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Trichoscopy: Essentials for the dermatologist

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World journal of Dermatology 2015年第2期4卷 63-68页

作者： juan Antonio Moreno romero Ramon Grimalt Department of Dermatology Hospital General de Catalunya Universitat Internacional de Catalunya

Noninvasive in vivo imaging techniques have become an important diagnostic aid for dermatology. Dermoscopy, also known as dermatoscopy, has been shown to increase the clinician's diagnostic accuracy when evaluating cutaneous neoplasms. Dermoscope, both hand-held and videodermoscope, are nowadays a basic instrument for almost all the dermatologists around the world. Trichoscopy is the term coined for dermoscopic imaging of the scalp and hair. Routinely using dermoscopy and recognizing the structures and patterns of the different types of alopecia will likely improve the observer's sensitivity for diagnosis and followup of hair and scalp disorders. Structures which may be visualized by trichoscopy include hair shafts of different types, the number of hairs in one pilosebaceous unit, hair follicle openings(dots), the peri and interfollicular areas and the vasculature. This review summarizes the current knowledge about trichoscopic findings which may aid in the diagnosis of alopecia. Besides diagnosing alopecia, it has the potential for obviating unnecessary biopsies and when a biopsy is still needed it is helpful in choosing an ideal biopsy site. Moreover, trichoscopy can be a valuable tool for evaluating the treatment response photographically at each follow-up. Finally, we have discussed the utility of dermoscopy in inflammatory scalp disorders and infections.

关键词： Alopecia Dermatosis Scalp Dermoscopy Dermatoscopy Epiluminiscence microscopy Diagnosis

TWOPHASE FLOW OF HIGHLY CONCENTRATED SLURRY IN A PIPELINE

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journal of Hydrodynamics 2004年第3期16卷 325-331页

作者： NIFu-sheng ZHAOLi-juan MATOUSEKV. VLASBLOMW.j. ZWARTBOLA. FacultyofMechanicalandElectricalEngineering HohaiUniversityChangzhou213022China SectionofDredgingTechnology DelftUniversityofTechnologyTheNetherlands

Hydraulic transport of sand is one of the key processes in river, lake,harbor and waterway dredging engineering. Understanding the flow resistance, solid distribution,flow stratification, transport economy, etc. , in the two-phase flow of sand-water mixture through apipeline is crucial to the design and operation of power drives of a dredger, and to theconstruction of a dredging project. This paper presents the intensive laboratory experimental dataand physical and numerical analyses on the highly concentrated slurry flow under an extended largerange of slurry mean velocities for three narrow-graded sands of different sizes. The investigationindicates that the solids concentration and particle size strongly affect the slurry flowcharacteristics.

关键词： two-phase flow hydraulic transport laboratory experiment modeling

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数字技术驱动下中国民歌变革及应对策略研究

湖北科技学院学报 2025年第1期45卷 80-85页

作者：胡娟方元河南职业技术学院音乐学院河南郑州450046

数字科技的崛起对音乐创作和传播方式带来了革命性的变化,同时也对中国民歌的传承和发展提出了新的课题。本研究旨在深入探讨数字化发展对中国民歌的影响,包括作品表演形式与作品的传承与创新,并详细分析其所面临的挑战和机遇,提出相应... 详细信息

数字科技的崛起对音乐创作和传播方式带来了革命性的变化,同时也对中国民歌的传承和发展提出了新的课题。本研究旨在深入探讨数字化发展对中国民歌的影响,包括作品表演形式与作品的传承与创新,并详细分析其所面临的挑战和机遇,提出相应的对策和建议。通过理论支持和实践指导,期望为传承和创新中国民歌作出积极贡献。

关键词：数字技术中国民歌变革应对

锆基金属有机框架捕获黄连中的生物碱类药物活性成分

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分析测试学报 2025年第1期44卷 188-194页

作者：司甜甜赵薇王慧张红玉刘小烨容蓉冯娟娟山东中医药大学药学院山东济南250355 济南大学化学化工学院山东济南250022

采用溶剂热法制备了锆基MOF-808,利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获,并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件,对黄连粗提液中药根碱的回... 详细信息

