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Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

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World Journal of Stem Cells 2017年第2期9卷 26-36页

作者： Estefania Caballano-Infantes josé Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya juan R Tejedo Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide 41092 SevilleSpain Biomedical Research Network on Diabetes and Related Metabolic Diseases(CIBERDEM) Instituto de Salud CarlosⅢ28029 MadridSpain Andalusian Center for Molecular Biology and Regenerative Medicine(CABIMER) 41092 SevilleSpain Andalusian Center for Molecular Biology and Regenerative Medicine Fundación Progreso y Salud41092 SevilleSpain Centre for Pharmacology and Therapeutics Division of Experimental MedicineImperial College LondonHammersmith Hospital CampusLondon W12 0NNUnited Kingdom

Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies.

关键词： Endoplasmic reticulum stress Mitochondrial function Nitric oxide Pluripotency Cell differentiation Mitochondrial biogenesis

Adsorption of cobalt by using inorganic components of sediment samples from water bodies

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International Journal of Sediment Research 2021年第4期36卷 524-531页

作者： Rocío Montes de Oca-Palma Marcos Solache-Ríos Melania Jiménez-Reyes josé juan García-Sánchez Perla Tatiana Almazán-Sánchez Instituto Nacional de Investigaciones Nucleares Departamento de Química Tecnológico de Estudios Superiores de Jocotitlán Cátedras CONACyT-Instituto Nacional de Investigaciones Nucleares

The adsorption of cobalt ions was evaluated using sediment samples from water bodies to investigate the adsorption properties of sediment and the behavior of these natural materials in the presence of nuclear and industrial waste. The two sediments(S1 and S2) were treated to eliminate humic and fulvic acids and then they were characterized by several techniques. The minerals found in both the sediments(X-ray diffraction) were quartz and albite; plus, goethite and muscovite in S1, and kaolinite and montmorillonite in S2. Point of zero charge(PZC) of S1 and S2 was 6.00 and 5.22, respectively. The specific area of S1(63.3 m2/g) is higher than S2(1.5 m2/g). Adsorption kinetics data for S1 and S2 were best fitted to the pseudo second-order model. The removal efficiency of S1 for cobalt was 96% with an adsorption capacity(qe) of 0.93 mg/g, and for S2 was 45% with a qeof 0.40 mg/g. The experimental data of the adsorption isotherms were adjusted to Langmuir and Freundlich models for S1 and S2, respectively. The thermodynamic parameters(enthalpy, entropy, and Gibb’s free energy) indicated that the adsorption processes were endothermic, spontaneous, and chemisorption mechanism. The results show that the adsorption capacities of the sediments depend on their composition. These water sediments have important adsorption properties for cobalt, and they can be used in the treatment of nuclear and industrial aqueous wastes.

关键词： Water-body sediment Cobalt ions Adsorption

Design and Implementation of an Extended Collectives Library for Unified Parallel C

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Journal of Computer Science & Technology 2013年第1期28卷 72-89页

作者： Carlos Teijeiro Guillermo L.Taboada juan Tourio Ramón Doallo jos C.Mourio Damivn A.Mallón Brian Wibecan Computer Architecture Group University of A Corua Galicia Supercomputing Center Jlich Supercomputing Centre Institute for Advanced SimulationForschungszentrum Jlich Industry Standard Servers Group Hewlett-Packard Company

Unified Parallel C （UPC） is a parallel extension of ANSI C based on the Partitioned Global Address Space （PGAS） programming model, which provides a shared memory view that simplifies code development while it can take advantage of the scalability of distributed memory architectures. Therefore, UPC allows programmers to write parallel applications on hybrid shared/distributed memory architectures, such as multi-core clusters, in a more productive way, accessing remote memory by means of different high-level language constructs, such as assignments to shared variables or collective primitives. However, the standard UPC collectives library includes a reduced set of eight basic primitives with quite limited functionality. This work presents the design and implementation of extended UPC collective functions that overcome the limitations of the standard collectives library, allowing, for example, the use of a specific source and destination thread or defining the amount of data transferred by each particular thread. This library fulfills the demands made by the UPC developers community and implements portable algorithms, independent of the specific UPC compiler/runtime being used. The use of a representative set of these extended collectives has been evaluated using two applications and four kernels as case studies. The results obtained confirm the suitability of the new library to provide easier programming without trading off performance, thus achieving high productivity in parallel programming to harness the performance of hybrid shared/distributed memory architectures in high performance computing.

