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Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

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journal of Animal Science and Biotechnology 2020年第2期11卷 453-467页

作者： Ahmed Elolimy Abdulrahman Alharthi Mohamed Zeineldin Claudia Parys juan j.loor Mammalian NutriPhysioGenomics Department of Animal SciencesUniversity of IllinoisUrbanaILUSA Department of Animal Sciences University of IllinoisUrbanaILUSA Department of Animal Production National Research CentreDokkiGizaEgypt Carl R.Woese Institute for Genomic Biology University of IllinoisUrbanaIllinoisUSA Department of Animal Medicine College of Veterinary MedicineBenha UniversityBenhaEgypt Evonik Nutrition&Care GmbH Hanau-WolfgangGermany Division of Nutritional Sciences Illinois Informatics InstituteUniversity of IllinoisUrbanaILUSA

Background:Recent studies underscored that divergence in residual feed intake(RFI)in mature beef and dairy cattle is associated with changes in ruminal microbiome and metabolome profiles which may contribute,at least in part,to better feed *** the rumen in neonatal calves during the preweaning period is underdeveloped until close to weaning,they rely on hindgut microbial fermentation to breakdown undigested diet *** leads to production of key metabolites such as volatile fatty acids(VFA),amino acids,and vitamins that could potentially be absorbed in the hind-gut and help drive growth and *** RFI divergence in neonatal calves is associated with changes in hindgut microbial communities and metabolites is largely ***,the objective of the current study was to determine differences in hindgut microbiome and metabolome in neonatal Holstein heifer calves retrospectively-grouped based on feed efficiency as mostefficient(M-eff)or least-efficient(L-eff)calves using RFI divergence during the preweaning ***:Twenty-six Holstein heifer calves received 3.8 L of first-milking colostrum from their respective dams within 6 h after *** were housed in individual outdoor hutches bedded with straw,fed twice daily with a milk replacer,and had ad libitum access to a starter grain mix from birth to weaning at 42 d of *** were classified into M-eff[n=13;RFI coefficient=−5.72±0.94 kg DMI(milk replacer+starter grain)/d]and L-eff[n=13;RFI coefficient=5.61±0.94 kg DMI(milk replacer+starter grain)/d]based on a linear regression model including the combined starter grain mix and milk replacer DMI,average daily gain(ADG),and metabolic body weight(MBW).A deep sterile rectal swab exposed only to the rectum was collected immediately at birth before colostrum feeding(i.e.,d 0),and fecal samples at d 14,28,and 42(prior to weaning)for microbiome and untargeted metabolome analyses using 16S rRNA gene sequencing and LC-MS.M

关键词： Feed efficiency Gut Metabolomics Microbiota Neonates Newborn Preweaning RFI

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Body condition score prior to parturition is associated with plasma and adipose tissue biomarkers of lipid metabolism and inflammation in Holstein cows

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journal of Animal Science and Biotechnology 2018年第2期9卷 439-450页

作者： Abdulrahman Alharthi Zheng Zhou Vincenzo Lopreiato Erminio Trevisi juan j.loor Mammalian Nutri Physio Genomics Department of Animal Sciences and Division of Nutritional Sciences University of Illinois Animal and Veterinary Sciences Clemson University 146 Poole Agricultural Center Department of Health Science Interdepartmental Services Centre of Veterinary for Human and Animal Health Magna Gr?cia University of Catanzaro Institute of Zootechnics Faculty of Agriculture Food and Environmental Science Università Cattolica del S.Cuore

