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Long-term Efficacy of Pulmonary Artery Desnervation Treatment in Heart Failure With Preserved Ejection Fraction:A Subgroup Analysis of 3-year Results From the PADN-5 Study

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Cardiology Discovery 2024年第3期4卷 206-212页

作者： Hang Zhang Wande Yu mengyu Zhang Wei Li Jing Kan Dujiang Xie juan Zhang Shaoliang Chen Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China rd College Nanjing Medical UniversityNanjingJiangsu 211166China.

Objective:The Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure(PADN-5)study proved that pulmonary artery denervation(PADN)is associated with significant improvements in hemodynamic and clinical outcomes in patients with combined pre-and post-capillary pulmonary hypertension(CpcPH).This study aimed to assess the 3-year clinical results of PADN in patients who had heart failure with preserved ejection fraction(HFpEF)developing into CpcPH(HFpEF-CpcPH).methods:In this post hoc analysis of the PADN-5 trial,38 patients with HFpEF were included in screening out of 98 patients with CpcPH who were randomly assigned to treatment with sildenafil and sham PADN(sham PADN(plus sildenafil)group,abbreviated as sham group)or PADN(PADN group).HFpEF in the PADN-5 trial was defined as a left ventricular ejection fraction≥50%,and CpcPH was defined as a mean pulmonary arterial pressure≥25 mmHg,a pulmonary arterial wedge pressure>15 mmHg,and a pulmonary vascular resistance>3.0 *** changes in the 6-minute walk distance(6-mWD)and the plasma concentration of N-terminal pro-brain natriuretic peptide(NT-proBNP)at 6-month and 3-year follow-up,as well as the clinical endpoint of the occurrence of clinical worsening,defined as cardiopulmonary-related death,rehospitalization,or heart or lung transplantation at 3-year follow-up were ***:Thirty-eight patients with HFpEF-CpcPH were assigned to the PADN group(n=19)or the sham group(n=19).At the 6-month follow-up,6-mWD(433(275,580)m vs.342(161,552)m),and reductions in NT-proBNP(−47%(−99%,331%)vs.−12%(−82%,54%))were significantly improved in the PADN group(all Pment resulted in marked increases in 6-mWD(450(186,510)m vs.348(135,435)m)and reductions in NT-proBNP(−55%(−99%,38%)vs.−10%(−80%,95%))(all Pm group,but by only 5 patients(26%)in the PADN group(hazard r

关键词： Heart failure Combined pre-and post-capillary pulmonary hypertension Pulmonary artery denervation 6-minute walk distance Clinical worsening

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Chronomodulated chemotherapy for locoregionally advanced nasopharyngeal carcinoma:A phase Ⅱ randomized controlled trial

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Radiation medicine and Protection 2024年第1期5卷 43-48页

作者： Xiaoxiao Chen Feng Jin Weili Wu Yuanyuan Li Jinhuan Long Xiuling Luo Xiuyun juan Li Pengxin Zhang mang Zhang Department of Head and Neck Oncology Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyang 550004China Departemnt of Oncology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001China

Objective:To validate the safety and efficacy of chronochemotherapy for locoregionally advanced nasopharyngeal carcinoma(NPC).methods:Participants for this phase II randomized controlled trial were recruited from the Department of Head and Neck Oncology at the Affiliated Cancer Hospital of Guizhou medical *** enrolled(128 in total,112 in the final analysis)between April 1,2017,and February 28,2018,were randomly divided into the chronochemotherapy and conventional chemotherapy *** the chronochemotherapy group,docetaxel was intravenously administered between 3:30 *** 4:30 *** day 1,followed by intravenous administration of cisplatin between 10:00 *** 10:00 *** day 1to day *** addition,5-fluorouracil was administered through a continuous intravenous pump between 10:00 *** 10:00 a.m.(2nd day)from day 1 to day *** the conventional chemotherapy group,docetaxel(on day 1),cisplatin(on day 2),and 5-fluorouracil(from day 1 to day 5,120 h in total)were administered without time-specific *** groups underwent intensitymodulated radiation therapy with 6-mV *** gross target volume(GTV)comprised the nasopharyngeal GTV and cervical lymph node *** primary endpoint was immune function,quantified by measuring dendritic cell and lymphocyte subsets,whereas the secondary endpoints were therapeutic efficacy and incidence of adverse *** Chi-square test was applied to compare total events between the groups,mann-Whitney U test was used to compare the DC subsets and toxicities,and Wilcoxon signed-rank test was used to compare the continuous variables between the two ***:Chronochemotherapy preserved immune function,as evidenced by elevated levels of myeloid dendritic cells(P=0.394)and higher CD4/CD8 ratio(P?0.781).No significant difference in overall response rate,measured as the sum of complete and partial response rates,was observed between the groups(P=0.711).A reduction in the incidence of vomiting(P=

