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Relational coordination and healthcare management in lung cancer

World Journal of Clinical Cases 2014年第12期2卷 757-768页

作者： José Antonio Vinagre Romero juan Del Llano Se?arís Carmen De Pablos Heredero Mark Nuijten Clinical Management Business Organization Entrepreneurship Health Administration Business Organization Universidad Rey Juan Carlos Respiratory Unit at La Paz University Hospital28046 Madrid Spain Community Health Gaspar Casal Foundation Universidad Pompeu Fabra-CRES 28006 Madrid Spain Economics Rey Juan Carlos University School of Social Sciences Doctoral Program in Business Organization and Entrepreneurship 28032 Madrid Spain Rotterdam School of Management Erasmus University University of Maastricht the University of Groningen 3062 PA Rotterdam The Netherlands

In the current socio-economic scenario characterized by a growing shortage of resources and progressive budget constraints, the need to better coordinate processes in health institutions appears as a relevant aspect to ensure the future sustainability of system. In this sense, Relational Coordination(RC) provides a valuable opportunity for the reconfiguration of clinical guidelines concerning isolated single-level considerations. In this research the RC model has been applied to explain best results in the process of diagnosing and offering clinical treatments for lung cancer. Lung cancer presents the higher rates of tumor's mortality worldwide. Through unstructured and informal interviews with clinicians at both levels(Primary/Specialist Care), a diagnosis of the situation in relation to joint management of lung cancer is provided. Solutions of continuity in terms of coordination are explained due to the observation of lack of effective knowledge transfer between the two levels. It is this disconnection which justifies the introduction of a modified model of RC for the study and implementation of transfer relations between the knowledge holders, in order to structure consolidated and cooperative evidence-based models that lead to a substantial shortening in the response times with a marked outcomes improvement. To our knowledge, the application of this model to a Public Health problem bringing together both levels of care, hasn't been made till now.

关键词： Relational Coordination Lung cancer Clinical pathway Dialogic practices High performance work systems Healthcare performance

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Anti-inflammatory effects of Mangifera indica *** in a model of colitis

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World Journal of Gastroenterology 2010年第39期16卷 4922-4931页

作者： Lucía Márquez Beatriz G Pérez-Nievas Icíar Gárate Borja García-Bueno José LM Madrigal Luis Menchén Gabino Garrido juan C Leza Department of Pharmacology School of MedicineUniversity Complutense and Centro de Investigación en Red de Salud Mental(CIBERSAM) Pharmaceutical Chemistry Center and University of La Habana Health Research Institute Hospital 12 de Octubre(I+12) Gastroenterology Service Hospital General Universitario Gregorio Maraón and CIBEREHD Department of Chemistry and Pharmacy University Católica del Norte

AIM:To investigate the effect of aqueous extract from Mangifera indica L.(MIE)on dextran sulfate sodium (DSS)-induced colitis in ***:MIE(150 mg/kg)was administered in two different protocols:(1)rectally,over 7 d at the same time as DSS administration;and(2)once daily over 14 d (by oral gavage,7 d before starting DSS,and rectally for 7 d during DSS administration).General observations of clinical signs were ***-inflammatory activity of MIE was assessed by myeloperoxidase(MPO)activity. Colonic lipid peroxidation was determined by measuring the levels of thiobarbituric acid reactive substances (TBarS).Reduced glutathione(GSH)levels,expression of inflammatory related mediators[inducible isoforms of nitric oxide synthase(iNOS)and cyclooxygenase (COX)-2,respectively]and cytokines[tumor necrosis factor(TNf)-αand TNf receptors 1 and 2]in colonic tissue were also ***(IL)-6 and TNf-α serum levels were also measured. RESULTS:The results demonstrated that MIE has anti-inflammatory properties by improvement of clinical signs,reduction of ulceration and reduced MPO activity when administered before *** addition,administration of MIE for 14 d resulted in an increase in GSH and reduction of TBarS levels and iNOS,COX-2, TNf-αand TNf R-2 expression in colonic tissue,and a decrease in IL-6 and TNf-αserum levels. CONCLUSION:MIE has anti-inflammatory activity in a DSS-induced rat colitis model and preventive administration(prior to DSS)seems to be a more effective protocol.