Background: Previous research has revealed a strong inflammatory response within adipose(AT) tissue during the transition into lactation. Whether this effect is a result of oxidative stress induced by lipolysis and fatty acid oxidation associated with differences in prepartum body condition score remains to be determined. The objectives of this study were to investigate systemic biomarkers of energy balance and inflammation and the expression of lipid metabolismand inflammation-related genes in AT during the transition period in dairy ***: Twenty multiparous Holstein cows were retrospectively divided by body condition score(BCS) prior to parturition into two groups(10 cows/group): BCS ≤ 3.25(Lo BCS) and BCS ≥ 3.75(Hi BCS). Subcutaneous adipose tissue was biopsied from the tail-head region at d-10, 7 and 20 relative to parturition. Plasma was used to evaluate biomarkers of energy balance(EBAL) [free fatty acids(NEFA), glycerol, insulin] and inflammation [IL-1β, haptoglobin, myeloperoxidase, and reactive oxygen metabolites(ROM)]. Although insulin concentration was not affected by BCS, NEFA was overal greater and glycerol lower in HiB CS cows. Greater activity of myeloperoxidase in plasma coincided with increased haptoglobin and IL-1β postpartum in LoB CS *** genes related with oxidative stress, the expression of the cytosolic antioxidant enzyme SOD1 was greater in LoB CS compared to HiB CS. Cows in LoB CS compared with HiB CS had greater overal expression of ABDH5 and ATGL along with ADIPOQ, indicating enhanced basal lipolysis and secretion of adiponectin. Expression of CPT1 A, ACADVL, and ACOX1 was greater overal in HiB CS than LoB CS indicating enhanced NEFA oxidation. Although the temporal increase in plasma NEFA regardless of BCS coincided with the profile of CPT1 A, the gradual decrease in genes related with reesterification of NEFA(PCK1) and glycerol efflux(AQP7) coupled with an increase in glycerol kinase(GK) suggested some stimulation of NEFA u

关键词： Body condition score Lipid mobilization Transition cow

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Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows

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journal of Animal Science and Biotechnology 2017年第3期8卷 660-669页

作者： Alea Agrawal Abdulrahman Alharthi Mario Vailati-Riboni Zheng Zhou juan j.loor Mammalian NutriPhysioGenomics Department of Animal Sciences and Division of Nutritional SciencesUniversity of illinois1207 West Gregory DriveUrbanaIL 61801USA

Background： G-protein coupled receptors（GPCR）, also referred as Free Fatty Acid Receptors（FFAR）, are widely studied within human medicine as drug targets for metabolic disorders. To combat metabolic disorders prevalent in dairy cows during the transition period, which co-occur with negative energy balance and changes to lipid and glucose metabolism, it may be helpful to identify locations and roles of FFAR and other members of the GPCR family in bovine ***： Quantitative RT-PCR（qPCR） of subcutaneous adipose, liver, and PMNL samples during the transition period（-10, ＋7, and ＋20 or ＋30 d） were used for expression profiling of medium-（MCFA） and long-chain fatty acid（LCFA）receptors GPR120 and GPR40, MCFA receptor GPR84, and niacin receptor HCAR2/3. Adipose samples were obtained from cows with either high（HI; BCS ≥ 3.75） or low（LO; BCS ≤ 3.25） body condition score（BCS） to examine whether FFAR expression is correlated with this indicator of health and body reserves. Supplementation of rumen-protected methionine（MET）, which may improve immune function and production postpartum, was also compared with unsupplemented control（CON） cows for liver and blood polymorphonuclear leukocytes（PMNL） samples. In adipose tissue, GPR84 and GPR120 were differentially expressed over time, while GPR40 was not expressed; in PMNL, GPR40 was differentially expressed over time and between MET vs. CON, GPR84 expression differed only between dietary groups, and GPR120 was not expressed; in liver, GPCR were either not expressed or barely ***： The data indicate that there is likely not a direct role in liver for the selected GPCR during the transition period, but they do play variable roles in adipose and PMN. In future, these receptors may prove useful targets and/or markers for peripartal metabolism and immunity.

