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Pharmacological Control of Estrus in Tropical Cattle,an Economical Assessment of different Synchronization Protocols

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Open Journal of Veterinary Medicine 2012年第3期2卷 151-157页

作者： juan J.molina Ivan molina Alejandro Jimenez Carlos S.Galina juan J.Romero Asesor Laboratorios Intervet Schering Plough BogotaColombia director Tecnico Agropecuaria Las Tinajas S.A. BogotaColombia departamento de Reproduccion Facultad de Medicina Veterinaria y ZootecniaUniversidad Nacional Autonoma de MexicoMexico CityMexico Programa de Investigacion en Medicina Poblacional Escuela de Medicina VeterinariaUniversidad NacionalHerediaCosta Rica Campus Benjamín Nunez HerediaCosta Rica

To compare the fertility results and to assess the cost-effectiveness of several synchronization protocols applied under the conditions of beef cattle enterprises in Colombia, 1658 multiparous zebu crossbred cows mostly Brahman and Nelore ranging between 2 - 6 parities were used. Five protocols of pharmacological treatments varying in hormones used, dosage and the time of application were tested. All cows were inseminated at 52 h by appointment. Pregnancy diagnosis was undertaken over 45 d after insemination by rectal palpation. The total cost per cow and the total cost per gestation, for each protocol, were calculated. Taking a herd of one-hundred cows as baseline for calculations, it was estimated the cost of the total amount of pregnancies possibly obtained in each protocol;then, the excess between the costs of a pregnant cow and the cost of a treated cow was estimated. Additionally, the costs due to cows empty after four services were calculated. A total of 874 pregnancies were registered (52.7%), with pregnancies per protocol varying between 46.9% and 66.2% (p d cow, varied between $64.08 and $97.47 and the cost per gestation from $126.01 to $177.26, without association between the cost of the treatment and the pregnancy rate. Protocol A was the best cost-effective with the lowest additional costs, the lowest amount of open days (2107.7 to 2231.7 d) and IA straws (average = 134), with an additional costs of $6940.00. Synchronization of estrus using pharmacological products seems to have a place in the management of cattle;however, caution should be called upon a careful assessment both from the part of the farm and the professional in charge of the enterprise to avoid using the technique indiscriminatively thus propitiating the use of a method that might not be cost efficient.

关键词： Tropics Bos Indicus Cost-Benefit Estru Synchronization

daily expression of sodium-dependent glucose cotransporter-1protein in jejunum during rat ontogeny

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Animal Nutrition 2019年第3期5卷 290-296页

作者： juan I.Baston Fabricio d.Cid Enrique Caviedes-Vidal juan G.Chediack Laboratorio de Fisiopatología Endometrial Instituto de Biología y Medicina Experimental(IByME)CONICETCiudad Autoonoma de Buenos AiresC1428ADNArgentina Laboratorio de Biología Integrativa“Prof.E.Caviedes Codelia” Facultad de QuímicaBioquímica y FarmaciaUniversidad Nacional de San LuisSan LuisD5700HHWArgentina Instituto Multidisciplinario de Investigaciones en Biología-San Luis(IMIBIO-SL CCT-SL)CONICETSan Luis D5700HHWArgentina

It is widely known that intestinal capacities such as the enzymatic hydrolysis of carbohydrates,lipids and proteins,and the subsequent absorption of the hydrolyzed *** evolutionary matched to dietary loads and feeding *** this study,we demonstrate that the protein expression of apically located sodium-dependent glucose cotransporter-1(SGLT-1)throughout rat ontogeny is daily adjusted to afford glucose uptake when the load of this metabolically essential monosaccharide in the intestinal lumen is *** jejunal expression of SGLT-1 protein in 14 one-day-old suckling pups was found to increase at dark and early light phase(Pd-old and juvenile 28-d-old rats,the cotransporter expression was high throughout the entire day(Pdult 90-d-old rats showed a well-developed circadian rhythm for SGLT-1 protein(Pd at late light and dark phase when the highest intestinal glucose load was *** our knowledge,these results are the first reporting the daily profile of SGLT-1 expression during rat early developmental stage and may contribute to understand the biological significance of a well-established molecular capacity to deal with the crucial increase of glucose load in the diet during the weaning process.

关键词： Intestinal SGLT-1 Protein expression daily rhythms Ontogeny Rat

Methods for discovery and characterization of cellulolytic enzymes from insects

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Insect Science 2010年第3期17卷 184-198页

作者： Jonathan d. Willis Cris Oppert juan L. Jurat-Fuentes department of Entomology and Plant Pathology University of Tennessee Knoxville Tennessee USA

Cellulosic ethanol has been identified as a crucial biofuel resource due to its sustainability and abundance of cellulose feedstocks. However, current methods to obtain glucose from lignocellulosic biomass are ineffective due to recalcitrance of plant biomass. Insects have evolved endogenous and symbiotic enzymes to efficiently use lignocellulosic material as a source of metabolic glucose. Even though traditional biochemical methods have been used to identify and characterize these enzymes, the advancement of genomic and proteomic research tools are expected to allow new insights into insect digestion of cellulose. This information is highly relevant to the design of improved industrial processes ofbiofuel production and to identify potential new targets for development of insecticides. This review describes the diverse methodologies used to detect, quantify, purify, clone and express cellulolytic enzymes from insects, as well as their advantages and limitations.

