检索结果-南通市图书馆

SARS-coV-2 outbreak impact on a trauma unit

World Journal of Orthopedics 2021年第10期12卷 751-759页

作者： Sarah Mills Aitor Ibarzábal-Gil José M Martínez-Diez Javier Pallarés-Sanmartín carlos Kalbakdij-Sánchez juan c rubio-suárez Itsaso Losantos-García E carlos Rodríguez-Merchán Department of Orthopedic surgery La Paz University HospitalMadridSpain Department of Biostatistics La Paz University HospitalMadrid 28046Spain Osteoarticular surgery Research Hospital La Paz Institute for Health Research–IdiPAZ(La Paz University Hospital–Autonomous University of Madrid)MadridSpain

BAcKGROUND From February 2020 onwards,our country has been hit by the coronavirus severe acute respiratory syndrome-2(SARS-coV-2)*** a glance,hospitals became overrun and had to reformulate all the assistance guidelines,focusing on the coronavirus disease *** year after the start of the pandemic,we present the results of a morbimortality *** To analyze how our department was affected by the outbreak in terms of morbimortality,and to analyze demographic data,admission to hospital-related data,and subgroups analyses for patients with hip fractures and *** We designed a study comparing data from patients who were admitted to our unit due to a lower limb fracture or a high energy trauma during the pandemic(from March to April 2020)to those admitted during the same period in 2019 before the *** the pandemic *** cohorts completed a minimum of 6 mo of *** The number of patients admitted to hospital in 2020 was nearly half of those in *** fractures in the elderly represented 52 out of 73 of the admitted *** patients had a positive test result for SARS-coV-2 *** with SARS-coV-2 infection were admitted to the hospital for a longer time than the non-infected(Pcture associated with a severe respiratory syndrome were mostly selected for conservative treatment(P=0.03).cONcLUSION Mortality and readmission rates were higher in the 2020 cohort and during follow-up,in comparison with the cohort in 2019.

关键词： Trauma department cOVID-19 pandemic SARS-coV-2 outbreak Hip fractures Morbimortality Polytraumatic patients

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mycobacterium avium subspecies paratuberculosis and its relationship with crohn's disease

引用

World Journal of Gastroenterology 2009年第4期15卷 417-422页

作者： juan Luis Mendoza Raquel Lana Manuel Díaz-rubio Inflammatory Bowel Disease Unit Department of GastroenterologyHospital Clínico San CarlosUniversidad Complutense Department of Internal Medicine Hospital Clínico San CarlosUniversidad Complutense

The hypothesis postulating that Mycobacterium avium paratuberculosis(MAP) is the cause of crohn's disease(cD) has been circulating for many *** in molecular techniques,such as polymerase chain reaction and culture methods,have enabled researchers to demonstrate that there is an association between MAP and ***,genome-wide association studies have identified novel susceptibility genes for cD,which are critical for generation of an adaptive immune response that is protective against intracellular pathogens,including *** ***,the role of MAP as a cause of cD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in cD ***,this review sought neither to confirm nor refute this,but instead to survey recent literature on the role of MAP in cD.

关键词：肺结核传染病治疗临床疗效

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hybrid Security Assessment Methodology for Web Applications

引用

computer Modeling in Engineering & Sciences 2021年第1期126卷 89-124页

作者： Roddy A.correa juan Ramon Bermejo Higuera Javier Bermejo Higuera juan Antonio SiciliaMontalvo Manuel Sanchez rubio A.Alberto Magrenan Universidad Tecnica Particular de Loja San Cayetano AltoLojaEcuador Escuela superior de Ingenieria y Tecnologia Universidad Internacional de La RiojaLogrono26006Spain Universidad de la Rioja Logrono26006Spain

