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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi yu ZHANG Zi yu LI Xin Xin LU Yao ZHANG Lu LIU Ru yu CHANG Min WU Shu ling gao yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

复杂协同攻击下一类非线性系统的分布式一致性滤波器设计

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控制与决策 2024年第1期39卷 189-195页

作者：高霞吴怀宇郑秀娟武汉科技大学机器人与智能系统研究院武汉430081 武汉科技大学冶金自动化与检测技术教育部工程研究中心武汉430081

针对复杂协同攻击下一类非线性系统的状态估计问题,提出一种分布式一致性递推滤波算法.首先,将拒绝服务攻击(denial of service, DoS)和虚假数据注入攻击(false data injection, FDI)现象描述为两个随机Bernoulli序列,并利用统一的框架... 详细信息

针对复杂协同攻击下一类非线性系统的状态估计问题,提出一种分布式一致性递推滤波算法.首先,将拒绝服务攻击(denial of service, DoS)和虚假数据注入攻击(false data injection, FDI)现象描述为两个随机Bernoulli序列,并利用统一的框架建立包含DoS和FDI的复杂协同攻击模型;然后,基于一致性理论设计具有分布式结构的递推滤波器,计算最优滤波器增益,并推导该滤波器估计误差满足均方有界的充分必要条件;最后,利用室内机器人的定位问题进行验证,仿真结果验证了所提出滤波器算法的有效性.

关键词：一致性滤波器状态估计 FDI攻击 DoS攻击室内机器人定位

Simultaneous guidance of electromagnetic and elastic waves via glide symmetry phoxonic crystal waveguides

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Chinese Physics B 2024年第3期33卷 363-368页

作者：雷林霖何灵娟廖清华刘文兴于天宝 School of Physics and Materials Science Nanchang UniversityNanchang 330031China

A phoxonic crystal waveguide with the glide symmetry is designed,in which both electromagnetic and elastic waves can propagate along the glide plane at the same *** to the glide symmetry,the bands of the phoxonic crystal super-cell degenerate in pairs at the boundary of the Brillouin *** is the so-called band-sticking effect and it causes the appearance of gapless *** adjusting the magnitude of the glide dislocation the edge bandgaps,the bandgap of the guided-modes at the boundary of the Brillouin zone,can be further *** photonic and phononic guided-modes can then possess only one mode for a certain frequency with relatively low group velocities,achieving single-mode guided-bands with relatively flat dispersion *** addition,there exists acousto-optic interaction in the cavity constructed by the glide *** proposed waveguide has potential applications in the design of novel optomechanical devices.

关键词： phoxonic crystals glide symmetry waveguide acousto-optic interaction

Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations

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Stroke & Vascular Neurology 2024年第4期9卷 439-445页

作者： An Tian Ziwei Cui Jian Ren Yeqing Ren Ming Ye Guilin Li Chuan He Xiaoyu Li gao Zeng Peng Hu Yongjie Ma Jiaxing yu Jingwei Li Lisong Bian Fan Yang Qianwen Li Feng ling Tao Hong Liyong Sun Hongqi Zhang Department of Neurosurgery Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurosurgery Beijing Haidian HospitalBeijingChina Department of Neurosurgery United Family HealthcareBeijingChina Department of Radiology Xuanwu Hospital Capital Medical UniversityBeijingChina

Background Surgical resection of the lesions remains the main treatment method for most symptomatic spinal cord cavernous malformations(SCCMs)to eliminate the occupation and associated subsequent lifelong haemorrhagic ***,the timing of surgical intervention remains controversial,especially for patients in the acute stage after severe *** Patients diagnosed with SCCMs who were surgically treated between January 2002 and December 2021 were selected and retrospectively *** Modified McCormick Scale(MMS)was used to evaluate neurological and disability *** medical information was reviewed,and all patients were followed up for at least 6 *** A total of 279 patients were ultimately *** regard to long-term outcomes,110(39.4%)patients improved,159(57.0%)remained unchanged and 10(3.6%)*** patients with an MMS score of 2–5 on admission,in univariate and multivariate analyses,a≤6 weeks period between onset and surgery(adjusted OR 3.211,95%CI 1.504 to 6.856,p=0.003)was a significant predictor of improved *** 69 patients who first presented with severe haemorrhage,undergoing surgery within 6 weeks of the onset of severe haemorrhage(adjusted OR 4.901,95%CI 1.126 to 21.325,p=0.034)was significantly associated with improvement of MMS *** Surgical timing can influence the long-term outcome of *** patients with symptomatic SCCMs,especially those with severe haemorrhage,early surgical intervention within 6 weeks can provide more benefit.