采用溶剂热法制备了锆基MOF-808,利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获,并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件,对黄连粗提液中药根碱的回收率达到85.78%,结合高效液相色谱技术建立了检测黄连粗提液中5种生物碱类活性成分的方法。方法的线性范围为0.1~300μg·L^(-1),检出限为0.02~0.05μg·L^(-1),相对标准偏差为0.40%~4.7%,加标回收率达到69.7%~128%。该研究实现了中药黄连中生物碱类活性成分的高效、快速富集与捕获,为MOFs材料在选择性捕获与富集中药有效成分等领域的研究提供了新思路。

关键词：金属有机框架选择性富集色谱分离生物碱活性成分黄连

Conserved quantities and adiabatic invariants of fractional Birkhoffian system of Herglotz type

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Chinese Physics B 2020年第4期29卷 303-311页

作者： juan-juan Ding Yi Zhang School of Mathematics and Physics Suzhou University of Science and TechnologySuzhou 215009China College of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011China

In order to further study the dynamical behavior of nonconservative systems,we study the conserved quantities and the adiabatic invariants of fractional Brikhoffian systems with four kinds of different fractional derivatives based on Herglotz differential variational ***,the conserved quantities of Herglotz type for the fractional Brikhoffian systems based on Riemann-Liouville derivatives and their existence conditions are established by using the fractional Pfaff-Birkhoff-d Alembert principle of Herglotz ***,the effects of small perturbations on fractional Birkhoffian systems are studied,the conditions for the existence of adiabatic invariants for the Birkhoffian systems of Herglotz type based on Riemann-Liouville derivatives are established,and the adiabatic invariants of Herglotz type are ***,the conserved quantities and adiabatic invariants for the fractional Birkhoffian systems of Herglotz type under other three kinds of fractional derivatives are established,namely Caputo derivative,Riesz-Riemann-Liouville derivative and Riesz-Caputo ***,an example is given to illustrate the application of the results.

关键词： fractional Birkhoffian system Pfaff-Birkhoff-d’Alembert principle adiabatic invariant Herglotz generalized variational principle

Arabidopsis SWC4 Binds DNA and Recruits the SWR1 Complex to Modulate Histone H2A.Z Deposition at Key Regulatory Genes

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Molecular Plant 2018年第6期11卷 815-832页

作者： Angeles Gomez-Zambrano Pedro Crevillen jose M. Franco-Zorrilla juan A. Lopez jordi Moreno-romero Pawel Roszak juan Santos-Gonzalez Silvia jurado jesus Vazquez Claudia Kohler Roberto Solano Manuel Pineiro jose A. jarillo Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid (UPM) - Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA) Campus Montegancedo UPM Pozuelo de Alarcon 28223 Madrid Spain Plant Molecular Genetics Department and Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientfficas 28049 Madrid Spain Proteomics Unit Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) 28029 Madrid Spain Department of Plant Biology Uppsala BioCenter Swedish University of Agricultural Sciences and Linnean Center for Plant Biology Uppsala 75652 Sweden Laboratory of Cardiovascular Proteomics Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) 28029 Madrid Spain Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientfficas and Universidad de Sevilla 41092 Sevilla Spain Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB Campus UAB Bellaterra Barcelona Spain The Sainsbury Laboratory Cambridge CB2 1LR UK

Deposition of the H2A.Z histone variant by the SWR1 complex （SWRI-C） in regulatory regions of specific loci modulates transcription. Characterization of mutations in Arabidopsis thaliana homologs of yeast SWRI-C has revealed a role for H2A.Z exchange in a variety of developmental processes. Nevertheless, the exact composition of plant SWRI-C and how it is recruited to target genes remains to be established. Here we show that SWC4, the Arabidopsis homolog of yeast SANT domain protein Swc4/Eaf2, is a DNA-binding protein that interacts with SWR1-C subunits. We demonstrate that the swc4-1 knockout mutant is embryo- lethal, while SWC4 RNAi knockdown lines display pleiotropic phenotypic alterations in vegetative and repro- ductive traits, including acceleration of flowering time, indicating that SWC4 controls post-embryonic processes. Transcriptomic analyses and genome-wide profiling of H2A.Z indicate that SWC4 represses tran- scription of a number of genes, including the floral integrator FT and key transcription factors, mainly by modulating H2A.Z deposition. Interestingly, SWC4 silencing does not affect H2A.Z deposition at the FLC locus nor expression of this gene, a master regulator of flowering previously shown to be controlled by SWR1-C. Importantly, we find that SWC4 recognizes specific AT-rich DNA elements in the chromatin regions of target genes and that SWC4 silencing impairs SWRI-C binding at FT. Collectively, our data suggest that SWC4 regulates plant growth and development by aiding SWR1-C recruitment and modulating H2A.Z deposition.

