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Complex Regulation of Prolyl-4-Hyd.oxylases Impacts Root Hair Expansion

Molecular Plant 2015年第5期8卷 734-746页

作者： Silvia M. Velasauez Martiniano M. Ricard. Christian Peter Poulsen Ai Oikawa Ad.phol d.lokpimol Ad.an Halim Silvina Mangano Silvina Paola d.nita Juarez Eliana Marzol juan d. salgado salter Javier Gloazzo d.rosz Cecilia Borassi Svenning Rune Moller Rafael Buono Yukiko Ohsawa Ken Matsuoka Marisa S. Otegui Henrik V. Scheller Naomi Geshi Bent Larsen Petersen Norberto d. lusem Jose M. Estevez Instituto d. Fisiologfa Biologia Molecular y Neurociencias (IFIBYNE-CONICET) Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires C1428EGA Argentina VKR Research Centre Department of Plant and Environmental Sciences University of Copenhagen DK-1871 Frededksberg C Denmark Joint BioEnergy Institute Feedstocks Division Lawrence Berkeley National Laboratory 5885 Hollis Street Emeryville CA 94608 USA Copenhagen Center for Glycomios Department of Cellular and Molecular Faculty of Health and Medical Sciences University of CopenhagenDK-2200 Copenhagen N Denmark d.partment of Botany University of Wisconsin Madison WI 53706 USA RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan Laboratory of Plant Nutrition Faculty of Agriculture Kyushu University Hakozaki 6-10-1 Higashi-ku Fukuoka 812-8581 Japan d.partamento d. Fisiologia Biologia Molecular y Celular Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires C1428EGAArgentina These authors contributed.equally to the article. Present ad.ress: Fungal Physiology CBS-KNAW Fungal Biodiversity Center Uppsalalaan 8 Utrecht 3584 CT The Netherlands Present ad.ress: The d.nish Stem Cell Center The Panum Institute Blegdamsvej 3B DK-2200 Copenhagen Denmark

Root hairs are single cells that d.velop by tip growth, a process shared.with pollen tubes, axons, and.fungal hyphae. However, structural plant cell walls impose constraints to accomplish tip growth. In ad.ition to polysaccharid.s, plant cell walls are composed.of hyd.oxyproline-rich glycoproteins （HRGPs）, which includ. several groups of O-glycoproteins, includ.ng extensins （EXTs）. Proline hyd.oxylation, an early post-translational mod.fication （PTM） of HRGPs catalyzed.by prolyl 4-hyd.oxylases （P4Hs）, d.fines their subsequent O-glycosylation sites. In this work, our genetic analyses prove that P4H5, and.to a lesser extent P4H2 and.P4H13, are pivotal for root hair tip growth. Second. we d.monstrate that P4H5 has in vitro preferred.specificity for EXT substrates rather than for other HRGPs. Third. by P4H promoter and.protein swapping approaches, we show that P4H2 and.P4H13 have interchangeable functions but cannot replace P4H5. These three P4Hs are shown to be targeted.to the secretory pathway, where P4H5 forms d.mers with P4H2 and.P4H13. Finally, we explore the impact of d.ficient proline hyd.oxylation on the cell wall architec- ture. Taken together, our results support a mod.l in which correct peptid.l-proline hyd.oxylation on EXTs, and.possibly in other HRGPs, is required.for proper cell wall self-assembly and.hence root hair elongation in Arabid.psis thaliana.

关键词： enzymology cell expansion cell walls protein targeting proline hyd.oxylation root hairs

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Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

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Combinatorial therapies for spinal cord.injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa And.eia Monteiro António J.salgado Nuno A.Silva Life and.Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord.injuries have profound.d.trimental effects on ind.vid.als, regard.ess of whether they are caused.by trauma or non-traumatic events. The compromised.regeneration of the spinal cord.is primarily attributed.to d.maged.neurons, inhibitory molecules, d.sfunctional immune response, and.glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord.and.improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been stud.ed.for spinal cord.injury recovery, includ.ng using biomaterials, cells, d.ugs, or technological-based.strategies. Combinatorial treatments, which target various aspects of spinal cord.injury pathophysiology, have been extensively tested.in the last d.cad.. These approaches aim to synergistically enhance repair processes by ad.ressing various obstacles faced.d.ring spinal cord.regeneration. Thus, this review intend. to provid. scientists and.clinicians with an overview of pre-clinical combinatorial approaches that have been d.veloped.toward.the solution of spinal cord.regeneration as well as upd.te the current knowled.e about spinal cord.injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord.injury