关键词： patients Surgical haemorrhagic

Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-Ming yu Yan Zhu Tao Jiang Ying gao Nan ling Na Wang John Shi Wei-Chun Pan Qi-Zhen Du Jun-Feng Yin Tea Research Institute Chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture College of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research Center， Agriculture and Agri-Food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN yu-ping WEI Hua FU yu ZHOU yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG yuan ZHU Sheng-ling LONG Jie-er gao Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

Two haplotype-resolved genome assemblies for AAB allotriploid bananas provide insights into banana subgenome asymmetric evolution and Fusarium wilt control

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Plant Communications 2024年第2期5卷 243-260页

作者： Wen-Zhao Xie yu-yu Zheng Weidi He Fangcheng Bi Yaoyao Li Tongxin Dou Run Zhou Yi-Xiong Guo Guiming Deng Wenhui Zhang Min-Hui yuan Pablo Sanz-Jimenez Xi-Tong Zhu Xin-Dong Xu Zu-Wen Zhou Zhi-Wei Zhou Jia-Wu Feng Siwen Liu Chunyu Li Qiaosong Yang Chunhua Hu Huijun gao Tao Dong Jiangbo Dang Qigao Guo Wenguo Cai Jianwei Zhang Ganjun Yi Jia-Ming Song Ou Sheng ling-ling Chen Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are one of the world’s most important fruit crops and play a vital role in food security for many developing *** banana cultivars are triploids derived from inter-and intraspecific hybrid-izations between the wild diploid ancestor species Musa acuminate(AA)and ***(BB).We report two haplotype-resolved genome assemblies of the representative AAB-cultivated types,Plantain and Silk,and precisely characterize ancestral contributions by examining ancestry mosaics across the *** asymmetric evolution is observed in their subgenomes,which can be linked to frequent homol-ogous exchange *** reveal the genetic makeup of triploid banana cultivars and verify that subge-nome B is a rich source of disease resistance *** 58.5%and 59.4%of Plantain and Silk genes,respectively,are present in all three haplotypes,with>50%of genes being differentially expressed alleles in different *** observed that the number of upregulated genes in Plantain is significantly higher than that in Silk at one-week post-inoculation with Fusarium wilt tropical race 4(Foc TR4),which con-firms that Plantain can initiate defense responses faster than ***,we compared genomic and transcriptomic differences among the genes related to carotenoid synthesis and starch metabolism between Plantain and *** study provides resources for better understanding the genomic architecture of culti-vated bananas and has important implications for Musa genetics and breeding.

关键词： bananas Plantain Silk asymmetric evolution homologous exchange Fusarium wilt

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红黏土裂隙湿化自愈行为及强度影响机制

中国公路学报 2024年第6期37卷 157-168页

作者：高乾丰吴昕阳曾铃余慧聪余涵长沙理工大学特殊环境道路工程湖南省重点实验室湖南长沙410114 长沙理工大学交通运输工程学院湖南长沙410114 长沙理工大学土木工程学院湖南长沙410114

许多黏性土在干缩开裂后受湿化作用会呈现裂隙自愈现象。为探究红黏土裂隙自愈行为及其对土体强度特性的影响机制,基于摄影识别与数字图像相关技术,分析湿化过程中红黏土试样顶面裂隙自愈与应变演化规律;并开展单轴拉伸试验与直剪试验,... 详细信息

许多黏性土在干缩开裂后受湿化作用会呈现裂隙自愈现象。为探究红黏土裂隙自愈行为及其对土体强度特性的影响机制,基于摄影识别与数字图像相关技术,分析湿化过程中红黏土试样顶面裂隙自愈与应变演化规律;并开展单轴拉伸试验与直剪试验,获取不同条件下红黏土的抗拉强度、抗剪强度及指标恢复率。最后采用扫描电镜观察裂隙自愈前后试样的微观形貌,阐明红黏土裂隙自愈及强度影响机制。结果表明:红黏土在湿化条件下表现出裂隙自愈行为,自愈过程中压应变区域不断向裂隙靠近,裂隙率快速减小并趋于稳定,裂隙自愈率可达90%以上;随饱水湿化时间增加,含裂隙红黏土的抗拉强度小幅提升,此时土表裂隙痕迹几乎消失;湿化条件下土颗粒膨胀程度有限,裂隙宽度越大其愈合难度越高,抗拉强度恢复程度也越低;裂隙深度增加后裂隙自愈率小幅提升,抗拉强度与黏聚力的恢复率增加,内摩擦角恢复率先减小后稳定;裂隙自愈主要源于土颗粒膨胀变形后引起裂隙两侧壁相互黏结,以及土颗粒崩解剥落后对裂隙的填充效应;由于细小颗粒与水混合后可能吸附在裂隙内形成假愈合现象,且土颗粒膨胀崩解将影响土体强度,故尽管表观上裂隙愈合程度良好,但抗拉强度与抗剪强度指标仅小幅恢复。

关键词：路基工程红黏土微观机制裂隙自愈强度特性

Efficacy and safety of Tianqi Pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson’s disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： yu Zhang Xiao-bo Zhu Yang Zhao Gui-yun Cui Wen-tao Li Can-xing yuan Jian-ping Huang Ying Wan Na Wu Lu Song Jia-hao Zhao Yan Liang Chuan-ying Xu Mei-juan Liu Chen gao Xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Parkinson’s Disease Center the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Neurology Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

Background Patients with Parkinson’s disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID).Amantadine is the main drug recommended for the treatment of LID by current guidelines,but it is far from meeting clinical *** Pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of *** This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***,setting,participants and interventions This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu,Zhejiang and Shanghai,*** hundred PD patients with≥0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 *** ensure unbiased results,all study participants,investigators and sponsors were unaware of group ***,the data analysts remained blinded until the analysis was *** outcome measures The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104).The key secondary end point was improvement of motor and non-motor *** analyses included all enrolled *** One hundred patients were enrolled and randomized into the two treatment *** changes in UDysRS at week 12 were–11.02 for the TPG group and–4.19 for the placebo group(treatment difference–6.83[–10.53 to–3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0%)in each of the *** This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Parkinson’s disease Tianqi Pingchan Granule Levodopa-induced dyskinesia