关键词： Inflammation Methionine Neutrophils Transition cow

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Essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells

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journal of Animal Science and Biotechnology 2016年第4期7卷 612-622页

作者： Shanshan Li Afshin Hosseini Marina Danes Carolina jacometo jianxin Liu juan j.loor Institute of Dairy Science College of Animal SciencesZhejiang University Department of Animal Sciences Mammalian Nutri Physio GenomicsUniversity of Illinois Department of Animal Science University of Lavras NUPEEC Departamento de Clínicas VeterináriaPrograma de Pós-Gradua??o em BiotecnologiaUniversidade Federal de Pelotas

Background： The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA （miRNA） in bovine mammary epithelial cells. Results： Triplicate cultures with the respective ＂optimal＂ amino acid （AA） ratio （OPAA = Lys：Met 2.9：1; Thr：Phe 1.05：1; Lys：Thr 1.8：1; Lys：His 2.38：1; Lys：Val 1.23：1） plus rapamycin （OPAARMC; positive control）, OPAA, Lys：Thr 2.1：1 （LT2.1）, Lys：Thr 1.3：1 （LT1.3）, Lys：His 3.05：1 （LH3.0）, or Lys：Val 1.62：1 （LV1.6） were incubated in lactogenic medium for 12 h. The expression of 15 lipogenic genes and 7 miRNA were evaluated. Responses to LT2.1, LT1.3, LH3.0, and LV1.6 relative to the control （OPAARMC） included up-regulated expression ofACSS2, FABP3, ACACA, FASN, SCD, LPIN1, INSIG1, SREBF1, PPARD, and NR1H3 （commonly known as LXR-a）. Furthermore, LV1.6 up-regulated expression of ACSL1, DGAT1, and RXRA and down-regulated PPARG expression. Although no effect of OPAA on expression of PPARG was observed, compared with the control, OPAA up-regulated expression of the PPAR targets ACSS2, FABP3, ACACA, FASN, SCD, LPIN1, INSIG1, and SREBF1. Compared with the control, the expression of the anti-lipogenic MIR27AB was down-regulated by OPAA, LT2.1, LT1.3 and LH3.0. In contrast, compared with the control, the expression of the pro-lipogenic MIR21 was up-regulated by LT2.1, LT1.3, LH3.0, and LV1.6. Conclusions： The observed up-regulation of lipogenic gene networks and the changes in expression of key miRNA involved in the control of lipogenic balance are indicative of a potentially important role of EAA ratios and mTOR signaling in the regulation of milk fat synthesis.

关键词： Amino acids Milk fat synthesis mTOR Nutrigenomics

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Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells

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Animal Nutrition 2019年第2期5卷 202-208页

作者： Einar Vargas-Bello-Pérez juan j.loor Philip C Garnsworthy The University of Nottingham Sutton Bonington Campus Department of Veterinary and Animal Sciences Faculty of Health and Medical SciencesUniversity of Copenhagen Department of Animal Sciences and Division of Nutritional Sciences University of Illinois1207 West Gregory DriveUrbana

The objective of this study was to determine how cytosolic triacylglycerols(TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids(FA). This objective was accomplished by addition of different FA to a FA-free medium used to culture mammary alveolar cells-large T antigen cells(MAC-T). Treatments consisted of adding FA(palmitate, stearate, oleate, linoleate,rumenic acid [CLA], elaidate and vaccinate) solutions to the medium at 100, 200, 300 and 400 mmol/L concentrations for a 24-h incubation period. At the end of each incubation period, cytosolic TAG, DNA and protein contents were measured. Palmitate, vaccenate, linoleate and CLA increased(P justed for DNA content. Overall, effects on cytosolic TAG accumulation depended on individual FA structure(chain length, degree of saturation, and number and orientation of FA double bonds). In addition, the long-chain FA used in this study did not have a detrimental effect on MAC-T cells as indicated by cytosolic protein and DNA contents reflecting their biological role in lipid accumulation.

