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Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic:Short and middle term outcomes

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World Journal of Methodology 2024年第2期14卷 107-126页

作者： Jacobo Trébol Ana Carabias-Orgaz María Carmen Esteban-Velasco Asunción García-Plaza juan Ignacio González-Munoz Ana Belén Sánchez-casado Felipe Carlos Parreno-Manchado Marta Eguía-Larrea José Antonio Alcázar-Montero Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Cirugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND The first wave of coronavirus disease 2019(COVID-19)pandemic in Spain lasted from middle March to the end of June *** population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable *** our centre,we managed patients previously and newly diagnosed with *** established a strategy based on limiting perioperative social contacts,preoperative screening(symptoms and reverse transcriptionpolymerase chain reaction)and creating separated in-hospital COVID-19-free pathways for non-infected *** also adopted some practice modifications(surgery in different facilities,changes in staff and guidelines,using continuously changing personal protective equipment…),that supposed new *** To analyse cancer patients with a decision for surgery managed during the first wave,focalizing on outcomes and pandemic-related *** We prospectively included adults with a confirmed diagnosis of colorectal,oesophago-gastric,liver-pancreatic or breast cancer with a decision for surgery,regardless of whether they ultimately underwent *** analysed short-term outcomes[30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection]and outcomes after 3 years(adjuvant therapies,oncological events,death,SARS-CoV-2 infection and vaccination).We also investigated modifications to usual *** From 96 included patients,seven didn’t receive treatment that period and four never(3 due to COVID-19).Operated patients:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortality 3.57%/0%,major complications 7.04%/25.00%,anastomotic leaks 0%/5.00%,3-years disease-free survival(DFS)82.14%/52.4%and overall survival(OS)78.57%/76.2%.Six liver metastases and six pancreatic cancers:no mortality,one major complication,three grade A/B liver failures,one bile leak;3-year DFS 0%/33.3%and OS 50.0%/33.3%(liver metastases/pancreatic carcinoma).5 g

关键词： COVID-19 SARS-CoV-2 Colon cancer Rectal cancer Breast cancer Liver cancer Pancreatic cancer Gastric cancer Oesophageal cancer Surgery

Paclitaxel-loaded hollow-poly（4-vinylpyridine） nano- particles enhance drug chemotherapeutic efficacy in lung and breast cancer cell lines

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Nano Research 2017年第3期10卷 856-875页

作者： Rafael Contreras-Caceres Maria C. Leiva Raul Ortiz Amelia diaz Gloria Perazzoli Miguel A.casado-Rodriguez Consolacion Melguizo Jose M. Baeyens juan M. Lopez-Romero Jose Prados Department of Organic Chemistry Faculty of Science University of Mdlaga 29071 Malaga Spain Institute of Biopathology and Regenerative Medicine (IBIMER) Center of Biomedical Research (CIBM) University of Granada 18100 Granada Spain Department of Anatomy and Embryology Faculty of Medicine University of Granada 18071 Granada Spain Biosanitary Institute of Granada (IBS. GRANADA) SAS-Universidad de Granada 18014 Granada Spain Department of Health Science University of Jaen 23071 Jadn Spain Department of Pharmacology Institute of Neuroscience Biomedical Research Center (CIBM) University of Granada 18100 Granada Spain

Paclitaxel （PTX）, one of the most effective cytotoxins for the treatment of breast and lung cancer, is limited by its severe side effects and low tumor selectivity. In this work hollow-poly（4-vinylpyridine）（hollow-p4VP） nanoparticles （NPs） have been used for the first time to generate PTX@p4VP NPs, employing a novel technique in which a gold core in the center of the NP is further oxidized to produce the hollow structure into which PTX molecules can be incorporated. The hollow-p4VP NPs exhibit good physicochemical properties and displayed excellent biocompatibility when tested on blood （no hemolysis） and cell cultures （no cytotoxicity）. Interestingly, PTX@p4VP NPs significantly increased PTX cytotoxicity in human lung （A-549） and breast （MCF-7） cancer cells with a significant reduction of PTX ICs0 （from 5.9 to 3.6 nM in A-549 and from 13.75 to 4.71 nM in MCF-7）. In addition, PTX@p4VP caused a decrease in volume of A-549 and MCF-7 multicellular tumor spheroids （MTS）, an in vitro system that mimics in vivo tumors, in comparison to free PTX. This increased antitumoral activity is accompanied by efficient cell internalization and increased apoptosis, especially in lung cancer MTS. Our results offer the first evidence that hollow- p4VP NPs can improve the antitumoral activity of PTX. This system can be used as a new nanoplatform to overcome the limitations of current breast and lung cancer treatments.

