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融合电化学原理与工业流程的高三二轮复习课——锂离子电池的原理及回收利用

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化学教育（中英文） 2024年第11期45卷 79-84页

作者：白建娥李明娟清华大学附属中学北京100084

高三二轮复习要接轨高考,将能力提升与素养发展放在首位。为了示范真实情境中应用已学知识与题给信息解决问题的思路方法,减缓学生面对复杂问题时的畏难情绪,设计了融合电化学原理与工业流程的复习课——锂离子电池的原理及回收利用。... 详细信息

高三二轮复习要接轨高考,将能力提升与素养发展放在首位。为了示范真实情境中应用已学知识与题给信息解决问题的思路方法,减缓学生面对复杂问题时的畏难情绪,设计了融合电化学原理与工业流程的复习课——锂离子电池的原理及回收利用。以锂离子电池的制备、实验室组装、充放电原理和回收利用为线索,围绕真实的情境素材设置了10个具有评价功能的挑战性任务。课堂上依据评价量表对学生表现进行即时评价与引导,促进其高阶思维的发展。施教后进行反思:挑战性任务最好逐一呈现;高阶思维发展需充足时间;不考的知识可能更有价值。

关键词：电化学锂离子电池工业流程二轮复习

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与算子相连的面积积分在乘积空间中的有界性

中国科学：数学 2024年第1期54卷 59-74页

作者：宋娟邓清泉湖北经济学院统计与数学学院武汉430205 湖北经济学院大数据与数字经济研究院武汉430205 华中师范大学数学与统计学学院武汉430079

本文假设自伴算子L_(1)与L_(2)的热半群满足非对角估计(GGe_(p0)),其中p_(0)∈[1,2).在乘积空间R^(n_(1))×R^(n_(2))中,本文通过自伴算子L_(1)与L_(2)的热半群定义了与算子相连的面积积分S,证明了当p∈(p0,p’0)时,面积积分S在L^(p)(R^... 详细信息

本文假设自伴算子L_(1)与L_(2)的热半群满足非对角估计(GGe_(p0)),其中p_(0)∈[1,2).在乘积空间R^(n_(1))×R^(n_(2))中,本文通过自伴算子L_(1)与L_(2)的热半群定义了与算子相连的面积积分S,证明了当p∈(p0,p’0)时,面积积分S在L^(p)(R^(n_(1))×R^(n_(2)))中的有界性.

关键词：面积积分乘积空间非对角估计

红鲫胚胎发育过程中Sox8基因对壬基酚胁迫的响应

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南方农业学报 2024年第4期55卷 1149-1159页

作者：张琼宇彭娟田雨苏孙远东永州职业技术学院公共基础学部湖南永州425100 湖南科技大学生命科学与健康学院湖南湘潭411201

【目的】明确红鲫SRY相关高迁移率族盒蛋白8基因(Sox8)表达模式及壬基酚(NP)暴露对红鲫胚胎发育过程中Sox8基因表达的影响,为揭示NP胁迫下红鲫胚胎发育畸形的分子机制提供科学依据。【方法】运用RACe克隆红鲫Sox8基因cDNA全长序列,通过P... 详细信息

【目的】明确红鲫SRY相关高迁移率族盒蛋白8基因(Sox8)表达模式及壬基酚(NP)暴露对红鲫胚胎发育过程中Sox8基因表达的影响,为揭示NP胁迫下红鲫胚胎发育畸形的分子机制提供科学依据。【方法】运用RACe克隆红鲫Sox8基因cDNA全长序列,通过ProtParam、ProtScale、InterPro、PredictProtein、DeepTMHMM等在线软件进行生物信息学分析,利用实时荧光定量PCR检测红鲫Sox8基因在各成体组织及不同胚胎发育阶段的表达情况,以及不同浓度NP暴露对红鲫胚胎期Sox8基因表达的影响。【结果】红鲫Sox8基因c DNA序列全长2163 bp,其开放阅读框(ORF)1176bp,共编码391个氨基酸残基;红鲫SOX8蛋白相对分子量为43798.30Da,理论等电点(pI)为6.90,脂溶指数为49.92,不稳定指数为66.04,总平均亲水性指数(GRAVY)为-1.026,其N端含有Sox_N二聚化结构域和HMG-box结构域;基于SOX8氨基酸序列相似性构建的系统发育进化树显示红鲫与鲫的亲缘关系最近。红鲫Sox8基因在各成体组织中广泛表达,以脑组织中的Sox8基因相对表达量最高,显著高于其他组织(P<0.05,下同);在红鲫胚胎发育过程中,Sox8基因的表达从受精后到14体节期呈逐渐下降趋势,但从21体节期开始Sox8基因相对表达量显著增高,直到孵化期始终维持在较高水平。在大多数情况下,NP暴露能显著影响红鲫胚胎发育过程中Sox8基因的表达,特别是14体节期后的发育阶段,NP暴露主要是不同程度地激活Sox8基因表达。【结论】Sox8基因表达在红鲫成体中具有组织特异性,且在胚胎发育过程中呈先降低后升高的变化趋势。NP暴露能显著影响红鲫胚胎发育过程中Sox8基因的表达,14体节期后Sox8基因表达水平升高可能是NP致畸红鲫胚胎的重要原因之一。

