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DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling

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Cancer Communications 2023年第7期43卷 838-843页

作者： Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón juan María Roldán-Romero María Santos Javier Lanillos carlos Valdivia Natalia martínez-Puente Javier de Nicolás-Hernández Scherezade Jiménez Manuel Pérez-martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto Cascón Hereditary Endocrine Cancer Group Spanish National Cancer Research Centre(CNIO)MadridSpain Proteomics Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) MadridSpain Monoclonal Antibodies Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Confocal Microscopy Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Anatomical Pathology Service Hospital of LeónLeónCastilla y LeónSpain Structural Biology Programme Spanish National Cancer Research Centre(CNIO)MadridSpain CNIO-Lilly Cell Signalling and Immunometabolism Section Spanish National Cancer Research Centre(CNIO)MadridSpain Spectroscopy and Nuclear Magnetic Resonance Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Josep Carreras Leukaemia Research Institute(IJC) BadalonaBarcelonaSpain Centro de Investigacion Biomedica en Red Cancer(CIBERONC) MadridSpain Institucio Catalana de Recerca i Estudis Avançats(ICREA) BarcelonaSpain Physiological Sciences Department School of Medicine and Health SciencesUniversity of Barcelona(UB)L’HospitaletBarcelonaSpain Histopathology Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Cell Signaling and Clinical Proteomics Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability *** 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2].

关键词： glioma remodeling cytoma

Light losses in hollow, prismatic light guides related to prism defects: a transmittance model

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Chinese Optics Letters 2015年第9期13卷 68-72页

作者： Berta García-Fernández Daniel Vázquez-Moliní Antonio álvarez Fernández-Balbuena Angel García-Botella juan carlos martínez Antón Department of Optics Faculty of Optics and Optometry University Complutense of Madrid Department of Physics Applied to Natural Resources School of Forestry EngineeringPolytechnic University of Madrid

Hollow, cylindrical, prismatic light guides （CPLGs） are optical components that, using total internal reflection （TIR）, are able to transmit high-diameter light beams in daylight and artificial lighting applications without relevant losses. It is necessary to study the prism defects of their surfaces to quantify the behavior of these optical components. In this Letter, we analyze a CPLG made of a transparent dielectric material. Scanning electron microscopy （SEM） and the topographic optical profilometry by absorption in fluids （TOPAF） imaging tech- nique are conducted to determine if there are defects in the corners of the prisms. A model for light guide trans- mittance that is dependent on prism defects is proposed. Finally, a simulation and an experimental study are carried out to check the validity of the proposed model.

关键词： Light losses in hollow a transmittance model prismatic light guides related to prism defects

Mapping microstructure to shock-induced temperature fields using deep learning

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npj Computational Materials 2023年第1期9卷 516-523页

作者： Chunyu Li juan carlos Verduzco Brian H.Lee Robert J.Appleton Alejandro Strachan School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA

The response of materials to shock loading is important to planetary science,aerospace engineering,and energetic *** activated processes,including chemical reactions and phase transitions,are significantly accelerated by energy localization into *** result from the interaction of the shockwave with the materials’microstructure and are governed by complex,coupled processes,including the collapse of porosity,interfacial friction,and localized plastic *** mechanisms are not fully understood and the lack of models limits our ability to predict shock to detonation transition from chemistry and microstructure *** demonstrate that deep learning can be used to predict the resulting shock-induced temperature fields in composite materials obtained from large-scale molecular dynamics simulations with the initial microstructure as the only *** accuracy of the Microstructure-Informed Shock-induced Temperature net(MISTnet)model is higher than the current state of the art and its evaluation requires a fraction of the computation cost.

关键词： microstructure Microstructure friction

Time-frequency multiresolution of fault-generated transient signals in transmission lines using a morphological filter

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Protection and Control of Modern Power Systems 2023年第2期8卷 85-98页

作者： juan carlos Quispe John Morales Eduardo Orduna Carlo Liebermann Michael Bruhns Peter Schegner Universidad Nacional de San juan-CONICET San JuanArgentina Universidad Tecnológica del Perú LimaPerú Technical University of Dresden DresdenGermany

The ongoing transformation of electrical power systems highlights the weaknesses of the protection schemes of traditional devices because they are designed and configured according to traditional characteristics of the ***,this work proposes a new methodology to study the fault-generated high frequency transient signals in transmission lines through multiresolution *** high frequency components are determined by a new digital filtering technique based on mathematical morphology theory and a spectral energy ***,wide spectra of signals in the time–frequency domain are *** performance of this method is verified on an electrical power system modeled in ATP-Draw,where simulation and test signals are developed for different locations,fault resistances,inception angles,high frequency noises,sampling frequencies,types of faults,and shapes of the structuring *** results show the characteristics of the fault such as the traveling wave frequency,location,and starting time.

关键词： Digital filter High frequency Mathematical morphology Time–frequency Traveling waves

Stem cells as an option for the treatment of COVID-19

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World Journal of Clinical Cases 2022年第18期10卷 6338-6340页

作者： Maria Veronica Cuevas-González juan carlos Cuevas-González Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32310ChihuahuaMexico Institute of Biomedical Sciences Autonomous University of Ciudad JuárezCiudad Juarez 32310ChihuahuaMexico

The application of stem cells is among the many strategies currently available for the treatment of multiple *** cells are characterized as undifferentiated cells that have the ability to differentiate towards multiple lineages and selfrenewal,among other *** the first umbilical cord stem cell transplant for the treatment of Fanconi anemia,the use of stem cells for the treatment of multiple diseases,including coronavirus disease 2019,has increased,showing promising results that require evaluation through research studies that include a longer follow-up ***,the main objective of this Letter is to provide an update on the use of stem cells in the treatment of severe acute respiratory syndrome coronavirus 2,as well as identify the main challenges and limitations presented by this type of therapy.