This study presents a methodology to evaluate and prevent security vulnerabilities issues for web *** analysis process is based on the use of techniques and tools that allow to perform security assessments of white box and black box,to carry out the security validation of a web application in an agile and precise *** objective of the methodology is to take advantage of the synergies of semi-automatic static and dynamic security analysis tools and manual *** one of the phases contemplated in the methodology is supported by security analysis tools of different degrees of coverage,so that the results generated in one phase are used as feed for the following phases in order to get an optimized global security analysis *** methodology can be used as part of other more general methodologies that do not cover how to use static and dynamic analysis tools in the implementation and testing phases of a Secure Software Development Life cycle(SSDLc).A practical application of the methodology to analyze the security of a real web application demonstrates its effectiveness by obtaining a better optimized vulnerability detection result against the true and false positive *** analysis with manual checking is used to audit the results,24.6 per cent of security vulnerabilities reported by the static analysis has been checked and it allows to study which vulnerabilities can be directly exploited *** phase is very important because it permits that each reported vulnerability can be checked by a dynamic second tool to confirm whether a vulnerability is true or false positive and it allows to study which vulnerabilities can be directly exploited *** analysis finds six(6)additional critical *** control analysis finds other five(5)important vulnerabilities such as Insufficient Protected Passwords or Weak Password Policy and Excessive Authentication Attacks,two vulnerabilities that permit brute force at

关键词： Web applications security vulnerability weakness security analysis white box black box interactive application security testing static application security testing dynamic application security testing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High prevalence of viable Mycobacterium avium subspecies paratuberculosis in crohn's disease

引用

World Journal of Gastroenterology 2010年第36期16卷 4558-4563页

作者： juan L Mendoza Amparo San-Pedro Esther culebras Raquel cíes carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre juan J Picazo Manuel Díaz-rubio Department of Gastroenterology Hospital Clinico San Carlos28040 MadridSpain Department of clinical Microbiology Hospital Clinico San Carlos28040 MadridSpain Department of Internal Medicine Hospital Clinico San Carlos28040 MadridSpain Department of Immunology Hospital Clinico San Carlos28040 MadridSpain

AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [crohn's disease(cD) and ulcerative colitis(Uc)].METHODS:Thirty patients with cD(15 with at least one NOD2/cARD15 mutation),29 with Uc,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood ***:MAP DNA was detected in all original blood samples and 8-wk blood cultures(cD,Uc and non-IBD).Positive MAP DNA status was confirmed by dot blot *** 69 cultures were negative by acid-fast Ziehl-Neelsen *** MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 cD patients,one Uc patient,and none of the non-IBD *** association was found between positive MAP cultures and use of immunosuppressive drugs or cDassociated single nucleotide ***:MAP is widely present in our area and MAP DNA can be recovered from the blood of cD,Uc and non-IBD ***,MAP spheroplasts were only found in cD patients.

关键词： Mycobacterium avium subspecies paratuberculosis crohn’s disease Ulcerative colitis Inflammatory bowel disease Polymerase chain reaction Genetic susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Software Project Effort Estimation Based on Multiple Parametric Models Generated Through Data clustering

引用

Journal of computer Science & Technology 2007年第3期22卷 371-378页

作者： juan J.cuadrado Gallego Daniel Rodríguez Miguel Angel Sicilia Miguel Garre rubio Angel García crespo Department of computer Science The University of Alcalá AlcaláSpain Department of computer Science carlos Ⅲ University.Madrid Spain

Parametric software effort estimation models usually consists of only a single mathematical relationship. With the advent of software repositories containing data from heterogeneous projects, these types of models suffer from poor adjustment and predictive accuracy. One possible way to alleviate this problem is the use of a set of mathematical equations obtained through dividing of the historical project datasets according to different parameters into subdatasets called partitions. In turn, partitions are divided into clusters that serve as a tool for more accurate models. In this paper, we describe the process, tool and results of such approach through a case study using a publicly available repository, ISBSG. Results suggest the adequacy of the technique as an extension of existing single-expression models without making the estimation process much more complex that uses a single estimation model. A tool to support the process is also presented. Keywords software engineering, software measurement, effort estimation, clustering

关键词： software engineering software measurement effort estimation clustering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MMALE—A Methodology for Malware Analysis in Linux Environments

引用

computers, Materials & continua 2021年第5期67卷 1447-1469页

作者： JoséJavier de Vicente Mohino Javier Bermejo Higuera juan Ramón Bermejo Higuera juan Antonio Sicilia Montalvo Manuel Sánchez rubio JoséJavier Martínez Herraiz Escuela superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogroño26006La RiojaSpain Departamento de ciencias de la computación de la Escuela Politécnica superior Universidad de Alcaláde HenaresAlcaláde HenaresMadridSpain

