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Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C

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World Journal of Gastroenterology 2015年第17期21卷 5421-5426页

作者： Sabela Lens jose L Calleja Ana Campillo jose A Carrion Teresa Broquetas Christie Perello juan de la Revilla Zoe Marino Maria-Carlota Londono jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns Liver Unit Hospital ClinicIDIBAPSCIBERehd08036 BarcelonaSpain Liver Unit Hospital Puerta del HierroIDIPHIMCIBERehd28222 MajadahondaMadridSpain Gastroenterology Department Hospital Reina Sofia31500 TudelaNavarraSpain Liver Unit Hospital Del MarIMIMCIBERehd08003 BarcelonaSpain Hematology Unit Hospital Clinic08036 BarcelonaSpain

Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and *** due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been *** collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in *** 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of *** age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver *** pancytopenia was diagnosed a median of 10 wk after the initiation of *** patients had pre-treatment hematological abnormalities related to *** six patients,antiviral treatment was interrupted at the onset of hematological *** patients died due to septic complications and one patient due to acute alveolar *** remaining patients *** pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver *** monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.

关键词： Aplastic anemia Hepatitis C Telaprevir Interferon Protease inhibitors

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Social media in cardiology:Reasons to learn how to use it

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World Journal of Cardiology 2019年第10期11卷 217-220页

作者： Rafael Vidal-Perez jose juan Gómez de Diego Julia Grapsa Ricardo Fontes-Carvalho jose Ramon Gonzalez-juanatey Heart Failure Unit Cardiology DepartmentHospital Clinico Universitario de SantiagoSantiago de Compostela 15706A CorunaSpain Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares SpainSantiago de Compostela 15706A CorunaSpain Cardiovascular Institute Hospital Universitario San CarlosMadrid 28040Spain Cardiology Department St Bartholomew HospitalBarts Health TrustLondon EC1A 7BEUnited Kingdom Cardiology Department Centro Hospitalar GaiaUniversity of PortoPorto 4434-502Portugal

Social media has changed the way we learn,educate,and interact with our *** dynamic nature of social media and their immediate availability through our portable devices(smartphones,tablets,smartwatches,etc.)is quickly transforming the way we participate in *** scope of these digital tools is broad as they deal with many different aspects:Teaching and learning,case discussion,congresses coverage,peer to peer interaction,research are examples worth *** scientific societies considered more innovative,are promoting these tools between their *** new concepts need to be known by the cardiologists to stay updated,as countless information is moving rapidly through these *** summarize the main reasons why learning how to use these tools to be part of the conversation is essential for the cardiologist in training or fully stablished.

关键词： Social media Cardiology Congress Learning Teaching Interaction Cardiovascular diseases Impact Factor Portable devices Smartphone Tablet

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Purification and Biochemical Characterization of a Protease Inhibitor Ⅱ Family from Jalapeno Pepper(Capsicum annuum L.)

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Advances in Bioscience and Biotechnology 2014年第7期5卷 661-668页

作者： juan Pablo Carrillo-Montes Roberto Arreguin-Espinosa jose Luis Munoz-Sanchez Manuel Soriano-Garcia Departamento de Quimica de Biomacromoleculas Instituto de QuimicaUniversidad Nacional Autonoma de MexicoMexico DFMexico Departamento de Bioquimica Escuela Nacional de Ciencias Biologicas del Instituto Politécnico NacionalMéxico DFMéxico

Capsicum annuum L. was initially domesticated in Mexico and northern Central America, and represented an ancient Neotropical plant food complex. The purpose of this paper is to report the isolation and purification of a novo-member of a protease inhibitor from jalapeño pepper (Capsicum annuum L.) (PIJP). The molecular weight of PIJP inhibitor is 5.95 kDa with 56 amino acids and 6 Cys residues with high inhibitory activity to trypsin with a Ki value of 95 nM. This inhibitor according to the alignment with homologous from NCBI and Pfam databases is a member of proteinase inhibitors II. It is worthwhile to mention a major compositional difference between the proteinase inhibitor II families which have 8 Cys residues. PIJP is the first purified proteinase inhibitor, member of this family with only 6 Cys residues.

关键词： Protease Inhibitory Activity Protease Inhibitor Protein Purification Jalapeno Pepper Capsicum annuum L.

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Sand veins and MISS from the Mesoproterozoic black shale (ca. 1.7 Ga) in North China:Implication for methane degassing from microbial mats

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Science China Earth Sciences 2008年第11期51卷 1525-1536页

作者： SHI XiaoYing JIANG GanQing ZHANG ChuanHeng GAO LinZhi LIU juan School of Earth Science and Resources China University of GeosciciencesBeijing 100083China State Key Laboratory of Geological Process and Mineral Resources Beijing 100083China Department of Geoscience University of NevadaLas VegasNV 89154-4010USA Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