关键词：红鲫 Sox8基因壬基酚胚胎发育毒性致畸

ZNT1 Involves Cuproptosis through Regulating MTF1-conduced expression of MT1X under Copper Overload

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生态毒理学报 2024年第4期19卷 53-70页

作者： Wu Yue Yang Tingyun Yan Bo Ai Youwei Chen Fang Ma juan Liu Sijin State Key Laboratory of environmental Chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese A cademy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Industrial activities such as smelting emissions,mineral combustion and industrial wastewater discharge might lead to copper pollution in the *** kind of copper pollution has harmful effects on aquatic o rganisms,plants and animals through direct or indirect ***,the current understanding of the toxicity of copper is rather *** overload can perturb intracellular homeostasis and induce oxidative stress and e ven cell ***,cuproptosis has been identified as a copper-dependent form of cell death induced by o xidative stress in *** uncover here that zinc transporter 1(ZNT1)is an important regulator involved in ***,we established the copper overload-induced cell death model with the overexpression of copper importer SLC31A1 in HeLa *** this model,we conducted unbiased genome-wide CRISPR-Cas9 screens in cells treated with *** results revealed a significant enrichment of ZNT1 gene in both library A and library B *** out of ZNT1 in HeLa cells notably prevented *** knockout of metal transcription factor 1(MTF1)in ZNT1-deficient cells nearly abolished their ability to resist copper-induced cell ***,overexpression of metallothionein 1X(MT1X)in the double-knockout cells could p artially restored the resistance to cuproptosis by loss of ***,knockout of ZNT1 could promote MT1X expression by activating *** a consequence,the interaction between MT1X and copper was e nhanced,reducing the flow of copper into mitochondria and eliminating mitochondria *** together,this study reveals the important role of ZNT1 in cuproptosis and shows MTF1-MT1X axis mediated resistance to c ***,our study will help to understand the regulatory mechanism of cellular and systemic copper homeostasis under copper overload,and present insights into novel treatments for damages caused by both genetic copper overload diseases and enviro

关键词： copper cuproptosis ZNT1 MT1X

Single Ti atoms coupled with Ti-O clusters enable low temperature hydrogen cycling by sodium alanate

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Rare Metals 2024年第6期43卷 2671-2681页

作者： Zhuang-He Ren Xin Zhang Wen-Xuan Zhang Zhen-Guo Huang Li-Mei Yang Ya-Xiong Yang Zheng-Long Li juan Li Wen-Ping sun Ming-Xia Gao Hong-Ge Pan Yong-Feng Liu State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhou 310027China School of Materials Science and engineering Zhejiang UniversityHangzhou 310058China School of Civil&environmental engineering.University of Technology Sydney Sydney2007 NSWAustralia Institute of Science and Technology for New energy Xi'an Technological UniversityXi'an 710021China College of Materials Science and engineering Zhejiang University of TechnologyHangzhou 310014China

Ti-based catalysts are known to improve the hydrogen storage performance of NaAlH4by facilitating the dissociation/recombination of H-H and Al-H *** catalytic activity of metallic Ti species strongly depends on its particle size and *** clusters and even single atoms are therefore highly desirable,but their controllable fabrication has been highly *** rein,we demonstrate a novel facile sonochemical synthesis of a Ti-O clusters featuring single Ti atom catalyst at room *** reducing TiCl_(4)by MgBu_(2)with ultrasound instead of heating as driving force,numerous single Ti atoms coupled with Ti-O clusters with Ti loading on graphene(Ti_(1)/Ti-O@G)up to 22.6 wt%have been successfully *** prepared Ti_(1)/Ti-O@G contributes high reactivity and superior catalytic activity,therefore enabling full dehydrogenation of NaAlH_(4)at 80℃in thermogravimetric mode and re-hydrogenation at 30℃and 10 MPa with 4.9 wt% H_(2).This fact indicates for the first time that single Ti atom catalyst with high loading is highly effective in catalyzing hydrogen cycling of NaAlH4at remarkably reduced temperatures.