In a computer environment,an operating system is prone to malware,and even the Linux operating system is not an *** recent years,malware has evolved,and attackers have become more qualified compared to a few years ***,Linux-based systems have become more attractive to cybercriminals because of the increasing use of the Linux operating system in web servers and Internet of Things(IoT)*** is the most employed OS,so most of the research efforts have been focused on its malware protection rather than on other operating *** a result,hundreds of research articles,documents,and methodologies dedicated to malware analysis have been ***,there has not been much literature concerning Linux security and protection from *** address all these new challenges,it is necessary to develop a methodology that can standardize the required steps to perform the malware analysis in depth.A systematic analysis process makes the difference between good and ordinary malware ***,a deep malware comprehension can yield a faster and much more efficient malware *** order to address all mentioned challenges,this article proposed a methodology for malware analysis in the Linux operating system,which is a traditionally overlooked field compared to the other operating *** proposed methodology is tested by a specific Linux malware,and the obtained test results have high effectiveness in malware detection.

关键词： Malware analysis methodology analysis Linux malware IoT malware

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

current treatment landscape for oligometastatic non-small cell lung cancer

引用

World Journal of clinical Oncology 2022年第6期13卷 485-495页

作者： Javier Garde-Noguera Margarita Martín-Martín Andres Obeso Miriam López-Mata Inigo Royo crespo Lira Pelari-Mici O juan Vidal Xabier Mielgo-rubio juan carlos Trujillo-Reyes Felipe couñago Department of Medical Oncology Hospital Arnau de VilanovaValencia 46015Spain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Thoracic surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain Department of Thoracic surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain Department of Medical Oncology Hospital Universitario y Politécnico La FeValencia 46026Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-small cell lung carcinoma(NScLc)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiological and endoscopic,has altered the way patients are *** the other hand,the arrival of new drugs with antitumoral activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control and prolonging ***,the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the *** of these advances have impacted the treatment of patients with advanced lung cancer,especially in a subgroup of these patients in which all of these treatment modalities *** poses a challenge for physicians who must decide upon the best treatment strategy for each patient,without solid evidence for one optimal mode of treatment in this patient *** aim of this article is to review,from a practical and multidisciplinary perspective,published evidence on the management of oligometastatic NScLc *** evaluate the different alternatives for radical ablative treatments,the role of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice.

关键词： Oligometastatic Non-small cell lung carcinoma Non-small cell lung cancer Oligometastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neoadjuvant treatment in non-small cell lung cancer:New perspectives with the incorporation of immunotherapy

引用

World Journal of clinical Oncology 2022年第5期13卷 314-322页

作者： carlos Aguado Luis chara Mónica Antonanzas Jose Maria Matilla Gonzalez Unai Jiménez Raul Hernanz Xabier Mielgo-rubio juan carlos Trujillo-Reyes Felipe counago Department of Medical Oncology Hospital Clínico Universitario San CarlosMadrid 28040Spain Department of Medical Oncology Hospital Universitario de GuadalajaraGuadalajara 19002Spain Department of Thoracic surgery Hospital Clínico Universitario de ValladolidValladolid 47005Spain Department of Thoracic surgery Hospital Universitario CrucesBarakaldoBizkaia 48903Basque CountrySpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic surgery Hospital de la Santa Creu I Sant PauBarcelona 08029CataloniaSpain Department of surgery Universitat Autonoma de BarcelonaBarcelona 08029CataloniaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The aim of neoadjuvant treatment in non-small cell lung cancer(NScLc)is to eliminate micrometastatic disease to facilitate surgical *** chemotherapy(chT)in localised NScLc has numerous advantages over other therapeutic modalities and is considered standard treatment in resectable *** with immune checkpoint inhibitors(IcI)improves long-term survival in advanced disease and has a better toxicity profile than conventional *** immunotherapy agents(anti-PD1/PD-L1),administered with or without chT,are currently being evaluated in the preoperative setting,with initial results showing better pathological response rates and more long-term ***,these drugs do not appear to increase the rate of severe adverse effects and/or postoperative ***,several questions still need to be resolved,including the identification of predictive biomarkers;comparative studies of immunotherapy alone vs combined treatment with chT and/or radiotherapy;the optimal duration of treatment;the timing of surgery;the need for adjuvant treatment;appropriate radiologic evaluation and mediastinal staging;and the correlation between pathological response and survival *** we review the current evidence for immunotherapy from a multidisciplinary perspective and discuss current and future controversies.