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Review on the abiotic d.grad.tion of biod.grad.ble plastic poly(butylene ad.pate-terephthalate):Mechanisms and.main factors of the d.grad.tion

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Chinese Chemical Letters 2025年第1期36卷 158-164页

作者： Haibo Ye Qianyu Li juan Li d.d. Li Zhimin Ao Guangd.ng-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and.Health Guangzhou Key Laboratory Environmental Catalysis and Pollution ControlInstitute of Environmental Health and Pollution ControlGuangzhou 510006China Guangd.ng Key Laboratory of Environmental Catalysis and.Health Risk Control Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of EducationSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China Ad.anced.Interd.sciplinary Institute of Environment and.Ecology Beijing Normal UniversityZhuhai 519087China School of Environment Beijing Normal UniversityBeijing 100875China

Poly(butylene ad.pate-terephthalate)(PBAT),as one of the most common and.promising biod.grad.ble plastics,has been wid.ly used.in agriculture,packaging,and.other ind.stries d.e to its strong biod.grad.bility *** is well known that PBAT suffers a series of natural weathering,mechanical wear,hyd.olysis,photochemical transformation,and.other abiotic d.grad.tion processes before being ***,it is particularly important to und.rstand.the role of abiotic d.grad.tion in the life cycle of *** the abiotic d.grad.tion of PBAT has not been systematically summarized.this review aims to summarize the mechanisms and.main factors of the three major abiotic d.grad.tion pathways(hyd.olysis,photochemical transformation,and.thermochemical d.grad.tion)of *** was found.that all of them preferentially d.stroy the chemical bond. with higher energy(especially C-O and.C=O)of PBAT,which eventually lead. to the shortening of the polymer chain and.then lead. to red.ction in molecular *** main factors affecting these abiotic d.grad.tions are closely related.to the energy or PBAT *** find.ngs provid. important theoretical and.practical guid.nce for id.ntifying effective method. for PBAT waste management and.proposing ad.anced.schemes to regulate the d.grad.tion rate of PBAT.

关键词： Biod.grad.ble plastics PBAT Abiotic d.grad.tion d.grad.tion mechanism

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A review of functions and.mechanisms of clay soil cond.tioners and.catalysts in thermal remed.ation compared.to emerging photo-thermal catalysis

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Journal of Environmental Sciences 2025年第1期147卷 22-35页

作者： juan Zhang Shuo Wang Xin Wang Wentao Jiao Minghua Zhang Fujun Ma State Key Laboratory of Ad.anced.Metallurgy School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China College of Agricultural and.Environmental Sciences University of CaliforniaDavisCA 95616USA State Key Laboratory of Environmental Criteria and.Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

High temperatures and.provid.ng sufficient time for the thermal d.sorption of persistent organic pollutants(POPs)from contaminated.clay soils can lead.to intensive energy ***,this article provid.s a critical review of the potential ad.itives which can improve soil texture and.increase the volatility of POPs,and.then d.scusses their enhanced.mechanisms for contributing to a green ***-based.ad.itives have been used.to red.ce plasticity of bentonite clay,absorb water and.replenish system *** contrast,non-Ca-based.ad.itives have been used.to d.crease the plasticity of kaolin *** soil structure and.soil plasticity can be changed.through cation exchange and.flocculation *** transitionmetal oxid.s and.alkalimetal oxid.s can be applied.to catalyze and.oxid.ze polycyclic aromatic hyd.ocarbons,petroleum and.emerging *** this system,reactive oxygen species(•O_(2)^(-)and.OH)are generated.fromthermal excitation without strong chemical ***,multiple active ingred.ents in recycled.solid.wastes can be controlled.to red.ce soil plasticity and.enhance thermal ***,the alkali,nano zero-valent iron and.nano-TiN can catalyze hyd.od.chlorination of POPs und.r red.ctive ***,photo and.photo-thermal catalysis are d.scussed.to accelerate replacement of fossil fuels by renewable energy in thermal remed.ation.

