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中国神经科学学会第十二届全国学术会议

作者： Xinli Xu Sofia Al?ada-Morais Nélio M.Gon?alves Joana M.Marques Sergio Valbuena Rui O.Beleza Francisco Q.Gon?alves Sofia Ferreira juan lerma Rodrigo A.Cunha Ricardo J.Rodrigues CNC-Center for Neuroscience and Cell Biology University of Coimbra

Current anti-epileptic drugs mostly control convulsions with a limited efficacy, and do not seize epileptogenesis. One of the structural-functional modifications occurring during epileptogenesis is an abnormal axonal sprouting. The hippocampal mossy fiber(MF) sprouting found in patients and in animal models of temporal lobe epilepsy(TLE)(Neuroscience14, 375-403) generates an aberrant excitatory feedback circuit in granule cells that is thought to contribute to the hyperexcitability underlying the seizure-prone state(Neurochem. Res.28, 1649-58). However, the mechanism underlying this aberrant re-wiring is still poorly understood. There is now a growing evidence for a sustained increase in extracellular ATP levels in different pathological conditions, prompting ATP as a danger signal in the brain(Front. Neurosci.9:148). Accordingly, we now measured a sustained increase of the evoked release of ATP from hippocampal nerve terminals of Sprague-Dawley rats subjected to Status Epilepticus(SE) induced by pilocarpineinjection. Concomitantly, we found in developing rat hippocampal neurons that the pharmacological activation of adenosine A receptors(ARs) with the selective agonist CGS21680(30 n M) induces the formation of abnormal secondary axons. This prompted us to propose that this abnormal sprouting is due to an abnormal reactivation of the developmental-related AR-driven axon formation and outgrowth. We have now found in hippocampal organotypic slices that the spontaneous MF sprouting was attenuated by the pharmacological blockade of ARs, since the current densities(p A/p F) recorded were significantly lower in the slices cultured in the presence of the selective AR antagonist SCH58261(100 n M). More importantly, we found that the animals subjected to a long-term systemic treatment with SCH58261(0.1 mg/kg, i.p.), beginning 10 hours after pilocarpine-induced SE in rats, displayed significantly less hippocampal MF sprouting. Interestingly, CD73 knockout(CD73 KO) mice(lackin

关键词： A2A receptors Mossy fiber sprouting Status epilepticus CD73

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Presence of Infectious Hypodermal and Haematopoietic Necrosis Virus (IHHNV) in Native Shrimps from Southern Mexico

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Open Journal of Marine Science 2017年第3期7卷 424-432页

作者： Ariadne Hernández-Pérez Jesús Alejandro Zamora-Briseñ o juan Antonio Pérez Vega Richard juan de Dios Mena-Loria Daniel Coronado-Molina Jorge Hernández-López Norma Angelica-López-Téllez Rossanna Rodríguez-Canul Laboratorio de Inmunología y Biología Molecular Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN) Unidad Mérida Yucatán México Centro de Investigaciones Biológicas del Noroeste Sonora México Centro Regional de Investigación Pesquera de lerma Campeche Instituto Nacional de la Pesca (CRIP Lerma-INP) Campeche México

A survey for Infectious Hypodermal and Haematopoietic Necrosis Virus (IHHNV) and White Spot Syndrome Virus (WSSV) was performed during two catching seasons of native shrimps in the Yucatan Coast in the Gulf of Mexico. The mtDNA COI barcode identified two endemic species;the southern pink shrimp Penaeus notialis (Pérez Fantante, 1967) and the northern pink shrimp Penaeus brasiliensis (Latreille, 1987) (previously described as Farfantepenaeus brasiliensis). The prevalence of IHHNV was of 18.18% in 2016, and of 8.57% in 2017. All organisms tested negative for WSSV. This is the first identification of wild shrimps in the state of Yucatan Mexico by mtDNA COI barcode as well as the first identification of IHHNV in such species. The presence of IHHNV in wild shrimps populations has a potential of persisting in the coast of Yucatan with putative detrimental effect on local fisheries because once established in natural waters and hosts;such pathogens are almost impossible to eradicate.

关键词： IHHNV WSSV mtDNA COI Barcode Penaeus notialis Penaeus brasiliensis Yucatan Peninsula

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