关键词： Arabidopsis SWC4 chromatin SWR1 complex H2A.Z deposition flowering time

Different strategies of treatment for uterine cervical carcinoma stage ⅠB2-ⅡB

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World journal of Clinical Oncology 2014年第2期5卷 86-92页

作者： Lucas Minig María Guadalupe Patrono Nuria romero juan Francisco Rodríguez Moreno jesús Garcia-Donas Gynecologic Oncology Program Clara Campal Comprehensive Cancer CenterHM Hospitales28050 Madrid Spain Gynecologic Oncology Program Medical Oncology Department Clara Campal Comprehensive Cancer Center HM Hospitales28050 Madrid Spain

Uterine cervical cancer is the second most common gynecological malignancy. It is estimated that over 35% of tumors are diagnosed at locally advanced disease, stage ⅠB2-ⅡB with an estimated 5-year overall survival of 60%. During the last decades, the initial treatment for these women has been debated and largely varies through different countries. Thus, radical concurrent chemoradiation is the standard of care in United Sated and Canada, and neoadjuvant chemotherapy followed by radical surgery is the first line of treatment in some institutions of Europe, Asia and Latin America. Until today, there is no evidence of which strategy is better over the other. This article describe the evidence as well as the advantages and disadvantages of the main strategies of treatment for women affected by uterine cervical cancer stage ⅠB2-ⅡB.

关键词： Locally advanced cervical cancer Federation of Gynecology and Obstetrics stage ⅠB2-ⅡB Radiotherapy Neoajuvant chemotherapy Radical hysterectomy

Solvent Property Induced Morphological Changes of ABA Amphiphilic Triblock Copolymer Micelles in Dilute Solution: A Self-consistent Field Simulation Study

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Chinese journal of Polymer Science 2014年第12期32卷 1704-1713页

作者： juan-juan Fan Yuan-yuan Han 崔杰 College of Information Technology Jilin Agricultural University State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

The morphological changes of ABA amphiphilic triblock copolymer micelles in dilute solution were systematically studied by tuning the solvent property using self-consistent field simulation. The solvent property was tuned by changing the Flory-Huggins interaction parameters between each type of blocks and solvent, respectively. The simulation results show that by changing the solvent properties, a series of micelle morphologies such as vesicle, cage-like, ring-shaped, rod-like and spherical micelle morphologies can be obtained. Variations of the free energy of the solution system and the surface area of micelles with the Flory-Huggins interaction parameters were calculated to better understand the effect of solvent property on micelle morphologies. In addition, a phase diagram showing the morphological changes of micelles with the Flory-Huggins interaction parameters is provided.

关键词： Solvent property Triblock copolymer Self-consistent field Simulation.

New open clusters found by manual mining of data based on Gaia DR2

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Research in Astronomy and Astrophysics 2021年第5期21卷 147-154页

作者： juan Casado Facultad de Ciencias Universidad Autnoma de Barcelona08193BellaterraCataloniaSpain

The physical nature of a series of 20 new open clusters is confirmed employing existing data on putative star members,mainly from the second Gaia Data Release(DR2).The clusters were discovered as overdensities of stars by visual inspection of either photographic DSS plates or proper motion plots of random source *** reported objects are not present in the most comprehensive or recent catalogs of stellar clusters and *** all of them,clumps of comoving stars are revealed in the proper motion *** parallaxes of the clumped stars are compatible with the real existence of open clusters over narrow ranges of *** density calculations,free of most noise from non-member sources,allow differentiating a cluster core and an extended cluster corona in some ***-magnitude diagrams generally show a definite main sequence that allows confirmation of the physical existence of the clusters and some of their *** of the new clusters seem to form a double system with a common *** of the new clusters challenge the claim of near completeness of the known OC population in the distance range from 1.0 to 1.8 kpc from the Sun(Kharchenko et al.).

关键词： astronomical databases:miscellaneous parallaxes proper motions(stars:)Hertzsprung-Russell CCM diagrams(Galaxy:)open clusters associations:individual