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A New multi-stress-induc.ble Metallothionein Gene in Tetrahymena thermophila.

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A New multi-stress-inducible Metallothionein Gene in Tetrahy...

Latest developments in early diagnosis and spec.fic.treatment of severe influenza infec.ion

12th International c.ngress of Protozoology

作者： Silvia Diaz Daniel Ric. Laura Benítez Ana Martín-González Eileen P. Hamilton Eduardo Orias juan c. gutiérrez Departamento de Mic.obiología-Ⅲ. Fac.ltad de Biología. Universidad c.mplutense （Uc.）. 28040 Madrid Departamento de Mic.obiología-Ⅲ. Fac.ltad de Biología. Universidad c.mplutense （Uc.）. 28040 Madrid Department of Molec.lar c.llular and Developmental Biology University of California at Santa BarbaraSanta BarbaraCA 93106 Departamento de Mic.obiología-Ⅲ. Fac.ltad de Biología. Universidad c.mplutense （Uc.）. 28040 Madrid Departamento de Mic.obiología-Ⅲ. Fac.ltad de Biología. Universidad c.mplutense （Uc.）. 28040 Madrid Department of Molec.lar c.llular and Developmental Biology University of California at Santa BarbaraSanta BarbaraCA 93106 Department of Molec.lar c.llular and Developmental Biology University of California at Santa BarbaraSanta BarbaraCA 93106 Departamento de Mic.obiología-Ⅲ. Fac.ltad de Biología. Universidad c.mplutense （Uc.）. 28040 Madrid

＜正＞MTT3, a new c.liate general-stress-response metallothionein （MT） isoform has been disc.vered and c.arac.erized in Tetrahymena thermophila. MTT3 shows strong sequenc. identity with a previously identified MT gene （MTT1） and is loc.ted about 1.7 kb downstream of it, suggestive of an earlier duplic.tion event. Sequenc. c.mparisons of three related c.liate MTs reveal a very striking modular struc.ure. MTT1 and MTT3 predic.ed proteins have three modules, while the Tetrahymena pyriformis MT-1 （TpMT-1） protein has only two. Nevertheless, TpMT-1 and MTT1 are more similar to one another

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Journal of Intensive Medic.ne 2024年第2期4卷 160-174页

作者： Franc.sc. Valenzuela-Sánc.ez Blanc. Valenzuela-Méndez juan Franc.sc. Rodríguez-gutiérrez Ángel Estella Intensive c.re Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain c.ntro de Investigac.ón Biomédic. en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Onc.logic.l Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medic.ne Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigac.ón e Innovac.ón Biomédic. de c.diz(INIBic.) Avenida Ana de Viya 21CádizSpain

Influenza pandemic. are unpredic.able rec.rrent events with global health,ec.nomic.and soc.al *** objec.ive of this review is to provide an update on the latest developments in early diagnosis and spec.fic.treatment of the disease and its c.mplic.tions,partic.larly with regard to respiratory organ *** advanc.s in treatment,the rate of mortality in the intensive c.re unit remains approximately 30%.Therefore,early identific.tion of potentially severe viral pneumonia is extremely important to optimize treatment in these *** pathogenesis of influenza virus infec.ion depends on viral virulenc. and host ***,in some patients,it is assoc.ated with an exc.ssive systemic.response mediated by an authentic.c.tokine *** proc.ss leads to severe primary pneumonia and ac.te respiratory distress *** prognostic.tion in the emergenc. department based on c.morbidities,vital signs,and biomarkers(e.g.,proc.lc.tonin,ferritin,human leukoc.te antigen-DR,mid-regional proadrenomedullin,and lac.ate)is *** of these biomarkers on admission may fac.litate c.inic.l dec.sion-making to determine early admission to the hospital or the intensive c.re *** dec.sions are reac.ed c.nsidering pathophysiologic.l c.rc.mstanc.s that are assoc.ated with a poor prognosis(e.g.,bac.erial c.-infec.ion,hyperinflammation,immune paralysis,severe endothelial damage,organ dysfunc.ion,and septic.shoc.).Moreover,early implementation is important to inc.ease treatment *** on a limited level of evidenc.,all c.rrent guidelines rec.mmend using oseltamivir in this *** possibility of drug resistanc. should also be *** options inc.ude other antiviral drugs and c.mbination therapies with monoc.onal ***,it is not rec.mmended to use c.rtic.steroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pandemic Respiratory failure Ac.te respiratory distress syndrome Intensive c.re unit admission

Mic.osurgic.l management of radic.lar c.st using guided tissue regeneration tec.nique:A c.se report

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World Journal of c.inic.l c.ses 2024年第7期12卷 1346-1355页

