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Debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

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Journal of Animal Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-López juan B.Ortiz-delgado Eva Vallejos-Vidal Lluis Tort Dariel Tovar-Ramírez Isabel M.Cerezo Miguel A.Moriñigo Carmen Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste SC CIBNORLa PazMexico Department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream(Sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic *** After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented *** terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic,antioxidant,immune,and symbiotic *** Dietary administration of *** enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools *** probiotic ye

关键词： Debaryomyces hansenii Intestine condition Low fish meal diet Microbiota Transcriptomics Yeast probiotic

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda juan F.López-Téllez Gloria delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yamixa delgado Caliani Gaytan Naydi Perez Eric Miranda Bryan Colón Morales Mónica Santos Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Department of Internal Medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a compelling need to investigate the intricate interplay among body mass index(BMI),pregesta-tional,and gestational maternal diabetes,and their potential impact on the occurrence of congenital heart defects(CHD)during neonatal ***:Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessment encompassed a range of variables,including maternal age,gestational age,BMI,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average maternal age was 26 years,within a range of 22 to 32 *** mean gestational age measured 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mothers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,compared to 200 without;and 148 cases exhibited an overweight or obese BMI,whereas 126 displayed a normal ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes mellitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between maternal BMI and the likelihood of *** results may aid in developing effective strategies to prevent and manage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty maternal health diabetes body mass index(BMI)

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Impact of device resistances in the performance of graphene-based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期 89-99页

作者： óscar Castelló Sofía M.López Baptista Kenji Watanabe Takashi Taniguchi Enrique Diez Jesús Enrique Velázquez-Pérez Yahya M.Meziani José M.Caridad juan A.delgado-Notario Department of Applied Physics University of Salamanca Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca Research Center for Electronic and Optical Materials National Institute for Materials Science Research Center for Materials Nanoarchitectonics National Institute for Materials Science Nanotechnology Group USAL–Nanolab University of Salamanca

In recent years, graphene field-effect-transistors(GFETs) have demonstrated an outstanding potential for terahertz(THz) photodetection due to their fast response and high-sensitivity. Such features are essential to enable emerging THz applications, including 6G wireless communications, quantum information, bioimaging and security. However, the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device, so-called access or parasitic resistances. In this work, we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET detectors. Such dual-gate architectures allow us to fine tune(decrease) the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector, respectively. Our results can be well understood by a series resistance model, as shown by the excellent agreement found between the experimental data and theoretical calculations. These findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

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Present and future cell therapies for pancreatic beta cell replenishment

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World Journal of Gastroenterology 2012年第47期18卷 6876-6884页

作者： juan domínguez-Bendala Camillo Ricordi Diabetes Research Institute University of Miami Leonard M.Miller School of MedicineMiamiFL 33136United States Department of Surgery University of Miami Miller School of MedicineMiamiFL 33136United States

If only at a small scale,islet transplantation has successfully addressed what ought to be the primary endpoint of any cell therapy:the functional replenishment of damaged tissue in *** years of less-thanoptimal approaches to immunosuppression,recent advances consistently yield long-term graft survival rates comparable to those of whole pancreas *** organ availability is the main hurdle that stands in the way of the widespread clinical utilization of this pioneering *** in stem cell research over the past decade,coupled with our decades-long experience with islet transplantation,is shaping the future of cell therapies for the treatment of *** we review the most promising avenues of research aimed at generating an inexhaustible supply of insulin-producing cells for islet regeneration,including the differentiation of pluripotent and multipotent stem cells of embryonic and adult origin along the beta cell lineage and the direct reprogramming of non-endocrine tissues into insulin-producing cells.

关键词： Human embryonic stem cells Induced pluripotent stem cells Mesenchymal stem cells Beta cell differentiation Reprogramming Islet transplantation

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High philopatry rates of Yellow-legged Gulls in the southeastern part of the Bay of Biscay

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Avian Research 2021年第3期12卷 391-398页

作者： Sergio delgado Alfredo Herrero Asier Aldalur juan Arizaga Department of Ornithology Aranzadi Sciences SocietyZorroagagaina 1120014 DonostiaSpain

Background:Philopatry rate is one of the main factors shaping population dynamics in colonial *** rates of philopatry are linked to populations with high dispersal,while high rates are linked to populations with a very high spatial structure pattern(i.e.,metapopulations).The Cantabrian Yellow-legged Gull(Larus michahellis)population is considered to be resident,with relatively low dispersal *** estimations of its philopatry rates are however still ***,we aimed to estimate philopatry rates in the main Yellow-legged Gull colonies of the province of Gipuzkoa,in the southeastern part of the Bay of ***:We analysed 734 resightings,during the breeding season at the colonies of Getaria,Santa Clara and Ulia,relative to a total of 3245 individuals ringed at birth in these same colonies during a period of 13 *** data were analysed using Multi-State Recapture models in ***:After controlling survival and resighting probability,the average dispersal rate among colonies was 4%(±SD=2%)when individuals are immature,decreasing to 1±1%)for adult breeding gulls(i.e.,philopatry rate was 99%).Annual survival rates were assessed to be 0.27±0.02 for birds in their first year of life and 0.87±0.01 for older *** probability of observing immature birds in the colonies was 0.08±0.01,as compared to 0.21±0.02 in adult ***:We obtained evidence of extremely high local philopatry rates,clearly within the upper limit found in gulls.A high philopatry favour a speciation in these species who are vulnerable to obtain the main food source(land-fills and fishing discard)which are transforming under new ecological process.