The Mesoproterozoic Chuanlinggou Formation (ca. 1.7 Ga) consists mainly of dark-gray to black shales that are widespread in the North China Platform. Abundant centimeter-scale sand veins are present within the shale layers of this unit, particularly in the middle part. Sand veins display ptygmatic shapes, perpendicular or with a high angle to bedding planes. They penetrate the black shale layers but are often terminated by thin, lenticular sandstone beds, forming small-scale ‘tepee-like’ structures. On bedding planes, sand veins are expressed as small ridges with 1–3 mm positive relief. Lack of polygonal shapes and their occurrence in thinly laminated, relatively deep-water shales preclude an origin from sand-filled desiccation cracks. Instead, their close association with microbially induced sedimentary structures (MISS) such as micro-wrinkles and gas blisters, putative bacterial fossils (possibly coccoidal cyanobacteria) and framboidal pyrites, suggests that they were formed by degassing of methane from microbial mat decay. Methane gas disrupted overlying sedimentary layers, creating fractures open to seawater. Fine-grained quartz sands, which were transported into the depositional environment by strong winds, filled the fractures. Sand-filled fractures were shortened and folded during burial compaction, forming ptygmatic shapes. The presence of dispersed dolomite and siderite in these sand veins suggests authigenic carbonate precipitation from anaerobic oxidation of methane (AOM). Sand veins are intensely distributed within the Chuanlinggou Formation and are spatially widespread in the North China Platform. If their methane origin is confirmed, they may have important implications for the Mesoproterozoic paleoclimate. With anoxic oceans and low seawater sulfate concentration during the Mesoproterozoic, methane release from microbial mat decay and/or microbial methanogenesis during shallow burial may have been proportionally higher than that of the modern marine e

关键词： sand veins methane degassing microbial mats Chuanlinggou Formation Mesoproterozoic North China Platform

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DESIGN OF AN ISOLATED WORD ASR FOR THE SPANISH TELEPHONE NETWORK

DESIGN OF AN ISOLATED WORD ASR FOR THE SPANISH TELEPHONE NET...

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International Conference on Signal Processing(ICSP’90)

作者： Maria Jesus Poza jose F.Mateosy juan A.Siles TELEFONICA INVESTIGACION Y DESARROLLO.Emilio Vargas6 28043 Madrid.Spain.

＜正＞The design of a system for speaker independent automatic recognition of isolated words over the Spanish telephone network is described,in addition to the necessary steps to collect a data base with utterances of...

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西班牙法格塞达公司与金属板材加工

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锻造与冲压 2007年第12期 40-40,42,43页

作者： juan jose Colas 法格锻压机床昆山有限公司总经理

作为全球领先的冲压及钣金成形设备制造商．西班牙法格塞达公司创建于1957年，是蒙德拉贡联合公司的最重要成员之一。西班牙法格塞达公司专业提供金属板材剪切与压型技术方面的先进工艺与设备．为全球广大客户在钢铁、汽车、家电、建材... 详细信息

作为全球领先的冲压及钣金成形设备制造商．西班牙法格塞达公司创建于1957年，是蒙德拉贡联合公司的最重要成员之一。西班牙法格塞达公司专业提供金属板材剪切与压型技术方面的先进工艺与设备．为全球广大客户在钢铁、汽车、家电、建材等许多行业生产制造各种先进的金属板材剪切线、压力机系统和多元化工艺设备。

关键词：金属板材加工西班牙设备制造商工艺设备钣金成形联合公司板材剪切生产制造

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In Vitro Propagation of Echeveria elegans, a Species of the Flora Endangered Mexican

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Journal of Environmental Science and Engineering(B) 2013年第9期2卷 555-558页

作者： juan jose Solis Mireya Reyna Manuel de Feria Marco Antonio Cardona Daniel Rojas Laboratory of Plant Biotechnology University of Guadalajara Ocotlan Jalisco 47840 Mexico Institute of Biotechnology of the Plants Central University "Marta Abreu" of Las Villas Santa Clara Villa Clara 54830 Cuba

The genus Echeveria has about 143 species that are unique to the Americas, 117 of which are presented in the Mexican Republic, mainly in the states of Hidalgo, Puebla and Oaxaca. Propagation can be done by cuttings, leaf cuttings or seeds, but these methods are insufficient to avoid the predation of many species. NOM-059-ECOL-2001 shows Echeveria elegans as species reported endangered. The objectives in this study were achieved in vitro propagation from axillary buds, as an alternative to multiplication and preservation species. We evaluated different concentrations and combinations of two growth regulators, 6-BAP （2.22, 4.44, 6.66 and 8.88 μM） and u-NAA （1.35 and 2.70 μM） on shoot formation from axillary buds and two culture media with different concentrations of MS salts, to achieve root plants grown in vitro. It was found by combining 6.66 μM of 6-BAP and 1.35μM of α-NAA favored the formation and development of new shoots. In the rooting stage, the best results are achieved with the treatment containing 50% of MS salts. Then the plants were transplanted into greenhouses and achieved a successful acclimatization. During this last phase of development, there were no phenotypic changes or presence of somaclonal variants.

关键词： Echeveria propagation growth regulators axillary bud.