关键词： paclitaxel poly(4-vinylpyridine)(p4VP) nanoparticles lung cancer breast cancer cytotoxicity multicellular tumorspheroids

New open clusters found by manual mining of data based on Gaia DR2

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Research in Astronomy and Astrophysics 2021年第5期21卷 147-154页

作者： juan casado Facultad de Ciencias Universidad Autnoma de Barcelona08193BellaterraCataloniaSpain

The physical nature of a series of 20 new open clusters is confirmed employing existing data on putative star members,mainly from the second Gaia Data Release(DR2).The clusters were discovered as overdensities of stars by visual inspection of either photographic DSS plates or proper motion plots of random source *** reported objects are not present in the most comprehensive or recent catalogs of stellar clusters and *** all of them,clumps of comoving stars are revealed in the proper motion *** parallaxes of the clumped stars are compatible with the real existence of open clusters over narrow ranges of *** density calculations,free of most noise from non-member sources,allow differentiating a cluster core and an extended cluster corona in some ***-magnitude diagrams generally show a definite main sequence that allows confirmation of the physical existence of the clusters and some of their *** of the new clusters seem to form a double system with a common *** of the new clusters challenge the claim of near completeness of the known OC population in the distance range from 1.0 to 1.8 kpc from the Sun(Kharchenko et al.).

关键词： astronomical databases:miscellaneous parallaxes proper motions(stars:)Hertzsprung-Russell CCM diagrams(Galaxy:)open clusters associations:individual

Female control of sperm ejection and retention in the cornsilk fly Euxesta eluta(Diptera:Ulididae)

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Insect Science 2023年第4期30卷 1183-1190页

作者： Solana Abraham Andrea Moyano Viviana diaz MGabriela Murua juan Rull Laboratorio de Investigaciones Ecoetologicas de Moscas de la Fruta y sus Enemigos Naturales(LIEMEN) PROIMI-BiotecnologiaCONICETTucumanArgentina Instituto de Tecnologia Agroindustrial del Noroeste Argentino(ITANOA) Estacion Experimental Agroindustrial Obispo Colombres(EEAOC)—CONICETTucumanArgentina

Promiscuous mating systems provide the opportunity for females to bias fertilization toward particular ***,distinguishing between male sperm com-petition and active female sperm choice is difficult for species with internal ***,species that store and use sperm of different males in different storing struc-tures and species where females are able to expel all or part of the ejaculates after cop-ulation may be able to bias *** report a series of experiments aimed at pro-viding evidence of female sperm choice in Euxesta eluta(Hendel),a species of ulidiid fly that expels and consumes ejaculates after *** found no evidence of greater reproductive success for females mated singly,multiply with the same male,or mated multiply with different *** *** possesses two spherical spermathecae and a bursa copulatrix for sperm storage,with a ventral *** was no significant difference in storing more sperm in spermathecae 24 h after copulation than immediately after *** mated with protein-fed males had greater reproductive success than similar females mated to protein-deprived ***-fed females prevented to consume the ejaculate,retained more sperm when mated to protein-fed males than when mated to protein-deprived *** results suggest that female *** can exert control of sperm retention of higher quality males through ejaculate ejection.

关键词： bursa copulatrix cornsilk fly cryptic female choice ejaculate consumption sperm choice spermathecae

Assessing a novel modelling approach with high resolution UAV imagery for monitoring health status in priority riparian forests

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Forest Ecosystems 2021年第4期8卷 810-830页

作者： juan Guerra-Hernandez Ramon A.diaz-Varela juan Gabriel Avarez-Gonzalez Patricia Maria Rodriguez-Gonzalez edata Centro de iniciativas empresariaisFundacion CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonInstituto Superior de Agronomia(ISA)Tapada da Ajuda1349-017 LisbonPortugal Biodiversity and Applied Botany Unit(GI BIOAPLIC 1809) Department of BotanyEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus Universitario27002 LugoSpain Sustainable Forest Management Unit(UXFS) Department of Agroforestry EngineeringEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus UniversitarioE-27002 LugoSpain

