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MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine

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World Journal of Hepatology 2015年第11期7卷 1530-1540页

作者： Iván Lyra-gonzález Laura E Flores-Fong Ignacio gonzález-García David Medina-Preciado juan Armendáriz-Borunda Departamento de Biología Molecular y Genómica CUCS Universidad de Guadalajara Instituto de Biología Molecular en Medicina y Terapia Génica O.P.D. Hospital Civil de Guadalajara "Fray Antonio Alcalde" O.P.D. Hospital Civil de Guadalajara "juan I. Menchaca" Departamento de Biología Molecular y Genómica CUCS Universidad de Guadalajara

Hepatocellular carcinoma(HCC) is the leading primary liver cancer and its clinical outcome is still poor. MicroRNAs(mi RNAs) have demonstrated an interesting potential to regulate gene expression at post-transcriptional level. Current findings suggest that mi RNAs deregulation in cancer is caused by genetic and/or epigenetic, transcriptional and post-transcriptional modifications resulting in abnormal expression and hallmarks of malignant transformation: aberrant cell growth, cell death, differentiation, angiogenesis, invasion and metástasis. The important role of mi RNAs in the development and progression of HCC has increased the efforts to understand and develop mechanisms of control overt this single-stranded RNAs. Several studies have analyzed tumoral response to the regulation and control of deregulated mi RNAs with good results in vitro and in vivo, proving that targeting aberrant expression of mi RNAs is a powerful anticancer therapeutic. Identification of up and/or down regulated mi RNAs related to HCC has led to the discovery of new potential application for detection of their presence in the affected organism. Mi RNAs represent a relevant new target for diagnosis, prognosis and treatment in a wide variety of pathologic entities, including HCC. This manuscript intends to summarize current knowledge regarding mi RNAs and their role in HCC development.

关键词： Hepatocellular carcinoma MicroRNAs Regulation Therapeutic targets

Integration of Probabilistic and Multi-Hazard Risk Assessment Within Urban Development Planning and Emergency Preparedness and Response: Application to Manizales,Colombia

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International Journal of Disaster Risk Science 2017年第3期8卷 270-283页

作者： gabriel A.Bernal Mario A.Salgado-Gálvez Daniela Zuloaga Julián Tristancho Diana gonzález Omar-Darío Cardona INGENIAR Ltda Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) Universidad Distrital Francisco Joséde Caldas Instituto de Estudios Ambientales(IDEA) Universidad Nacional de Colombia Sede Manizales

The details of a multi-hazard and probabilistic risk assessment, developed for urban planning and emergency response activities in Manizales, Colombia, are presented in this article. This risk assessment effort was developed under the framework of an integral disaster risk management project whose goal was to connect risk reduction activities by using open access and state-of-theart risk models. A probabilistic approach was used for the analysis of seismic, landslide, and volcanic hazards to obtain stochastic event sets suitable for probabilistic loss estimation and to generate risk results in different metrics after aggregating in a rigorous way the losses associated to the different hazards. Detailed and high resolution exposure databases were used for the building stock and infrastructure of the city together with a set of vulnerability functions for each of the perils considered. The urban and territorial ordering plan of the city was updated for socioeconomic development and land use using the hazard and risk inputs and determinants, which cover not only the current urban area but also those adjacent areas where the expansion of Manizales is expected to occur. The emergency response capabilities of the city were improved by taking into account risk scenarios and after updating anautomatic and real-time post-earthquake damage assessment.

