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Collaborative integration of Fe-N_(x)active center into defective sulfur/selenium-doped carbon for efficient oxygen electrocatalysts in liquid and flexible Zn-air batteries

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Chinese Chemical Letters 2024年第9期35卷 421-425页

作者： Yufeng Wu mingjun Jing juan Li Wenhui Deng mingguang Yi Zhanpeng Chen meixia Yang Jinyang Wu Xinkai Xu Yanson Bai Xiaoqing Zou Tianjing Wu Xianyou Wang National Base for International Science&Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryKey Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationXiangtan UniversityXiangtan 411105China

Strategic active site organization is imperative for the advancement of effective and long-lasting catalysts of oxygen reduction ***,the controllable multi-active site design is a highly intricate topic for catalyst *** pre-trapping and post-activation strategy,Fe-N bonding structure and S,Se functionalized heteroatom are integrated into a conductive porous *** this process,the nitrogen-abundant polymer 1,3,5-triformylbenzene-tris(4-aminophenyl)benzene(Tf-TAPA)adsorbs Fe^(3+)under the intrinsically metal anchoring ability of N atoms and simultaneously in-situ assembles longchain ***,the Fe^(3+)is transformed into Fe-N_(x)moieties with the conversion of the organic chain to incompletely graphitized ***,the alteration of the electronic configuration achieved through the introduction of dual-atom S and Se leads to a pronounced enhancement in catalytic *** from the Fe-N_(x)bonding structure,dense structural defects,and conductive carbon networks,the resultant Fe-S,Se/NCNs possesses a positive half-wave potential of 0.86 V and a 90%current retention rate,outstripping the Pt/C ***,the liquid and flexible ZAB driven by Fe-S,Se/NCNs achieves large power densities of 259.7 and 164.7 m W/cm^(2),*** study provides a new comprehension in developing an efficient and stable m-N-C oxygen electrocatalyst.

关键词： Atomic regulation Chalcogens co-doped Catalytic performance Noble metal-free electrocatalyst Zn-air battery

Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated􀀖􀄮􀀏􀀙􀄮􀀏􀀚􀄮􀀏􀀔􀀕􀄮􀀐􀀷􀁈􀁗􀁕􀁄􀁋􀁜􀁇􀁕􀁒􀁛􀁜􀁏􀁄􀁗􀁈􀁇􀀃􀀥􀁌􀁏􀁈􀀃􀀤􀁆􀁌􀁇􀀃􀁌􀁑􀀃􀀦􀁋􀁒􀁏􀁈􀁖􀁗􀁄􀁖􀁌􀁖

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 151-161页

作者： Teng Liu Ren-Xue Wang Jun Han Zhong-Die Li Jonathan ASheps Li-juan Zheng Xiao-Xiao Xu Victor Ling Jian-She Wang Department of Pediatrics Shanghai Medical CollegeFudan UniversityThe Center for Pediatric Liver DiseasesChildren’s Hospital of Fudan UniversityShanghaiChina BC Cancer Agency VancouverBritish Columbia V5Z 1L3Canada University of Victoria-Genome BC Proteomics Center University of VictoriaVictoriaBritish Columbia V8Z 7X8Canada Shanghai Key Laboratory of Birth Defect ShanghaiChina

Background and Aims:We asked if comprehensive bile acid profiling could provide insights into the physiopathology of ABCB4-mutated patients and evaluated the prognostic value of taurine-conjugated tetrahydroxylated bile acid(tauro-THBA)in ***:Serum bile acid profiles were evaluated in 13 ABCB4-mutated patients with 65 healthy controls by ultra-high-performance liquid chromatography/multiple-reaction monitoring-mass spectrometry(UPLC/mRm-mS).The concentration of tauro-THBA was compared between ABCB4-mutated patients with different *** areas under the curve(AUCs)of tauro-THBA were compared between ABCB11-mutated patients with native liver survival and those who died or underwent liver transplantation before 3 years of age by receiver operating characteristic curve(ROC),with another patient cohort for further ***:The overall hydrophobicity indices of bile acids in ABCB4-mutated patients(12.99±3.25 m)were significantly lower than those of healthy controls(14.02±1.74 m,pmarkedly increased bile acid modifications including conjugation,sulfation,and *** in the tauro-THBA concentration in ABCB4-mutated patients with different prognoses were not *** analysis indicated that levels of tauro-THBA ofm yielded an AUC of 0.900 with a sensitivity of 80%and specificity of 87.5%for ABCB11-mutated patients with different prognoses(p=0.0192).Of the 15 patients with good prognosis,14 were classified correctly and four of the five patients with a poor prognosis were classified correctly(14:15 vs.1:5,p=0.005)with tauro-THBA as a ***:Tauro-THBA concentration may be a biomarker for predicting the clinical outcome in low gammaglutamyl transferase intrahepatic cholestasis patients.