关键词： Oxidative stress Ulcerative colitis Inflammation Polyphenols Mangifera indica Antioxidants

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Atmospheric deposition of 7Be,210Pb and 210Po during typhoons and thunderstorm in Shanghai, China and global data synthesis

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Science China Earth Sciences 2020年第4期63卷 602-614页

作者： juan DU Mark BASKarAN Jinzhou DU State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Department of Geology Wayne State UniversityDetroit 48202USA

Atmospherically-delivered ~7Be,^(210)Po and ^(210)Pb in bulk precipitation and air samples collected around the globe have provided valuable quantification on the rates of removal, as well as proportional mixing of attendant air masses;however, such studies during thunderstorm and typhoon events are limited. We report the first continuous time-series rainwater sampling and analysis of ~7Be,^(210)Pb and ^(210)Po from two typhoons and one thunderstorm during 2015 summer in Shanghai. The depositional fluxes within individual rain events of typhoons and thunderstorms varied by a factor of 10 for ~7Be, 5.7 for ^(210)Pb, 7.4 for ^(210)Po,and 7.0 for ~7Be/^(210)Pb activity ratios(ar). Such large observed variations in the depositional fluxes of ~7Be,^(210)Pb,^(210)Po and ~7Be/^(210)Pb activity ratios were attributed to air masses injected from surrounding high pressure system adjoining the typhoon to low pressure system within the typhoon. Based on ~7Be/^(210)Pb activity ratios, we estimated the variations in the fraction of maritime and continental air masses into the typhoon. Observed constancy in the ^(210)Po/^(210)Pb ar indicates that the residence times of air masses contributing to the typhoon during heavy rain are similar. from a synthesis of global fallout of ~7Be and ^(210)Pb during pulse events(precipitation≥50 mm from single rainout event), we quantify the importance of pulse events in the atmospheric fallout of these radionuclides.

关键词： 7Be 210Pb 210Po Typhoon Thunderstorm Air masses intrusions

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Mice with a heterozygous Lrp6 deletion have impaired fracture healing

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Bone Research 2016年第2期4卷 101-109页

作者： Travis A Burgers juan f Vivanco Juraj zahatnansky Andrew J Vander Moren James J Mason Bart O Williams Center for Cancer and Cell Biology Program for Skeletal Disease and Tumor Microenvironment Van Andel Research Institute Grand Rapids MhUSA faculfad de Ingenieria y Ciencias Adolfo Ib6fiez University Vifia del Mar Chile padnos College of Engineering and Computing Grand Valley State University Grand Rapids MI USA

Bone fracture non-unions, the failure of a fracture to heal, occur in 10%-20% of fractures and are a costly and debilitating clinical problem. The Wnt/fl-catenin pathway is critical in bone development and fracture healing. Polymorphisms of linking low-density lipoprotein receptor-related protein 6 （LRP6）, a Wnt-binding receptor, have been associated with decreased bone mineral density and fragility fractures, although this remains controversial. Mice with a homozygous deletion of Lrp6 have severe skeletal abnormalities and are not viable, whereas mice with a heterozygous deletion have a combinatory effect with Lrp5 to decrease bone mineral density. As fracture healing closely models embryonic skeletal development, we investigated the process of fracture healing in mice heterozygous for Lrp6 （Lrp6~/-） and hypothesized that the heterozygous deletion of Lrp6 would impair fracture healing. Mid-diaphyseal femur fractures were induced in Lrp6~^- mice and wild-type controls （Lrp6~/~）. fractures were analyzed using micro-computed tomography （~CT） scans, biomechanical testing, and histological analysis. Lrp6~/- mice had significantly decreased stiffness and strength at 28 days post fracture （Pf） and significantly decreased BV/TV, total density, immature bone density, and mature area within the callus on day-14 and -21 Pf; they had significantly increased empty callus area at days 14 and 21 Pf. Our results demonstrate that the heterozygous deletion of Lrp6 impairs fracture healing, which suggests that Lrp6 has a role in fracture healing.

关键词： bone Mice with a heterozygous Lrp6 deletion have impaired fracture healing

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Antibacterial and corrosive properties of copper implanted austenitic stainless steel

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 293-298页

作者： juan Xiong Bo-fan Xu Hong-wei Ni School of Physics and Electronic Technology Hubei University Wuhan 430062 China School of Material and Metallurgy Wuhan University of Science and Technology Wuhan 430081 China

Copper ions were implanted into austenitic stainless steel （SS） by metal vapor vacuum arc with a energy of 100 keV and an ions dose range of （0.5-8.0）× 10^17 cm^-2. The Cu-implanted SS was annealed in an ar atmosphere furnace. Glancing X-ray diffraction （GXRD）, transmission electron microscopy （TEM） and Auger electron spectroscopy （AES） were used to reveal the phase compositions, microstructures, and concentration profiles of copper ions in the implanted layer. The results show that the antibacterial property of Cu-implanted SS is attributed to Cu9.9fe0.1, which precipitated as needles. The depth of copper in Cu-implanted SS with annealing treatment is greater than that in Cu-implanted SS without annealing treatment, which improves the antibacterial property against S. aureus. The salt wetting-drying combined cyclic test was used to evaluate the corrosion-resistance of antibacterial SS, and the results reveal that the antibacterial SS has a level of corrosion-resistance equivalent to that of un-implanted SS.

