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First-line cisplatin,docetaxel,and cetuximab for patients with recurrent or metastatic head and neck cancer:A multicenter cohort study

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World Journal of Clinical Oncology 2022年第2期13卷 147-158页

作者： Agustin Falco Mariano Leiva Albano Blanco Guido Cefarelli Andres rodriguez juan Melo Federico Cayol Manglio Miguel Rizzo Alejandro Sola Hernan rodriguez Montani Matias Chacon Diego Enrico Federico Waisberg Department of Medical Oncology Head and Neck UnitAlexander Fleming Cancer InstituteBuenos Aires 1428Argentina Department of Medical Oncology Alexander Fleming Cancer InstituteBuenos Aires 1426Argentina Department of Medical Oncology Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina Department of Medical Oncology Hospital Universitario AustralPilar 1629Argentina Department of Medical Oncology Fundación Centro Oncológico de Integración RegionalMendoza 5500Argentina Department of Medical Oncology Hospital Italiano RosarioSanatorio de la MujerRosario 2001Argentina

BACKGROUND The targeted therapy cetuximab[directed at the epidermal growth factor receptor(EGFR)]in combination with 5-fluorouracil and platinum-based chemotherapy(the EXTREME regimen)has shown substantial efficacy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck(R/M SCCHN).Thus,this scheme has been established as the preferred first-line option for these ***,more recently,a new strategy combining platinum,taxanes,and cetuximab(the TPEx regimen)has demonstrated similar efficacy with a more favorable toxicity profile in clinical *** To evaluate the safety and efficacy of the TPEx scheme as first-line therapy in advanced SCCHN in a multicenter cohort *** This retrospective multicenter cohort study included patients with histologically confirmed recurrent or metastatic SCCHN treated with first-line TPEx at five medical centers in Argentina between January 1,2017 and April 31,*** consisted of four cycles of docetaxel,cisplatin,and cetuximab followed by cetuximab maintenance *** outcomes and toxicity profiles were collected from medical *** response was assessed by the investigator in accordance with Response Evaluation Criteria in Solid Tumors(version 1.1).Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 4.0).RESULTS Twenty-four patients were *** median age at diagnosis was 58 years(range:36-77 years).The majority of patients(83.3%)received at least four chemotherapy cycles in the initial *** the included group,the overall response rate was 62.5%,and 3 patients achieved a complete response(12.5%).The median time to response was 2.4 mo[95% confidence interval(CI):1.3-3.5].With a median follow-up of 12.7 mo(95%CI:8.8-16.6),the median progression-free survival(PFS)was 6.9 mo(95%CI:6.5-7.3),and the overall survival rate at 12 mo was 82.4%.Patients with documented tumor response s

关键词： Recurrent and/or metastatic head and neck cancer TPEx schema Cetuximab Docetaxel Cisplatin First-line

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Prepartum dietary energy intake alters adipose tissue transcriptome profiles during the periparturient period in Holstein dairy cows

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Journal of Animal Science and Biotechnology 2020年第2期11卷 410-423页

作者： Andrea Minuti Massimo Bionaz Vincenzo Lopreiato Nicole A.Janovick Sandra L.rodriguez-Zas James K.Drackley juan J.Loor Department of Animal Sciences Food and NutritionFaculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly Animal and Rangeland Sciences Oregon State UniversityCorvallisOR 97330USA Department of Animal Sciences Division of Nutritional SciencesUniversity of IllinoisUrbanaIL 61801USA