关键词： biofuels cellulases cellulase discovery methods cellulase substrate insect digestive fluids lignocellulosic biomass

COMPLEX CONCEPT LATTICES FOR SIMULATING HUMAN PREdICTION IN SPORT

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Journal of Systems Science & Complexity 2013年第1期26卷 117-136页

作者： ARANdA-CORRAL Gonzalo A BORREGO-díAZ Joaquín GALáN-PáEZ juan Universidad de Huelva.department of Information Technology Crta.Palos de La Frontera s/n.21819 Palos de La Frontera Universidad de Sevilla.department of Computer Science and Artificial Intelligence Avda.Reina Mercedes s/n.41012 Sevilla

In order to address the study of complex systems,the detection of patterns in their dynamics could play a key role in understanding their *** particular,global patterns are required to detect emergent concepts and trends,some of them of a qualitative *** concept analysis(FCA) is a theory whose goal is to discover and extract knowledge from qualitative data(organized in concept lattices).In complex environments,such as sport competitions,the large amount of information currently available turns concept lattices into complex *** authors analyze how to apply FCA reasoning in order to increase confidence in sports predictions by means of detecting regularities from data through the management of intuitive and natural attributes extracted from publicly available *** complexity of concept lattices-considered as networks with complex topological structure- is *** is applied to building a knowledge based system for confidence-based reasoning,which simulates how humans tend to avoid the complexity of concept networks by means of bounded reasoning skills.

关键词： Bounded rationality complex networks formal concept analysis sport forecasting.

Conserved quantities and adiabatic invariants of fractional Birkhoffian system of Herglotz type

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Chinese Physics B 2020年第4期29卷 303-311页

作者： juan-juan ding Yi Zhang School of Mathematics and Physics Suzhou University of Science and TechnologySuzhou 215009China College of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011China

In order to further study the dynamical behavior of nonconservative systems,we study the conserved quantities and the adiabatic invariants of fractional Brikhoffian systems with four kinds of different fractional derivatives based on Herglotz differential variational ***,the conserved quantities of Herglotz type for the fractional Brikhoffian systems based on Riemann-Liouville derivatives and their existence conditions are established by using the fractional Pfaff-Birkhoff-d Alembert principle of Herglotz ***,the effects of small perturbations on fractional Birkhoffian systems are studied,the conditions for the existence of adiabatic invariants for the Birkhoffian systems of Herglotz type based on Riemann-Liouville derivatives are established,and the adiabatic invariants of Herglotz type are ***,the conserved quantities and adiabatic invariants for the fractional Birkhoffian systems of Herglotz type under other three kinds of fractional derivatives are established,namely Caputo derivative,Riesz-Riemann-Liouville derivative and Riesz-Caputo ***,an example is given to illustrate the application of the results.

关键词： fractional Birkhoffian system Pfaff-Birkhoff-d’Alembert principle adiabatic invariant Herglotz generalized variational principle

Prevalence of and risk factors for erectile dysfunction in young nondiabetic obese men:results from a regional study

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Asian Journal of Andrology 2020年第4期22卷 372-378页

作者： María molina-Vega Maite Asenjo-Plaza María JoséBanderas-donaire María dolores Hernández-Ollero Silvia Rodríguez-Moreno juan Jálvarez-Millán Pablo Cabezas-Sanchez Fernando Cardona-díaz juan Alcaide-Torres Lourdes Garrido-Sánchez daniel Castellano-Castillo Francisco J Tinahones JoséC Fernández-García department of Endocrinology and Nutrition Virgen de la Victoria University Hospital(IBIMA)Málaga UniversityMálaga 29010Spain Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadrid 28029Spain Cruz de Humilladero Primary Care Center Málaga 29010Spain Teatinos Primary Care Center Málaga 29010Spain Chemical Sanitary Consulting(CQS Lab) Madrid 28003Spain

Erectile dysfunction(Ed),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with *** this study,we aimed to determine the prevalence of Ed and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BMI]≥30 kg m−2)men from primary *** function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging Males'Symptoms[AMS scale]),and body composition analysis(Tanita MC-180MA)were *** testosterone was determined using high-performance liquid chromatography–mass *** logistic regression analysis was used to study the factors associated with *** prevalence was 42.1%.Subjects with Ed presented higher BMI,waist circumference,number of components of the metabolic syndrome,AMS score,insulin resistance,and a more unfavorable body composition than those without *** logistic regression analysis showed that a pathological AMS score(odds ratio[OR]:4.238,Pdegree of obesity(BMI≥40 kg m−2,OR:2.602,P=0.005,compared with BMI 30–34.9 kg m−2),high-density lipoprotein(HdL)-cholesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were factors independently associated with *** conclusion,we demonstrate that,in a primary care-based cohort of nondiabetic young obese men,Ed affected>40%of subjects.A pathological AMS score,the degree of obesity,and age were positively associated with Ed,while elevated HdL-cholesterol levels were inversely associated with the odds of presenting *** prospective studies are needed to evaluate the long-term consequences of Ed in this population.