关键词： Long chain fatty acid Mammary cells Trans fatty acid Triacylglycerol accumulation Vaccenic acid

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Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows

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journal of Animal Science and Biotechnology 2017年第3期8卷 624-635页

作者： Mario Vailati-Riboni johan S.Osorio Erminio Trevisi Daniel Luchini juan j.loor Mammalian Nutri Physio Genomics Department of Animal Sciences and Division of Nutritional SciencesUniversity of IllinoisUrbanaIL 61801USA Istituto di Zootecnica Facolt àdi Scienze Agrarie Alimentari e AmbientaliUniversità Cattolica del Sacro Cuore29122 PiacenzaItaly Adisseo NA AlpharettaGA 30022USA. Dairy and Food Science Department South Dakota State University1111 College Ave113H Alfred DairyScience HallBrookings SD 57007USA

Background： Feeding higher-energy prepartum is a common practice in the dairy industry. However, recent data underscore how it could reduce performance, deepen negative energy balance, and augment inflammation and oxidative stress in fresh cows. We tested the effectiveness of rumen-protected methionine in preventing the negative effect of feeding a higher-energy prepartum. Multiparous Holstein cows were fed a control lower-energy diet（CON, 1.24 Mcal/kg DM; high-straw） during the whole dry period（-50 d）, or were switched to a higher-energy（OVE, 1.54 Mcal/kg DM）, or OVE plus Smartamine M（OVE ＋ SM; Adisseo NA） during the last 21 d before *** cows received the same lactation diet（1.75 Mcal/kg DM）. Smartamine M was top-dressed on the OVE diet（0.07% of DM） from -21 through 30 d in milk（DIM）. Liver samples were obtained via percutaneous biopsy at -10, 7 and 21 DIM. Expression of genes associated with energy and lipid metabolism, hepatokines, methionine cycle, antioxidant capacity and inflammation was ***： Postpartal dry matter intake, milk yield, and energy-corrected milk were higher in CON and OVE ＋ SM compared with OVE. Furthermore, milk protein and fat percentages were greater in OVE ＋ SM compared with CON and OVE. Expression of the gluconeogenic gene PCK1 and the lipid-metabolism transcription regulator PPARA was again greater with CON and OVE ＋ SM compared with OVE. Expression of the lipoprotein synthesis enzyme MTTP was lower in OVE ＋ SM than CON or OVE. Similarly, the hepatokine FGF21, which correlates with severity of negative energy balance, was increased postpartum only in OVE compared to the other two groups. These results indicate greater liver metabolism and functions to support a greater production in OVE ＋ SM. At 7 DIM, the enzyme GSR involved in the synthesis of glutathione tended to be upregulated in OVE than CON-fed cows, suggesting a greater antioxidant demand in overfed cows. Feeding OVE ＋ SM resulted in lower similar express

关键词： Energy Methionine Nutrigenomics Transition period

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Dietary N-carbamylglutamate or L-arginine improves fetal intestinal amino acid profiles during intrauterine growth restriction in undernourished ewes

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Animal Nutrition 2022年第1期8卷 341-349页

作者： Hao Zhang Xiaoyun Liu Yi Zheng Ying Zhang juan j.loor Hongrong Wang Mengzhi Wang State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation ScienceShihezi 832000China Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China Department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA

Our previous studies demonstrated that prenatal in utero growth restriction impairs postnatal intestinal ***,improving postpartal intestinal absorption capacity and growth by manipulating the maternal diet prepartum is of *** work was conducted to determine whether supplementation of N-carbamylglutamate(NCG)or rumen-protected L-arginine(RP-Arg)increased fetal intestinal amino acid(AA)profiles in intrauterine growth retardation(IUGR)*** d 35 of gestation,Hu ewes(n=32)carrying twin fetuses were randomized into 4 groups(8 ewes and 16 fetuses in each group),where diets were as follows:100%of nutrient requirements recommended by National Research Council(NRC,2007)(CON);50%of nutrient requirements recommended by NRC(2007)(RES);RES+RPArg(20 g/d),(RES+ARG);and RES+NCG(5 g/d),(RES+NCG).On d 110 of gestation,both fetal and maternal tissues were collected and *** with RES,solute carrier family 1,member 5(SLC1A5)was upregulated(Pjejunum,duodenum and ileum when supplementing NCG and *** to RES,RP-Arg or NCG supplementation to RES resulted in upregulation(P<0.05)of peptide transporter 1 protein abundance within the fetal *** or RP-Arg supplementation to RES also upregulated phosphorylated mechanistic target of rapamycin(pmTOR)-to-mTOR ratio in the fetal ileum induced by IUGR(P<0.05).As a result,during IUGR,supplementation of Arg or NCG affected intestinal AA profiles in the fetus in part through controlling mTOR signal transduction as well as AA and peptide *** studies should be conducted to understand the role(if any)of the placenta on the improvement of growth and AA profiles independent of the fetal *** would help demonstrate the relative contribution of intestinal uptake in fetal life.