Background:The aim of the study was to investigate the effect of energy overfeeding during the dry period on adipose tissue transcriptome profiles during the periparturient period in dairy ***:Fourteen primiparous Holstein cows from a larger cohort receiving a higher-energy diet(1.62 Mcal of net energy for lactation/kg of dry matter;15%crude protein)for ad libitum intake to supply 150%(OVR)or 100%(CTR)of energy requirements from dry off until parturition were *** calving,all cows received the same lactation *** adipose tissue(SAT)biopsies were collected at−14,1,and 14d fromparturition(d)and used for transcriptome profiling using a bovine oligonucleotide *** mining of differentially expressed genes(DEG)between treatments and due to sampling time was performed using the Dynamic Impact Approach(DIA)and Ingenuity Pathway Analysis(IPA).Results:There was a strong effect of over-feeding energy on DEG with 2434(False discovery rate-corrected P<0.05)between OVR and CTR at−14 d,and only 340 and 538 at 1 and 14 *** most-impacted and activated pathways in the Kyoto Encyclopedia of Genes and Genomes(KEGG)database that were highlighted by DIA analysis at−14 d in OVR *** included 9 associated with carbohydrate metabolism,with‘Pyruvate metabolism’,‘Glycolysis/gluconeogenesis’,and‘Pentose phosphate pathway’among the *** surprisingly,OVR led to marked activation of lipid metabolism(e.g.‘Fatty acid biosynthesis’and‘Glycerolipid metabolism’).Unexpected metabolic pathways that were activated at−14 d in OVR included several related to metabolism of amino acids(*** chain)and of cofactors and vitamins(thiamin).Among endocrine and immune system pathways,at−14 d OVR led to marked activation of‘PPAR signalling’and‘Antigen processing and presentation’.Among key pathways affected over time in OVR,a number were related to translation(*** signaling),endocrine/immune signaling(CXCR4 and IGF1),and lipid metabolism(oxidative

关键词： Periparturient cow Prepartum overfeeding Subcutaneous adipose tissue Transcriptome

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Effect of the Nutritional Supplement VIUSlD Vet on the Productivity of Fattening Pigs in a Low-Input Farming System

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Journal of Environmental Science and Engineering(B) 2015年第11期4卷 607-613页

作者： juan Carlos rodriguez-Fernandez Vicente Mendez-Garcia Ibrain Calero-Herrera Kolima Pena-Calzada Osdany Martinez-Torres Jorge Gomez-Abdura Department of Veterinary Medicine and Animal Husbandry University of Sancti Spiritus Sancti Spiritus 60100 Cuba Department of Production Swine Farm of Jatibonico Jatibonico 62200 Cuba Veterinary Laboratory Provincial Institute of Veterinary Medicine Sancti Splritus 60100 Cuba

The objective of the study was to evaluate the effect of the nutritional supplement VIUSID vet on the mortality and the productivity behaviour of fattening pigs in a low-input farming system. Two experiments were carried out at a pig farm in the municipality of Jatibonico, Sancti Spiritus province, Cuba. The farm has a low level of specialization, pigs are fed using local resources such as sugarcane （Saccharum officinarum） juice and locally produced concentrated feed. In both studies, the treatment consisted in administering together with the feed 2.0 g of VIUSID vet per Kg of feed. Results showed that in low-input rearing conditions, supplying VIUSID vet significantly reduced deaths （17.65%） in the pigs treated, favoured leukocyte and lymphocyte counts, and significantly improved weight gain （16.33%） and feed efficiency （14.41%）.

关键词： VIUSID pigs additive Glycyrrhiza glabra.

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Estimate of the Crystallization Kinetics in Stoichiometry Compositions Films of Ge:Sb:Te

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Journal of Surface Engineered Materials and Advanced Technology 2012年第1期2卷 44-46页

作者： Carlos Virgilio Rivera.rodriguez Eduardo Morales Sanchez Jesus Gonzalez Hernandez Evgen Prokhorov juan Munoz Saldana Gerardo Trapaga Martinez Ciencias Ambientales del Instituto Nacional de Investigaciones Nucleares La MarquesaMexico CICATA-IPN Unidad Queretaro QueretaroMexico Centro de Investigacion en Materiales Avanzados ChihuahuaMexico CINVESTAV-Qro. QueretaroMexico

The aim of this work is to compare the isothermal crystallization kinetic in the films along GeTe-Sb2Te3 line with composition Ge2Sb2Te5, Ge1Sb2Te4 Ge1Sb4Te7 and Ge4Sb1Te5 using mainly Johnson–Mehl–Avrami-Kolmogorov (JMAK) model. Results obtained have shown different crystallization mechanism in the investigated films. In Ge2Sb2Te5 and Ge1Sb2Te4 films the analysis of the kinetic results (Avrani coefficient) showed that at the beginning of crystallization a metastable phase appeared with the Ge1Sb4Te7 composition, this is followed by the nucleation and growth of the stable fcc phase up to full crystallization. In contrast Ge4Sb1Te5 and Ge1Sb4Te7 films show diffusion control growing from small dimension grains with decreasing nucleation rate.