关键词： COVID-19 Stem cells Multiple diseases Undifferentiated cells Appropriate treatment Cytokines granulocyte-macrophage colony-stimulating factor

A regionalized IO-model to value seasonal recreational ecosystem services in a mountain National Park in Spain

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Journal of Mountain Science 2022年第1期19卷 211-227页

作者： Víctor martIN BARROSO Mónica de CASTRO-PARDO Pascual FERNÁNDEZ martÍnez João C.AZEVEDO Department of Applied Economics I and history and economic institutions Faculty of Law and Social SciencesUniversidad Rey Juan CarlosCampus of VicálvaroTulipanMóstoles 28933Spain Department of Financial and Actuarial Economics and Statistics-Statistics and Operational Research Complutense University of MadridCampus of SomosaguasPozuelo de Alarcon 28223Spain Centro de Investigação de Montanha Instituto Politécnico de BragançaCampus de Santa ApolóniaBragança 5300-253Portugal

Recreational Ecosystem Services(RES)are among the most frequently evaluated ecosystem *** are seen as a major opportunity for sustainable development in areas of high ecological value resulting from the presence of emblematic species,habitats or scenery,often integrated in conservation areas,in particular in mountain areas affected by depopulation,rising environmental risks and ***,the assessment of RES has been based on Contingent Valuation and Choice Experiments,methods with limitations related to their ***,Input-Output(IO)models provide a very accurate and effective way of valuation of RES with regional information regarding interindustry *** data on nature tourist expenditure may be only available annually,tourism inflows have a strong seasonal behavior,which impacts the profitability of several local economic *** this paper,we firstly constructed a novel regionalized IO-model based on Cross-Industry Location Quotients using employment data and,secondly,based on Monte Carlo simulation,we estimated nature tourist expenditure monthly using data on nature tourism *** method allowed for a more precise RES evaluation,estimating direct,indirect and induced monthly economic impacts of nature-based *** method was applied to the Ordesa and Monte Perdido(OMP)National Park in the Spanish *** estimate the average tourist expenditure,we collected and analyzed spending on commerce,hospitality and restaurants,leisure,and transport of 385 *** suggest that using a regionalized IO model leads to a considerable reduction of over-estimation of the economic impact of tourist expenditure estimated by conventional *** into consideration the direct,indirect and induced effects of tourist expenditure in 2016-2018,the total annual output effect in the OMP National Park amounted to€208.8 million,while the total income effect amounted to€86.29 ***,a total of

关键词： Input-Output Monte Carlo Simulation Location quotients Recreational Ecosystem Services Nature tourism Sustainable mountain development

In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： Ana Lmartínez-López carlos JGonzález-Navarro Paula Aranaz JoséLVizmanos juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition Research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health Research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROS)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROS

Smart Contract to Traceability of Food Social Selling

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Computers, Materials & Continua 2023年第3期74卷 4703-4728页

作者： Cristian Valencia-Payan JoséFernando Grass-Ramírez Gustavo Ramirez-Gonzalez juan carlos Corrales University of Cauca Calle 5#4-70190003Popayan-CaucaColombia

Traditionally,food sustainability has been considered solely in the stage of agricultural ***,globalization,the expansion of the food production industry,and the emergence of supermarket chains that control the retail food market require specific significant changes in supply chains in the food sector and,therefore,we need to address the economic,social,and environmental impacts of these *** the other hand,social selling has increased rapidly in recent years,with a further boom,following current events related to the coronavirus disease(COVID-19).This explosion of social sales,where there are usually no control and regulation entities,can bring problems associated with mishandling *** this paper,we expose how Blockchain technology supports the traceability of social sales by validating the data provided by the chain participants such as digital health passports,production and transport data in the sale process;the proposed solution generates recommendations on productmanagement considering the agreements previously made by the network *** evaluate the proposed smart contracts,we useHyperledger Caliper,obtaining an average throughput of 12.6 transactions per second and an average latency of 0.3 s for the asset update *** also use a study case to evaluate the proposed project platform’s selling-transport stage using Internet of Things(IoT)sensors.

关键词： Blockchain reliability smart contracts social selling traceability artisan sweets

Robotic transanal total mesorectal excision:Is the future now?

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 834-847页

作者： juan carlos Sebastián-Tomás Aleix martínez-Pérez Elías martínez-López Nicola de'Angelis Marcos Gómez Ruiz Eduardo García-Granero Department of Surgery Universidad de ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario Marqués de ValdecillaSantander 39008Spain Grupo de Investigación en Innovación Quirúrgica Instituto de Investigación Biomédica Valdecilla(IDIVAL)Santander 39008Spain Department of General and Digestive Surgery Hospital Universitarioy Politécnico la FeValencia 46026Spain

Total mesorectal excision(TME)is the standard surgical treatment for the curative radical resection of rectal *** invasive TME has been gaining ground favored by the continuous technological *** procedures,such as transanal TME(TaTME),have been introduced to overcome some technical limitations,especially in low rectal tumors,obese patients,and/or narrow *** earliest TaTME reports showed promising results when compared with the conventional laparoscopic ***,recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national *** TaTME(R-TaTME)has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins,and also offers all those advantages provided by the robotic technology in terms of improved precision and *** short-term results have been reported for R-TaTME,but further studies are needed to assess the real role of the new technique in the long-term oncological or functional *** present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature,with a special focus on the potential benefits,harms,and future perspectives for this novel approach.

关键词： Rectal cancer Minimally-invasive surgery Robotics Total mesorectal excision Transanal approach Natural orifice surgery