关键词： copper ion implantation stainless steel antibacterial property corrosion resistance

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Decomposition and Products of Wheat and Rice Straw from a fACE Experiment Under flooded Conditions

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Pedosphere 2009年第3期19卷 389-397页

作者： LIU juan HAN Yong CAI Zu-Cong State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） Graduate University of the Chinese Academy of Sciences Beijing 100049 （China） School of Environmental Science and Technology Zhejiang Forestry University Lin＇an Hangzhou 311300 （China）

Winter wheat and rice straw produced under ambient and elevated CO2 in a China rice-wheat rotation free-air CO2 enrichment （fACE） experiment was mixed with a paddy soil at a rate of 10 g kg^-1 （air-dried）, and the mixture was incubated under flooded conditions at 25℃ to examine the differences in decomposition as well as the products of crop residues produced under elevated CO2. Results showed that the C/N ratio and the amount of soluble fraction in the amended rice straw grown under elevated CO2 （fR） were 9.8% and 73.1% greater, and the cellulose and lignin were 16.0% and 9.9% lesser than those of the amended rice straw grown under ambient CO2 （ar）, respectively. Compared with those of the ar treatment, the CO2-C and CH4-C emissions in the fR treatment for 25 d were increased by 7.9% and 25.0%, respectively; a higher ratio of CH4 to CO2 emissions induced by straw in the fR treatment was also observed. In contrast, in the treatments with winter wheat straw, the CO2-C and CH4-C emissions, the ratio of straw-induced CH4 to CO2 emissions, and the straw composition were not significantly affected by elevated CO2, except for an 8.0% decrease in total N and a 9.7% increase in C/N ratio in the wheat straw grown under elevated CO2. Correlation analysis showed that the net CO2-C and CH4-C emission from straw and the ratio of straw-induced CH4 to CO2 emissions were all exponentially related to the amount of soluble fraction in the amended straw （P 〈0.05）. These indicated that under flooded conditions, the turnover and CH4 emission from crop straw incorporated into soil were dependent on the effect of elevated CO2 on straw composition, and varied with crop species. Incorporation of rice straw grown under elevated CO2 would stimulate CH4 emission from flooded rice fields, whereas winter wheat straw grown under elevated CO2 had no effect on CH4 emission.

关键词： carbon cycle CH4 CO2 emissions soluble fraction

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Analysis Microstructure of Weld Metal for HQ130+QJ63 High Strength Steel

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Journal of Iron and Steel Research International 2002年第1期9卷 50-54页

作者： WANG juan LI Ya-jiang SUN Jun-sheng Shandong University

The microstructure in the weld metals for HQ130 + QJ63 high strength steels,which are welded by ar-CO_2 gas shielded metal arc welding,was analyzed by means of microscope and scan electron microscope(SEM).The relative content of different microstructure was evaluated with XQf-2000 micro-image *** effect of acicular ferrite content on the impact toughness was also *** test results indicated that the main microstructure in the weld metals of HQ130 + QJ63 high strength steels is acicular ferrite and a few pro-eutectic ferrite on the boundary of original austenite *** the fusion zone there are columnar grains whose direction coefficient(X) is 3.22,but the microstructure in the center of the weld metal is isometric grain,whose direction coefficient X = *** order to avoid welding crack and improve welding technology the weld heat input should be strictly controlled in 10-16 kJ/***,the main microstructure in the weld metals is fine acicular ferrite and the content of pro-eutectic ferrite is *** impact toughness in the weld metals of HQ130+ QJ63 steels can be ensured and can meet the requirements for application in engineering and machinery.

关键词： high strength steel gas shielded metal arc welding weld metal micro-image

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KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells

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International Journal of Oral Science 2013年第4期5卷 200-205页

作者： juan Xu Bo Yu Christine Hong Cun-Yu Wang Department of Stomatology Chinese People's Liberation Army General Hospital Division of Oral Biology and Medicine School of DentistryUniversity of California Section of Orthodontics School of DentistryUniversity of California Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California