关键词： Crystallization Ge:Sb:Te JMAK Model

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特乌拉达市政礼堂双城系

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城市环境设计 2013年第8期 88-99页

作者：弗朗西斯科·曼加多 juan rodriguez Roland Halbe

特乌拉达-莫莱拉是一个不同寻常的市中心。尽管它被划分为两个独立的物理单元,但却属于同一个行政主体。场地位于阿里坎特,一处由山脉向大海倾斜的山谷处,城市充分利用陆地和海洋两个实体,定义了建筑环境,充当视觉向导。作为新的城市开... 详细信息

特乌拉达-莫莱拉是一个不同寻常的市中心。尽管它被划分为两个独立的物理单元,但却属于同一个行政主体。场地位于阿里坎特,一处由山脉向大海倾斜的山谷处,城市充分利用陆地和海洋两个实体,定义了建筑环境,充当视觉向导。作为新的城市开发项目的一部分,市政礼堂从特拉乌达拔地而起,位于城市海拔较高的地块上。从这一点,越过散落着小小的白色建筑间的山谷,人们可以看到海边的莫莱拉小镇。独一无二的场地位置使建筑成为连接两个城市中心的桥梁。两个中心虽然就物理位置而言是彼此分离的,但两者的领地、景观和文化

关键词：场地位置建筑礼堂公共建筑莫莱

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Socioeconomic Aspects for Coastal Mollusk Commercial Fishing in Costa Chica,Guerrero,Mexico

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Natural Resources 2018年第6期9卷 229-241页

作者： Lizeth Galeana-Rebolledo Rafael Flores-Garza juan Violante-Gonzalez Pedro Flores-rodriguez Sergio Garcia-Ibanez Victor Landa-Jaime Arcadio Valdes-Gonzalez Centro de Ciencias de Desarrollo Regional Pino s/n.Col.El RobleAcapulcoMéxico Facultad Ecologia Marina Gran Via TropicalN°20Fraccionamiento Las PlayasAcapulcoMexico Departamento de Estudios para el Desarrollo Sustentable de Zonas Costeras San Patricio-MelaqueMexico Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo LeonCiudad UniversitariaSan Nicolas de los GarzaMexico

An important part of the fishing activity in Mexico is carried out in the coastal strip and has a strong social, economic and ecological importance. In the state of Guerrero, mollusks fishing is coastal and craftwork activity focused on a small number of species and without information on biology and reproductive or ecological aspects for most species caught. This research was carried out in the Costa Chica region, Guerrero, Mexico and the aims were: 1) To analyze the socioeconomic features of cooperative societies of fishing production;and 2) To know the diversity of mollusks caught by coastal fishing and the species that have the greatest importance in fishing. From February to April 2013-2015, seven fish coop units, four piers and places where seafood is sold were visited. For the socio-economic analysis and the determination of the species that have more importance in the coastal fishing, a total of 67 surveys were applied. In order to determine the cast of species, the specimens captured by the fishermen were used, which were identified and counted. A total of 67 interviews were analyzed and an average of $1806.00 was estimated as weekly economic income just as a product of fishing, it was also estimated that on average the fishermen work 4.3 days a week. Fisheries cooperatives market most of their produce directly to restaurateurs and locals on the piers. Replacement of older adults by young fishermen from the same region was observed, most are adults between 22 and 39 years old. 25 species of mollusks of economic importance were registered for the coastal fishermen of the Costa Chica. Six species were identified as the main target for catching fishermen. The fishing of mollusks in Costa Chica is not subject to any type of control, which has led to overfishing reflected in the decline sizes and banks in populations of commercial importance.

关键词： Molluscs Coastal Fishing Socioeconomic Fisherman

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Isolation,Identification and Germplasm Preservation of Different Native Spirulina Species from Western Mexico

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American Journal of Plant Sciences 2013年第12期4卷 65-71页

作者： Rout Nutan Prasad Khandual Sanghamitra Gutierrez-Mora Antonia Gallardo-Valdéz juan rodriguez-Garay Benjamin Ibarra-Montoya JLuis Vega-Valero Guillermo Centro de Investigación y Asistencia en Tecnología y Diseno del Estado de Jalisco A.C.Av.Normalistas#800Colinas de la NormalGuadalajaraJaliscoMexico Biotecnología Mexicana de Microalgas S.A.de C.V.Sta.Maria 136 Conlonia TepeyacZapopanJaliscoMexico