关键词： Emergency response Manizales (Colombia) Multi-hazard risk assessment Probabilistic hazard analysis Probabilistic risk assessment Urban planning

NO-ARBITRAGE SYMMETRIES

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Acta Mathematica Scientia 2022年第4期42卷 1373-1402页

作者： Iván DEGANO Sebastián FERRANDO Alfredo gonzález Departamento de Matemática.Facultad de Ciencias Exactas y Naturales Universidad Nacional de Mar del Plata 7600Argentina Department of Mathematics Ryerson University350 Victoria St.TorontoOntario M5B 2K3Canada

The no-arbitrage property is widely accepted to be a centerpiece of modern financial mathematics and could be considered to be a financial law applicable to a large class of(idealized) *** paper addresses the following basic question:can one characterize the class of transformations that leave the law of no-arbitrage invariant?We provide a geometric formalization of this question in a non probabilistic setting of discrete time-the so-called trajectorial *** paper then characterizes,in a local sense,the no-arbitrage symmetries and illustrates their meaning with a detailed *** context makes the result available to the stochastic setting as a special case.

关键词： No arbitrage symmetry convexity preserving maps non-probabilistic markets

Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 134-140页

作者： gabriel Alfonso Gutiérrez-Rebolledo Mariana Zuleima Pérez-gonzález Alejandro Zamilpa María Adelina Jiménez-Arellanes Unidad de Investigación Médica en Farmacología Hospital de EspecialidadesCentro Médico Nacional Siglo XXI(CMN-SXXI)Instituto Mexicano del Seguro Social(IMSS)Av.Cuauhtémoc 330Col.DoctoresDeleg.Cuauhtémoc06720 Ciudad de México(CDMX)Mexico Centro de Investigación Biomédica del Sur(CIBIS) IMSSArgentina No.1Col.Centro62790 XochitepecMorelosMexico

Objective:To identify the anti-inflammatory activity through two murine models and in the median Lethal Dose(LD_(50)) of three dietary supplements that contain Moussonia ***:The anti-inflammatory activity of three dietary supplements(Cicatrisan/Gastricus^(R),Gastinol^(R),and Gastrovita^(R)) EtOH extracts was evaluated by TPA and by carrageenan murine models;also,median Lethal Dose(LD_(50)) was *** was quantified by High-Performance Liquid Chromatography.β-sitosterol,stigmasterol and the mixture of ursolic and oleanolic acids were identified in all supplements by TLC;however,none of these dietary supplements contain ***:For the TPA model,Cicatrisan/Gastricus^(R)generated a notable effect with 38.24%*** in the carrageenan model,it also exhibited noteworthy anti-inflammatory activity of ear edema with 66.39%of paw edema inhibition at 150 mg/kg,followed by Gastinol^(R) and Gastrovita^(R) with 50%at 300 mg/***,LD_(50) was >2 g/kg for all supplements,when was administered intragastrically and Body Weight(BW) gain in mice was not altered after 14 ***:Of the three food supplements containing ***,only the EtOH extract from the Cicatrisan/Gastricus^(R)formulation(tablets) showed significant anti-inflammatory activity in both experimental models and the LD_(50) was > 2 g/kg.

关键词： Moussonia deppeana Food supplements Acute inflammation Mexican medicinal plants Herbal remedies Traditional medicine

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Hydrogen evolution reaction

Modernist heritage and memory politics in Spain:shifting values for the adaptive reuse of Seville’s former police headquarters

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Built Heritage 2023年第4期7卷 55-68页

作者： Plácido gonzález Martínez School of Architecture University of SevilleAvda.Reina Mercedes 241012SevilleSpain College of Architecture and Urban Planning Tongji University1239 Siping RoadShanghai200092China

The political significance of modernist heritage architecture continues to be an unsolved question,particularly its identification and *** Spain,the chronology of modernism stretches through the whole of the Spanish Civil War and Franco’s *** passing of legislation on memory politics in Spain(*** 2007 Law of Historical Memory and the 2022 Law of Democratic Memory)offers a unique opportunity to address this unsolved question by discussing two uncharted heritage debates:namely,the motivations for the heritagisation of modernist architecture in Spain and the challenges in the adaptive reuse of modernist buildings with controversial *** former police headquarters in Seville exemplifies the complexities of both debates and to what extent conflicting views about heritage architecture may determine debates about its *** a documentary review of the heritagisation of Seville’s former police headquarters,a discourse analysis of intervention proposals and press articles and interviews with relevant stakeholders,this study explored how the rise of memory politics in Spain has changed the interpretation of the former police headquarters’significance in the last two decades and influenced the choices for its adaptive reuse.