关键词： Bile acids mDR3 BSEP PFIC Liquid chromatography-mass spectrometry

Detailed characterization of kHz-rate laser-driven fusion at a thin liquid sheet with a neutron detection suite

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High Power Laser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin m.Knight Connor m.Gautam Colton R.Stoner Bryan V.Egner Joseph R.Smith Chris m.Orban juan J.manfredi Kyle D.Frische michael L.Dexter Enam A.Chowdhury Anil K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of materials Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(<1 μm) D_2O liquid sheet employing a measurement suite. At relativistic inte... 详细信息

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(m) D_2O liquid sheet employing a measurement suite. At relativistic intensity(~ 5 × 10^(18)W/cm^(2))and high repetition rate(1 kHz), the system produces deuterium±deuterium(D-D) fusion, allowing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an EJ-309 organic scintillator with pulse-shape discrimination, a ~3He proportional counter and a set of 36 bubble detectors. Time-of-flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 meV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser±target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

关键词： high-repetition-rate laser-driven fusion laser-plasma interaction liquid target neutron detectors

Curcumin for gastric cancer:mechanism prediction via network pharmacology,docking,and in vitro experiments

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui Yang Ya-Nan Wei Bi-juan Xiao Si-Yi Li Xin-Long Li Liang-Jun Yang Hua-Feng Pan Geng-Xin Chen The Second School of Clinical medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Centre for Translational medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric cancer(GC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** Network pharmacological approaches were used to perform network analysis of *** first analyzed Lipinski’s Rule of Five for the use of *** latent targets were predicted using the Pharmmapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the GeneCard,OmIm,DrugBank and TTD network ***,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping GC-related *** intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(mAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their *** levels of hub targets CYP3A4,mAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose *** Curcumin can play an anti-GC role through a variety of

关键词： Curcumin Gastric cancer Network pharmacology molecular docking Survival analysis

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

Network Pharmacology and Experimental Study of momordicineⅠand momordicineⅡfrom Bitter melon Saponins in Inhibiting Fat Accumulation

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Biomedical and Environmental Sciences 2024年第5期37卷 526-530页

作者： HUANG Shi Ting LI Shang Yuan LI Xin Yu ZHU Ying ZHU Lin ZHANG Jia Yan ZHAO Yan Sheng DAGLIA maria XIAO Xiang BAI juan School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Department of Pharmacy University of Napoli FedericoⅡVia D.Montesano 4980131 NaplesItaly International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013JiangsuChina

Bitter melon(momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical ***,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).

关键词： melon momordica subtropical

Secondary metabolites of Entomopathogenic Fungi, Biological Alternative for the Control of Agricultural Pests and Disease: Present and Perspectives

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Advances in Enzyme Research 2024年第1期12卷 1-15页

作者： Nallely San juan-maldonado Silvia Rodríguez-Navarro Alejandro Angel-Cuapio José Norberto Vásquez Bonilla juan Esteban Barranco-Florido Departamento de Producció n Agr&#237cola y Animal Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico Divisió n de Ingenier&#237a Qu&#237mica y Bioqu&#237mica Tecnol&#243gico Nacional de M&#233xico/TES de Ecatepec Ecatepec de Morelos M&#233xico Departamento de Sistemas Bioló gicos Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico

The use of entomopathogenic fungi (EF) in recent years has been highly effective against the different orders of insects considered pests of agricultural importance and their conidia have been commonly applied, but it has been reported that these are sensitive to the environmental conditions. For this reason, biopesticides products have been formulated based on secondary metabolites, recently. These biomolecules participate as biological control agent, such as: cyclic depsipeptides, amino acids, polyketides, polyphenols and terpenoids, affecting their morphology, life cycle and insect behavior. The use of secondary metabolites of entomopathogenic fungi opens the possibility of application in a more efficient way for the control of agricultural pests in a compatible with the environment and human health;therefore, it is important to know, analyzing the type of molecules, their effects, and their different methods of application.

关键词： Secondary metabolites Entomopathogenic Fungi Biological Control Agent

Designing Symmetric Gradient Honeycomb Structures with Carbon‑Coated Iron‑Based Composites for High‑Efficiency microwave Absorption

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Nano-micro Letters 2024年第11期16卷 224-241页

作者： Yu Zhang Shu‑Hao Yang Yue Xin Bo Cai Peng‑Fei Hu Hai‑Yang Dai Chen‑ming Liang Yun‑Tong meng Ji‑Hao Su Xiao‑juan Zhang min Lu Guang‑Sheng Wang School of Chemistry Beihang UniversityBeijing 100191People’s Republic of China School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002People’s Republic of China School of Chemical Engineering Northeast Electric Power UniversityJilin 132000People’s Republic of China College of Chemistry and materials Engineering Beijing Technology and Business UniversityBeijing 100048People’s Republic of China

The impedance matching of absorbers is a vital factor affecting their microwave absorption(mA)*** this work,we controllably synthesized material of Institute Lavoisier 88C(mIL-88C)with varying aspect ratios(AR)as a precursor by regulating oil bath conditions,followed by one-step thermal decomposition to obtain carbon-coated iron-based *** the precursor mIL-88C(Fe)preparation conditions,such as the molar ratio between metal ions and organic ligands(m/O),oil bath temperature,and oil bath time,influenced the phases,graphitization degree,and AR of the derivatives,enabling low filler loading,achieving well-matched impedance,and ensuring outstanding mA *** mOF-derivatives 2(mD_(2))/polyvinylidene Difluoride(PVDF),mD_(3)/PVDF,and mD4/PVDF absorbers all exhibited excellent mA properties with optimal filler loadings below 20 wt%and as low as 5 wt%.The mD_(2)/PVDF(5 wt%)achieved a maximum effective absorption bandwidth(EAB)of 5.52 GHz(1.90 mm).The mD_(3)/PVDF(10 wt%)possessed a minimum reflection loss(RL_(min))value of−67.4 at 12.56 GHz(2.13 mm).A symmetric gradient honeycomb structure(SGHS)was constructed utilizing the high-frequency structure simulator(HFSS)to further extend the EAB,achieving an EAB of 14.6 GHz and a RL_(min) of−59.0 *** research offers a viable inspiration to creating structures or materials with high-efficiency mA properties.

关键词： mIL-88C(Fe) Fe/Fe_(3)O_(4)/Fe_(3)C@C Controllable preparation Symmetric gradient honeycomb structure microwave absorbing

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(msCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human mSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration