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Combined cell-based therapy strategies for the treatment of Parkinson's disease:focus on mesenchymal stromal cells

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Neural Regeneration Research 2023年第3期18卷 478-484页

作者： Jannette Rodríguez-Pallares María garcía-Garrote juan A.Parga Joséluis Labandeira-garcía Laboratory of Cellular and Molecular Neurobiology of Parkinson´s Disease Research Center for Molecular Medicine and Chronic Diseases(CiMUS)IDISDepartment of Morphological SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain Networking Research Center on Neurodegenerative Diseases(CIBERNED) MadridSpain

Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia *** is an effective and well-tolerated dopamine replacement ***,levodopa provides only symptomatic improvements,without affecting the underlying pathology,and is associated with side effects after long-term ***-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson’s disease *** studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum,release dopamine,integrate into the host neural circuits,and improve motor *** of the limiting factors for cell therapy in Parkinson’s disease is the low survival rate of grafted dopaminergic *** factors could cause cell death of dopaminergic neurons after grafting such as mechanical trauma,growth factor deprivation,hypoxia,and *** factors play an essential role in the survival of grafted ***,direct,timely,and controllable delivery of neurotrophic factors into the brain faces important *** types of cells secrete neurotrophic factors constitutively and co-transplantation of these cells with dopaminergic neurons represents a feasible strategy to increase neuronal *** this review,we provide a general overview of the pioneering studies on cell transplantation developed in patients and animal models of Parkinson’s disease,with a focus on neurotrophic factor-secreting cells,with a particular interest in mesenchymal stromal cells;that co-implanted with dopaminergic neurons would serve as a strategy to increase cell survival and improve graft outcomes.

关键词： brain repair cell replacement co-grafts dopaminergic neurons fetal ventral mesencephalic tissue mesenchymal stem cells neural grafting neural transplantation neuroblasts neurotrophic factors

Comprehensive control for unified power quality conditioners

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Journal of Modern Power Systems and Clean Energy 2017年第4期5卷 609-619页

作者： Miguel OCHOA-GIMéNEZ Aurelio garcíA-CERRADA juan luis ZAMORA-MACHO Gamesa Electric S.A. 28823 CosladaMadridSpain School of Engineering Comillas Pontifical University28015 MadridSpain

This paper presents a comprehensive control strategy for unified power quality conditioners(UPQCs) to compensate for both voltage and current quality *** controllers for the series and shunt components of the UPQC are, equally, divided into three blocks: à main controller, which deals with the fundamental-frequency issues such as active and reactive power flow;` harmonic controller, which ensures zero-error tracking while compensating voltage and current harmonics;′ the set-point generation block, which handles the different control objectives of the UPQC. The controller design procedure has been simplified to the selection of three parameters for each converter. Furthermore, the proposed strategy can be implemented measuring only four variables, which represents a reasonable number of sensors. In addition, a pulse width modulation(PWM)-based modulation with fixed switching frequency is used for both converters. The proposed control strategy has been validated experimentally under different conditions, including grid-frequency variations.

关键词： Unified power quality conditioner(UPQC) Powerquality Harmoniccontrol Pulse width modulation(PWM)

Performance assessment of two-dimensional hydraulic models for generation of flood inundation maps in mountain river basins

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Water Science and Engineering 2019年第1期12卷 11-18页

作者： juan Pinos luis Timbe Department of Water Resources and Environmental Sciences University of Cuenca

Hydraulic models for the generation of flood inundation maps are not commonly applied in mountain river basins because of the difficulty in modeling the hydraulic behavior and the complex topography. This paper presents a comparative analysis of the performance of four twodimensional hydraulic models (HEC-RAS 2D, Iber 2D, Flood Modeller 2D, and PCSWMM 2D) with respect to the generation of flood inundation maps. The study area covers a 5-km reach of the Santa B-arbara River located in the Ecuadorian Andes, at 2330 masl, in Gualaceo. The model's performance was evaluated based on the water surface elevation and flood extent, in terms of the mean absolute difference and measure of fit. The analysis revealed that, for a given case, Iber 2D has the best performance in simulating the water level and inundation for flood events with 20- and 50-year return periods, respectively, followed by Flood Modeller 2D, HEC-RAS 2D, and PCSWMM 2D in terms of their performance. Grid resolution, the way in which hydraulic structures are mimicked, the model code, and the default value of the parameters are considered the main sources of prediction uncertainty.

关键词： Two-dimensional hydraulic models Flood modeling Flood extent Water surface elevation High mountain river Ecuador

A 3D Bioprinted Gut Anaerobic Model for Studying Bacteria–Host Interactions

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Research 2023年第3期6卷 697-710页

作者： Liqin Cheng Tingting Liu Qiong Liu Liming Lian Guosheng Tang luis Santiago Mille Fabricio Romero garcía Lars Engstrand Yu Shrike Zhang juan Du Centre for Translational Microbiome Research(CTMR) Department of MicrobiologyTumorand Cell BiologyKarolinska InstitutetStockholmSweden Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical School65 Landsdowne StreetCambridgeMA 02139USA Science for Life Laboratory StockholmSweden

The role of the human intestinal tract in host–microbe interactions has been highlighted in recent *** 3-dimensional(3D)models have been developed to reproduce the physiological characteristics of the human gut and to investigate the function of the gut *** challenge for 3D models is to recapitulate the low oxygen concentrations in the intestinal ***,most earlier 3D culture systems used a membrane to physically separate bacteria from the intestinal epithelium,which has sometimes made the studies of bacteria adhering to or invading cells less *** report the establishment of a 3D gut epithelium model and cultured it at high cell viability under an anaerobic *** further cocultured intestinal bacteria including both commensal and pathogen directly with epithelial cells in the established 3D model under the anaerobic *** subsequently compared the gene expression differences of aerobic and anaerobic conditions for cell and bacterial growth via dual RNA *** study provides a physiologically relevant 3D gut epithelium model that mimics the anaerobic condition in the intestinal lumen and supplies a powerful system for future in-depth gut–microbe interactional investigations.

关键词： epithelium Host Bacteria

Preparation and Characterization of Flexible, Transparent and Thermally Stable Aromatic Co-polyamides

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Chinese Journal of Polymer Science 2019年第2期37卷 136-141页

作者： José Antonio Tec-Sánchez Andrés Iván Oliva Arias Manuel Aguilar-Vega juan Valerio Cauich-Rodríguez José luis Santiago-garcía Unidad de Materiales Centro de Investigación Científica de Yucatán A. C. Centro de Investigación y de Estudios Avanzados del IPN Unidad Mérida Departamento de Física Aplicada

Two aromatic co-polyamides were synthesized combining two diacid monomers containing bulky pendant groups, 5-(9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximido)isophthalic acid(DEAIA) and 5-tert-butylisophthalic acid(TERT), with 4,4′-(hexafluoroisopropylidene)dianiline(HFA) or 2,3,5,6-tetramethyl-1,4-phenylenediamine(Durene) by direct polycondensation. The structures of the obtained aromatic co-polyamides were confirmed by FTIR, Raman and 1 H-NMR. The co-copolyamide films, DHTH and DDTD, exhibited rms-roughness values between 0.94 and 1.60 nm, respectively. Moreover, they presented good thermal stability up to300 °C. Young's moduli of the co-polyamide films were between 4.1 and 4.3 GPa. X-ray diffraction results showed that the co-polyamide films were amorphous due to the incorporation of both bulky pendant groups, tert-butyl and dibenzobarrelene. The combination of bulky pendant groups provided intrinsically transparent co-polyamide films with a transmittance higher than 88% in the range of 400-780 *** to these outstanding film and optical properties, they are suggested to be flexible substrates in applications for solar cell and other portable electronic devices.

关键词： Co-polyamides Flexible films Transmittance Thermal stability Polycondensation

Symmetrization for Fractional Elliptic and Parabolic Equations and an Isoperimetric Application(Dedicated to Haim Brezis,great master of analysis,on his 70th birthday)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 661-686页

作者： Yannick SIRE juan luis VAZQUEZ Bruno VOLZONE johns hopkins university Krieger Hall3401 N.Charles StBaltimoreM D21218USA. departamento de matemticas universidad autnoma de madrid28049 M adridSpain dipartimento di ingegneria universit degli studi di napoli"parthenope"80143 Italia.

This paper develops further the theory of symmetrization of fractional Laplacian operators contained in recent works of two of the authors. This theory leads to optimal estimates in the form of concentration comparison inequalities for both elliptic and parabolic equations. The authors extend the theory for the so-called restricted fractional Laplacian defined on a bounded domain Ω of R^N with zero Dirichlet conditions outside of Ω. As an application, an original proof of the corresponding fractional Faber-Krahn inequality is derived. A more classical variational proof of the inequality is also provided.

