检索结果-南通市图书馆

Genes & Diseases 2022年第6期9卷 1419-1422页

作者： francisco Gallardo-Chamizo Nieves Lara-Urena juan F.Correa-Vazquez Jose C.Reyes Benoit R.Gauthier Mario Garcia-Dominguez Cell Dynamics and Signaling Department CABIMERCSICUniversidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Genome Biology Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Cell Therapy and Regeneration Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabo´licas Asociadas(CIBERDEM) Madrid 28029Spain

To the Editor,Constricted oxygen and glucose supplies are common conditions that healthy cells following a stress such an ischemic insult as well as cancer cells within a solid tumor need to overcome in order to *** conditions are a serious challenge for cells,which accurately measure the impact to make a life or death *** cancer cells,aberrant gene expression and/or protein regulation,frequently linked to appearing mutations,may confer selective advantages to survive under these adverse *** the past years,cumulative evidence indicates that protein modification by covalent attachment of the Small Ubiquitin-like MOdifier(SUMO)plays a role in cell survival after oxygen and glucose deprivation(OGD).

关键词： cancer deprivation colon

Design and Development of Impeller Synergic Systems of Electromagnetic Type to Levitation/Suspension Flight of Symmetrical Bodies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Electromagnetic Analysis and Applications 2012年第1期4卷 42-52页

作者： francisco Bulnes juan Carlos Maya Isaías Martínez 不详

Using certain models of twistor surfaces for fields of force and the mathematical relationships that lie among fields, lines, surfaces and flows of energy, it has been designed and developed a flight electromagnetic type system based on the synergic study of their electromagnetic field geodesics to generate vehicle levitation, suspension and movement without being in contact with the surface. The idea of such work is to obtain a new flight and impulse patent of an electromagnetic vehicle by principles of super-conduction and some laws of the current like Eddy currents and principles which are very similar to mechanics of sidereal objects like galaxies or stars under models of twistor surfaces. This vehicle will be controlled by one microchip that will be programmed by conscience operators algebra of electromagnetic type that leads to the flow of Eddy currents, the iso-rotations and suspension of the special geometrical characteristics vehicle, generating also on the vehicle structure certain “magnetic conscience” that provokes all movements like succeeding to the sidereal objects in the universe.

关键词： Electromagnetic Levitation Twistor Surfaces of Impulse Symmetrical Space of Iso-Rotations Superconductive Quantum Algebra Magnetic Conscience Operators

A Comparative Analysis of Vessels Detained under the PSC Agreements of Paris, Tokyo and Vina del Mar

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Shipping and Ocean Engineering 2014年第11期4卷 291-306页

作者： francisco Piniella Emilio Rodriguez-Diaz juan Ignacio Alcaide Department of Maritime Studies University of C6diz Puerto Real E-11510 Spain

Twenty years ago, in 1992, the International Maritime Organization set the objective of extending the regional Port State Control agreements to the world scale. This would be achieved, it was hoped, by ＂exporting＂ the model of the Paris MoU （Memorandum of Understanding） agreement of 1982 to other regional areas. Now would seem to be a good time to consider the prospects for a future scenario where all the countries involved form a truly global network with uniform procedures. The authors of this article put forward an earlier objective that could be the beginning of that global policy, fi＇om a detailed look at the three most important regional agreements （Paris, Tokyo and Vifia del Mar） that encompass geographically the following areas, respectively： Europe plus Canada, the Asia-Pacific, and South America. To this end, we first make a theoretical comparison based on the legal standards of application, and then present a study made of all the vessels detained under the three agreements, with a view to determining whether or not there are different kinds of behaviours, with regard to the flags and ＂recognised organizations＂ used by the vessels to certify their levels of safety. The numerical variables we have taken as basic with respect to compliance with the international standards are： the date that the vessel＇s keel was laid （age of the vessel） and as significant categorical variables, the type of vessel, the flag, the typology of that flag, the corresponding classification society, and whether or not that society is a member of the IACS （International Association of Classification Societies）. The results show a similar trend between the Paris and Tokyo agreements, but in the case of Vifia del Mar, the level of efficacy in the control appears to be insufficient in comparison with the standard of the other two.

关键词： Port state control flags of convenience maritime safety globalization.