Spirulina is an edible algae and has a wide range of pharmaceutical applications in addition to its nutritional value. Isolation and identification of several Spirulina species were conducted in the western part of Mexico especially in the state of Jalisco. The purification strategy consisted of five optimized processing steps: 1) washing and centrifugation, 2) chemical treatment, 3) micromanipulation, 4) serial dilution, and 5) plating. Four species were isolated from different locations and two out of these four species were identified taxonomically up to the species level: Spirulina subsalsa and S. major. For short term conservation (30 days), the strains were maintained in liquid and solid agar medium at 10?C and 4?C. For medium term (few months), they were preserved in solid medium under a dried condition as agar flakes and for long term, cryopreservation was employed by using 5% and 10% DMSO, glycerol and methanol as osmoprotectants in liquid nitrogen. For short term preservation nearly 90% liquid and 100% agar recovered strains were viable after one month at both temperatures. In the case of the agar flakes, cells were viable after three months of conservation at room temperature. Cryopreservation did not give any suitable results after three months of conservation. Variable and two-step improved cryopreservation processes are now in progress for conservation.

关键词： Germplasm Cryopreservation Spirulina Long Term Preservation

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Convective drying of yellow discarded onion (Angaco INTA): Modelling of moisture loss kinetics and effect on phenolic compounds

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Information Processing in Agriculture 2020年第2期7卷 333-341页

作者： Marıa Celia Roman Maria Paula Fabani Lorena Celina Luna Gabriela Egly Feresin German Mazza Rosa.rodriguez Instituto de Ingeniera Quımica-Grupo Vinculado al PROBIEN(CONICET-UNCo) Facultad de IngenierıaUniversidad Nacional de San JuanArgentina Instituto de Biotecnologıa Facultad de IngenierıaUniversidad Nacional de San JuanArgentina Instituto de Investigacio´n y Desarrollo en Ingenierıa de Procesos Biotecnologı´a y Energı´as AlternativasCONICET-Universidad Nacional del ComahueNeuquenArgentina

The Angaco INTA onion variety is the most cultivated and its production,mostly is destined for *** to their high-quality standards of these markets,many onions are *** drying process seems to be a promising solution that not only give added value to this product,but also extend shelf *** this work,the influence of convective drying process,at 60 and 70C,on the kinetic behavior,antioxidant activity,phenolic and flavonoid contents of discarded onion slices were *** that,the Angaco INTA onion is a variety genetically developed to have shorter cultivation times in this region;the phenolic compounds content in this onion variety,the drying kinetics and its influence on this content have never been *** this study,the phenolic compounds contributions to dehydrated product quality was evaluated,observing that the convective drying increased the total soluble phenolic and flavonoid contents and antioxidant properties for both temperatures,being highest at 70*** rehydration ratios were similar to the slices dried at 60 and 70*** models were used for describing the obtained drying curve equation of onion slices,being the Midilli’s model the one that presented the best ***’s model of water diffusion fitted all experimental data with acceptable correlation *** the achieved findings,70C is the optimum temperature to produce the dehydrated Angaco INTA onion.

关键词： Drying Antioxidant activity Phenolic content Kinetic model

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The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases

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Translational Neurodegeneration 2020年第2期9卷 270-289页

作者： Isabel Ubeda-Bañon Daniel Saiz-Sanchez Alicia Flores-Cuadrado Ernesto Rioja-Corroto Melania Gonzalez-rodriguez Sandra Villar-Conde Veronica Astillero-Lopez juan Pablo Cabello-de la Rosa Maria Jose Gallardo-Alcañiz Julia Vaamonde-Gamo Fernanda Relea-Calatayud Lucia Gonzalez-Lopez Alicia Mohedano-Moriano Alberto Rabano Alino Martinez-Marcos Neuroplasticity and Neurodegeneration Laboratory Ciudad Real Medical SchoolCRIBUniversity of Castilla-La Mancha13005Ciudad RealSpain Neurology Service Ciudad Real General University Hospital13005Ciudad RealSpain Pathology Service Ciudad Real General University Hospital13005Ciudad RealSpain Faculty of Health Sciences University of Castilla-La ManchaTalavera de la ReinaSpain Neuropathology Department and Tissue Bank CIEN FoundationCarlos III Health InstituteMadridSpain

Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative *** etiologies are idiopathic,and treatments are symptomatic and orientated towards cognitive or motor ***,both are proteinopathies with pathological aggregates(plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in Alzheimer’s disease,and Lewy bodies mostly composed of α-synuclein in Parkinson’s disease).These deposits appear in the nervous system in a predictable and accumulative sequence with six neuropathological *** disorders present a long prodromal period,characterized by preclinical signs including ***,the olfactory system,particularly the anterior olfactory nucleus,is initially and preferentially affected by the *** atrophy revealed by magnetic resonance imaging must be complemented by histological analyses to ascertain whether neuronal and/or glial loss or neuropil remodeling are responsible for volumetric *** has been proposed that these proteinopathies could act in a prion-like manner in which a misfolded protein would be able to force native proteins into pathogenic folding(seeding),which then propagates through neurons and glia(spreading).Existing data have been examined to establish why some neuronal populations are vulnerable while others are resistant to pathology and to what extent glia prevent and/or facilitate proteinopathy *** approaches reveal a number of hubs in the olfactory system(anterior olfactory nucleus,olfactory entorhinal cortex and cortical amygdala)that are key interconnectors with the main hubs(the entorhinal–hippocampal–cortical and amygdala–dorsal motor vagal nucleus)of network dysfunction in Alzheimer’s and Parkinson’s diseases.

关键词： α-Synuclein Amyloid-β Anterior olfactory nucleus Hyposmia Tau protein

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A Comparative Study for Successful Treatment per Gender in a Specialized Smoking Cessation Unit in the Albacete University Hospital during Two Years

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Journal of Health Science 2015年第3期3卷 103-112页

作者： Francisco Javier Callejas Gonzalez Genoves Crespo Marta Cruz Ruiz Javier Esquinas Lopez Cristina Tarraga Lopez Pedro juan Pablo Bermejo Lopez Tornero Molina Ana Isabel Pastrana Calderon juan Molina Cano Angel rodriguez Montes Jose Antonio Pneumonology Department The Albacete University Hospital Complex (CHUA) Albacete 02006 Spain Thoracic Surgery Department The Albacete University Hospital Complex (CHUA) Albacete 02006 Spain Pneumonology Department Vall d'Hebron University Hospital Barcelona 08035 Spain Integrated Care Management The Albacete University Hospital Complex (CHUA) Albacete 02006 Spain College of Computer Engineering Castilla-La Mancha University (UCLM) Albacete 02071 Spain General and Digestive Surgery Department La Paz University Hospital Madrid 28046 Spain

Objective： Analysis of abstinence rates of smokers per gender at 3, 6, 9 and 12 months in a Smoking Cessation Unit from January 2008 to December 2009. Methods： Descriptive retrospective study. Analysis of socio-demographic variables, smoking patterns, associated comorbidities, continuous abstinence rates, success, relapses, failure and dropping out. Results： 278 smokers started treatment （33%）; 55.4% males and 44.6% females （mean age of 48.3 and 44.06 years, respectively）. The main associated comorbidities were： psychiatric （38.7%）, cardiovascular （dyslipemia 25%） and respiratory （COPD （chronic obstructive pulmonary disease） 9.7%） in females; cardiovascular （dyslipemia 34.4%）, psychiatric （34.4%） and respiratory （COPD 19.5%） in males. VRN （Varenicline） was prescribed in 40.2% males and 32.2% females; NRT （nicotine replacement therapy） was used in 46.6% and 38.7%, respectively; bupropion was employed in 6.5% and 21.8%, respectively. Psychological counseling was offered only to 7.8% males and 8.1% females. The continuous abstinence rates in males at 3, 6, 9 and 12 months were 51.3%, 37.7%, 32.5% and 30.5%, respectively, and were 45.2%, 29.8%, 25.0% and 24.2% for females. Failure was 9.7% for females and 18.8% for males. Success was more frequent for those on VRN （n = 41 males; n = 12 females）. No relapses were indicated for 42 females and 71 males. The percentage of relapses was higher at 3 months （29.0% females, 19.5% males）. Conclusions： The study observed differences in treating abstinence between genders （in the abstinence rates and failure index）. This implies having to consider incorporating the gender variable into the diagnosis, treatment and prevention of smoking.

关键词： Smoking smoking cessation gender continuous abstinence successful treatment failure relapse

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