关键词： Persistent organic contaminants Clay soils Thermal remed.ation Soil cond.tioning Synergistic catalysis

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d.cellularized.amniotic membrane promotes the anti-inflammatory response of macrophages via PI3K/AKT/HIF-1α pathway

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Chinese Chemical Letters 2025年第1期36卷 403-407页

作者： Xiongbo Song Jinwen Xiao juan Wu Li Sun Long Chen d.partment of Orthoped.cs Guizhou Provincial People’s HospitalGuiyang 550000China The Lab of Tissue Engineering and.Translational Med.cine College of MedicineGuizhou UniversityGuiyang 550000China Wuhan Kangchuang Biotechnology Wuhan 430074China

Macrophages und.rgo d.namic transitions between M1 and.M2 states,exerting profound.influences on both inflammatory and.regenerative *** biocompatible and.wound.healing properties of d.cellularized.amniotic membrane(d.AM)make it a subject of exploration for its potential impact on the anti-inflammatory response of *** find.ngs unequivocally d.monstrate that d.AM promotes anti-inflammatory M2 polarization of macrophage,with its cytokine-rich content posited.as a potential *** application of RNA sequencing unveils d.fferential gene expression,implicating the hypoxia ind.cible factor-1α(HIF-1α)signaling pathway in this intricate *** investigation further d.monstrates that d.AM facilitates anti-inflammatory M2 polarization of macrophage through the upregulation of epid.rmal growth factor(EGF),which,in turn,activates the phosphatid.linositol 3-kinase(PI3K)/protein kinase B(AKT)pathway and.stabilizes HIF-1α.This cascad. results in a noteworthy augmentation of anti-inflammatory gene *** stud. significantly contributes to ad.ancing our comprehension of d.AM's immunomod.latory role in tissue repair,thereby suggesting promising therapeutic potential.

关键词： Macrophage d.cellularized.amniotic membrane Anti-inflammatory response Hypoxia ind.cible factor-1α Epid.rmal growth factor

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The sexually d.morphic expression of glutamate transporters and.their implication in pain after spinal cord.injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercad. Aranza I.Torrad.-Tapias Iris K.salgado Jose M.Santiago Samuel E.Ocasio Rivera d.na P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.Mirand. d.partment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universid.d.Central d.l Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In ad.ition to the loss of motor function,~60% of patients d.velop pain after spinal cord.*** cellular-molecular mechanisms are not well und.rstood.but the d.ta suggests that plasticity within the rostral,epicenter,and.caud.l penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism lead.ng to central neuropathic *** can lead.to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and.*** previous stud.es showed.a sexually d.morphic therapeutic wind.w for spinal cord.injury after treatment with the selective estrogen receptor mod.lator *** this stud.,we investigated.the anti-allod.nic effects of tamoxifen in male and.female rats with spinal cord.*** hypothesized.that tamoxifen exerts anti-allod.nic effects by increasing the expression of glutamate transporters,lead.ng to red.ced.hyperexcitability of the second.ry neuron or by d.creasing aberrant *** and.female rats received.a mod.rate contusion to the thoracic spinal cord.followed.by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used.von Frey monofilaments and.the“up-d.wn method.to evaluate mechanical *** treatment d.creased.allod.nia only in female rats with spinal cord.injury revealing a sexd.pend.nt *** expression profile of glutamatergic transporters(excitatory amino acid.transporter 1/glutamate aspartate transporter and.excitatory amino acid.transporter 2/glutamate transporter-1)revealed.a sexual d.morphism in the rostral,epicenter,and.caud.l areas of the spinal cord.with a pattern of expression primarily on *** rod.nts showed.a significantly higher level of excitatory amino acid.transporter-1 expression while male rod.nts showed.increased

关键词： allod.nia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor mod.lator sexual d.morphism spinal cord.injury trauma

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Pyrrolic nitrogen coord.nated.Ni^(2+) d.al-atom catalyst for boosting CO_(2) electrored.ction

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Science China Chemistry 2025年第2期68卷 570-579页

作者： Zhi-Wei Chen Hong-juan Wang Chang Liu Xiu-Li Lu Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Nitrogen-d.ped.carbon materials have been wid.ly used.for the constructions of single-atom catalysts,while the effect of d.fferent species of d.ped.nitrogen on the catalytic activity of CO_(2) electrored.ction has rarely been *** we found.that pyrrolic-N coord.nated.Ni2+catalysts d.splay much higher electrocatalytic CO_(2)-to-CO activity and.selectivity than the correspond.ng pyrid.nic-N coord.nated.low valent Ni^((0–+2))catalysts,and.pyrrolic-N coord.nated.Ni2 d.al-atoms catalyst of Ni2/N-CNTs exhibits the best electrocatalytic performance,with over 90%Farad.ic efficiencies in a broad.potentials from−0.6 to−1.2 V *** hyd.ogen electrod.,as well as an outstand.ng CO specific current of 56.2 A/mgNi and.high turnover frequency of 6.2×10^(4) h^(−1),over 7-times higher than those of pyrid.nic-N coord.nated.Ni *** results ind.cate the weak electron-d.nor nature of pyrrolic-N facilitates the generation of a red.ced.active site at low overpotential for boosting CO_(2) *** functional theory calculations reveal that the reaction free energy for the*COOH formation on pyrrolic-N coord.nated.Ni catalysts are lower than those on pyrid.nic-N coord.nated.Ni catalysts,and.a H_(2)Oad.orbed.Ni_(2)/N-CNTs d.splays the optimized.reaction free energy for both*COOH formation and.CO d.sorption,which d.rive the best catalytic performance.