Outcomes of abdominal surgery in patients with liver cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第9期22卷 2657-2667页

作者： juan C Lopez-Delgado Josep Ballus francisco Esteve Nelson L Betancur-Zambrano Vicente Corral-Velez Rafael Manez Antoni J Betbese Joan A Roncal Casimiro Javierre Hospital Universitari de Bellvitge Intensive Care Department L'Hospitalet de Llobregat 08907 Barcelona Spain IDIBELL (Institut d'Investigacio Biomedica Bellvitge Biomedical Investigation Institute of Bellvitge) Research Team of Area of Innate Immunity and Pathology of the Critical Patient L'Hospitalet de Llobregat 08908 Barcelona Spain Hospital de la Santa Creu i Sant Pau Intensive Care Department 08041 Barcelona Spain Physiological Sciences II Department Universitat de Barcelona Campus Bellvitge 08907 Barcelona Spain

Patients suffering from liver cirrhosis(LC) frequently require non-hepatic abdominal surgery,even before liver *** is an important risk factor itself for surgery,due to the higher than average associated morbidity and *** high surgical risk occurs because of the pathophysiology of liver disease itself and to the presence of contributing factors,such as coagulopathy,poor nutritional status,adaptive immune dysfunction,cirrhotic cardiomyopathy,and renal and pulmonary dysfunction,which all lead to poor *** evaluation of these factors and the degree of liver disease can help to reduce the development of complications both during and after abdominal *** the emergency setting,with the presence of decompensated LC,alcoholic hepatitis,severe/advanced LC,and significant extrahepatic organ dysfunction conservative management is preferred.A multidisciplinary,individualized,and specialized approach can improve outcomes;preoperative optimization after risk stratification and careful management are mandatory before *** techniques can also improve *** review the impact of LC on surgical outcome in non-hepatic abdominal surgeries required in this cirrhotic population before,during,and after surgery.

关键词： Liver cirrhosis Outcomes Coagulopathy Nutritional status Abdominal surgery Adaptive immune dysfunction Cirrhotic cardiomyopathy

Capsule endoscopy in patients refusing conventional endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第23期20卷 7424-7433页

作者： Javier Romero-Vázquez Federico Argüelles-Arias Josefa Maria García-Montes ángel Caunedo-álvarez francisco Javier Pellicer-Bautista juan Manuel Herrerías-Gutiérrez Gastroenterology Service Virgen Macarena University Hospital41071 SevilleSpain

Capsule endoscopy is nowadays the diagnostic technique of choice in the study of small bowel pathologies,allowing the non-invasive study of the entire *** has led,together with new technical advances,to the creation of two new models(PillCam ESO and PillCam Colon)for the study of esophageal and colonic *** two new capsules offer an interesting alternative to conventional endoscopy in the study of the upper and lower digestive tracts,because traditional endoscopy is often unpleasant and uncomfortable for the patient,can be painful,often requires moderate or deep sedation and is not without complications(hemorrhage,perforation,etc.).PillCam Colon is particularly important for its usefulness in the diagnosis of colonic polyps,and is a potentially useful tool in cases of incomplete colonoscopy or in colorectal cancer screening,even more when most patients are reluctant to undergo screening programs due to the said disadvantages of conventional *** article discusses the advantages of capsule endoscopy over conventional endoscopy,its current application possibilities and indications in routine clinical *** the various sections of the work,we assess the application of endoscopic capsule in different sections of the digestive tract(esophagus,stomach,and colon)and finally the potential role of panendoscopy with PillCam Colon.

关键词： Conventional endoscopy Capsule endoscopy Esophageal capsule endoscopy Colon capsule endoscopy Panendoscopy

Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第9期12卷 1367-1372页

作者： francisco Eizayaga Camila Scorticati juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg juan C Perazzo Laboratory of Portal Hypertension Department of Pathophysiology School of Pharmacy and BiochemistryUniversity of Buenos AiresBuenos AiresArgentina Catedra de Farmacología School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina Laboratory of Portal Hypertension Department of Pathophysiology School of Pharmacy and Biochemistry University of Buenos Aires Buenos AiresArgentina

AIM： To study the blood-brain barrier integrity in prehepatic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 dafer ligation when portal pressure is spontaneously normalized. METHODS： Adult male Wistar rats were divided into four groups： Group Ⅰ： Sham14d, sham operated; Group Ⅱ： PHil, portal vein stenosis, （both groups were used 14 days after surgery）; Group Ⅲ： Sham4od, Sham operated and Group Ⅳ： PH4od Portal vein stenosis （Groups Ⅱ and Ⅳ used 40 d afer surgery）. Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS： Forty days afer stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION： The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility. Hemodynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment.

关键词： Blood-brain barrier Rats Prehepatic portal hypertension

Measuring frailty in patients with severe aortic stenosis:a comparison of the edmonton frail scale with modified fried frailty assessment in patients undergoing transcatheter aortic valve replacement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2020年第7期17卷 441-446页

作者： francisco J Romeo Maximiliano Smietniansky Mariela Cal Cristian Garmendia juan M Valle Raleigh Ignacio MSeropian Mariano Falconi Pablo Oberti Vadim Kotowicz Carla RAgatiello Daniel H Berroca Division of Interventional Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Internal Medicine and Geriatrics Hospital Italiano de Buenos AiresBuenos AiresArgentina Division Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Cardiovascular Surgery Hospital Italiano de Buenos AiresBuenos AiresArgentina

Frailty is generally defined as a clinical syndrome of decreased physiologic reserve which drives to increased vulnerability and susceptibility to different stressors together with poor recovery to homeostasis.[1]The relevance of frailty status in a wide range of prospective cohorts is mostly related to an increasing burden in both mortality,hospital readmissions,disability,and falls.

关键词： Aortic stenosis Frailty Transcatheter aortic valve replacement

Opposing roles of plant laticifer cells in the resistance to insect herbivores and fungal pathogens

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2021年第3期2卷 93-104页

作者： Lourdes Castelblanque Javier García-Andrade Clara Martínez-Arias juan J.Rodríguez francisco J.Escaray Ernestina Aguilar-Fenollosa Josep A.Jaques Pablo Vera Instituto de Biología Moleculary Celular de Plantas Universitat Politécnica de Valéncia-C.S.I.CCiudad Politécnica de la InnovaciònEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain Universitat Jaume I Departament de Ciéncies Agráries i del Medi NaturalCampus del Riu Sec12003 Castellòde la PlanaSpain

More than 12,000 plant species(ca.10%of flowering plants)exude latex when their tissues are *** is produced and stored in specialized cells named“laticifers”.Laticifers form a tubing system composed of rows of elongated cells that branch and create an internal network encompassing the entire *** constitute a recent evolutionary achievement in ecophysiological adaptation to specific natural environments;however,their fitness benefit to the plant still remains to be *** identification of Euphorbia lathyris mutants(pil mutants)deficient in laticifer cells or latex metabolism,and therefore compromised in latex production,allowed us to test the importance of laticifers in pest *** provided genetic evidence indicating that laticifers represent a cellular adaptation for an essential defense strategy to fend off arthropod herbivores with different feeding habits,such as Spodoptera exigua and Tetranychus *** marked contrast,we also discovered that a lack of laticifer cells causes complete resistance to the fungal pathogen Botrytis ***,a latex-derived factor required for conidia germination on the leaf surface was *** factor promoted disease susceptibility enhancement even in the non-latex-bearing plant *** speculate on the role of laticifers in the coevolutionary arms race between plants and their enemies.

关键词： latex Euphorbia lathyris disease resistance disease susceptibility plant defense

Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez juan Luis Bonilla-Palomas María Anguita-Gámez María García JoséLuis Bernal Náyade Del Prado Cristina Fernández-Pérez Julián Pérez-Villacastin juan JoséGómez-Doblas francisco Javier Elola Cardiology Department Hospital Universitario Severo OchoaMadridSpain Cardiology Department Hospital Universitario Reina SofíaCórdobaSpain Cardiology Department Hospital San Juan de la CruzÚbedaSpain Cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management Control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain Cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BACKGROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older ***,there are little data on in-hospital mortality in patients with HF≥75 years in *** A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and *** was performed using the International Classification of Diseases,10th ***≥75 years with HF as the principal diagnosis were *** calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(ICCU)in the *** We included 354,792 HF episodes of patients over 75 *** mean age was 85.2±5.5 years,and 59.2%of patients were *** most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%CI:1.07–1.07,P<0.001]and was lower in women(OR=0.96,95%CI:0.92–0.97,P<0.001).The main predictors of mortality were the presence of cardiogenic shock(OR=19.5,95%CI:16.8–22.7,P<0.001),stroke(OR=3.5,95%CI:3.0–4.0,P<0.001)and advanced cancer(OR=2.6,95%CI:2.5–2.8,P<0.001).In hospitals with ICCU,the in-hospital risk-adjusted mortality tended to be lower(OR=0.85,95%CI:0.72–1.00,P=0.053).CONCLUSIONS In-hospital mortality in patients with HF≥75 years between 2016 and 2019 was 12.7%,higher in males and elderly *** main predictors of mortality were cardiogenic shock,stroke,and advanced *** was a trend toward lower mortality in centers with an ICCU.

关键词： patients mortality diagnosis

Endoscopic ultrasound-guided drainage of pelvic collections and abscesses

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2010年第6期2卷 223-227页

作者： Ignacio Fernandez-Urien juan J Vila francisco JavierJimenez Endoscopy Unit Gastroenterology DepartmentHospital de Navarra

Pelvic abscesses are usually the end stage in the progression of an *** may occur from surgical complications,generalized abdominal infections such as appendicitis or diverticulitis,or from localized infections such as pelvic inflammatory disease or inflammatory bowel *** surgery has been considered as the treatment of choice by some authors,pelvic abscesses can be managed by non-invasive methods such as ultrasound and computed tomography-guided *** development of therapeutic linear echoendoscopes has allowed the endoscopist to perform therapeutic ***,endoscopic ultrasonography(EUS)-guided drainage of pelvic collections has been demonstrated to be feasible,efficient and *** allows the endoscopist to insert stents and drainage catheters into the abscess cavity which drains through the large *** article reviews technique, current results and future prospects of EUS-guided drainage of pelvic lesions.

关键词： Endoscopic ultrasound Abscess Collection Pelvis Drainage