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MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4

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World Journal of Diabetes 2024年第3期15卷 488-501页

作者： Qi-Shun Wu Dan-Na Zheng Cheng Ji Hui Qian juan jin Qiang He Graduate School Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou 314408Zhejiang ProvinceChina Department of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 314408Zhejiang ProvinceChina Molecular Inspection Laboratory School of MedicineJiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina Department of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310060Zhejiang ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a major complication of diabetes *** tubular epithelial cell(TEC)damage,which is strongly associated with the inflammatory response and mesenchymal trans-differentiation,plays a significant role in DKD;However,the precise molecular mechanism is *** recently identified microRNA-630(miR-630)has been hypothesized to be closely associated with cell migration,apoptosis,and ***,the association between miR-630 and DKD and the underlying mechanism remain *** To investigate how miR-630 affects TEC injury and the inflammatory response in DKD *** Streptozotocin was administered to six-week-old male rats to create a hypergly cemic diabetic *** the second week of modeling,the rats were divided into control,DKD,negative control of lentivirus,and miR-630 overexpression *** 8 wk,urine and blood samples were collected for the kidney injury assays,and renal tissues were removed for further molecular *** target gene for miR-630 was predicted using bioinformatics,and the association between miR-630 and toll-like receptor 4(TLR4)was confirmed using in vitro investigations and double luciferase reporter gene *** of miR-630 in DKD rats led to changes in body weight,renal weight index,basic blood parameters and histopathological *** The expression level of miR-630 was reduced in the kidney tissue of rats with DKD(P<0.05).The miR-630 and TLR4 expressions in rat renal TECs(NRK-52E)were measured using quantitative reverse transcription polymerase chain *** mRNA expression level of miR-630 was significantly lower in the high-glucose(HG)and HG+mimic negative control(NC)groups than in the normal glucose(NG)group(P<0.05).In contrast,the mRNA expression level of TLR4 was significantly higher in these groups(P<0.05).However,miR-630 mRNA expression increased and TLR4 mRNA expression significantly decreased in the HG+miR-630 mimic group than in the HG

关键词： Diabetic kidney disease MicroRNA-630 Toll-like receptor 4 Mouse model Renal tubular epithelial cells damage Hyperglycemic model

Design and synthesis of polyoxovanadate-based framework for efficient dye degradation

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Tungsten 2024年第2期6卷 447-453页

作者： Qing Lan Su-juan jin Zheng Wang Xu-Yang Li Yan Xiong Zhuo-Cheng Wang Shan-Shan Liu Zhi-Ming Zhang Qiang Zhao Engineering Technology Research Center of Henan Province for Solar Catalysis School of Chemical and Pharmaceutical EngineeringNanyang Normal UniversityNanyang 473061China Institute of New Energy Materials&Low Carbon Technology Tianjin University of TechnologyTianjin 300384China

A new polyoxovanadate-based framework material[Cu(en)_(2)]_(4)V_(18)O_(42)(H_(2)O)·6H_(2)O(1)was designed and synthesized by hydrothermal reaction of NaVO_(3),Cu(NO_(3))_(2)·6H_(2)O and 1,2-diaminoethane(en)via carefully adjusting the pH value of the reaction *** structure of the title compound has been determined by single-crystal X-ray diff raction analysis,thermogravimetric analysis,infrared spectra and elemental *** structural analysis demonstrate the three-dimensional(3D)framework structure of compound 1,which was composed of the[V_(18)O_(42)(H_(2)O)]_(8)−({V_(18)O_(42)(H_(2)O)})anions linked by the Cu^(2+)*** 1 represents the fi rst 3D framework based on{V_(18)O_(42)(H_(2)O)}polyoxoanions and copper ***-driven degradation of residual organic pollutants in industrial wastewater is still a major problem for human *** experiments reveal that compound 1 possesses of excellent photocatalytic activity for the degradation of methylene blue and rhodamine B.