关键词： Intrauterine growth restriction L-arginine Fetal sheep N-carbamylglutamate Intestinal amino acids

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Association of residual feed intake with abundance of ruminal bacteria and biopolymer hydrolyzing enzyme activities during the peripartal period and early lactation in Holstein dairy cows

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journal of Animal Science and Biotechnology 2018年第3期9卷 717-726页

作者： Ahmed A.Elolimy josé M.Arroyo FernANDa Batistel Michael A.Iakiviak juan j.loor Mammalian Nutri Physio Genomics Department of Animal SciencesUniversity of Illinois Department of Animal Sciences University of Illinois Departamento de Nutrición Animal Instituto de Producción Animal Facultad de Veterinaria Universidad de la Republica Division of Nutritional Sciences Illinois Informatics Institute University of Illinois

Background: Residual feed intake(RFI) in dairy cattle typically calculated at peak lactation is a measure of feed efficiency independent of milk production level. The objective of this study was to evaluate differences in ruminal bacteria, biopolymer hydrolyzing enzyme activities, and overall performance between the most-and the leastefficient dairy cows during the peripartal period. Twenty multiparous Holstein dairy cows with daily ad libitum access to a total mixed ration from d-10 to d 60 relative to the calving date were used. Cows were classified into most-efficient(i.e. with low RFI, n = 10) and least-efficient(i.e. with high RFI, n = 10) based on a linear regression model involving dry matter intake(DMI), fat-corrected milk(FCM), changes in body weight(BW), and metabolic ***: The most-efficient cows had ~ 2.6 kg/d lower DMI at wk 4, 6, 7, and 8 compared with the least-efficient cows. In addition, the most-efficient cows had greater relative abundance of total ruminal bacterial community during the peripartal period. Compared with the least-efficient cows, the most-efficient cows had 4-fold greater relative abundance of Succinivibrio dextrinosolvens at d-10 and d 10 around parturition and tended to have greater abundance of Fibrobacter succinogenes and Megaspheara elsdenii. In contrast, the relative abundance of Butyrivibrio proteoclasticus and Streptococcus bovis was lower and Succinimonas amylolytica and Prevotella bryantii tended to be lower in the most-efficient cows around calving. During the peripartal period, the most-efficient cows had lower enzymatic activities of cellulase, amylase, and protease compared with the least-efficient ***: The results suggest that shifts in ruminal bacteria and digestive enzyme activities during the peripartal period could, at least in part, be part of the mechanism associated with better feed efficiency in dairy cows.

关键词： Dairy cows Enzyme activity Peripartal period RFI Rumen bacteria

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Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows

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journal of Animal Science and Biotechnology 2018年第1期9卷 145-155页

作者： Afshin Hosseini Mustafa Salman Zheng Zhou james K.Drackley Erminio Trevisi juan j.loor Department of Animal Sciences and Division of Nutritional Sciences University of Illinois Department of Animal Nutrition and Nutritional Diseases University of Ondokuz May?s Istituto di Zootecnica Facoltàdi Scienze Agrarie Alimentari ed AmbientaliUniversità Cattolica del Sacro Cuore

