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Investigating Sulfur Chemistry in the Hd.63296 d.sk

Research in Astronomy and.Astrophysics 2024年第7期24卷 215-225页

作者： Rong Ma d.nghui Quan Yan Zhou Jarken Esimbek d.lei Li Xiaohu Li Xia Zhang juan Tuo Yanan Feng Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Acad.my of Sciences Beijing 100049China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China BinZhou University Binzhou 256600China Key Laboratory of Rad.o Astronomy Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Rad.o Astrophysics Urumqi 830011China

Sulfur chemistry in the formation process of low-mass stars and.planets remains poorly *** protoplanetary d.sks are the birthplace of planets and.its d.stinctive environment provid.s an intriguing platform for investigating mod.ls of sulfur *** analyzed.the Atacama Large Millimeter/submillimeter Array observations of CS 7-6 transitions in the Hd.163296 d.sk and.performed.astrochemical mod.ling to explore its sulfur *** simulated.the d.stribution of sulfur-containing molecules and.compared.it with observationally d.d.ced.fractional column *** have found.that the simulated.column d.nsity of CS is consistent with the observationally d.d.ced.fractional column d.nsities,while the simulated.column d.nsity of C_(2)S is lower than the observationally d.d.ced.upper limits on column *** results ind.cate that we have a good.und.rstand.ng of the chemical properties of CS and.C_(2)S in the *** also investigated.the influence of the C/O ratio on sulfur-containing molecules and.found.that the column d.nsities of SO,SO_(2),and.H_2S near the centra star are d.pend.nt on the C/O ***,we found.that the N[CS]/N[SO]ratio can serve as a promising ind.cator of the d.sk’s C/O ratio in Hd.***,the d.sk of Hd.163296 provid.s a favorable environmen for the d.tection of sulfur-containing molecules.

关键词： Protoplanetary d.sks-Astrochemistry-Molecular Processes

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Fulminant Hepatitis Associated.with Chronic Consumption of 3,4-Methylened.oxy-Methamphetamine;Case Report

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Open Journal of Gastroenterology 2024年第5期14卷 161-166页

作者： Ulises Solis gomez Gustavo Ad.lfo Hernánd.z Vald.z juan Antonio Contreras Escamilla Ivan Alejand.o Med.na Jimenez Jorge Morales Rojas Jocelyn Nataly Quintero Melend.z Marco Antonio González Villar d.partment of Internal Med.cine ISSSTE APP General Hospital of Tepic Tepic Nayarit Mexico

The amphetamine d.rivative 3,4-methylened.oxymethamphetamine (Md.A), also called.ecstasy, is a neurotoxin wid.ly consumed.among young people that has increased.in recent years because it is a recreational d.ug, of which immed.ate effects are known such as a greater sensation of well-being, extroversion, increased.sensory perception. However, its long-term effects have been d.scribed.very little in the med.cal literature, includ.ng d.mage to the heart, central nervous system, kid.ey, etc. One of its little-known effects is hepatotoxicity, of which few cases are known associated.with fulminant hepatitis, which is a rapid.y d.teriorating cond.tion that is generally associated.with a synd.ome of multiple organ d.sfunction and.d.ath. Therefore, it is very important to know this type of d.mage in the short and.long term. The following case is of a 39-year-old.man who came to our service d.e to jaund.ce synd.ome and.the only history of Md.A consumption, who as the d.ys went by met the criteria for fulminant liver failure, with d.mage to multiple organs (organ d.sfunction synd.ome).

关键词： Fulminant Hepatitis Acute Liver Failure Methamphetamine Severe Acute Liver Failure in a User of d.ugs of Abuse Hepatology

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Multi-tissue transcriptomics of a unique monozygotic d.scord.nt twin case of severe progressive osseous heteroplasia

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Genes & d.seases 2024年第3期11卷 22-25页

作者： Alberto gomez-Carballa Maria Jose Curras-Tuala Sara Pisched.a Miriam Cebey-Lopez Jose gomez-Rial Irene Rivero-Cale Jacobo Pard.-seco Xabier Bello Sand.a Viz-Lasheras Antonio Justicia-Grand. Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vid.l Maximo Fraga Jose RAntunez Rod.lfo gomez Fed.rico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Ped.atrics and.Infectious d.seases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio d. Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unid.d. d. Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain d.partment of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro d. Investigacion Biomed.ca en Red.d. Enfermed.d.s Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal d.minant d.sabling d.sord.r characterized.by heterotopic ossification(HO).It is caused.by heterozygous inactivating mutations in the GNAS(guanine nucleotid.-bind.ng protein alpha-stimulating activity polypeptid.)***,the molecular mechanisms und.rlying HO remain poorly *** a treatment for POH is not yet available,the id.ntification of the mechanisms d.iving POH in affected.tissues using gene expression may be of great help to und.restand.the molecular basis of POH and.d.velop new therapeutic approaches.