关键词： Nasopharyngeal carcinoma Chronochemotherapy Intensity-modulated radiotherapy Dendritic cells Adverse events Randomized controlled trial

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Comparison of biological fitness in crosses between subspecies of meccus phyllosomus （Hemiptera： Reduviidae： Triatominae） in southern mexico

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Insect Science 2017年第1期24卷 114-121页

作者： Jose Alejandro martinez-Ibarra Benjamin Nogueda-Torres Luis Fernando Salazar-montano juan Carlos Garcia-Lino Demver Arroyo-Reyes juan Angel Hernandez-Navarro Area de Entomologia medica Universidad de Guadalajara Ciudad Guzman Jalisco Mexico Becario de COFAA Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional D.F. Mexico Carrera de medicina Departamento de Salud y Bienestar Centro Universitario del Sur Universidad de Guadalajara Ciudad Guzman Jalisco Mexico

Understanding the biological parameters of some triatomine subspecies of meccus phyllosomus （Burmeister） is a crucial first step in estimating the epidemiologie importance of this group. Biological parameters related to hatching, lifetime, number of blood meals to molt, percentage of females at the end of the cycle, number of laid eggs, and mortality for each instar of 3 m. phyllosomus subspecies [m. p. mazzottii （Usinger）, m. p. pallidipennis （Stal）, and m. p. phyllosomus] and their laboratory hybrids were evaluated and compared. No significant differences （P 〉 0.05） were found among the experimental hybrids （maPa, maPhy, PaPhy） and reciprocal cohorts. In 5 （hatching, number of blood meals to molt, accumulative mortality, percentage of females, and mean number of laid eggs） of the 6 studied parameters （with the exception of development time）, the hybrid cohorts had better fitness results than the parental cohorts involved in each set of crosses. The increase in hybrid fitness found in our study could lead to an increase in the epidemiologic risks caused by transmission of Trypanosoma cruzi to humans.

关键词： biological parameters Chagas disease meccus subspecies mexico tri- atomines Trypanosoma cruzi transmission

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基于相位传递函数的分块镜共相位倾斜误差检测

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光学学报 2024年第4期44卷 117-127页

作者：张璐赵伟瑞赵跃进刘娟北京理工大学光电学院北京100081 精密光电测试仪器及技术北京市重点实验室北京100081

消除拼接主镜式望远镜的分块子镜间的共相位倾斜(tip-tilt)误差是有效提升集光能力、实现共相位成像的关键之一。提出了一种基于相位传递函数(PTF)的分块子镜的tip-tilt高精度检测方法。在分块镜的共轭面处设置具有离散孔结构的光阑,将... 详细信息

