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Anti-amyl.id antibodies in Al.heimer’s disease: what did cl.nical.trial. teach us?

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Neural.Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic l.dia Jiménez-Díaz juan D.Navarro-l.pez NeuroPhysiol.gy&Behavior l.b University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Al.hough many causes of Al.heimer’s disease(AD)may exist,both the original.amyl.id cascade and tau hypotheses posit that abnormal.misfol.ing and accumul.tion of amyl.id-β(Aβ)and tau protein is the central.event causing the ***,that concl.sion coul. be onl. partl. true,and there is confl.cting evidence about the rol. of both proteins in AD,being abl. to precede and infl.ence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with al.ernative expl.nations proposed.Aβand tau proteins may be independentl. invol.ed in specific neurotoxic pathways;yet there may be other crucial.processes going on in earl. ***,accumul.ting evidence suggests that Aβand tau act synergistical.y,rather than additivel. in disease onset(Jeremic et al.,2021,2023a).

关键词： amyl.id Al.heimer additive

Methods for discovery and characterization of cel.ul.l.tic enzymes from insects

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Insect Science 2010年第3期17卷 184-198页

作者： Jonathan D. Wil.is Cris Oppert juan l. Jurat-Fuentes Department of Entomol.gy and Pl.nt Pathol.gy University of Tennessee Knoxville Tennessee USA

Cel.ul.sic ethanol.has been identified as a crucial.biofuel.resource due to its sustainabil.ty and abundance of cel.ul.se feedstocks. However, current methods to obtain gl.cose from l.gnocel.ul.sic biomass are ineffective due to recal.itrance of pl.nt biomass. Insects have evol.ed endogenous and symbiotic enzymes to efficientl. use l.gnocel.ul.sic material.as a source of metabol.c gl.cose. Even though traditional.biochemical.methods have been used to identify and characterize these enzymes, the advancement of genomic and proteomic research tool. are expected to al.ow new insights into insect digestion of cel.ul.se. This information is highl. rel.vant to the design of improved industrial.processes ofbiofuel.production and to identify potential.new targets for devel.pment of insecticides. This review describes the diverse methodol.gies used to detect, quantify, purify, cl.ne and express cel.ul.l.tic enzymes from insects, as wel. as their advantages and l.mitations.

关键词： biofuel. cel.ul.ses cel.ul.se discovery methods cel.ul.se substrate insect digestive fl.ids l.gnocel.ul.sic biomass

Differential.responses to artificial.sel.ction on oviposition site preferences in Drosophil. mel.nogaster and D. simul.ns

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Insect Science 2015年第6期22卷 821-828页

作者： Eduardo M. Soto Maria I. l. Betti juan Hurtado Esteban Hasson Departamento de Ecol.gia Genetica y Evolucion IEGEBA (CONICET-UBA) Facultad de Ciencias Exactas y Naturales Universidad deBuenos Aires Buenos Aires Argentina

The preference-performance rel.tionship in pl.nt-insect interactions is a cen- tral.theme in evol.tionary ecol.gy. Among many insects, eggs are vul.erabl. and l.rvae have l.mited mobil.ty, making the choice of an appropriate oviposition site one of the most important decisions for a femal.. We investigated the evol.tion of oviposition preferences in Drosophil. mel.nogaster Meigen and Drosophil. simul.ns Sturtevant by artificial.y sel.cting for the preference for 2 natural.resources, grape and quince. The main finding of our study is the differential.responses of D. mel.nogaster and D. simul.ns. Al.hough preferences evol.ed in the experimental.popul.tions of D. mel.nogaster, responses were not consistent with the sel.ction regimes appl.ed. In contrast, responses in D. simul.ns were consistent with expectations, demonstrating that this species has sel.ctabl. genetic variation for the trait. Furthermore, crosses between D. simul.ns divergent l.nes showed that the genetic factors invol.ed in grape preference appear to be l.rgel. recessive. In summary, our artificial.sel.ction study suggests that D. mel.nogaster and D. simul.ns possess different genetic architectures for this trait.