关键词： Unified Parallel C collective operation programmability partitioned global address space high performance computing

利用企业社会责任提高顾客参与度——Zurita市场营销策略分析

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利用企业社会责任提高顾客参与度——Zurita市场营销策略分析

作者： juan josé PRADO 上海外国语大学

学位级别：硕士

近几十年中,中国的飞速发展引起了全球许多公司和企业家的关注,他们有意迈入中国这个充满活力但竞争激烈的市场。在此背景下,西班牙设计师在上海创立了年轻时装品牌Zurita Madrid。该品牌所处的行业在2018年的估值超过1.5万亿人民币,成... 详细信息

近几十年中,中国的飞速发展引起了全球许多公司和企业家的关注,他们有意迈入中国这个充满活力但竞争激烈的市场。在此背景下,西班牙设计师在上海创立了年轻时装品牌Zurita Madrid。该品牌所处的行业在2018年的估值超过1.5万亿人民币,成千上万的品牌相互竞争,希望能吸引到更多的客户群。本文基于Zurita的社会积极性和环保举措,研究其营销策略、与顾客的关系以及品牌本身。为更好地了解该品牌的策略和工作背景,本文采用一手数据和二手数据(包括网络资料和出版书籍)开展研究。文献综述部分集中于客户参与理论的背景和现状,同时分析了该公司营销策略的核心内容——企业社会责任理论(CSR)。此外,作者还通过问卷调查开展了一项实证研究,以了解客户对中国企业社会责任的看法。尽管Zurita在社会和环保活动上投入了诸多资源,但经过对其社交网络和网络形象的深入分析,本文发现这些投入并未增加粉丝数量和网络影响力。本文采用了PESTEL、SWOT分析等策略及品牌识别棱柱模型等工具,判断这一结果的出现源于中国市场特征或是该公司的营销能力仍然有待提高。本研究创新性地重点关注了Zurita Madrid营销策略的特定要素。该公司的日常活动及营销活动都涉及大量的企业社会责任,这在时尚界十分罕见。有关外国公司在中国运营的英语研究也很少,因此我们希望弥补这一领域的空白。作者在研究中观察了公司改进营销策略的哪些内容可以提高客户参与度。调查结果以及其他建议的运用有望在保持对企业社会责任关注的同时,增强并改善公司的营销成果,提高收益。本文还为管理人员提供了一项包括人力资源在内的实施计划,并在结尾处呈现研究结论、研究过程的局限性,以及研究的进一步方向。

关键词：客户参与企业社会责任数字营销中国时装行业

Contrasting levels of genotype by environment interaction for life history and morphological traits in invasive populations of Zaprionus indianus(Diptera:Drosophilidae)

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Insect Science 2020年第5期27卷 1090-1100页

作者： Nicolas J.Lavagnino Marcos Imberti Victoria E.Ortizj Nicolas Flaibani juan jose Fanara Laboratorio de Evolucion Departamento de EcologiaGenetica y EvolucidnFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina IEGEBA-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

It has been demonstrated that phenotypic plasticity and genotype by envi-ronment interaction are important for coping with new and heterogeneous environments during *** indianus Gupta(Diptera:Drosophilidae)is an Afrotropical invasive fly species introduced to the South American continent in *** species is generalist and polyphagous,since it develops and feeds in several different fruit *** characteristics of *** suggest that phenotypic plasticity and genotype by environment interaction may be important in this species invasion *** this sense,our aim was to investigate the role of genetic variation for phenotypic plasticity(geno-type by environment interaction)in *** invasion of the South American ***,we quantified quantitative genetic variation and genotype by environment in-teractions of morphological and life history traits in different developmental environments,that is,host *** was done in different populations in the invasive range of ***-anus in *** showed that *** populations have considerable amounts of quantitative genetic ***,genotype by environment interactions was detected for the different traits analyzed in response to the different developmental ***,the amounts and patterns of these parameters differed between *** interpreled these results as the existence of diferences in evolutionary potential be-tween populations that have an important role in the short-and long-term success of the *** invasion process.

关键词： biological invasion genotype by env ironment interaction invaded range life history traits morphological traits Zaprionus indianus

A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study

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Oncology Research 2023年第2期31卷 207-220页

作者： GUSTAVO MARTÍN VILLOLDO MARÍA TERESA POMBO MARIANA ARIS JOAQUÍN CHEMI PABLO MANDÓ SUPRIYA NAGARAJU juan CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA AMAT josÉLEÓN MELLADO josÉMORDOH ALBERTO VILLARONGA MARÍA MARCELA BARRIO Urology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immunohistochemistry Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Centro de Investigaciones Oncológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Department MD Anderson Cancer CenterHoustonTX77030USA Pathology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive *** induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor *** searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment ***-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by *** polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+*** addition,PD-1/PD-L1 staining was *** results correlated with BCG *** most non-responders,Th1/Th2 markers were compared in pre-and post-BCG *** was 65.6%in the study *** responders had a higher G/T ratio and a greater number of degranulated EPX+*** combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower ***-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of ***-L1/PD-1 expression was not associated with the response to *** results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity.