Background:Black alder(Alnus glutinosa)forests are in severe decline across their area of distribution due to a disease caused by the soil-borne pathogenic Phytophthora alni species complex(class Oomycetes),“alder Phytopththora”.Mapping of the different types of damages caused by the disease is challenging in high density ecosystems in which spectral variability is high due to canopy *** obtained by unmanned aerial vehicles(UAVs)may be particularly useful for such tasks due to the high resolution,flexibility of acquisition and cost efficiency of this type of *** this study,*** decline was assessed by considering four categories of tree health status in the field:asymptomatic,dead and defoliation above and below a 50% threshold.A combination of multispectral Parrot Sequoia and UAV unmanned aerial vehicles-red green blue(RGB)data were analysed using classical random forest(RF)and a simple and robust three-step logistic modelling approaches to identify the most important forest health indicators while adhering to the principle of parsimony.A total of 34 remote sensing variables were considered,including a set of vegetation indices,texture features from the normalized difference vegetation index(NDVI)and a digital surface model(DSM),topographic and digital aerial photogrammetry-derived structural data from the DSM at crown ***:The four categories identified by the RF yielded an overall accuracy of 67%,while aggregation of the legend to three classes(asymptomatic,defoliated,dead)and to two classes(alive,dead)improved the overall accuracy to 72% and 91% *** the other hand,the confusion matrix,computed from the three logistic models by using the leave-out cross-validation method yielded overall accuracies of 75%,80% and 94% for four-,three-and two-level classifications,***:The study findings provide forest managers with an alternative robust classification method for the rapid,effective assessment of area

关键词： Alder RPAS Multi-spectral Defoliation Texture variables 3D point cloud Tree health monitoring

Ballistic impact response of flexible and rigid UHMWPE textile composites:Experiments and simulations

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Defence Technology（防务技术） 2023年第4期22卷 37-53页

作者： Hongxu Wang Dakshitha Weerasinghe Paul J.Hazell Damith Mohotti Evgeny V.Morozov juan P.Escobedo-diaz School of Engineering and Information Technology The University of New South WalesCanberraACT2600Australia

This study elaborates on the effects of matrix rigidity on the high-velocity impact behaviour of UHMWPE textile composites using experimental and numerical *** composite samples were manufactured of a plain-weave fabric(comprising Spectra?1000 fibres)and four different matrix ***-velocity impact tests were conducted by launching a spherical steel projectile to strike on the prepared samples via a gas *** experimental results showed that the textile composites gradually changed from a membrane stretching mode to a plate bending mode as the matrix rigidity and thickness *** composites deformed in the membrane stretching mode had higher impact resistance and energy absorption capacity,and it was found that the average energy absorption per ply was much higher in this mode,although the number of broken yarns was smaller in the perforated ***,the flexible matrix composites always had higher perforation resistance but larger deformation than the rigid matrix counterparts in the tested thickness and velocity range.A novel numerical modelling approach with enhanced computational efficiency was proposed to simulate textile composites in mesoscale *** simulation results revealed that stress and strain development in the more rigid matrix composite was localised in the vicinity of the impact location,leading to larger local deformation and inferior perforation resistance.

关键词： Impact behaviour Textile composite UHMWPE fibre Energy absorption Finite element analysis

Photosynthetic and Molecular Markers of CO_2-mediated Photosynthetic Downregulation in Nodulated Alfalfa

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Journal of Integrative Plant Biology 2013年第8期55卷 721-734页

作者： Alvaro Sanz-Sez Gorka Erice Iker Aranjuelo Ricardo Aroca juan Manuel Ruíz-Lozano Jone Aguirreolea juan Jos Irigoyen Manuel Sanchez-diaz Department of Plant Biology University of NavarraPamplonaE-31008Spain Department of Plant Biology University of BarcelonaBarcelonaE-8028Spain Department of Plant Biology University of Illinois at Urbana-Champaign61801USA Agrobiotechnology Institute Public University of NavarraMutilva BajaE-31192Spain Department of Soil Microbiology and Symbiotic Systems Zaidin Experimental Station(CSIC)GranadaE-18008.Spain

