatitis C Outcomes

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin m.Flores-martinez Rasajna Nadella michael J.Bannon Lourdes Escobedo minerva maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila juan A.Gonzalez-Barrios Gonzalo Flores maria E.gutierrez-Castillo Armando JEspadas-Alvarez Irma A.martínez-Dávila Porfirio Nava Daniel martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Increased myo-inositol in the posterior cingulate cortex in first-episode major depressive patients

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Advances in Bioscience and Biotechnology 2013年第6期4卷 45-52页

作者： Lily magally Granados-Dominguez Enrique O.Flores-gutierrez Sarael Alcauter juan Jose Cervantes marina Torres-Alvarez maria Corsi-Cabrera Laboratory for Sleep Research Faculty of PsychologyUniversidad Nacional Autonoma de Mexico(UNAM)Mexico CityMexico Sub-Department of Clinical Investigations Instituto Nacional de Psiquiatria Ramon de la Fuente MunizMexico CityMexico

major depressive disorder (mDD) is a severe, disabling pathology characterized, in addition to affective, cognitive and motor symptoms, by self-focused attention and rumination. During recursive self-focused processes and rumination, the posterior cingulate cortex (PCC) is activated. In vivo proton magnetic resonance spectroscopy (mRS) is a noninvasive imaging technique that can directly assess living biochemistry in localized brain regions. The aim of this study, therefore, was to use 1H-mRS as a means of analyzing brain metabolites in the PCC of a group of first-episode, unmedicated mDD patients. PCC metabolite levels were analyzed at 3-T in a single voxel located bilaterally over the PCC in 7 patients diagnosed for the first time with mDD and with no previous pharmacological treatment, as well as in 9 control subjects. Differences in metabolite levels between groups were compared using independent t-tests. myo-inositol was significantly higher, and NAA + NAAG/Cr significantly lower, in mDD patients than in controls. The other brain metabolites showed no statistical differences. The present results suggest that alterations in PCC metabolite levels are likely involved in mDD pathophysiology, and may help to improve our understanding of mDD and the role of the PCC in some symptoms of depression.

关键词： major Depressive Disorder Posterior Cingulate Cortex metabolites ^(1)H-mRS myo-Inositol N-Acetyl-Aspartate