关键词： Aging Males'Symptoms score erectile dysfunction International Index of Erectile Function-5 questionnaire obesity testosterone

South Asian dairy smallholders: A scoping review of practices and zoonoses

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 446-452页

作者： Emily Schembri Angus J d Campbell juan Pablo Villanueva-Cabezas Melbourne School of Population and Global Health The University of MelbourneVictoriaAustralia The Nossal Institute for Global Health The University of MelbourneVictoriaAustralia The Peter doherty Institute for Infection and Immunity The University of Melbourne and the Royal Melbourne HospitalVictoriaAustralia

Objective: To identify and discuss on-farm management practices linked to bacterial zoonosis risk in smallholder dairy farmers in South Asia. Methods: This scoping review was conducted as per the PRISMA-ScR guidelines. Five hundred and two publications were retrieved from five online databases using a comprehensive search strategy. Studies were selected if they discussed a farm management practice which impacted human health within a South Asian country. Results: Twenty-two studies were included. Seven management practices relevant to farmers, livestock and their shared environment were identified including raw milk consumption, farm hygiene management, personal protective equipment uses, animal vaccination, cleaning udders, hand washing and disposal of afterbirth materials. Preventive practices were found to be utilized at lower frequencies compared to risk increasing practices. Awareness of bacterial zoonoses is particularly low within the region. Conclusions: Based on the results of this review, it was determined that improving farmer awareness of bacterial zoonotic diseases may favor several of the presented leverage points within the South Asian smallholder dairy system. Relying on formal school education to improve this awareness may not solve this problem, instead, more focus on accessible and affordable zoonoses education and farming programs is required.

关键词： Management practices Zoonoses dairy Smallholder system

QUANTIFYING NANOP ARTICLE TRANSPORT IN VIVO USING HYP ERSPECTRAL IMA GING WITH A dORSAL SKINFOLd WINdOW CHAMBER

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 8-17页

作者： TREVOR d.MCKEE juan CHEN IAN CORBIN GANG ZHENG RAMA KHOKHA Ontario Cancer Institute University Health Network TorontoOntario STTARR Innovation Center University Health Network TorontoCanada department of Medical Biophysics University of Toronto TorontoCanada Advanced Imaging Research Center University of Texas Southwestern Medical Center at dallas dallas USA

We have developed a noninv asive imaging method to quantify in viwo drug delivery pharmaco-kinetics without the need for blood or tissue collection to determine drug *** combining the techniques of hy perspectral imaging and a dorsal skinfold window chamber,this method enabled the real-time monitoring of vascular transport and tissue deposition of nano-particles labeled with near infrared(NIR)*** this imaging method,we quantified the delivery pharmacokinetics of the native high-density lipoprotein(HdL)and epidermal growth factor receptor(EGFR)-targeted HdL nanoparticles and demonstrated these HdLs had long circulation time in blood stream(half-life>12h).These HdL nanoparticles could eficiently carry cargo diR-BOA to extravasate from blood vesels,difuse through extr acellular matrix,and penetrate and be retained in the tumor *** EGFR targeting specificity of EGFR-targeted HdL(EGFR-specific peptide conjugated HdL)was also visualized in vivo by competitive inhi bition with excess EGFR specifc *** summary,this imaging technology may help point the way toward the development of novel imaging based pharmacokinetic assays for preclinical drugs and evaluation of drug delivery eficiency,providing a dynamic window into the devel opment and application of novel drug delivery systems.

关键词： specificity kinetics competitive

Ni nanoparticles confined by yolk-shell structure of CNT-mesoporous carbon for electrocatalytic conversion of CO_(2): Switching CO to formate

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Journal of Energy Chemistry 2022年第7期31卷 224-229,I0006页

作者： juan du Aibing Chen College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018HebeiChina

Electrochemical reduction of CO_(2)(CO_(2)ER) to formate has been a promising route to produce value-added *** low-cost and efficient electrocatalysts with high product selectivity is still a grand ***,a novel Ni nanoparticles-anchored CNT coated by mesoporous carbon with yolk-shell structure (CNT/Ni@mC) catalysis was designed for CO_(2)*** nanoparticles were confined in the cavity between CNT and mesoporous carbon shell and the confined space can be controlled by tuning the amount of silica *** mesoporous carbon shell and confined space are beneficial to charge transmission during CO_(2)*** contrast to previous studies,the CNT/Ni@mC catalyst presents selectivity toward formate rather than *** in situ attenuated total reflection Fourier transform infrared spectroscopy measurements indicate the presence of a COO* intermediate that converts to formate under CO_(2)ER *** well-defined structural feature of the confined space of the Ni-based catalyst for selective CO_(2)ER to formate may facilitate in-depth mechanistic understandings on structural factors that affect CO_(2)ER performance.

关键词： Carbon dioxide electrochemical reduction Nickel-based catalyst Formate Yolk-shell CNT