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Pharmacological strategies in extracorporeal membrane oxygenation weaning failure: a call to action

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Emergency and Critical Care Medicine 2023年第2期3卷 43-45页

作者： francisco J.González-Ruiz francisco M.Baranda-Tovar Luis A.Baeza-Herrera JoséD.Utrilla-Álvarez Ricardo E.Quirázco-Cordova Gustavo Rojas-Velasco Department of Cardiovascular Critical Care National Institute of Cardiology“Dr.Ignacio Chávez”Mexico CityMexico National Institute of Cardiology.juan Badiano 1 Belisario Dominguez Secc 16Tlalpan14080Mexico CityMexico

Extracorporeal membrane oxygenation has emerged as a viable alternative for stabilizing and improving critically ill patients in acute cardiovascular ***,the weaning stage has been associated with a high morbidity and mortality *** makes searching for strategies that reduce failure in this final process *** a new approach must be tried and included in our protocols,seeking the patient’s well-being at all *** this article,the authors discuss their point of view regarding potential pharmacological alternatives and the mechanism of action involved,which could decrease the mortality associated with this therapeutic.

关键词： β-Blockers Extracorporeal membrane oxygenation Inodilators Mechanical circulatory support Pharmacological strategies

Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

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World Journal of Stem Cells 2017年第2期9卷 26-36页

作者： Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil francisco J Bedoya juan R Tejedo Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide 41092 SevilleSpain Biomedical Research Network on Diabetes and Related Metabolic Diseases(CIBERDEM) Instituto de Salud CarlosⅢ28029 MadridSpain Andalusian Center for Molecular Biology and Regenerative Medicine(CABIMER) 41092 SevilleSpain Andalusian Center for Molecular Biology and Regenerative Medicine Fundación Progreso y Salud41092 SevilleSpain Centre for Pharmacology and Therapeutics Division of Experimental MedicineImperial College LondonHammersmith Hospital CampusLondon W12 0NNUnited Kingdom

Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies.

关键词： Endoplasmic reticulum stress Mitochondrial function Nitric oxide Pluripotency Cell differentiation Mitochondrial biogenesis

Fracture Mechanics on Aluminum Specimens

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World Journal of Mechanics 2021年第12期11卷 237-257页

作者： juan Jose Mejia Briseno francisco Casanova-del-Angel Tecnologico Nacional de Mexico Instituto Tecnol&#243 gico de Pachuca Pachuca Estado de Hidalgo Mexico Seccion de Estudios de Posgrado e Investigació n Escuela Superior de Ingenier&#237 a y Arquitectura Unit. Adolfo Lopez Mateos Instituto Polit&#233 cnico Nacional Ciudad de M&#233 xico Mexico

ASTM standards for A413 aluminum alloy specimen assays were used based on standard E399-05, with a minimum requirement of three specimens. Linear elastic fracture mechanic testing was carried out in plane strain conditions and fracture toughness of the tested aluminum, critical stress intensity factor was determined. Four specimens with the selected geometry were made, since in the pre-cracking process a non-acceptable propagation of crack may be present, i.e., the crack does not propagate in a parabolic manner. In like manner, the Type SE (B) specimen, that is, a beam subject to bending under a monotonic load, was used. Stress efforts were induced in the experiment, the load mode for such experiments is mode I, determining a temporary value of the KQ apparent stress intensity factor. When such value complies with the validity criteria of E-399 Standard, it becomes the stress intensity factor KIC of material.