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Update on the treatment of type 2 diabetes mellitus

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World Journal of Diabetes 2016年第17期7卷 354-395页

作者： juan jose Marin-Penalver Iciar Martin-Timon Cristina Sevillano-Collantes Francisco Javier del Canizo-Gomez Section of Endocrinology Hospital Universitario Infanta Leonor Facultad de Medicina Universidad Complutense 28031 MadridSpain

To achieve good metabolic control in diabetes and keep long term, a combination of changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal glycated hemoglobin significantly, decreases risk of macrovascular and microvascular complications. At present there are different treatments, both oral and injectable, available for the treatment of type 2 diabetes mellitus(T2DM). Treatment algorithms designed to reduce the development or progression of the complications of diabetes emphasizes the need for good glycaemic control. The aim of this review is to perform an update on the benefits and limitations of different drugs, both current and future, for the treatment of T2 DM. Initial intervention should focus on lifestyle changes. Moreover, changes in lifestyle have proven to be beneficial, but for many patients is a complication keep long term. Physicians should be familiar with the different types of existing drugs for the treatment of diabetes and select the most effective, safe and better tolerated by patients. Metformin remains the first choice of treatment for most patients. Other alternative or second-line treatment options should be individualized depending on the characteristics of each patient. This article reviews the treatments available for patients with T2 DM, with an emphasis on agents introduced within the last decade.

关键词： Type 2 diabetes mellitus Treatment Oral antidiabetic agents Injectable antidiabetic agents Older people Renal impairment Future treatments

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Application of a Sulfur Removal Hydrometallurgical Process in a Lead-Acid Battery Recycling Plant in Costa Rica

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Open Journal of Air Pollution 2017年第1期6卷 18-26页

作者： Marta Navarro-Monge Germain Esquivel-Hernandez jose Pablo Sibaja Brenes jose Carlos Mora-Barrantes Ricardo Sanchez-Murillo juan Valdes-Gonzalez Pablo Bolanos-Ulloa Atmospheric Laboratory Chemistry DepartmentNational University of Costa RicaHerediaCosta Rica Chemistry Department National University of Costa RicaHerediaCosta Rica Pb Metals S.A. CartagoCosta Rica

This study presents the implementation of a desulphurization process for lead recycling under different chemical and physical conditions using pyro-metallurgical processes. Desulphurization was done using a hydrometallurgical process using sodium carbonate as a desulphurization agent and different lead-bearing loads compositions. Waste characterization included: SO2 concentrations in the stack emissions, total lead content in the furnace ash, the total lead content in the slag, and the toxicity characteristic leaching procedure (TCLP). A significant reduction in SO2 emissions was achieved (~55% reduction) where mean SO2 concentrations changed from 2193 ± 135 ppm to 1006 ± 62 ppm after the implementation of the modified processes. The desulfurized lead paste (i.e. the metallic fraction lead of the battery) of the modified process exhibited an improvement in the concentration of the lead in the TCLP test, with an average value of 1.5 ppm which is below US EPA limit of 5 ppm. The traditional process TCLP mean value for the TCLP was 54.2 ppm. The total lead content in the bag house ashes shows not significant variations, when comparing the desulphurization (67.6% m/m) and non-desulphurization process (64.9% m/m). The total lead mean content in the slag was higher in the desulphurization process (2.49% m/m) than the traditional process (1.91% m/m). Overall, the implementation of a new desulphurization method would potentially increase the operation costs in 10.3%. At the light of these results, a combination of hydrometallurgical and pyro-metallurgical processes in the recycling of lead-acid batteries can be used to reduce the environmental impact of these industries but would increase the operational costs of small lead recyclers.

关键词： Lead-Acid Battery Recycling Hydrometallurgical and Pyro-Metallurgical Processes Hazardous Waste Management

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Fruit Set in Orange with Phytohormones and Its Relation to Endogenous Levels of GA3

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Journal of Life Sciences 2013年第8期7卷 836-838页

作者： juan jose Galvan Luna Luis Alonso Valdez Aguilar Andres Martinez Cano Ovidio Salazar Salazar Departamento de Horticultura Universidad Aut6noma Agraria Antonio Narro Saltillo 25315 Coahuila Mexico Division de Postgrado Universidad Autonoma de Tamaulipas Ciudad Victoria Tamaulipas Mexico

This research work aims to contribute in increasing the fruit set in citrus, given its importance in determining fruit yield. The authors evaluated the effects of phytohormones （auxins, gibberellins and cytokinins） in the mooring and features of orange fruit in cultivars Washington navel and Thomson （Citrus sinensis （L.） Osb.）, The experiment was established in a split plot randomized complete block design with five treatments and four replications. Flower tissue samples were stored in liquid N until the extraction of gibberellins and the identification and quantification of GA3. The results showed statistically significant difference （P 〈 0.05） between treatments in the number of fruits retained 129 d after flowering and the percentage of final tie. GA3 content ranged, on a dry weight basis, from 1.66 mg＇g1 in the control to 20.79 mg.g-1 in the high dose. The mean dose （32.2 mg.L-1 auxins, gibberellins 32.2 mg L-1 and 83.2 mg.L-1 cytokinins） caused the largest increase in fruit set.

关键词： Orange Washington navel Thomson auxins gibberellins cytokinins.

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