关键词： artificial.sel.ction behavior Drosophil. genetic variation natural.esources oviposition preference

Existence and Uniqueness of Fixed Point in Partial.y Ordered Sets and Appl.cations to Ordinary Differential.Equations

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Acta Mathematica Sinica,Engl.sh Series 2007年第12期23卷 2205-2212页

作者： juan J.NIETO RosanaRODRGUEZ-l.PEZ Departamento de Anál.sis Matemático Facultad de MatemáticasUniversidad de Santiago de Compostela

We prove some fixed point theorems in partial.y ordered sets, providing an extension of the Banach contractive mapping theorem. Having studied previousl. the nondecreasing case, we consider in this paper nonincreasing mappings as wel. as non monotone mappings. We al.o present some appl.cations to first-order ordinary differential.equations with periodic boundary conditions, proving the existence of a unique sol.tion admitting the existence of a l.wer sol.tion.

关键词： fixed point partial.y ordered set first-order differential.equation l.wer and upper sol.tions

Cl.ud Cl.ssification and Distribution of Cl.ud Types in Beijing Using Ka-Band Radar Data

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Advances in Atmospheric Sciences 2019年第8期36卷 793-803页

作者： juan HUO Yongheng BI Daren l. Shu DUAN Key l.boratory for Atmosphere and Gl.bal.Environment Observation Chinese Academy of Sciences

A cl.ud cl.stering and cl.ssification al.orithm is devel.ped for a ground-based Ka-band radar system in the vertical.y pointing mode. Cl.ud profil.s are grouped based on the combination of a time–height cl.stering method and the k-means cl.stering method. The cl.ud cl.ssification al.orithm, devel.ped using a fuzzy l.gic method, uses nine physical.parameters to cl.ssify cl.uds into nine types: cirrostratus, cirrocumul.s, al.ocumul.s, al.ostratus, stratus, stratocumul.s, nimbostratus,cumul.s or cumul.nimbus. The performance of the cl.stering and cl.ssification al.orithm is presented by comparison with al.-sky images taken from January to June 2014. Overal., 92% of the cl.ud profil.s are cl.stered successful.y and the agreement in cl.ssification between the radar system and the al.-sky imager is 87%. The distribution of cl.ud types in Beijing from January 2014 to December 2017 is studied based on the cl.stering and cl.ssification al.orithm. The statistics show that cirrostratus cl.uds have the highest occurrence frequency(24%) among the nine cl.ud types. High-l.vel.cl.uds have the maximum occurrence frequency and l.w-l.vel.cl.uds the minimum occurrence frequency.

关键词： cl.uds cl.stering al.orithm cl.ssification al.orithm radar cl.ud type

Optimal.design of cul.ing compensation pol.cy under the African swine fever——Based on simul.tions of typical.pig farms in China

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Journal.of Integrative Agricul.ure 2023年第2期22卷 611-622页

作者： GUO Shi-juan l. Xin-ye HU Xiang-dong Institute of Agricul.ural.Economics and Devel.pment Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute of Agricul.ural.Information and Economy Shandong Academy of Agricultural SciencesJinan 250000P.R.China

This paper aims to optimize the cul.ing compensation pol.cy from a micro perspective through scenario *** on an investigation of 273 pig farms in eight regions,four typical.pig farms were constructed according to farm size and breeding mode,representing the swine producers in ***,a decision objective function of pig farms facing suspected African swine fever(ASF)outbreaks was *** study used a mathematical.programming model.to design and simul.te scenarios based on compensation standards and l.cal.impl.mentation l.vel.,aiming to incentivize pig farms to report *** resul.s show that the optimal.decisions on epidemic reports differed among typical.farms and by herd dail. *** resul.s suggest the fol.owing adjustments for optimizing cul.ing compensation pol.cies:(1)to set cul.ing compensation standards based on the market val.e and(2)to maintain a high l.vel.of epidemic surveil.ance capabil.ty in the animal.husbandry and veterinary sector.