关键词： Non-muscle invasive bladder cancer BCG predictive biomarkers Lymphocyte polarization

Spectrophotometric determination of the formation constants of Calcium(Ⅱ) complexes with 1,2-ethylenediamine,1,3-propanediamine and 1,4-butanediamine in acetonitrile

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Green Energy & Environment 2017年第1期2卷 51-57页

作者： Jacqueline González González Mónica Nájera-Lara Varinia López-Ramírez juan Antonio Ramírez-Vázquez josé J.N.Segoviano-Garfias Programa de Maestría en Biociencias División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca Colegio del Nivel Medio Superior de Salamanca(ENMS) Departamento de Ingeniería Bioquímica Instituto Tecnológico Superior de Irapuato (ITESI) Departamento de Ciencias Ambientales División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca

In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the complexes: Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine in acetonitrile, were carried on. By processing the spectrophotometric data with the HypSpec program allows the determination of the formation constants. The logarithmic values of the formation constants obtained for Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine were log β_(110) = 4.69, log β_(110)= 5.25 and log β_(110) = 4.072, respectively.

关键词： Calcium(Ⅱ)complexes Solution equilibria Artificial photosynthesis Absorbance molar Speciation

Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis

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World Journal of Gastroenterology 2005年第46期11卷 7261-7265页

作者： Jesús Sáez juan Martínez Celia Trigo josé Sánchez-Payá Luis Compay Raquel Laveda Pilar Grió Cristina García Miguel Pérez-Mateo Section of Gastroenterology and Department of Internal Medicine Hospital General Universitario de Alicante Alicante Spain Service of Clinical Laboratory Hospital General Universitario de Alicante Alicante Spain Service of Preventive Medicine Hospital General Universitario de Alicante Alicante Spain Section of Gastroenterology and Department of Internal MedicineHospital General Universitario de Alicante AlicanteSpain

AIM: To assess the usefulness of urinary trypsinogen-2 test strip, urinary trypsinogen activation peptide (TAP),and serum and urine concentrations of the activation peptide of carboxypeptidase B (CAPAP) in the diagnosisof acute ***: Patients with acute abdominal pain and hospitalized within 24 h after the onset of symptoms were prospectively studied. Urinary trypsinogen-2 was considered positive when a clear blue line was observed (detection limit 50 μg/L). Urinary TAP was measured using a quantitative solid-phase ELISA, and serum and urinary CAPAP by a radioimmunoassay ***: Acute abdominal pain was due to acute pancreatitis in 50 patients and turned out to be extrapancreatic in origin in 22 patients. Patients with acute pancreatitis showed significantly higher median levels of serum and urinary CAPAP levels, as well as amylase and lipase than extrapancreatic controls. Median TAP levels were similar in both groups. The urinary trypsinogen-2 test strip was positive in 68% of patients with acute pancreatitis and 13.6% in extrapancreatic controls (P<0.01). Urinary CAPAP was the most reliable test for the diagnosis of acute pancreatitis (sensitivity 66.7%, specificity 95.5%, positive and negative predictive values 96.6% and 56.7%, respectively), with a 14.6 positive likelihood ratio for a cut-off value of 2.32 nmol/***: In patients with acute abdominal pain,hospitalized within 24 h of symptom onset, CAPAP in serum and urine was a reliable diagnostic marker of acute pancreatitis. Urinary trypsinogen-2 test strip showed a clinical value similar to amylase and *** TAP was not a useful screening test for the diagnosis of acute pancreatitis.

关键词： Acute pancreatitis Urinary trypsinogen-2 Urinary trypsinogen activation peptide Activation peptide of carboxypeptidase B Acute abdominal pain

Multiparameter resonant imaging for studying cell interactions

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Light(Science & Applications) 2018年第1期7卷 652-653页

作者： joséjuan-Colás Thomas F Krauss Department of Physics The University of YorkHeslignton YO105DDUK Department of Electronic Engineering The University of YorkHeslignton YO105DDUK

The development of optical microscopy techniques has provided major insights into the machinery of life,from molecules to cells to tissues and *** techniques have been particularly successful in this respect by elucidating biological pathways and helping us understand the complex relationships that underpin all living *** example,the first use of fluorescence as an analytical tool in 18641 paved the way for the study of biological entities and interactions,but it was not until nearly 60 years later,in the 1930s,that fluorophores were first employed to perform biological investigations into specific tissue components and bacteria that do not *** advances led to the first labeling of an antibody with a visible label in 19413,which gave birth to the field of immunofluorescence and allowed us obtain unprecedented insight into antibody structure.

关键词： organs insight visible