关键词： Hydrogen storage Nanocatalysis Transition metals Single Ti atoms NaAlH_(4)

基于电子商务平台发展视角下的饲料产品云物流发展

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中国饲料 2024年第14期 141-144页

作者：徐娟广安职业技术学院四川广安638000

电子商务平台的崛起和快速发展为饲料产品云物流的发展提供了新的机遇。通过电子商务平台,饲料企业可以更加便捷地与客户进行交流和互动,开拓多元化销售渠道,实现物流运输模式的创新。同时,电子商务平台也为饲料产品的采购、配送和售后... 详细信息

电子商务平台的崛起和快速发展为饲料产品云物流的发展提供了新的机遇。通过电子商务平台,饲料企业可以更加便捷地与客户进行交流和互动,开拓多元化销售渠道,实现物流运输模式的创新。同时,电子商务平台也为饲料产品的采购、配送和售后服务提供了更加科学可行的方案。在电子商务平台迅速发展的背景下,饲料产品云物流建设已成为饲料行业发展的必然趋势。

关键词：电子商务平台饲料产品云物流配送

Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： juan sun Jin-Xiu Zhang Meng-Shi Li Meng-Bin Qin Ruo-Xi Cheng Qing-Ru Wu Qiu-Ling Chen Dan Yang Cun Liao Shi-Quan Liu Jie-An Huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).MeTHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SReBP2 in hepatocytes

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Protein & Cell 2024年第2期15卷 98-120页

作者： Shanshan Yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng Yiyuan Zhang Shuhui sun Kang Wang jian Yin Shuai Ma Si Wang juan Carlos Izpisua Belmonte Weiqi Zhang Jing Qu Guang-Hui Liu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Xuanwu Hospital Capital Medical University Beijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Aging Biomarker Consortium Beijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Aging increases the risk ofliver diseases and systemic susceptibility to aging-related ***,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely ***,we constructed the first single-nucleus transcriptomic landscape of primate liver aging,in which we resolved cell type-specific gene expression fluctuation in hepatocytes across three liver zonations and detected aberrant cell-cell interactions between hepatocytes and niche *** in-depth dissection of this rich dataset,we identifed impaired lipid metabolism and upregulation of chronic inflammation-related genes prominently associated with declined liver functions during *** particular,hyperactivated sterol regulatory element-binding protein(SReBP)signaling was a hallmark of the aged liver,and consequently,forced activation of SReBP2 in human primary hepatocytes recapitulated in vivo aging phenotypes,manifesting as impaired detoxification and accelerated cellular *** study expands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases.

关键词： single-nucleus RNA sequencing liver hepatocytes aging senescence SReBP2

2023: Weather and Climate extremes Hitting the Globe with emerging Features

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Advances in Atmospheric Sciences 2024年第6期41卷 1001-1016页

作者： Wenxia ZHANG Robin CLARK Tianjun ZHOU Laurent LI Chao LI juan RIVeRA Lixia ZHANG Kexin GUI Tingyu ZHANG Lan LI Rongyun PAN Yongjun CHeN Shijie TANG Xin HUANG Shuai HU State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Met Office Hadley Centre Exeter EX13PBUK University of Chinese Academy of Sciences Beijing 100049China Laboratoire de Météorologie Dynamique CNRSSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75230France Max Planck Institute for Meteorology Hamburg 20146Germany Instituto Argentino de Nivología Glaciología Y Ciencias Ambientales(IANIGLA)CCT CONICETMendoza CP 5500Argentina Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Asia-Pacific Typhoon Collaborative Research Center Shanghai 201306China

Globally,2023 was the warmest observed year on record since at least 1850 and,according to proxy evidence,possibly of the past 100000 *** in recent years,the record warmth has again been accompanied with yet more extreme weather and climate events throughout the ***,we provide an overview of those of 2023,with details and key background causes to help build upon our understanding of the roles of internal climate variability and anthropogenic climate *** also highlight emerging features associated with some of these extreme *** extremes are occurring earlier in the year,and increasingly simultaneously in differing parts of the world(e.g.,the concurrent hot extremes in the Northern Hemisphere in July 2023).Intense cyclones are exacerbating precipitation extremes(e.g.,the North China flooding in July and the Libya flooding in September).Droughts in some regions(e.g.,California and the Horn of Africa)have transitioned into flood *** extremes also show increasing interactions with ecosystems via wildfires(e.g.,those in Hawaii in August and in Canada from spring to autumn 2023)and sandstorms(e.g.,those in Mongolia in April 2023).Finally,we also consider the challenges to research that these emerging characteristics present for the strategy and practice of adaptation.

关键词： weather and climate extremes temperature extremes extreme precipitation drought wildfires