关键词： Polyoxovanadate Framework Polyoxovanadate-based framework Photocatalytic Organic pollutants

Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome

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Protein & Cell 2024年第9期15卷 704-709页

作者： jing Wang Hui-juan jin Yi Lu Zi-Han Wang Teng-Yan Li Lan Xia Hong-Jun Li Bin-Bin Wang Su-Ren Chen Department of Medical Genetics and Developmental Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Key Laboratory of Cell Proliferation and Regulation Biology Ministry of EducationDepartment of BiologyCollege of Life SciencesBeijing Normal UniversityBeijing 100875China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Urology Peking Union Medical College HospitalBeijing 100005China Center for Genetics National Research Institute of Family PlanningBeijing 100081China NHC Key Laboratory of Reproductive Health Engineering Technology Research(NRIFP) Beijing 100081China

Dear Editor,Male infertility is a widespread health problem and affects approximately 6%–8%of the male population(Jiao et al.,2021).Acephalic spermatozoa syndrome(ASS),a rare but severe type of teratozoospermia,is ch... 详细信息

关键词： al. infertility finally

High-performance terahertz modulators induced by substrate field in Te-based all-2D heterojunctions

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Light(Science & Applications) 2024年第3期13卷 577-586页

作者： Pujing Zhang Qihang Liang Qingli Zhou jinyu Chen Menglei Li Yuwang Deng Wanlin Liang Liangliang Zhang Qinghua Zhang Lin Gu Chen Ge Kui-juan jin Cunlin Zhang Guozhen Yang Department of Physics Key Laboratory of Terahertz OptoelectronicsMinistry of Educationand Beijing Advanced Innovation Center for Imaging Theory and TechnologyCapital Normal UniversityBeijing 100048China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering Beijing National Center for Electron Microscopy and Laboratory of Advanced MaterialsTsinghua UniversityBeijing 100084China

High-performance active terahertz modulators as the indispensable core components are of great importance for the next generation communication ***,they currently suffer from the tradeoff between modulation depth and ***,we introduce two-dimensional(2D)tellurium(Te)nanofilms with the unique structure as a new class of optically controlled terahertz modulators and demonstrate their integrated heterojunctions can successfully improve the device performances to the optimal and applicable levels among the existing all-2D broadband *** photoresponse measurements confirm the significant impact of the stacking *** first clarify the direction of the substrate-induced electric field through first-principles calculations and uncover the unusual interaction mechanism in the photoexcited carrier dynamics associated with the charge transfer and interlayer exciton *** advances the fundamental and applicative research of Te nanomaterials in high-performance terahertz optoelectronics.

关键词： performance field terahertz

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郑州市发展数字贸易的SWOT分析及对策

济源职业技术学院学报 2024年第2期23卷 13-17页

作者：靳娟河南财政金融学院经济与贸易学院河南郑州451464

数字经济不仅改变了全球的生产方式,而且对世界贸易产生了重大的影响,数字经济国际化就表现为数字贸易。2022年郑州市数字经济规模接近6000亿元,领跑全省。郑州市数字经济的快速发展,大大促进了数字贸易的增长。在分析了郑州市发展数字... 详细信息

数字经济不仅改变了全球的生产方式,而且对世界贸易产生了重大的影响,数字经济国际化就表现为数字贸易。2022年郑州市数字经济规模接近6000亿元,领跑全省。郑州市数字经济的快速发展,大大促进了数字贸易的增长。在分析了郑州市发展数字贸易的必要性基础上,借助SWOT分析方法,剖析了郑州市发展数字贸易的内部优势、劣势和外部机遇、挑战,提出郑州市应从加快数字基础设施建设、完善数字贸易规则、创新发展数字核心产业、引进数字企业及人才、扩大与“一带一路”国家数字贸易规模等方面促进数字贸易快速发展。

关键词：数字贸易数字贸易规则郑州市跨境电商 SWOT法

Strong Anisotropic Order Parameters at All-Nitride Ferromagnet/Superconductor Interfaces

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Chinese Physics Letters 2024年第2期41卷 102-111页

作者： Qiao jin Meng Yang Guozhu Song Nan Zhao Shengru Chen Haitao Hong Ting Cui Dongke Rong Qianying Wang Yiyan Fan Chen Ge Can Wang Jiachang Bi Yanwei Cao Liusuo Wu Shanmin Wang Kui-juan jin Zhi-Gang Cheng Er-Jia Guo Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics&Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China

Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their *** competition arises from the interplay between Cooper pairs and ferromagnetic exchange *** proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM *** fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined *** magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external ***,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)*** observe the intriguing competition of interfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.