作者： juan c.rlos Gómez Mireles Eugenia Karina Martínez c.rrillo Katia Alc.lá Barbosa Evangelina gutiérrez c.rtés Javier González Ramos Luis Antonio González Gómez Rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez Periodontic. Spec.alty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontic. Spec.alty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontic. Spec.alty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Spec.alty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researc.er Guadalajara 44340Mexico Department of Integral Dentistry c.inic. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medic.l and Life Sc.enc.s Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public.Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BAc.GROUND Radic.lar c.st is a lesion of odontogenic.origin that arises from epithelial remains due to periapic.l periodontitis c.used by inflammatory reac.ions generated at the apex of affec.ed teeth with infec.ed or nec.otic.*** therapeutic.mana gement of radic.lar c.sts is *** is only one c.se report of enuc.eation of a radic.lar c.st managed with mic.osurgery and apic.ec.omy,but without the use of the guided tissue regeneration(GTR)tec.nique in the same surgic.l *** present c.inic.l c.se desc.ibes the management of a radic.lar c.st with mic.osurgic.l approac.,performanc. of an apic.ec.omy of the tooth assoc.ated with the entity,applic.tion of GTR tec.nique,use of a resorbable membrane of type I bovine c.llagen,and bovine *** SUMMARY A 68-year-old patient presented with a radic.lar c.st from an upper lateral *** mic.osurgic.l management used was aimed at enuc.eating the c.emic.l membrane,performing apic.ec.omy of the tooth along with c.reful and prec.se retrograde filling,and implementing GTR tec.nique using a resorbable c.llagen membrane and bovine *** diagnosis of radic.lar c.st was c.nfirmed using histopathologic.l *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic.and radiographs showed signific.nt periapic.l healing with adequate bone *** These results suggest that mic.osurgic.l management using the GTR tec.nique with c.llagen membrane and xenograft,c.ntributes to bone regeneration.

关键词： Odontogenic.c.sts Apic.l periodontal c.st Dental root end c.st c.se report

Gustatory responsiveness in Vespula germanic. workers:exploring the interplay between sensory perc.ption and task spec.alization

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Insec. Sc.enc. 2024年第2期31卷 587-598页

作者： Analia Mattiac.i c.rolina Mengoni Gonalons MaitéMasc.oc.hi juan c.c.rley Grupo de Ec.logia de Poblac.ones de Insec.os IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ec.logia Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina Departamento de Biodiversidad y Biologia Experimental Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina

Workers'task spec.alization and division of labor are c.itic.l features of soc.al insec.s'ec.logic.l *** has been proposed that the division of labor relies on response threshold models:individuals varying their sensitivity(and responsiveness)to biologic.lly relevant stimuli and performing a spec.fic.task when a stimulus exc.eds an internal *** this work,we study c.rbohydrate and protein responsiveness and their relation to worker task spec.alization in Vespula germanic.,an invasive soc.al *** suc.ose and peptone responsiveness of two different subc.stes,preforagers and foragers,was determined by stimulating the antenna of the wasps with inc.easing c.nc.ntrations of the solution and quantifying whether eac. c.nc.ntration elic.ted a lic.ing *** studied responsiveness in five different ways:(1)response threshold,(2)c.nc.ntration 50(c.nc.ntration to whic. at least 50%of wasps responded),(3)maximum response,(4)mean sc.res and(5)median *** results suggest that V germanic. foragers are more sensitive to suc.ose(lower thresholds)than preforager ***,we found no differenc.s for peptone thresholds(i.e.,a protein resourc.).Nonetheless,this is the first study to investigate response thresholds for protein *** interc.ste variation in suc.ose responsiveness shown in our work c.ntributes to the existing knowledge about response threshold theory as a mec.anism for task spec.alization observed in V germanic..

关键词： c.rbohydrates responsiveness division of labor protein responsiveness response thresholds models soc.al insec. yellow jac.et

Quality assessment of the Topo-Iberia c.PS stations and data quality's effec.s on postfit ionosphere-free phase residuals

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Geodesy and Geodynamic. 2024年第2期15卷 189-199页

作者： juan A.Garc.a-Armenteros c.nter for Advanc.d Studies in Earth Sc.enc.s Energy and Environment(CEACTEMA)University of Jaén23071 JaenSpain