Background： The objective of the study was to evaluate the effect of overfeeding a moderate energy diet and a2,4-thiazolidinedione（TZD） injection on blood and hepatic tissue biomarkers of lipid metabolism, oxidative stress,and inflammation as it relates to insulin ***： Fourteen dry non-pregnant cows were fed a control（CON） diet to meet 100% of NRC requirements for3 wk, after which half of the cows were assigned to a moderate-energy diet（OVE） and half of the cows continued on CON for 6 wk. All cows received an intravenous injection of 4 mg TZD/kg of body weight（BW） daily from 2 wk after initiation of dietary treatments and for 2 additional week. Compared with CON cows and before TZD treatment, the OVE cows had lower concentration of total protein, urea and albumin over time. The concentration of cholesterol and tocopherol was greater after 2 wk of TZD regardless of diet. Before and after TZD, the OVE cows had greater concentrations of AST/GOT, while concentrations of paraoxonase, total protein, globulin, myeloperoxidase, and haptoglobin were lower compared with CON cows. Regardless of diet, TZD administration increased the concentration of ceruloplasmin, ROMt, cholesterol, tocopherol, total protein, globulin, myeloperoxidase and beta-carotene. In contrast,the concentration of haptoglobin decreased at the end of TZD injection regardless of diet. Prior to TZD injection, the mR NA expression of PC, ANGPTL4, FGF21, INSR, ACOX1, and PPARD in liver of OVE cows was lower compared with CON cows. In contrast, the expression of HMGCS2 was greater in OVE compared with CON cows. After 1 wk of TZD administration the expression of IRS1 decreased regardless of diet; whereas, expression of INSR increased after 2 wk of TZD injection. Cows fed OVE had lower overal expression of TNF, INSR, PC, ACOX1, FGF21, and PPARD but greater HMGCS2 expression. These differences were most evident before and after 1 wk of TZD injection, and by 2 wk of TZD differences in expression for

关键词： Inflammation Insulin sensitivity Nutrition PPAR

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Knockout of butyrophilin subfamily 1 member A1(BTN1A1) alters lipid droplet formation and phospholipid composition in bovine mammary epithelial cells

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journal of Animal Science and Biotechnology 2020年第4期11卷 975-985页

作者： Liqiang Han Menglu Zhang Zhiyang Xing Danielle N.Coleman Yusheng Liang juan j.loor Guoyu Yang College of Animal Science and Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002PR China Department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbanaIllinois 61801USA.

Background: Milk lipids originate from cytoplasmic lipid droplets(LD) that are synthesized and secreted from mammary epithelial cells by a unique membrane-envelopment process. Butyrophilin 1 A1(BTN1 A1) is one of the membrane proteins that surrounds LD, but its role in bovine mammary lipid droplet synthesis and secretion is not well ***: The objective was to knockout BTN1 A1 in bovine mammary epithelial cells(BMEC) via the CRISPR/Cas9 system and evaluate LD formation, abundance of lipogenic enzymes, and content of cell membrane phospholipid(PL) species. Average LD diameter was determined via Oil Red O staining, and profiling of cell membrane phospholipid species via liquid chromatography-tandem mass spectrometry(LC-MS/MS).Results: Lentivirus-mediated infection of the Cas9/sg RNA expression vector into BMEC resulted in production of a homozygous clone BTN1 A1^((-/-)). The LD size and content decreased following BTN1 A1 gene knockout. The m RNA abundance of fatty acid synthase(FASN) and peroxisome proliferator-activated receptor-gamma(PPARG) was downregulated in the BTN1 A1^((-/-))clone. Subcellular analyses indicated that BTN1 A1 and LD were co-localized in the cytoplasm. BTN1 A1 gene knockout increased the percentage of phosphatidylethanolamine(PE) and decreased phosphatidylcholine(PC), which resulted in a lower PC/PE ***: Results suggest that BTN1 A1 plays an important role in regulating LD synthesis via a mechanism involving membrane phospholipid composition.

关键词： Lipid droplet Mammary epithelial cell Milk fat globule Phospholipid

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