关键词： Metallography A413 Aluminum Fracture Mechanics Stress Efforts Fractography

Design and Development of Impeller Synergic Systems of Electromagnetic Type to Levitation/Suspension Flight of Symmetrical Bodies

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Journal of Electromagnetic Analysis and Applications 2012年第1期4卷 42-52页

作者： francisco Bulnes juan Carlos Maya Isaías Martínez 不详

Using certain models of twistor surfaces for fields of force and the mathematical relationships that lie among fields, lines, surfaces and flows of energy, it has been designed and developed a flight electromagnetic type system based on the synergic study of their electromagnetic field geodesics to generate vehicle levitation, suspension and movement without being in contact with the surface. The idea of such work is to obtain a new flight and impulse patent of an electromagnetic vehicle by principles of super-conduction and some laws of the current like Eddy currents and principles which are very similar to mechanics of sidereal objects like galaxies or stars under models of twistor surfaces. This vehicle will be controlled by one microchip that will be programmed by conscience operators algebra of electromagnetic type that leads to the flow of Eddy currents, the iso-rotations and suspension of the special geometrical characteristics vehicle, generating also on the vehicle structure certain “magnetic conscience” that provokes all movements like succeeding to the sidereal objects in the universe.

关键词： Electromagnetic Levitation Twistor Surfaces of Impulse Symmetrical Space of Iso-Rotations Superconductive Quantum Algebra Magnetic Conscience Operators

Measuring frailty in patients with severe aortic stenosis:a comparison of the edmonton frail scale with modified fried frailty assessment in patients undergoing transcatheter aortic valve replacement

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Journal of Geriatric Cardiology 2020年第7期17卷 441-446页

作者： francisco J Romeo Maximiliano Smietniansky Mariela Cal Cristian Garmendia juan M Valle Raleigh Ignacio MSeropian Mariano Falconi Pablo Oberti Vadim Kotowicz Carla RAgatiello Daniel H Berroca Division of Interventional Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Internal Medicine and Geriatrics Hospital Italiano de Buenos AiresBuenos AiresArgentina Division Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Cardiovascular Surgery Hospital Italiano de Buenos AiresBuenos AiresArgentina

Frailty is generally defined as a clinical syndrome of decreased physiologic reserve which drives to increased vulnerability and susceptibility to different stressors together with poor recovery to homeostasis.[1]The relevance of frailty status in a wide range of prospective cohorts is mostly related to an increasing burden in both mortality,hospital readmissions,disability,and falls.

关键词： Aortic stenosis Frailty Transcatheter aortic valve replacement

Physical Activation of Elderly and the Decrease of Falling Risk

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Health 2014年第11期6卷 1116-1123页

作者： Martha ornelas Verónica Benavides juan F. Aguirre Gabriel Gastélum Judith M. Rodríguez-Villalobos Faculty of Physical Culture Sciences Autonomous University of Chihuahua Chihuahua México

A Physical Activation Program was designed and implemented with a particular emphasis in recovering of motor independence, and in an indirect manner;the increase of activities was carried out in a social context in such a way that it allowed isolated elderly to develop their ability to perform daily activities diminishing the burden on their caregivers. 30 people were randomly selected: 15 subjects in the experimental group and 15 in the control group;7 women and 8 men each group. Subjects aged between 60 - 84 years with a mean age of 78 years and a standard deviation of 6.5 were applied in a three-month Physical Activation Program with a 45-min daily sessions. Results obtained showed that physical activity in elderly, systematically improved their amplitude and joint mobility which impact directly and indirectly their quality of life, reducing their risk of falling.

关键词： Physical Activation Older Adult Risk of Falling Joint Mobility

Seasonal variation and chemical composition of particulate matter： A study by XPS, ICP-AES and sequential microanalysis using Raman with SEM/EDS

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Journal of Environmental Sciences 2018年第12期30卷 32-49页

作者： Lucy T.González francisco E.Longoria-Rodríguez Margarita Sánchez-Domínguez Cesar Leyva-Porras Karim Acuna-Askar Boris I.Kharissov Alejandro Arizpe-Zapata juan M.Alfaro-Barbosa Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Laboratorio de Química Analítica AmbientalCódigo Postal 64570MaonterreyN.L.Mexico Centro de Investigación en Materiales Avanzados SC Unidad MonterreyAlianza Notre 202 Código Postal 66628 Apodaca Nueuo León Mexico Centro de Investigación en Materiales Avanzados SC Miguel de Cervantes # 120 Código Postal 31109 Chihuahua Chih. Mexico Universidad Autónoma de Nuevo León Facultad de Medicina Laboratorio de Biorremediación AmbientalCódigo Postal 64460 MonterreyN.L. Mexico