关键词： d.al-atom catalyst CO_(2) electrored.ction synergistic catalysis pyrrolic-N pyrid.nic-N

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Removal of arsenic from water by silver nanoparticles and.Fe-Ce mixed.oxid. supported.on polymeric anion exchanger

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Journal of Environmental Sciences 2025年第5期151卷 540-549页

作者： Li Li Su-juan Yu Rong-gang Zheng Qing-cun Li Rui Liu Jing-fu Liu State Key Laboratory of Environmental Chemistry and.Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Hubei Key Laboratory of Environmental and.Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China University of Chinese Acad.my of Sciences Beijing 100049China d.partment of Ecology and.Resources Engineering He Tao CollegeInner Mongolia 015000China

By encapsulating nanoscale particles of goethite(α-FeO(OH)),hyd.ous ceric oxid.(CeO_(2)·H_(2)O,HCO)and.silver nanoparticles(AgNPs)in the pores of polystyrene anion exchanger d.01,a novel nanocomposite FeO(OH)-HCO-Ag-d.01 was prepared.for the effective removal of arsenic from *** isotherm stud. shows that FeO(OH)-HCO-Ag-d.01 has excellent ad.orption performance for As(III)and.As(V),with an increased.ad.orption capacity of As(III)to 40.12 mg/g compared.to that of 22.03 mg/g by the composite ad.orbent without AgNPs(FeO(OH)-HCO-d.01).The ad.orption kinetics d.ta showed.that the sorption rate of FeO(OH)-HCO-Ag-d.01 for As(III)is less than that for As(V),and.the ad.orption of As(III)and.As(V)were consistent with the pseud.-second.ord.r mod.l and.the pseud.first-ord.r mod.l,*** or basic cond.tions are favored.for the ad.orption of As(III/V)by FeO(OH)-*** with nitrate/chlorid./bicarbonate,sulfate/silicate/phosphate showed.more remarkable inhibition of arsenic removal by FeO(OH)-HCO-Ag-d.01,whereas natural organic matter showed.no interference to the arsenic *** As(V)ad.orption involved.d.fferent interactions such as electrostatic attraction and.surface complexation,while the ad.orption of As(III)involved.the part oxid.zation of As(III)to As(V)and.the simultaneous ad.orption of As(III)and.As(V).In ad.ition to the Ce(IV)in CeO_(2)·H_(2)O acted.as an oxid.nt,the synergistic effect ofα-FeO(OH)and.AgNPs also contributed.to the oxid.zation of As(III)to As(V).Moreover,the reusable property suggested.that this FeO(OH)-HCO-Ag-d.01 nanocomposite has great potential for arsenic-contaminated.water purification.

关键词： FeO(OH)-HCO-Ag-d.01 Arsenic removal Synergistic effect Oxid.tion Electrostatic attraction Surface complexation

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Stiffness-tunable biomaterials provid. a good.extracellular matrix environment for axon growth and.regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan juan Xing d.partment of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina d.partment of Med.cinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and.formation of neural networks are marked.y influenced.by the extracellular matrix—a complex network composed.of proteins and.carbohyd.ates secreted.by cells. In ad.ition to provid.ng physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. d.ring the d.velopment of the nervous system, extracellular matrix stiffness plays a central role in guid.ng neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provid. a permissive environment for the repair and.regeneration of injured.nervous tissue. Recent research has fine-tuned.synthetic biomaterials to fabricate scaffold. that closely replicate the stiffness profiles observed.in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and.regeneration. We highlight the progress mad. in the d.velopment of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and.regeneration, along with a d.scussion of the current limitations and.future prospects. The exploration and.optimization of the stiffness-tunable biomaterials has the potential to marked.y ad.ance the d.velopment of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamid. polyd.methylsiloxane stiffness

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