消除拼接主镜式望远镜的分块子镜间的共相位倾斜(tip-tilt)误差是有效提升集光能力、实现共相位成像的关键之一。提出了一种基于相位传递函数(PTF)的分块子镜的tip-tilt高精度检测方法。在分块镜的共轭面处设置具有离散孔结构的光阑,将其作为tip-tilt检测系统的入瞳,借助傅里叶分析,推导建立了误差检测系统的PTF与tip-tilt的函数关系,通过对探测得到的点扩散函数进行傅里叶分析,得到PTF,依据建立的函数关系即可实现tip-tilt的高精度检测。对所提方法进行了仿真分析和实验验证,检测精度的均方根(RmS)值为2.99×10^(-3)λ(λ为波长)。所提方法结构简单,只需要设置一个具有离散孔结构的光阑,可用于拼接式主镜、稀疏孔径系统的共相位tip-tilt误差检测。

关键词：傅里叶光学相位传递函数分块镜倾斜误差离散孔光阑傅里叶变换

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Contribution of extracellular vesicles to steatosis-related liver disease and their therapeutic potential

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World Journal of Hepatology 2024年第9期16卷 1211-1228页

作者： margarita montoya-Buelna Inocencia G Ramirez-Lopez Cesar A San juan-Garcia Jose J Garcia-Regalado mariana S millan-Sanchez Ulises de la Cruz-mosso Jesse Haramati Ana L Pereira-Suarez Jose macias-Barragan Laboratorio de Inmunología Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Ciencias de la Salud Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doctorado en Ciencias Biomédicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inmunología Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Red de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inmunobiología Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigación en Ciencias Biomédicas Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extracellular vesicles(EVs)are small particles released by many cell types in different tissues,including the liver,and transfer specific cargo molecules from originating cells to receptor *** process generally culminates in activation of distant cells and inflammation and progression of certain *** global chronic liver disease(CLD)epidemic is estimated at 1.5 billion patients *** and liver cancer are the most common risk factors for ***,hepatitis C and B virus infection and obesity are also highly associated with ***,the etiology of many CLD pathophysiological,cellular,and molecular events are *** in hepatic lipid metabolism can lead to lipotoxicity events that induce EV ***,we aimed to present an overview of EV features,from definition to types and biogenesis,with particular focus on the molecules related to steatosis-related liver disease,diagnosis,and therapy.

关键词： Extracellular vesicles Exosomes Chronic liver disease Hepatocellular carcinoma Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

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基于FLAC3D数值模拟的巷道优化支护分析与应用

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煤矿机电 2024年第3期45卷 16-22页

作者：徐娟天地(常州)自动化股份有限公司江苏常州213015 中煤科工集团常州研究院有限公司江苏常州213015

在矿压作用下,花草滩煤矿+1300 m水平西翼轨道大巷发生严重变形,矿压显著,对巷道使用产生影响。为确保该巷道支护方案的经济合理性,必须对其支护方式进行优化设计。以花草滩煤矿+1300 m水平西翼轨道大巷为工程背景,运用FLAC3D数值模拟,... 详细信息

在矿压作用下,花草滩煤矿+1300 m水平西翼轨道大巷发生严重变形,矿压显著,对巷道使用产生影响。为确保该巷道支护方案的经济合理性,必须对其支护方式进行优化设计。以花草滩煤矿+1300 m水平西翼轨道大巷为工程背景,运用FLAC3D数值模拟,模拟在不同锚杆排距、锚杆间距、锚索排距、锚索间距和锚杆直径条件下的围岩位移,并分析选择确定了最具经济和安全效益的支护方案。在工业实践中运用确定的支护方案进行开拓,并对开拓后的+1300 m水平西翼轨道大巷变形数据进行监测分析。结果表明,优化支护后巷道围岩变形量显著降低,实现了围岩控制的预期要求。

关键词：大巷数值模拟围岩位移优化支护

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Rehabilitation of degraded areas in northeastern Patagonia, Argentina: Effects of environmental conditions and plant functional traits on performance of native woody species

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Journal of Arid Land 2020年第4期12卷 653-665页

作者： juan m ZEBERIO Carolina A PÉREZ National University of Río Negro Atlantic HeadquartersCenter for Environmental Studies from Norpatagonia(CEANPa)Viedma 8500Argentina National Council of Scientific and Technical Research(CONICET) Viedma 8500Argentina Ecological and Environmental Systems Research Laboratory(LISEA) National University of La PlataLa Plata 1900Argentina