关键词： Symmetrization, Fractional Laplacian, Nonlocal elliptic and parabolicequations, Faber-Krahn inequality

Experimental analysis of infragravity waves in two eroded microtidal beaches

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Acta Oceanologica Sinica 2017年第5期36卷 31-43页

作者： MARIO Conde-Frias luis Otero juan Camilo Restrepo juan Carlos Ortiz Geosciences Research Group GE04 Department of PhysicsUniversidad del NorteBarranquilla 081007Colombia

This work aims to contribute to the characterization and understanding ofinfragravity waves on two beaches with erosion problems. For this reason, we have used an array of ADCP and a pressure sensor to measure wave parameters and pressure inside and outside of the surf zone during the dry and rainy period in the beaches of Galerazamba and Manzanillo del Mar （both dissipative and eroded beaches） located in the Colombian Caribbean coast. Based on these measurements, we have carried out a spectral analysis in order to identify the frequency components that characterize the wave and its energy; thus, we identified the characteristic frequencies of iufragravity waves to finally filter the infragravity signal on each beach in different seasonal periods. Among the results of the Welch spectrum applied to surface elevation time series, we found that, the frequencies＇ energy of the sea-swell band decreases due to bottom friction and wave breaking as the wave approaches the shore, while the frequencies＇ energy of the infragravity band increases significantly. In addition, for the wavelet analysis, we could observe how the energy of the infragravity band, especially the lowest frequencies gain energy as the waves approaches the coast. Furthermore, based on the infragravity wave obtained from the extreme wave event registered during the field campaign we can conclude that the contribution of this signal is important in the erosion problems presented in the beaches of Galerazamba and Manzanillo del Mar. Finally, these results show the need to realize other studies that allow us to understand deeply, the role of infragravity waves on the morphological changes that occurs in these beaches.

关键词： infragravity waves long waves experimental analysis fourier analysis wavelet transform

Primary malignant melanoma of the biliary tract: A case report and literature review

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World Journal of Clinical Cases 2019年第16期7卷 2302-2308页

作者： Soledad Cameselle-garcía José luis Fírvida Pérez María C Areses Jesús Daniel Fernández de Castro juan Mosquera-Reboredo Jesús garcía-Mata Department of Medical Oncology Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Digestive Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Pathology Hospital San RafaelA Coruna 15009Spain

BACKGROUND Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another *** paper reviews the most important characteristics of MBT cases published in the literature and reports a new *** patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with *** patient remains disease-free 36 mo after the treatment of metastatic lung *** SUMMARY A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical *** resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic *** the suspicion of biliary tract neoplasia,cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of ***-pathological diagnosis was *** intervention,the patient was referred to the Department of Medical Oncology,where a primary origin was excluded in the skin,mucosa,and *** confirmed diagnosis of primary biliary tract *** tomography was performed 12 mo after the procedure revealed several subcentimetric lung *** resection was *** confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract,the patient was started on immunotherapy with *** to treatment was *** patient remains disease-free 36 mo after the treatment of metastatic lung *** The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy.

关键词： Biliary tract Case report Immunotherapy Malignant melanoma

Software Project Management Approaches for Global Software Development： A Systematic Mapping Study

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Tsinghua Science and Technology 2018年第6期23卷 690-714页

作者： Manal El Bajta Ali Idri Joaquín Nicolás Ros José luis Fernández-Alemán juan Manuel Carrillo de Gea Félix garcía Ambrosio Toval Software Project Management Research Team Ecole Nationale SuperieuredInformatique et d'Analyse des Systemes (ENSIAS)Mohammed V University Rabat 713 Morocco Department of Informaticay Sistemas University of Murcia Murcia 30100 Spain ALARCOS Research GroupDepartment of Information Systems and Technologies University of Castilla-La Mancha (UCLM) Ciudad Real13071 Spain

Global Software Development （GSD） is a well established field of software engineering with the benefits of a global environment. Software Project Management （SPM） plays a key role in the success of GSD. As a result, the need has arisen to study and evaluate the downsides of SPM for GSD, to thereby pave the way for the development of new methods, techniques, and tools with which to tackle them. This paper aims to identify and classify research on SPM approaches for GSD that are available in the literature, to identify their current weaknesses and strengths, and to analyze their applications in industry. We performed a Systematic Mapping Study （SMS） based on six classification criteria. Eighty-four papers were selected and analyzed. The results indicate that interest in SPM for GSD has been increasing since 2006. As a class of approaches, the most frequently reported methods （40%） are those used for coordination, planning, and monitoring, along with estimation techniques that can be used to better match a distributed project. SPM for GSD requires further investigation by researchers and practitioners, particularly with respect to cost and time estimations. These findings will help overcome the challenges that must to be considered in future SPM research for GSD, especially regarding collaboration and time-zone differences.

关键词： Software Project Management (SPM) Global Software Development (GSD) SPM approaches Systematic Mapping Study (SMS)