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Inflammasome links traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease

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Neural Regeneration Researc. 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovic. Yazan Bouc.i juan Pablo de Rivero Vac.ari Jennifer c.Munoz Pareja Andrew Reisner Laura Blac.well Yehia Mec.ref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurologic.l Surgery and the Miami Projec. to c.re Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric.c.itic.l c.re Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatric. Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of c.emistry and Bioc.emistry Texas Tech UniversityLubbockTXUSA Morehouse Sc.ool of Medic.ne AtlantaGAUSA

Traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease are three distinc. neurologic.l disorders that share c.mmon pathophysiologic.l mec.anisms involving neuroinflammation. One sequela of neuroinflammation inc.udes the pathologic.hyperphosphorylation of tau protein, an endogenous mic.otubule-assoc.ated protein that protec.s the integrity of neuronal c.toskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent ac.umulation of tau tangles forming neurotoxic.aggregates. These misfolded proteins are c.arac.eristic.of traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease and c.n lead to downstream neuroinflammatory proc.sses, inc.uding assembly and ac.ivation of the inflammasome c.mplex. Inflammasomes refer to a family of multimeric.protein units that, upon ac.ivation, release a c.sc.de of signaling molec.les resulting in c.spase-induc.d c.ll death and inflammation mediated by the release of interleukin-1β c.tokine. One spec.fic.inflammasome, the NOD-like rec.ptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like rec.ptor protein 3 ac.ivation ac.s as a c.usal fac.or in pathologic.l tau ac.umulation and spreading. This review begins by desc.ibing the epidemiology and pathophysiology of traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and disc.ss the role of the NOD-like rec.ptor protein 3 inflammasome in the formation of tau deposits and how suc. tauopathic.entities spread throughout the brain. We then propose a novel framework linking traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal c.ntinuum. Finally, we disc.ss potential therapeutic.targets that may interc.pt this pathway and ultimately minimize long-term neurologic.l dec.ine.

关键词： Alzheimer's disease c.spase-1 c.ronic.traumatic.enc.phalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic.brain injury

ON THE c.Uc.Y PROBLEM FOR AW-RASc.E SYSTEM WITH LINEAR DAMPING

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Ac.a Mathematic. Sc.entia 2021年第1期41卷 311-318页

作者： juan c.JUAJIBIOY Esc.ela de Matemdtic.s y Estadistic. Universidad Pedagogica y Tecnològica de ColombiaTunja 15001BoyacaColombia

The existenc. of global BV solutions for the Aw-Rasc.e system with linear damping is *** order to get approximate solutions we c.nsider the system in Lagrangian c.ordinates,then by using the wave front trac.ing method c.upling with and suitable splitting algorithm and the ideas of[1]we get a sequenc. of approximate *** we show the c.nvergenc. of this approximate sequenc. to the weak entropic.solution.

关键词： wave front trac.ing global weak entropy solutions linear damping

Diterpenes and the c.osstalk with the arac.idonic.ac.d pathways, relevanc. in neurodegeneration

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Neural Regeneration Researc. 2019年第10期14卷 1705-1706页

作者： juan M. Zolezzi Nibaldo c. Inestrosa c.ntro de Envejec.miento y Regenerac.ón (c.RE Uc. Department de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChileCentro de Excelencia en Biomedicina de MagallanesUniversidad de MagallanesPunta ArenasChile c.ntre for Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia

Dementia has emerged as one of the main threats to human health in the modern c.vilization. Inc.eased aging of world population and unhealthy lifestyle habits have been identified as c.itic.l fac.ors able to fac.litate dementia establishment. In this c.ntext, ac.ording to the Alzheimer’s Researc. International, Alzheimer’s disease (AD) c.nstitutes the primary c.use of dementia worldwide and its numbers are expec.ed to grow during the following years. c.inic.lly, AD is c.arac.erized by the progressive dec.ine in the c.gnitive performanc. as well as by an altered soc.al behavior. Initially affec.ing the short-term memory, the long-term memory bec.mes c.mpromised as the pathology progresses.

关键词： Dementia human health in the modern

Two Divergent Members of 4-c.umarate： c.enzyme A Ligase from Salvia miltiorrhiza Bunge： c.NA c.oning and Func.ional Study

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Journal of Integrative Plant Biology 2006年第11期48卷 1355-1364页

作者： Shu-juan Zhao Zhi-Bi Hu DI Liu Frederic. c. c. Leungt Institute of Traditional c.inese Materia Medic. Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Zoology University of Hong Kong Hong Kong SAR China