Elevated CO2 leads to a decrease in potential net photosynthesis in long-term experiments and thus to a reduction in potential growth. This process is known as photosynthetic downregulation. There is no agreement on the definition of which parameters are the most sensitive for detecting CO2 acclimation. In order to investigate the most sensitive photosynthetic and molecular markers of CO2 acclimation, the effects of elevated CO2, and associated elevated temperature were analyzed in alfalfa plants inoculated with different Sinorhizobium meliloti strains. Plants （Medicago sativa L. cv. Aragon） were grown in summer or autumn in temperature gradient greenhouses （TGG）. At the end of the experiment, all plants showed acclimation in both seasons, especially under elevated summer temperatures. This was probably due to the lower nitrogen （N） availability caused by decreased N2-fixation under higher temperatures. Photosynthesis measured at growth CO2 concentration, rubisco in vitro activity and maximum rate of carboxylation were the most sensitive parameters for detecting downregulation. Severe acclimation was also related with decreases in leaf nitrogen content associated with declines in rubisco content （large and small subunits） and activity that resulted in a drop in photosynthesis. Despite the sensitivity of rubisco content as a marker of acclimation, it was not coordinated with gene expression, possibly due to a lag between gene transcription and protein translation.

关键词： Carbon dioxide Medicago sativa (alfalfa) photosynthetic downregulation RbcL and RbcS Sinorhizobium meliloti.

Promiscous female Euxesta eluta derive nutrients for ovarian development by expelling and consuming ejaculates

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Insect Science 2020年第3期27卷 545-557页

作者： Solana Abraham Gisela Castillo Viviana diaz Guido Van Nieuwenhove Gabriela Murua juan Rull Laboratorio de Investigaciones Ecoetologicas de Moscas de la Fruta y sus Enemigos Naturales(LIEMEN) PROIMI-BiotecnologiaCONICETTucumanArgentina Fundacion Miguel Ullo Instde EntomologiaDepto ZoologiaMiguel Lillo 251San Miguel de TucumanTucumanArgentina Facultad de Ciencias Naturales e I.M.L Universidad Nacional de TucumanSan Miguel de TucumanTucumanArgentina Estacion Experimental Agroindustrial Obispo Colombres(EEAOC)_ITANOA CONICET TucumanArgentina

Seminal gifts range from important material donations to items that provide little direct benefit to ***,female silk corn flies Euxesta eluta expel and consume male ejaculates immediately after *** evolution and function of this peculiar behavior are currently *** performed a series of experiments aimed to:determine if females under different dietary regimes derive nutrients or water for survival and/or reproduction from ejaculate consumption,if males suffer a fitness cost from supplying females with ejaculates,and if females prefer to mate and/or are more likely to store sperm from well fed than nutritionally stressed presumably inferior *** revealed that protein deprived *** females derive nutrients for ovarian development through consumption of ejaculates of protein fed *** seminal products affecting survival appear to be transferred in the consumed ***,ovarian development,in contrast to testes growth,occurs in detriment of *** preferred to mate with protein fed males,yet sperm retention in spermathecae was extremely rare after a single *** finding suggests that females could be exerting post copulatory control.A key question that remained to be addressed for the understanding of this puzzling and promiscuous mating system is what ecological factors or male traits drive females to retain sperm from one or several males in order to achieve and/or maximize fertilization potential.

关键词： anautogeny polyandry postcopulatory female control seminal gifts sperm storage

Rectal cancer treatment: improving the picture

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World Journal of Gastroenterology 2007年第44期13卷 5805-5812页

作者： juan A diaz-Gonzalez Leire Arbea Javier Aristu Department of Oncology Clinica Universitaria Universtity of Navarra Pamplona 31080 Spain

Multidisciplinary approach for rectal cancer treatment is currently well defined. Nevertheless, new and promising advances are enriching the portrait. Since the US NIH Consensus in the early 90's some new characters have been added. A bird's-eye view along the last decade shows the main milestones in the development of rectal cancer treatment protocols. New drugs, in combination with radiotherapy are being tested to increase response and tumor control outcomes. However, therapeutic intensity is often associated with toxicity. Thus, innovative strategies are needed to create a better-balanced therapeutic ratio. Molecular targeted therapies and improved technology for delivering radiotherapy respond to the need for accuracy and precision in rectal cancer treatment.

关键词： Rectal cancer Chemoradiotherapy Intensitymodulated radiation therapy Molecular targeted therapy