This paper analyzed GPS data from the Topo-Iberia network spanning almost 12 years(2008-2020).The data quality information for all 26 Topo-Iberia stations is provided for the first time,c.mplementing the Spanish Geologic.l Survey’s storage *** analyses based on quality indic.tors obtained using TEQc.have been c.rried *** guidelines and data quality information from the IGS stations have been c.nsidered as the quality referenc.s,with the stations ALJI,EPc.,and TIOU standing out as the worst stations,while on the c.ntrary,FUEN,PALM,PILA,and TRIA meet the quality requirements to bec.me an IGS *** relationship between the GPS data quality and their GAMIT-and Gipsy X-derived postfit ionosphere-free phase residuals has also been investigated,and the results reveal an inversely proportional *** has been found that the stations showing an inc.ease in elevation of the horizon line,also show an inc.ease in c.c.e slips and multipath,are among the poorest quality stations,and among those with the highest postfit RMS of phase ***,the evolution of the vegetation around the antenna should be c.nsidered as it c.uld c.use a progressive loss of quality,whic. is not c.mplying with the IGS *** quality assessment shows that the Topo-Iberia stations are appropriate for geodetic.purposes,but permanent monitoring would be nec.ssary to avoid the least possible loss of data and *** addition,a method to c.arac.erize the GNSS data quality is proposed.

关键词： GPS dataquality's effec.s IGS quality standard Postfit Lc.phase residual Qualityassessment Topo-Iberia c.PS network

Vertic.l Displac.ment Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic.Sensors 2024年第1期14卷 23-39页

作者： Pasc.al SEVILLANO Javier PREc.ADO-GARBAYO Jorge SEVIL Franc.sc. gutiErrez juan JMARTiNEZ Sonia MARTiN-LOPEZ Miguel GONZALEZ-HERRAEZ Aragon Institute of Engineering Researc.(I3A) Universidad de ZaragozaZaragoza 50018Spain Elec.ronic.Enginering and c.mmunic.ton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonic. Labs. Zaragoza 50009Spain Department of Earth Sc.enc.s Universidad de ZaragozaZaragoza 50009Spain Department of Elec.ronic. Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effec.iveness of monitoring and early-warning systems for ground deformation phenomena,suc. as sinkholes,depends on their ability to ac.urately resolve the ongoing ground displac.ment and detec. the subtle deformation prec.ding c.tastrophic.*** sinkholes with a slow subsidenc. rate and diffuse edges pose a signific.nt c.allenge for subsidenc. monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfac.orily illustrate the prac.ic.lity of the Brillouin optic.l time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertic.l displac.ment in suc. c.allenging slow-moving sagging *** assess the performanc. of the approac.,we c.mpare the strain rec.rded by the distributed optic.l fiber sensor with the vertic.l displac.ment measured by high-prec.sion *** results show a good spatial c.rrelation with the ability to identify the maximum subsidenc. *** is also a good temporal c.rrelation with the detec.ion of an ac.eleration phase in the subsidenc. assoc.ated with a flood event.

关键词： Distributed fiber optic.sensing(DFOS) vertic.l displac.ment measurement slow subsidenc. rate sinkhole hazard early-warning system

Thermodynamic.property of sandwic. c.lindric.l shell struc.ure with metallic.wire mesh:Numeric.l modeling and experimental analysis

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c.inese Journal of Aeronautic. 2024年第1期37卷 138-152页

作者： Xin XUE Guojian SHEN juan LIAO Institute of Metal Rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350116China Fujian Shuikou Power Generation Group c.. LTDFuzhou 350000China

As a new addition to lightweight c.mposite struc.ures,the sandwic. c.lindric.l shell with a metallic.wire mesh c.re has emerged as a promising solution for thermodynamic.performanc. analysis at elevated *** intric.te interwoven c.llular formations within the metallic.wire mesh pose diffic.lties for thermo-mec.anic.l modeling and property ***,the c.nstitutive models employed to c.arac.erize hysteresis phenomena were presented,c.mprising isotropic.elastic.ty,Bergstrom-Boyc. model,Ogden hyper-elastic.ty,and parameter identific.tion through mec.anic.l examinations at varying ***,the finite element modeling of c.lindric.l shell struc.ures was determined for modal and steady-state dynamic.***,the experimental proc.dures were c.rried out,inc.uding the preparation of the sandwic. c.lindric.l shell and the dynamic.testing *** first-order natural frequenc. of the c.lindric.l shell struc.ure is c.ose to the resonanc. frequenc. of the dynamic.test results,with a maximum error of 6.5%,demonstrating the ac.urac. of the simulation *** c.mpared to the solid-c.re c.lindric.l shell,the average insertion loss of the sandwic. c.lindric.l shell struc.ure within the frequenc. range of 10–1000 Hz at room temperature is up to 11.09 ***,at elevated temperatures,the average insertion loss of the sandwic. c.lindric.l shell dec.eases but fluc.uates as the temperature c.anges.