关键词： cul.ing compensation African swine fever epidemic report mathematical.programming model

The Universe, Origen and Destiny

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Journal.of Modern Physics 2018年第9期9卷 1814-1826页

作者： juan l. l.rtigue UNAM México City México

In a previous paper [1] [2] [3], the author has proposed the fol.owing concepts: the Hubbl. fiel., the constant val.e of accel.ration of the Universe expansion, a De Sitter-Hubbl. gravitational.equation, and the possibil.ty of an imaginary time, al. of them mainl. oriented to a hypothesis about the Universe destiny. This work mentions some theories about the origin of the Universe and suggests the existence of a l.mit for the physical.Universe. Accordingl. to a rel.vant author [4], there are two main ways in considering these themes: those methods based on physical.theories and those founded in metaphysical.concepts of phil.sophy and rel.gion. After some comments on such theories, this paper agrees that, in the physical.search, the Big Bang seems to be the most probabl. origin of the physical.Universe, space and time. On the metaphysical.approach, the creation ex nihil. seems to be the commonest hypothesis for such origin. Besides, it is assumed that the Creator woul. have set two driving and successive conditions: transcendence and ethics. Reference is made to the arrow of time and to the proper time, a physical.concept aimed to define both frozen and imaginary times, which woul. correspond to a space without time, and another space with imaginary time. A diagram is proposed for the Eucl.dic space, incl.ding a worl.-l.ne throughout the space-l.ke.

关键词： Hubbl. Fiel.

Effect of rel.tive humidity on the desul.urization performance of cal.ium-based desul.urizer

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Journal.of Environmental.Sciences 2024年第4期138卷 179-188页

作者： juan l. Yu Fu Haiyan Yu HuanWang Zhe Wang Haiyan Chen School.of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China Guangyuan Emergency Management bureau Guangyuan 628000China

l.w desul.urization efficiency impedes the wide appl.cation of dry desul.urization technol.gy,which is a l.w-cost and simpl. process,and one significant sol.tion is the devel.pment and manufacture of high-performance *** this study,firstl.,a steam jet mil. was used to digest quickl.me;then,we util.zed numerical.simul.tion to study the fl.w fiel. distribution and anal.ze the driving factors of quickl.me digestion;and l.stl.,the desul.urization performance of the desul.urizer was eval.ated under different rel.tive *** resul.s show that the desul.urizer prepared via the steam jet mil. had better apparent activity than traditional.***,the entire jet fl.w fiel. of the steam jet mil. is in a supersonic and highl. turbul.nt fl.w state,with high crushing intensity and good particl. accel.ration *** contact with the nascent surface maximizes the formation of sl.ked *** experiments demonstrated that the operating time with 100%desul.urization efficiency and the“break-through”time for the desul.urizer prepared via the steam jet mil. is l.nger than that of traditional.desul.urizers,and has significant advantages,especial.y at l.w fl.e gas rel.tive *** with traditional.desul.urizers,the desul.urizer prepared via steam jet mil. expands the range of acceptabl. fl.e gas temperature,and the fail.re temperature is 1.625 times that of traditional.*** work breaks through the technical.bottl.neck of l.w dry desul.urization efficiency,which is an important step in pushing forward the appl.cation of dry desul.urization.

关键词： Dry desul.urization Rel.tive humidity Desul.urization efficiency High-efficiency desul.urizer Quickl.me digestion

The Extension Degree Conditions for Fractional.Factor

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Acta Mathematica Sinica,Engl.sh Series 2020年第3期36卷 305-317页

作者： Wei GAO Wei Fan WANG juan l.G.GUIRAO School.of Information Science and Technol.gy Yunnan Normal UniversityKunming 650500P.R.China Department of Mathematics Zhejiang Normal UniversityJinhua 321004P.R.C hina Departamento de Matematica Apl.cada y Estadistica.Universidad Pol.tecnica de Cartagena Hospital de Marina30203-CartagenaRegion de MurciaSpain

In Gao’s previous work, the authors determined several.degree conditions of a graph which admits fractional.factor in particul.r settings. It was reveal.d that these degree conditions are tight if b = f(x) = g(x) = a for al. vertices x in G. In this paper, we continue to discuss these degree conditions for admitting fractional.factor in the setting that several.vertices and edges are removed and there is a difference Δ between g(x) and f(x) for every vertex x in G. These obtained new degree conditions reformul.te Gao’s previous concl.sions, and show how Δ acts in the resul.s. Furthermore,counterexampl.s are structured to reveal.the sharpness of degree conditions in the setting f(x) =g(x) + Δ.

关键词： Fractional factor degree condition independent set