关键词： Non-small cell lung cancer Neoadjuvant Immune checkpoint inhibitors Immunotherapy Anti-PD1 Anti-PD-L1 complete pathological response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsunami of immunotherapy reaches mesothelioma

引用

World Journal of clinical Oncology 2022年第4期13卷 267-275页

作者： Xabier Mielgo-rubio Ana cardena Gutierrez Veronica Sotelo Pena Maria Virginia Sanchez Becerra Andrea Maria Gonzalez Lopez Adriana Rosero juan carlos Trujillo-Reyes Felipe counago Department of Medical Oncology Hospital Universitario Fundacion AlcorconAlcorcon 28922MadridSpain Department of Medical Oncology Hospital Universitario Nuestra Senora de CandelariaSanta Cruz de TenerifeCanarias 38010Spain Department of Medical Oncology Hospital Virgen de La LuzCuenca 16002Spain Department of Medical Oncology Hospital Universitario Del HenaresCoslada 28822MadridSpain Department of Thoracic surgery Hospital Universitari de la Santa Creu i Sant PauUniversitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quironsalud MadridPozuelo de Alcorcon 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department Universidad Europea de MadridVillaviciosa de Odon 28670MadridSpain

Malignant pleural mesothelioma(MPM) is the most common type of malignant mesothelioma. It is a rare tumor linked to asbestos exposure and is associated with a poor prognosis. Until very recently, patients with advanced or unresectable disease had limited treatment options, primarily based on doublet chemotherapy with cisplatin and pemetrexed. In 2020 and 2021, after more than a decade with no major advances or new drugs, two phase Ⅲ clinical trials published results positioning immunotherapy as a promising option for the first-and second-line treatment of MPM. Immunotherapy has revolutionized the treatment of many cancers and is also showing encouraging results in malignant mesothelioma. Both immune checkpoint inhibition and dual cytotoxic T-lymphocyte–associated antigen 4 and programmed death-ligand 1 pathway blockade resulted in significantly improved overall survival in randomized phase Ⅲ trials. In the check Mate 743 trial, first-line therapy with nivolumab plus ipilimumab outperformed standard chemotherapy, while in the cONFIRM trial, nivolumab outperformed placebo in patients previously treated with chemotherapy. These two trials represent a major milestone in the treatment of MPM and are set to position immunotherapy as a viable alternative for treatment-naive patients and patients with progressive disease after chemotherapy.

关键词： Mesothelioma Malignant pleural mesothelioma Immunotherapy Immune checkpoint inhibitors cytotoxic T-lymphocyte–associated antigen 4 Programmed cell death protein 1 Nivolumab Ipilimumab Immunotherapy combo check Mate 743 cONFIRM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2

引用

World Journal of clinical Oncology 2022年第4期13卷 276-286页

作者： Maria Eugenia Olmedo Raquel cervera Luis cabezon-Gutierrez Yolanda Lage Elena corral de la Fuente Ana Gomez Rueda1,Xabier Mielgo-rubio juan carlos Trujillo Felipe counago Department of Medical Oncology Ramon y Cajal University HospitalMadrid 28034Spain Department of Medical Oncology Del Henares University HospitalCoslada 28822MadridSpain Medical Oncology Hospital Universitario de TorrejonTorrejon de Ardoz 28850MadridSpain Medical Oncology Department Hospital Universitario Ramon y CajalMadrid 28034Spain Department of Medical Oncology Foundation Alcorcon University HospitalAlcorcón 28922MadridSpain Department Thoracic surgery Hospital de la Santa Creu I Sant PauBarcelona 08029CataloniaSpain Department of surgery Universitat Autonoma de BarcelonaBarcelona 08029CataloniaSpain Department of Radiation Oncology Hospital Universitario Quironsalud MadridPozuelo 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridMadrid 28670Spain

The 2004 discovery of EGFR mutations,followed by ALK rearrangements,ushered in a targeted therapy era for advanced non-small cell lung cancer(NScLc).Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with *** the last decade,rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted *** genome studies of lung adenocarcinoma have identified other possible therapeutic targets,including RET,NTRK fusions,c-MET alterations,and activating mutations in KRAS,BRAF,and HER2,all with frequencies greater than 1%.Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical *** review updates the therapeutic arsenal that especially targets those genes.

关键词： BRAF NTRK KRAS MET RET HER2 Non-small cell lung cancer Targeted therapy Uncommon mutations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：