关键词： Dispersal rates Metapopulation Philopatry Ringing Survival Seagulls

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Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies

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World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： Esteban juan Fiore Luciana María domínguez juan Bayo Mariana Gabriela García Guillermo Daniel Mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

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Macrofaunal communities of threatened subtidal maёrl seabeds on Tenerife (Canary Islands, north-east Atlantic Ocean) in summer

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Acta Oceanologica Sinica 2012年第1期31卷 98-105页

作者： Rodrigo Riera juan dom.ngo delgado Myriam Rodríguez Óscar Monterroso Eva Ramos Centro de Investigaciones Medioambientales del Atlántico(CIMA SL) C/Arzobispo Elías Yanes Área de Ecología Departamento de Sistemas FísicosQuímicos y Naturales.Facultad de Ciencias ExperimentalesUniversidad Pablo de Olavide

This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of maerl beds from the Canary Islands. Maerl beds and Cymodocea nodosa meadows of the Canary Islands are considered biodiversity hot-spots in terms of taxonomic and functional biodiversity with a broad geographical and depth ranges. The authors have studied the structure of the macrofaunal assemblages on different habitat types （Cymodocea, Caulerpa, sabellid field, garden eel and maerl beds）. Samples were taken at a range of depths between 14 and 46 m. Correlations were performed among abiotic variables （granulometry, organic matter, nitrogen and phosphates） and the most abundant taxa. Similarity analysis was performed to explore the patchiness of seabeds at a local scale. Significant differences were found in macrofaunal assemblages among seabed types, with highest abundances and lowest biodiversity in sabellid fields, where the sabellid Bispira viola dominated. The polychaetes Aponuphis bilineata and Chone filicauda and the mollusc Turritella brochii were the most abundant taxa on maerl beds. The mosaic of granulometric conditions would explain the associated macroinfaunal community structure and contribute to the creation of diversity on these relatively well preserved seabeds at a local scale.

关键词： Macrofauna Polychaetes Amphipods Molluscs soft-bottoms subtidal Tenerife Canary Islands

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2023年甘肃积石山M_(S)6.2地震:一次逆冲为主的浅源强震

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地震 2024年第1期44卷 167-174页

作者：杨彦明苏淑娟中国地震局地质研究所地震动力学国家重点实验室北京100029 内蒙古自治区地震局内蒙古呼和浩特010010 中国矿业大学(北京)煤炭精细勘探与智能开发全国重点实验室北京100083

基于区域数字地震台网波形数据,在三维空间内利用波形拟合反演方法获得2023年12月18日甘肃积石山M_(S)6.2地震最佳震源机制解,结果表明:节面Ⅰ走向305°,倾角56°,滑动角61°;节面Ⅱ为走向169°,倾角43°,滑动角125°;矩震级M_(W)6.02... 详细信息

基于区域数字地震台网波形数据,在三维空间内利用波形拟合反演方法获得2023年12月18日甘肃积石山M_(S)6.2地震最佳震源机制解,结果表明:节面Ⅰ走向305°,倾角56°,滑动角61°;节面Ⅱ为走向169°,倾角43°,滑动角125°;矩震级M_(W)6.02。最佳拟合的空间精细位置为102.377°E,35.968°N,深度9 km。结果显示,地震破裂沿NW方向扩展。初步推断此次地震的发震断层面为节面Ⅱ,发震断层是拉脊山北缘断裂(积石山东缘断裂),是一次逆冲为主,兼少量走滑分量的浅源强震事件。

关键词： 2023年积石山M_(S)6.2地震震源机制解质心深度逆冲断层拉脊山北缘断裂

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Microbial and size characterization of airborne particulate matter collected on sticky tapes along US–Mexico border

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Journal of Environmental Sciences 2017年第3期29卷 207-216页

作者： Amir Gonzalez-delgado Manoj K.Shukla David W.DuBois juan P.Flores-Mdrgez Joel A.Hernandez Escamilla Evangelina Olivas Plant and Environmental Sciences Department New Mexico State UniversityMSC 3Q Skeen Hall Room N 127P.O.Box 30003Las CrucesNM 88003-8003USA Universidad Autonoma de Ciudad Judrez UACJAv.Plutarco Elias Calles 1020Fovisste ChamizalCiudad JudrezChihuahua C.P.32310Mexico

Particulate matter （PM） emissions from various sources can affect significantly human health and environmental quality especially in the Chihuahuan Desert region along US- Mexico border. The objective of this study was to use the low-cost sticky tape method to collect airborne PM for size characterization and identification of fungal spores. Sticky tape samplers were placed at 1.0 and 2.0 m above the ground surface at experimental sites in Ciudad Ju＆ez, Mexico and at 0.6, 1.2 and 1.8 m at New Mexico sites, USA. Soil samples were collected in both countries to determine fungal diversity, texture and moisture content. Dust particles collected from all of the experimental sites had a dominant texture of clay （〈0.002 mm）. The dominant textures identified from soil samples collected from the US and Mexican sites were loam and sandy clay loam, respectively. Alternaria, Penicillium and Fusarium were frequently found funguses in the US sites while Alternaria and Aspergillus were commonly observed in the Mexican sites. The sticky tapes also showed a similar diversity of fungal microorganisms present in the airborne PM at both Mexico and US sites. Alternaria, Penicillium and Aspergillus were the three groups of airborne fungal microorgan- isms consistently present in the US and Mexican sites. The low-cost sticky tape method has the potential to be used for characterizing different airbome microorganisms and dust particles.

关键词： Fungal sporesSticky tapeParticle sizeMicroorganismDust

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