Degradation processes affect a vast area of arid and semi-arid lands around the world and damage the environment and people′s health. Degradation processes are driven by human productive activities that cause direct and indirect effects on natural resources, such as species extinction at regional scale, reduction and elimination of vegetation cover, soil erosion, etc. In this context, ecological rehabilitation is an important tool to recover key aspects of the degraded ecosystem. Rehabilitation trials rely on the use of native plant species with characteristics that allow them to obtain high survival and growth rates. The aim of this work was to assess the survival and growth of native woody species in degraded areas of northeastern Patagonia and relate them to plant functional traits and environmental variables. We observed high early and late survival rates, and growth rates in Prosopis flexuosa DC. var. depressa F.A. Roig and Schinus johnstonii F.A. Barkley, and low values in Condalia microphylla Cav. and Geoffroea decorticans(Gillies ex Hook. & Arn.) Burkart. Early survival rates were positively associated with specific leaf area(SLA) and precipitation, but negatively associated with wood density, the maximum mean temperature of the warmest month and the minimum mean temperature of the coldest month. Late survival rates were positively associated with SLA and soil organic matter, but negatively associated with plant height and precipitation. The temperature had a positive effect on late survival rates once the plants overcame the critical period of the first summer after they were transplanted to the field. Prosopis flexuosa and S. johnstonii were the most successful species in our study. This could be due to their functional traits that allow these species to acclimatize to the local environment. Further research should focus on C. microphylla and G. decorticans to determine how they relate to productive conditions, acclimation to environmental stress, auto-eco

关键词： arid lands Condalia microphylla Geoffroea decorticans Prosopis flexuosa Schinus johnstonii survival rates height growth basal diameter growth

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电化学法深度处理电厂脱硫废水

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电化学（中英文） 2024年第4期30卷 49-57页

作者：韦聚才易娟吴旭华中科技大学环境科学与工程学院湖北武汉430074 湖北华德莱节能减排科技有限公司湖北武汉430223

本文介绍了一种用于处理电厂脱硫废水的电聚浮+电解联合工艺深度,实现废水中SS、COD和氯离子的有效去除。通过线性伏安扫描法探究了电厂脱硫废水中亚硫酸根和氯离子在β-PbO_(2)电极表面的反应机理和相关动力学参数,以此验证了β-PbO_(2... 详细信息

本文介绍了一种用于处理电厂脱硫废水的电聚浮+电解联合工艺深度,实现废水中SS、COD和氯离子的有效去除。通过线性伏安扫描法探究了电厂脱硫废水中亚硫酸根和氯离子在β-PbO_(2)电极表面的反应机理和相关动力学参数,以此验证了β-PbO_(2)是良好的亚硫酸盐电催化氧化和电产活性氯的材料。实验室自制方形连续推流式电解槽,分为电聚浮段和电解段。电沉积法自制钛基β-PbO_(2)网状电极为电解阳极。若以《火电厂石灰石-石膏湿法脱硫废水水质控制指标》(DL/T 997-20006)COD排放标准为处理终点,3.5 V电解电压下某电厂脱硫废水处理能耗仅为10.78 kWh·m^(–3)。电解电压为4.0 V时,电解槽运行300 min可去除废水中的绝大多数的COD和氯离子,二者去除率分别为91.43%和92.98%。验证了工艺路线的技术可行性和经济可行性。

关键词：脱硫废水二氧化铅电催化 COD 亚硫酸脱氯

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基于LAmOST DR8光谱搜寻白矮星

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天文学进展 2024年第1期42卷 102-114页

作者：蔡靖豪韩占文邢丽峰任娟娟李蛟中国科学院云南天文台昆明650216 中国科学院大学北京100049 中国科学院天体结构与演化重点实验室昆明650011 云南省国际超新星研究重点实验室昆明650216 中国科学院国家天文台北京100101