Mesenchymal stem cells （MSCs） have been identified and isolated from dental tissues, including stem cells from apical papilla, which demonstrated the ability to differentiate into dentin-forming odontoblasts. The histone demethylase KDM6B （also known as JMJD3） was shown to play a key role in promoting osteogenic commitment by removing epigenetic marks H3K27me3 from the promoters of osteogenic genes. Whether KDM6B is involved in odontogenic differentiation of dental MSCs, however, is not known. Here, we explored the role of KDM6B in dental MSC fate determination into the odontogenic lineage. Using shRNA-expressing lentivirus, we performed KDM6B knockdown in dental MSCs and observed that KDM6B depletion leads to a significant reduction in alkaline phosphate （ALP） activity and in formation of mineralized nodules assessed by Alizarin Red staining. Additionally, mRNA expression of odontogenic marker gene SP7 （osterix, OSX）, as well as extracellular matrix genes BGLAP （osteoclacin, OCN） and SPP1 （osteopontin, OPN）, was suppressed by KDM6B depletion. When KDM6B was overexpressed in KDM6B-knockdown MSCs, odontogenic differentiation was restored, further confirming the facilitating role of KDM6B in odontogenic commitment. Mechanistically, KDM6B was recruited to bone morphogenic protein 2 （BMP2） promoters and the subsequent removal of silencing H3K27me3 marks led to the activation of this odontogenic master transcription gene. Taken together, our results demonstrated the critical role of a histone demethylase in the epigenetic regulation of odontogenic differentiation of dental MSCs. KDM6B may present as a potential therapeutic target in the regeneration of tooth structures and the repair of craniofacial defects.

关键词： bone morphogenic protein dental mesenchymal stem cell epigenetics KDM6B odontogenic differentiation

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Vector Magnetic field Measurement of NOAA ar 10197

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Chinese Journal of Astronomy and Astrophysics 2006年第4期6卷 470-476页

作者： Hong-fei Liang Hai-juan Zhao fu-Yuan Xiang National Astronomical Observatories / Yunnan Observatory Chinese Academy of Sciences Kunming 650011 Graduate School of Chinese Academy of Sciences Beijing 100049 Yunnan Normal University Kunming 650092 National Satellite Meteorological Center China Meteorological Administration Beijing 100081 Xiangtan University Xiangtan 411105

A set of two-dimensional Stokes spectral data of NOAA ar 10197 obtained by the Solar Stokes Spectral Telescope （S^3T） at the Yunnan Observatory are quafitatively analyzed. The three components of the vector magnetic field, the strength H, inclination 7 and azimuth X, are derived. Based on the three components, we contour the distributions of the longitudinal magnetic field and transverse magnetic field. The active region （ar） has two different magnetic polarities apparent in the longitudinal magnetic map due to projection effect. There is a basic agreement on the longitudinal magnetic fields between the S^3T and SOHO/MDI magnetograms, with a correlation coefficient PBl = 0.911. The transverse magnetic field of the ar has a radial distribution from a center located in the southwest of the ar. It is also found that the transverse magnetic fields obtained by Huairou Solar Observing Station （HRSOS） have a similar radial distribution. The distributions of transverse magnetic field obtained by S^3T and HRSOS have correlation coefficients, PAzimu = 0.86 and PBt =0.883, in regard to the azimuthal angle and intensity.

关键词： line: profiles -- sun: sunspots -- sun: vector magnetic field -- polarization

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Responses of antioxidant enzyme and photosynthesis in rape seedling to the combined stresses of acid rain and ultraviolet-B radiation

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Journal of Environmental Sciences 2005年第6期17卷 1038-1041页

作者： LIANG Chan-juan HUANG Xiao-hua TAO Wen-yi ZHOU Qing The Key Laboratory of Industrial Biotechnology Ministry of Education Southern Yangtze University Wuxi 214036 China College of Chemistry and Environmental Science Nanjing Normal University Nanjing 210097 China School of Biotechnology Southern Yangtze University Wuxi 214036 China

Effects of the simulated acid rain（ar） and ultraviolet-B（UV-B, 280-320 nm） radiation with a single or two ways simultaneously （ar ＋ UV-B） on the antioxidant enzyme and photosynthesis of the rape seedlings were investigated by the hydroponic culture. The results of static experiment indicated that the tolerance of rape seedling to single stress（ar or UV-B） is stronger than that to dual stresses（ar ＋ UV-B）. furthermore, the dual stresses had additive effect on catalase activity, and a synergistic effect on MDA content, net photosynthesis rate, water use efficiency as well as intercellular CO2 concentration. Meanwhile, it has an independent effect on chlorophyll content, stomatal conductance, and transpiration rate as well as membrane permeability. During 64 h restoration course, the dynamic change in the curves of physiological and biochemical indices were not identical, and none of them show a simple linear variation. According to the static and dynamic experiments, it was found that a responsive sequence of catalase activity, membrane permeability, MDA content and photosynthetic characteristics to the above-mentioned stresses was as follows： ar ＋ UV-B 〉 UV-B 〉 ar.

关键词： combined stresses elevated UV-B radiation simulated acid rain rape seedling CAT activity photosynthesis

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