关键词： Heritagisation Modernism 20th century heritage Memory politics Dark heritage Adaptive reuse

Maschke Type Theorems for Weak Hopf Quasigroups

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Algebra Colloquium 2020年第2期27卷 213-230页

作者： J.N.Alonso Alvarez J.M.Fernández Vilaboa R.gonzález Rodríguez Departamento de Matematicas Vniversidade de Vigo Campus Universitario Lagoas-MarcosendeE-36280 VigoSpain Departamento de Matematicas Universidade de Santiago de Compostela E-15771 Santiago de CompostelaSpain Departamento de Matematica Aplicada II Universidade de Vigo Campus Universitario Lagoas-MarcosendeE-36310 VigoSpain

In this paper we give necessary and sufficient conditions for a comodule magma over a weak Hopf quasigroup to have a total integral,thus extending the theories developed in the Hopf algebra,weak Hopf algebra and non-associative Hopf algebra *** this result we also deduce a version of Maschke’s theorems for right(H,B)-Hopf triples associated to a weak Hopf quasigroup H and a right H-comodule magma B.

关键词： (weak)Hopf algebra (weak)Hopf quasigroup integral Maschke theorem

Tribological performance of tributylmethylammonium bis(trifluoromethylsulfonyl)amide as neat lubricant and as an additive in a polar oil

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Friction 2019年第3期7卷 282-288页

作者： Rubén gonzález Diego RAMOS David BLANCO Alfonso FERNáNDEZ-gonzález Jose L.VIESCA Mark HADFIELD Antolin HERNáNDEZ BATTEZ Department of Marine Science and Technology University of OviedoAsturias 33203Spain Department of Construction and Manufacturing Engineering University of OviedoAsturias 33203Spain Department of Physical and Analytical Chemistry University of OviedoAsturias 33006Spain Department of Design and Engineering Bournemouth UniversityPoole BH12 5BBUK

The ionic liquid(IL) tributylmethylammonium bis(trifluoromethylsulfonyl)amide([N4441][NTf2]) was used as neat lubricant and as an additive(1.5 wt%) in a polar oil to study its friction and wear reducing *** tests were completed for 90 minutes at room temperature and 100 °C in a reciprocating configuration at loads of 30 and 70 N,10 Hz-frequency,and 4 mm stroke *** volume was measured by confocal microscopy and the surface-IL interaction determined by *** main findings were that neat IL showed the best tribological behavior;the IL-containing mixture behaved similar to the base oil regarding friction,however outperformed the antiwear behavior of the base oil under higher temperature;surface-IL chemical interaction was found mainly at 100 °C.

关键词： ionic liquid additive friction wear polar oil

Deposition of carbon nanotubes onto glass fibers using ultrasound standing waves

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Frontiers of Materials Science 2021年第3期15卷 471-475页

作者： Julio Alejandro RODRÍGUEZ-gonzÁlez Carlos RUBIO-gonzÁlez Alfonso PÉREZ-SÁNCHEZ Centro de Ingeniería y Desarrollo Industrial Departamento de EnergíaAv.Pie de la Cuesta#702Col.Desarrollo San PabloC.P.76125QuerétaroQroMexico

Carbon nanotubes(CNTs)are special types of carbon nanostructures with exceptional physical and mechanical properties such as high elastic modulus,high electrical and thermal conductivities,as well as high surface area and large aspect ratios[1].Given their tubular structure and size,CNTs are conceptualized as one-dimensional nanostructures with a crystalline structure of carbon sp2 hybridization formed by carbon–carbon covalent bonds[1].

关键词： carbon fibers exceptional