During the winter period（January–March 2016）, the total suspended particles（TSP） and particulate matter smaller than 2.5 μm（PM2.5） were characterized by the application of various analytical techniques in four zones of the Metropolitan Area of Monterrey in Mexico. To evaluate the seasonal variation of some elements in the particulate matter, the results of this study were compared with those obtained during the summer season（July–September 2015）. The speciation of the C_（1s） signal by X-ray photoelectron spectroscopy revealed the contribution of aromatic and aliphatic hydrocarbons as the main components in both seasons. Conversely, carboxylic groups associated with biogenic emissions were detected only in winter. The percentages of SO_4^（2-） ions were lower in winter, possibly caused by the decrease in the solar radiation, and relative humidity recorded. The results of the ICP analysis revealed that Fe, Zn and Cu were the most abundant metals in both TSP and PM2.5 in the two seasons. There were significant seasonal variations for concentrations of As, Ni and Zn in the urban area and for Fe, As, Cd, Ni and Zn in the industrial zone. This was attributed to the greater burning of fuels as well as to an increase in vehicular traffic, the effect of thermal inversion and changes in some meteorological parameters. The results of the sequential microanalysis by Raman spectroscopy and SEM/EDS allowed observation of deposits of carbonaceous material on the particles and to perform the speciation of particles rich in Fe and Pb, which helped infer their possible emission sources.

关键词： Seasonal variation Total suspended particles PM2.5 X-ray photoelectron spectroscopy Micro-Raman spectroscopy

Hyalinizing clear cell carcinoma-a rare entity in the oral cavity: A case report

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World Journal of Clinical Cases 2020年第1期8卷 133-139页

作者： Alejandro Donohue-Cornejo Oslei Paes de Almeida Celeste Sánchez-Romero León francisco Espinosa-Cristóbal Simón Yobanny Reyes-López juan Carlos Cuevas-González Stomatology Department Biomedical Sciences InstituteAutonomous University of Ciudad JuárezChihuahua 32310México Diagnosis Department Oral Pathology SectionDentistry Faculty of PiracicabaState University of CampinasSão Paulo 13414-903Brazil

BACKGROUND Hyalinizing clear cell carcinoma(HCCC)is an uncommon tumor that originates in the salivary *** neoplasia constitutes less than 1%of minor salivary gland *** SUMMARY A 67-year-old female visited the maxillofacial surgery department owing to a smooth,slightly yellowish protruding mass on the left side of the floor of the mouth,at the level of the molars;the tumor mass had a soft consistency on palpation and did not adhere to deep *** microscopical analysis of the excisional biopsy showed that the lesion was composed of sheets and cords of clear cells separated by thick eosinophilic bands of hyaline *** glandular tissue was absent,periodic acid-Schiff with and without diastase stains,and immunohistochemical reactions were performed to confirm the *** is the second case reported in the literature of HCCC arising in the floor of the *** HCCC is a rare salivary gland tumor that has not been studied *** diagnosis is usually challenging,because clinically,it can be confused with a benign neoplasm.

关键词： Hyalinizing clear cell carcinoma Salivary gland tumor Immunohistochemical reactions Case report

Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 961-966页

作者： Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz juan francisco Loro Ferrer Alfonso Antón López Eurocanarias Oftalmológica Las Palmas de Gran Canaria 35004Spain Universidad de Las Palmas de Gran Canaria(ULPGC) Las Palmas de Gran Canaria 35001Spain Department of Research Hospital Universitario de Gran Canaria Doctor NegrínLas Palmas de Gran Canaria 35019Spain Universidad Internacional de Cataluna(UIC) Barcelona 08195Spain Institut Catalàde Retina(ICR) Barcelona 08017Spain Parc de salut Mar Barcelona 08024Spain

AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the ***: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were ***: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery.

关键词： femtosecond laser-assisted cataract surgery refractive lens exchange optical coherence tomography optic nerve head macula