白矮星是中小质量恒星演化末期残留的简并内核,是宇宙中绝大多数恒星的演化归宿。白矮星的大样本观测性质不仅可以为恒星演化理论提供检验与约束,还可以被用于研究银河系的形成历史与演化。结合Gaia的高精度测光和周年视差数据,在LAmOS... 详细信息

白矮星是中小质量恒星演化末期残留的简并内核,是宇宙中绝大多数恒星的演化归宿。白矮星的大样本观测性质不仅可以为恒星演化理论提供检验与约束,还可以被用于研究银河系的形成历史与演化。结合Gaia的高精度测光和周年视差数据,在LAmOST第八次数据发布(DR8)低分辨率光谱数据中搜寻白矮星。通过使用模版匹配的方法,在LAmOST DR8中共找到4692颗白矮星和85颗激变变星,其中2876个目标在之前的工作中已经被证认为白矮星,1854个目标为首次在LAmOST中发现的白矮星。目视确认后对白矮星光谱型进行了详细的分类。经过对比,该白矮星样本的完备性为80%,分类的准确性达到99%,最终得到的LAmOST白矮星很好地反映不同类型的白矮星在Gaia CmD图上的分布。

关键词：白矮星光谱 LAmOST

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二硫化钼薄膜增强超高强度不锈钢摩擦学及疲劳性能研究

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表面技术 2024年第15期53卷 45-56页

作者：杜娟孙涛朱凯樊小强朱旻昊成都飞机工业(集团)有限责任公司成都610073 西南交通大学材料科学与工程学院成都610031

目的通过表面处理技术提高USS122G不锈钢摩擦学性能及力学性能。方法采用闭合场非平衡磁控溅射技术在USS122G不锈钢表面沉积moS_(2)薄膜,分别测试了镀moS_(2)薄膜的USS122G不锈钢力学性能、抗腐蚀性能、弯曲性能、低周疲劳性能及滚动接... 详细信息

目的通过表面处理技术提高USS122G不锈钢摩擦学性能及力学性能。方法采用闭合场非平衡磁控溅射技术在USS122G不锈钢表面沉积moS_(2)薄膜,分别测试了镀moS_(2)薄膜的USS122G不锈钢力学性能、抗腐蚀性能、弯曲性能、低周疲劳性能及滚动接触疲劳性能,探索了在干摩擦与石墨烯润滑脂条件下的摩擦学性能,并通过扫描电镜与XRD对moS_(2)薄膜进行形貌与成分分析。结果成功在USS122G不锈钢表面沉积了moS_(2)薄膜,镀moS_(2)薄膜的USS122G不锈钢的纳米硬度为6.8GPa。镀膜后的USS122G不锈钢的阻抗模量为1.06×10^(5)Ω·cm^(2),腐蚀电流密度为1.91×10^(‒6)A/cm^(2)。镀moS_(2)薄膜的USS122G镀层脱落的最大弯曲力约为3695N。在滚动接触疲劳测试中,镀moS_(2)试样较未镀膜的USS122G钢的磨痕深度更浅、宽度更窄。moS_(2)薄膜能有效提升USS122G不锈钢基底的减摩与耐磨性,在干摩擦条件下,与未镀膜的USS122G不锈钢相比,镀moS_(2)薄膜的USS122G不锈钢的摩擦因数从0.8降低至0.06~0.07,磨损率从1.68×10^(‒5)mm^(3)/(N·m)减少到9.41×10^(‒8) mm^(3)/(N·m)。在脂润滑条件下,USS122G不锈钢的摩擦因数在0.12左右,镀moS_(2)薄膜后摩擦因数一直稳定在0.103左右。结论镀moS_(2)薄膜的USS122G较未镀膜的USS122G不仅提升了疲劳性能,还显著改善了摩擦学性能,提高了基底的使用寿命。

关键词：二硫化钼薄膜 USS122G不锈钢润滑脂摩擦学性能

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