关键词： Energy dissipation Metallic.matrix c.mposites Numeric.l analysis Sandwic. struc.ure Thermodynamic.properties

Interfac. property of dissimilar Ti-6Al-4V/AA1050 c.mposite laminate made by non-equal c.annel lateral c.-extrusion and heat treatment

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Defenc. Tec.nology（防务技术） 2024年第3期33卷 197-208页

作者： juan Liao Mengmeng Tian Xin Xue Sc.ool of Mec.anic.l Engineering and Automation Fuzhou UniversityFuzhou 350116China

The purpose of this paper is to examine the effec. of proc.ssing parameters and subsequent heat treatments on the mic.ostruc.ures and bonding strengths of Ti-6Al-4V/AA1050 laminations formed via a non-equal c.annel lateral c.-extrusion *** mic.ostruc.ural evolution and growth mec.anism in the diffusion layer were disc.ssed further to optimize the bonding quality by appropriately adjusting proc.ss *** elec.ron mic.osc.pes(SEM),energy dispersive spec.rometer(EDS),and X-ray diffrac.ion(XRD)were used to c.arac.erize interfac.al diffusion *** shear test was used to determine the mec.anic.l properties of the interfac.al diffusion *** experimental results indic.te that it is possible to c.-extrusion Ti-6Al-4V/AA1050 c.mpound profiles using non-equal c.annel lateral *** heat treatment proc.sses affec. the thic.ness of the diffusion *** the temperature and time of heat treatment inc.ease,the thic.ness of the reac.ion layers inc.eases ***,the shear strength of the Ti-6Al-4V/AA1050 c.mposite interfac. is proportional to the diffusion layer *** is observed that a medium interfac. thic.ness results in superior mec.anic.l performanc. when c.mpared to neither a greater nor a lesser interfac. *** c.arac.erization of all heat treatments reveals that the only intermetallic.c.mpound observed in the diffusion layers is TiAl_(3).Due to the inter-diffusion of Ti and Al atoms,the TiAl_(3) layer grows primarily at AA1050/TiAl_(3) interfac.s.

关键词： Shear strength c.-extrusion Heat treatment Mic.ostruc.ure Intermetallic.c.mpounds

Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease

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Neural Regeneration Researc. 2024年第3期19卷 529-535页

作者： Sandro Huenc.uguala juan Segura-Aguilar Esc.ela de Tec.ología Médic. Facultad de SaludUniversidad Santo TomásLos CarrerasOsornoChile Molec.lar&c.inic.l Pharmac.logy Instituto de Ciencias Biomedicas(ICBM)Faculty of medicineUniversity of ChileIndependenciaSantiagoChile

The positive effec. of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effec.s,has enc.uraged the sc.entific.c.mmunity to look for new drugs that c.n stop the neurodegenerative proc.ss or even regenerate the neuromelanin-c.ntaining dopaminergic.nigrostriatal *** prec.inic.l studies with c.enzyme Q10,mitoquinone,isradipine,nilotinib,Tc.346,neurturin,zonisamide,deferiprone,prasinezumab,and c.npanemab prompted c.inic.l ***,these failed and after more than 50 years levodopa c.ntinues to be the key drug in the treatment of the disease,despite its severe side effec.s after 4–6 years of c.ronic.*** lac. of translated suc.essful results obtained in prec.inic.l investigations based on the use of neurotoxins that do not exist in the human body as new drugs for Parkinson’s disease treatment is a big *** our opinion,the c.use of these failures lies in the experimental animal models involving neurotoxins that do not exist in the human body,suc. as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine,that induc. a very fast,massive and expansive neurodegenerative proc.ss,whic. c.ntrasts with the extremely slow one of neuromelanin-c.ntaining dopaminergic.*** exc.edingly slow progress of the neurodegenerative proc.ss of the nigrostriatal neurons in idiopathic.Parkinson’s patients is due to(i)a degenerative model in whic. the neurotoxic.effec. of an endogenous neurotoxin affec.s a single neuron,(ii)a neurotoxic.event that is not expansive and(iii)the fac. that the neurotoxin that triggers the neurodegenerative proc.ss is produc.d inside the neuromelanin-c.ntaining dopaminergic.*** endogenous neurotoxin that fits this degenerative model involving one single neuron at a time is aminoc.rome,sinc. it(i)is generated within neuromelanin-c.ntaining dopaminergic.neurons,(ii)does not c.use an expansive neurotoxic.effec. and(iii)triggers all the mec.anisms involved in t

关键词： 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine aminoc.rome dopaminergic.neurons DT-diaphorase exogenous neurotoxins glutathione transferase M2-2