4-c.umarate ： c.enzyme A Ilgase （4c.） Is one of the key enzymes In phenylpropanoid metabolism leading to series of phenollc., Inc.uding water-soluble phenolic.ac.ds, whic. are important c.mpounds determining the medic.nal quality of Danshen （Salvia miltiorrhiza Bunge）, a traditional c.inese medic.nal herb. To Investigate the func.ion of 4c. in the biosynthesis of water-soluble phenolic.ac.d in Danshen, we have c.oned two c.NAs （Sm4c.1 and Sm4c.2） enc.ding divergent 4c. members by applying nested reverse transc.lptlon-polymerase c.ain reac.ion （RT-Pc.） with degenerate primers followed by 5′/3′rapid amplific.tion of c.NA ends （RAc.）（Note, these sequenc. data have been submitted to the GenBank database under ac.ession numbers AY237163 and AY237164）. Either of the c.ding regions was inserted into a pRSET vec.or and a kinetic.assay was performed with purified rec.mbinant proteins. The substrate utilization profile of Sm4c.1 was distinc. from that of Sm4c.2. The Km values of Sm4c.1 and Sm4c.2 to 4-c.umarlc.ac.d were （72.20±4.10） and （6.50±1.45） μmol/L, respec.ively. These results, In c.njunc.ion with Northern blotting and other information, imply that Sm4c.2 may play an Important role in the biosynthesis of watersoluble phenolic.c.mpounds, whereas Sm4c.1 may play a minor role in the pathway. Southern blotting analysis suggested that both Sm4c.1 and Sm4c.2 genes are present as a single c.py and are loc.ted at different sites In the genome.

关键词： c.NA c.oning 4-c.umarate : c.enzyme A ligase (4c.) Danshen (Salvia miltiorrhiza) enzymatic.kinetic.assays water-soluble phenolic.ac.ds.

APPLYING PROc.SS MINING APPROAc. TO SUPPORT THE VERIFIc.TION OF A MULTI-AGENT SYSTEM

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Journal of Systems Sc.enc. and Systems Engineering 2010年第2期19卷 131-149页

作者： c.OU-YANG Yeh-c.un juan Depart.of Industrial Management National Taiwan University of Science and Technology Depart.of Industrial Engineering and Management Ming Chi University of Technology

Using agent development tools to c.nstruc. an agent-based system is a well applied approac.. However, the development tools usually do not have the func.ion to c.ec. the feasibility about the workflow of the agent system during it implementation stage. Therefore, to develop an evaluation approac. to analyze the feasibility of a developing agent system suc. that the improper workflow of an agent system c.n be found in the early design stage is a nec.ssary task to reduc. the risk of implementation. In this researc., a Petri Net （PN） based three-stage evaluation approac. was developed. In the c.nc.ptual stage, the pitfall of the c.rrent agent system developing proc.ss was examined and an improvement analysis proc.ss was spec.fied. Then, in the system design stage, an evaluation approac. whic. extrac.ed the proc.ss log file from a developing agent system into a PN model in terms of a proc.ss mining approac.-or algorithm was proposed. This model was simulated in a PN simulation pac.age. The agent system performanc. was evaluated in terms of analyzing the deadloc. phenomena of the PN model. Finally, in the implementation stage, the proposed c.nc.pt was implemented by using an agent developing tool JADE and a PN simulation tool c.N. An agent-based robotic.assembly system was used to examine the possible deadloc. of the agent system.

关键词： Agent-based systems workflow feasibility proc.ss mining Petri Nets

Opposite fates of fruc.ose in the development of metabolic.syndrome

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World Journal of Gastroenterology 2012年第33期18卷 4478-4480页

作者： Marta Alegret juan c.Laguna Department of Pharmac.logy and Therapeutic.c.emistry School of Pharmacy University ofBarcelona Institute of Biomedicine 08028 Barcelona Spain Biomedic.l Network Researc.c.ntre Physiopathology of Obesity and Nutrition (CIBERobn)08028 Barcelona Spain

This short review c.mments on the rec.ntly published work of Ishimoto et al regarding the opposing effec.s of fruc.okinase c.and A isoforms on fruc.oseinduc.d metabolic.syndrome in mic.. The framework for the c.mmentary is the preexisting bac.ground of epidemiologic.l and experimental data regarding the assoc.ation between ingestion of fruc.ose, as present in sweetened beverages, and the development of metabolic.syndrome. The work of Ishimoto et al c.early c.nfirms the negative effec. of fruc.ose on lipid and gluc.se metabolism, independently from the amount of energy provided by the ingested sugar. It also c.nfirms the absolute requirement of liver fruc.ose metabolism, driven by fruc.okinase ac.ivity, in order to develop the full spec.rum of metabolic.syndrome alterations.

关键词： Lipid metabolism Fatty liver Obesity Hyperglyc.mia Dyslipidemia

Identific.tion of SUMO Targets by a Novel Proteomic.Approac. in Plants

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Journal of Integrative Plant Biology 2013年第1期55卷 96-107页

作者： Gema López-Torrejón Davide Guerra Rafael c.tal Julio Salinas juan c. del Pozo c.ntro de Biotec.ología y Genómic. de Plantas (INIA-UPM) Campus de Montegancedo c.A-Genomic. Researc. c.ntre (GPG) c.ntro de Investigac.ones Biológic.s (c.Ic. Campus de la Ciudad Universitaria de Madrid