关键词： proximity Superconductor titanium

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弘扬沂蒙精神推进共同富裕的逻辑机理

临沂大学学报 2024年第5期46卷 32-40页

作者：杨晋娟临沂大学马克思主义学院山东临沂276000

弘扬沂蒙精神促进共同富裕,不仅是新时代革命老区发展的需要,也是满足沂蒙人民追求美好生活的需要。沂蒙精神内嵌着人民对民主、自由、平等、公正、富裕等价值目标的追求,这些价值目标被融入“革命”与“解放”的话语体系中,成为建立和... 详细信息

弘扬沂蒙精神促进共同富裕,不仅是新时代革命老区发展的需要,也是满足沂蒙人民追求美好生活的需要。沂蒙精神内嵌着人民对民主、自由、平等、公正、富裕等价值目标的追求,这些价值目标被融入“革命”与“解放”的话语体系中,成为建立和维系沂蒙党群同心、军民情深的价值内核。这一价值内核在社会主义革命和建设时期以及改革开放和社会主义现代化建设新时期,从沂蒙地区的社会实践中获得滋养并不断壮大,成为新时代沂蒙党群接续奋斗的精神动力。新时代沂蒙党群需要进一步凝练思想共识,发挥党建引领作用,探求实现共同富裕的多维路径。

关键词：沂蒙精神价值内核共同富裕美好生活

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新媒体赋能红色文化融入高校思政课的价值与实现路径

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南通职业大学学报 2024年第1期38卷 32-36页

作者：王金娟江苏建筑职业技术学院马克思主义学院江苏徐州221116

红色文化具有天然的育人价值。新媒体赋能红色文化融入高校思政课可使红色文化的育人价值最大化,丰富思政课教学内容,拓展红色文化的传播渠道。为此,针对现存问题,提出新媒体赋能红色文化融入高校思政课的具体路径:搭建资源共享的新媒... 详细信息

红色文化具有天然的育人价值。新媒体赋能红色文化融入高校思政课可使红色文化的育人价值最大化,丰富思政课教学内容,拓展红色文化的传播渠道。为此,针对现存问题,提出新媒体赋能红色文化融入高校思政课的具体路径:搭建资源共享的新媒体学习平台,创新红色文化融入思政课的内容和形式,提高思政课教师运用新媒体的能力。

关键词：红色文化高校思政课新媒体

基于AHP方法的GMDSS缺陷导致船舶滞留风险评估

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广州航海学院学报 2024年第1期32卷 24-29页

作者：张丹肖锦娟重庆交通大学航运与船舶工程学院重庆400074

在GMDSS检查过程中,导致船舶滞留的主要影响因素有证书资料配备、设备问题和人员三大方面.基于层次分析法(AHP)建立综合评价分析模型,计算导致船舶滞留的证书、设备、船员等因素的权重及影响程度,结果表明,设备问题在GMDSS缺陷导致船舶... 详细信息

在GMDSS检查过程中,导致船舶滞留的主要影响因素有证书资料配备、设备问题和人员三大方面.基于层次分析法(AHP)建立综合评价分析模型,计算导致船舶滞留的证书、设备、船员等因素的权重及影响程度,结果表明,设备问题在GMDSS缺陷导致船舶滞留风险中的权重最高.针对GMDSS缺陷导致的船舶滞留问题提出对策建议.

关键词： GMDSS 船舶滞留 PSC检查层次分析法应对措施