检索结果-南通市图书馆

重建与转型:1884-1911年新疆城市发展刍议

在线全文

学校读者我要写书评

暂无评论

四川师范大学学报（社会科学版） 2014年第1期41卷 151-156页

作者：付娟四川大学历史文化学院成都610064 四川音乐学院人文社科学院成都610021

晚清西北边疆危机下,阿古柏等内乱使新疆城市损毁殆尽。戡乱后,清政府为保疆固边,从1884至1911年间采取了诸如新疆建省、新政改革等一系列政策措施,新疆城市获得了一个重要的"黄金"发展时期。特别值得关注的是,此次城市重建并非简单的... 详细信息

晚清西北边疆危机下,阿古柏等内乱使新疆城市损毁殆尽。戡乱后,清政府为保疆固边,从1884至1911年间采取了诸如新疆建省、新政改革等一系列政策措施,新疆城市获得了一个重要的"黄金"发展时期。特别值得关注的是,此次城市重建并非简单的封建传统城市建筑恢复,在整个中国城市近代化转型背景下,新疆城市重建不可避免地在城市自然结构和社会结构等方面都悄然发生着转型式变迁,尽管规模较小或不显著,但仍称得上是新疆城市近代化转型的基础和肇始,其意义不可忽视。

关键词：新疆城市重建转型

Research on the Novel Computer Network Intrusion Detection Model based on Improved Particle Swarm Optimization Algorithm

在线全文

学校读者我要写书评

暂无评论

International Journal of Technology Management 2016年第8期 72-75页

作者： juan fu Hai Hu Leping Wang Gongqing College Nanchang UniversityGongqing CityJiangxi332020China

In this paper, we conduct research on the novel computer network intrusion detection model based on improved particle swarmoptimization algorithm. TCP fl ood attack, UDP fl ood attack, ICMP fl ood attack, deformity of message attack, the application layer attack is themost typical DDOS attacks, DDOS attacks are also changing to upgrade at the same time, scholars research on DDOS attack defense measuresbecome more and more has the application value and basic practical signifi cance. Network security protection is a comprehensive project, nomatter what measures to take that safety is always relative, so as the network security administrator, should change with the network securitysituation and the security requirements, moderate to adjust security policies, so as to achieve the target. Under this basis, we propose the newperspective on the IDS system that will then enhance the robustness and safetiness of the overall network system.

关键词： Particle Swarm Optimization Intrusion Detection Algorithm Computer Network

THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP,and its upregulation participates in preeclampsia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2021年第3期8卷 353-363页

作者： fu-Mei Duan Li-juan fu Yong-Heng Wang Enoch Appiah Adu-Gyamfi Ling-Ling Ruan Zeng-Wei Xu Shi-Quan Xiao Xue-Mei Chen Ying-Xiong Wang Tai-Hang Liu Yu-Bin Ding School of Public Health and Management Chongqing Medical UniversityChongqing400016PR China Department of Bioinformatics The School of Basic MedicineChongqing Medical UniversityChongqing400016PR China The Joint International Research Laboratory of Reproduction and Development Ministry of EducationChongqing400016PR China Department of Herbal Medicine School of Traditional Chinese MedicineChongqing Medical UniversityChongqing400016PR China Department of Reproductive Medicine The Third Affiliated HospitalChongqing Medical UniversityChongqing401120PR China

Preeclampsia is a pregnancy complication which threatens the survival of mothers and *** originates from abnormal placentation,especially insufficient fusion of the cytotrophoblast cells to form the *** this study,we found that THBS1,a matricellular protein that mediates cell-to-cell and cell-to-matrix interactions,is downregulated during the fusion of primary cytotrophoblast and BeWo cells,but upregulated in the placenta of pregnancies complicated by ***,THBS1 was observed to interact with CD36,a membrane signal receptor and activator of the cAMP signaling pathway,to regulate the fusion of cytotrophoblast *** of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio,while the effects of THBS1 were abolished by a CD36-blocking *** results suggest that THBS1 signals through a CD36-mediated cAMP pathway to regulate syncytialization of the cytotrophoblast cells,and that its upregulation impairs placental formation to cause ***,THBS1 can serve as a therapeutic target regarding the mitigation of abnormal syncytialization and preeclampsia.