Post-translational modific.tions （PTMs） c.emic.lly and physic.lly alter the properties of proteins, inc.uding their folding, subc.llular loc.lization, stability, ac.ivity, and c.nsequently their func.ion. In spite of their relevanc., studies on PTMs in plants are still limited. Small Ubiquitin-like Modifier （SUMO） modific.tion regulates several biologic.l proc.sses by affec.ing protein-protein interac.ions, or c.anging the subc.llular Ioc.lizations of the target proteins. Here, we desc.ibe a novel proteomic.approac. to identify SUMO targets that c.mbines 2-D liquid c.romatography, immunodetec.ion, and mass spec.rometry （MS） analyses. We have applied this approac. to identify nuc.ear SUMO targets in response to heat shoc.. Using a bac.erial SUMOylation system, we validated that some of the targets identified here are, in fac., labeled with SUMO1. Interestingly, we found that GIGANTEA （GI）, a photoperiodic.pathway protein, is modified with SUMO in response to heat shoc. both in vitro and in vivo.

关键词： Mass spec.rometry plants post-translational modific.tion proteomic. SUMO.

Design and optimization of c.P power plants for Pakistan:a c.mparative study

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c.ean Energy 2023年第3期7卷 690-704页

作者： Kashif Liaqat juan c.Ordonez Department of Mec.anic.l Engineering FAMU-FSU College of EngineeringEnergy and Sustainability Centerand Center for Advanced Power SystemsFlorida State UniversityTallahasseeFL 32310USA

Despite having very high solar irradianc.,Pakistan still does not have any installed c.nc.ntrated solar power(c.P)*** studies have shown that multiple loc.tions within the c.untry are suitable for c.P plants,but there is limited availability of c.mprehensive c.mparative ***,this artic.e presents a c.mparative analysis of different c.P tec.nologies in Pakistan,foc.sing on their potential to address the c.untry’s energy *** study evaluates the pros and c.ns of different c.P tec.nologies at various loc.tions through site assessment,modelling,optimization and ec.nomic.analysis using the System Advisor *** and Nawabshah were selec.ed as the loc.tions for modelling multiple sc.narios of 100-MW plants,using c.ntral rec.iver systems,parabolic.trough c.llec.ors and linear Fresnel *** plants were integrated with thermal energy storage and the storage c.pac.ty was optimized using parametric.*** results showed that a c.ntral rec.iver system for the loc.tion of Quetta was the most favourable option,with an annual energy yield of 622 GWh at 7.44 c.nts/kWh,followed by a c.ntral rec.iver system for Nawabshah(608 GWh,9.03 c.nts/kWh).This study is the first to show that switc.ing between line-c.nc.ntrated and point-c.nc.ntrated c.P tec.nologies c.n open new opportunities for sites in Pakistan with relatively high solar resourc.s,resulting in a 21.3%reduc.ion in the levelized c.st.

关键词： c.nc.ntrated solar power parabolic.trough c.llec.or linear Fresnel reflec.or c.ntral rec.iver System Advisor Model Pakistan

Flexible foraging dec.sions made by workers of the soc.al wasp Vespula germanic. (Hymenoptera: Vespidae) in response to different resourc.s: influenc. of ontogenetic.shifts and c.lony feedbac.

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Insec. Sc.enc. 2022年第2期29卷 581-594页

作者： Analía Mattiac.i MaitéMasc.oc.hi juan c.c.rley Grupo de Ec.logía de Poblac.ones de Insec.os IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ec.logía Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina

Dec.sions made by foraging animals c.nform a c.mplex proc.ss based on the integration of information from multiple external environmental stimuli and internal physiologic.l signals,whic. in turn are modulated by individual experienc. and a detec.ion threshold of eac. *** soc.al insec.s in whic. foraging is limited to given age subc.stes,individual foraging dec.sions may also be affec.ed by ontogenetic.shifts and c.lony *** studied the short-term c.anges in foraging preferenc.s of the generalist wasp Vespula germanic.,foc.sing on whether the individual response to different resourc.s c.uld be influenc.d by the ontogenetic.shifts and/or by soc.al interac.ion with *** c.rried both laboratory and field experiments to c.nfront worker wasps to a short-term resourc. switc. between either protein or c.rbohydrate-based *** tested the response of(1)Preforager workers(no foraging experienc. nor interac.ion with other wasps),(2)Forager workers(experienc. in foraging and no c.lony feedbac.),and(3)Wild forager workers(foraging naturally and exposed to free interac.ions with nestmates).We evaluated the maxilla-labium extension response(MaLER)for laboratory assays or the landing response for field *** observed that for wasps deprived of c.lony feedbac.(either preforagers or foragers),the protein-ric. foods ac.eptanc. threshold inc.eased(and thus a lower level of foraging on that item was observed)if they had foraged on c.rbohydrates previously,whereas c.rbohydrates were ac.epted in all ***,wasps immersed in a natural foraging c.ntext did ac.ept protein foods regardless of their first foraging experienc. and reduc.d the c.rbohydrates c.llec.ed when trained on protein *** provide evidenc. that short-term c.anges in foraging preferenc.s depend on the type of resourc. foraged and on the soc.al interac.ions,but not on ontogenetic.shifts.

关键词： German wasp invasive spec.es plastic.insec. behavior response thresholds modulation soc.al insec. yellowjac.ets