关键词： cAMP Cell fusion Preeclampsia THBS1 Trophoblast

Autophagy Attenuates MnCl2-induced Apoptosis in Human Bronchial Epithelial Cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2016年第7期29卷 494-504页

作者： YUAN Zhun YING Xian Ping ZHONG Wei Jian TIAN Shi Min WANG Yu JIA Yong Rui CHEN Wen fu juan Ling ZHAO Peng ZHOU Zong Can Department of Toxicology Peking University Health Science CenterBeijing 100191China Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety Peking University Health ScienceCenterBeijing 100191China Department of Toxicology Shanghai Municipal Center for Disease Control&PreventionShanghai 200336China Chinese Academy of Inspection and Quarantine Comprehensive Test Center Beijing 100123China Medical and Healthy Analytical Center Peking University Health Science CenterBeijing 100191China Department of Toxicology Faculty of Preventive MedicineSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080GuangdongChina

Objective To investigate the role of autophagy in MnC l2-induced apoptosis in human bronchial epithelial 16 HBE *** Cell proliferation was measured by MTT *** membrane potential（MMP） and apoptosis were measured by flow *** vacuoles were detected by fluorescence *** levels of apoptosis and autophagy-related proteins were measured by western *** 16 HBE cell proliferation was inhibited by Mn Cl2 in a dose-and time-dependent *** Cl2-induced 16 HBE cell growth inhibition was related to MMP depolarization prior to the induction of *** data revealed that Mn Cl2-induced apoptosis in 16 HBE cells was mediated by decreased expression of Bcl-2 and increased levels of cleaved *** was observed that when we exposed 16 HBE cells to MnCl2 in a dose-dependent manner,the formation of autophagic vacuoles and the levels of LC-3B-II were *** interference of LC3 B in these Mn Cl2-exposed cells demonstrated that MMP loss and apoptosis were ***,the pan-caspase inhibitor Z-VAD-FMK increased the cellular levels of Bcl-2 and decreased apoptosis,but did not affect the cellular levels of LC3 B in Mn Cl2-treated 16 HBE *** Mn Cl2 dose-and time-dependently inhibits 16 HBE cell proliferation and induces MMP loss and *** acts in a protective role against Mn Cl2-induced apoptosis in 16 HBE cells.

关键词： Manganese chloride Apoptosis Mitochondrial membrane potential Autophagy 16HBE cells

在线全文

学校读者我要写书评

暂无评论

论鸦片贸易合法化对中国近代禁烟的影响

四川师范大学学报（社会科学版） 2006年第6期33卷 132-135页

作者：付娟四川音乐学院社科部成都610021

在第二次鸦片战争后,中英签订“准许鸦片输入中国合法化”条约,不仅加剧了中国的土药泛滥,导致国内烟毒问题更加严重,还影响到清政府的禁烟政策,使本属中国内政的禁烟上升为需经外交协商的敏感问题。

关键词：鸦片贸易合法化禁烟影响

在线全文

学校读者我要写书评

暂无评论

我国居民消费的现实困境与提升策略

区域经济评论 2021年第4期 107-115页

作者：傅娟国家信息中心大数据发展部北京100045

在国内经济增长新旧动能转换和构建国内国际“双循环”新发展格局的关键时期,消费俨然成为拉动国内经济增长的第一大引擎。随着国内疫情防控取得明显成效,我国消费虽整体持续稳步向好,但在地域分布、消费模式、消费领域等方面却呈明显... 详细信息

在国内经济增长新旧动能转换和构建国内国际“双循环”新发展格局的关键时期,消费俨然成为拉动国内经济增长的第一大引擎。随着国内疫情防控取得明显成效,我国消费虽整体持续稳步向好,但在地域分布、消费模式、消费领域等方面却呈明显分化态势。面对居民消费能力不足、消费意愿下降和消费便利度低下的三大现实困境,应继续增强居民消费意愿,积极引导新型消费发展,促进消费结构优化升级,大力拓展城乡消费渠道,以增强居民消费对经济增长的拉动作用。

关键词：居民消费经济增长 “双循环”

Current asthma control predicts future risk of asthma exacerbation： a 12-month prospective cohort study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第17期125卷 2986-2993页

作者： WEI Hua-hua ZHOU Ting WANG Lan ZHANG Hong-ping fu juan-juan WANG Lei JI Yu-lin WANG Gang Department of Respiratory and Critical Care West China Hospital Sichuan University Chengdu Sichuan 610041 China Pneumology Group Department of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Respiratory and Sleep Medicine John Hunter Hospital Hunter Medical Research Institute Newcastle University NSW 2305 Australia

Background The performance of asthma control test （ACT） at baseline for predicting future risk of asthma exacerbation has not been previously demonstrated. This study was designed to explore the ability of the baseline ACT score to predict future risk of asthma exacerbation during a 12-month follow-up. Methods This post hoc analysis included data from a 12-month prospective cohort study in patients with asthma （n=290）. The time to the first asthma exacerbation was analyzed and the association between baseline ACT scores and future risk of asthma exacerbation was calculated as adjusted odds ratio （OR） using Logistic regression models. further, sensitivity and specificity were estimated at each cut-point of ACT scores for predicting asthma exacerbations. Results The subjects were divided into three groups, which were uncontrolled （U, n=128）, partly-controlled （PC, n=111）, and well controlled （C, n=51） asthma. After adjustment, the decreased ACT scores at baseline in the U and PC groups were associated with an increased probability of asthma exacerbations （OR 3.65 and OR 5.75, respectively）, unplanned visits （OR 8.03 and OR 8.21, respectively） and emergency visits （OR 20.00 and OR 22.60, respectively） over a 12-month follow-up period. The time to the first asthma exacerbation was shorter in the groups with U and PC asthma （all P 〈0.05）. The baseline ACT of 20 identified as the cut-point for screening the patients at high risk of asthma exacerbations had an increased sensitivity of over 90.0% but a lower specificity of about 30.0%. Conclusion Our findings indicate that the baseline ACT score with a high sensitivity could rule out patients at low risk of asthma exacerbations and predict future risk of asthma exacerbations in clinical practice.

关键词： asthma control test future risk asthma exacerbation

New High Efficiency LED Lighting Solution

在线全文

学校读者我要写书评

暂无评论

Semiconductor Photonics and Technology 2008年第3期14卷 213-216页

作者： DING Ke NIU Ping-juan fu Xian-song School of Information and Communication Engineering Tianjin Polytechnic University Tianjin 300160 CHN

As the quality of power LED improves and the cost of power LED reduces, semiconductor lighting will replace incandescent and fluorescent lighting gradually, causing another revolution on the lighting history. And its driving solution has been greatly accelerated. Based on the white power LED I-V characteristics and the application ambiance, proposed is a new LED lighting solution, suiting indoor and outdoor illumination. According to the test results, the design is optimized, and the electrical efficiency is 95% and the output current deviation is 13.0%.

关键词： LED lighting electrical efficiency output current deviation

Effects of nocturnal snacks on body composition in patients with liver cirrhosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第12期16卷 1458-1467页

作者： Yong-Bo Yu Xiu-juan fu Guo-Fen Xu Ling-Yun Niu Ruo-Nan Duan Jia Yao Ning-Hui Zhao Department of Neurology Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina Department of Gastroenterology Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina Department of Nutrition Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Patients with liver cirrhosis are universally malnourished and the nocturnal snacks intervention is the currently recommended nutritional intervention for patients with liver *** composition is an important indicator for the assessment of nutritional *** investigated the effects of nocturnal snacks(200 kcal/day)for 3 months on body composition in patients with liver *** patients with liver cirrhosis and 30 healthy controls were enrolled,and differences in body composition were detected using InBody 720,a body composition *** patients were further randomized into a normal diet group(three meals a day)and nocturnal snacks group(three meals a day+nocturnal snacks).The effect of nocturnal snacks on the body composition of patients with cirrhosis was assessed after 3 months of *** Body fat mass(BFM),skeletal muscle mass(SMM),fat free mass,visceral fat area(VFA),and body cell mass(BCM)were significantly lower in the liver cirrhosis patients than in the healthy *** 3 months’intervention,BFM,VFA and BCM were significantly higher in the nocturnal snacks group than in the normal diet group,with no significant differences in total caloric intake and daily ***,there was no significant difference in SMM between the nocturnal snacks and normal diet *** Long-term nocturnal snacks may improve body composition indices such as BFM,VFA and BCM in patients with ***,the improvement was minor for SMM.

关键词： Liver cirrhosis Malnutrition Nocturnal snacks Body composition Nutritional intervention