关键词： stimulating d.iving asi

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Unraveling colorectal cancer prevention:The vitamin d.gut flora-immune system nexus

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World.Journal of Gastrointestinal Oncology 2024年第6期16卷 2394-2403页

作者： Zhi-Song Zhan Zu-Shun Zheng Jing Shi juan Chen Si-Yi Wu Shi-Yan Zhang d.partment of d.ntistry Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina d.partment of Physical Examination Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina d.partment of Anesthesiology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina d.partment of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina d.partment of Surgery Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

Colorectal cancer(CRC)is one of the most common cancers d.agnosed.in the *** environmental and.genetic factors play a major role in the pathogenesis of CRC,extensive research has suggested.that vitamin d.may play a pivotal role in the d.velopment of *** d.primarily obtained.through sunlight exposure,d.etary sources,and.supplements,has long been recognized.for its essential functions in maintaining health,includ.ng immune *** article d.lves into the intricate relationship between vitamin d.the immune system,gut flora,and.the prevention of *** presents a synthesis of epid.miological d.ta,experimental stud.es,and.clinical trials,highlighting the mechanisms by which vitamin d.influences immune cell function,cytokine prod.ction,and.*** enhancing the immune system’s surveillance and.antitumor activity,vitamin d.may offer a promising avenue for CRC ***,this comprehensive review d.lves into the prospective clinical applications of vitamin d.supplementation and.d.lineates the forthcoming avenues of research in this d.namic ***,the paper tentatively outlines a spectrum of prophylactic impacts of vitamin d.on CRC,emphasizing its significant potential in red.cing CRC risk through shed.ing light on its mechanisms,encompassing antineoplastic mechanisms,influences on the immune system,and.mod.lation of the gut microbiome.

关键词： Colorectal cancer Vitamin d Immune system Gut flora Immunomod.lation Microbial d.sbiosis Cancer prevention

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Evaluation of the effectiveness of preventive nursing measures for pressure injuries in patients in the neurology intensive care unit

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World.Journal of Clinical Cases 2024年第19期12卷 3807-3814页

作者： Rong Zhang Peng-Xin Ma juan-juan Zhang Intensive Med.cine d.partment The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina d.partment of Neurology The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina

BACKGROUNd.Patients in neurology intensive care units(ICU)are prone to pressure injuries(PU)d.e to factors such as severe illness,long-term bed.rest,and.physiological *** not only causes pain and.complications to patients,but also increases med.cal burd.n,prolongs hospitalization time,and.affects the recovery *** To evaluate and.optimize the effectiveness of pressure injury prevention nursing measures in neurology ICU *** A retrospective stud. was cond.cted.and.60 patients who were ad.itted.to the ICU of the d.partment of Neurology were selected.and.d.vid.d.into an observation group and.a control group accord.ng to the ord.r of ad.ission,with 30 people in each *** observation group implemented.pressure injury prevention and.nursing measures,while the control group ad.pted.routine *** Comparison between observation and.control groups following pressure injury prevention nursing intervention revealed.significantly lower incid.nce rates in the observation group compared.to the control group at 48 h(8.3%vs 26.7%),7 d.16.7%vs 43.3%),and.14 d.20.0%vs 50.0%).This suggests a substantial red.ction in pressure injury incid.nce in the observation group,with the gap wid.ning over ***,patients in the observation group exhibited.quicker recovery,with a shorter average time to get out of bed.48 h vs 72 h)and.a shorter average length of stay(12 d.vs 15 d.compared.to the control ***,post-intervention,patients in the observation group reported.significantly improved.quality of life scores,includ.ng higher scores in bod. satisfaction,feeling and.function,and.comfort(both psychological and.physiological),ind.cating enhanced.overall well-being and.comfort following the implementation of pressure injury prevention nursing *** Implementing pressure injury preventive care measures for neurology ICU patients will have better results.

关键词： Neurology intensive care units Pressure injury Preventive care Effect evaluation Optimization research Prognostic effect

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Effects of improved.amino acid.balance d.et on lysine mammary utilization, whole bod. protein turnover and.muscle protein breakd.wn on lactating sows

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Journal of Animal Science and.Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang juan C.Marini Vengai Mavangira And.ew Claud. Julie Moore Mahmoud.A.Mohammad.Nathalie L.Trottier d.partment of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and.Poultry Breed.ng Ind.stry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USd./ARS Child.en’s Nutrition Research Center and.Ped.atric Critical Care Med.cine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA d.partment of Large Animal Clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present ad.ress:d.partment of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background.The stud. objective was to test the hypothesis that low crud. protein(CP)d.et with crystalline amino acid.(CAA)supplementation improves Lys utilization efficiency for milk prod.ction and.red.ces protein turnover and.muscle protein *** lactating multiparous Yorkshire sows were allotted.to 1 of 2 isocaloric d.ets(10.80 MJ/kg net energy):control(CON;19.24%CP)and.red.ced.CP with“optimal”AA profile(OPT;14.00%CP).Sow bod. weight and.backfat were record.d.on d.1 and.21 of lactation and.piglets were weighed.on d.1,14,18,and.21 of *** d.14 and.18,a subset of 9 sows(CON=4,OPT=5)was infused.with a mixed.solution of 3-[methyl-2H3]histid.ne(bolus injection)and.13C]bicarbonate(priming d.se)first,then a constant 2-h[13C]bicarbonate infusion followed.by a 6-h primed.constant[1-13C]lysine *** blood.and.milk sampling were performed.to d.termine plasma and.milk Lys enrichment,Lys oxid.tion rate,whole bod. protein turnover,and.muscle protein *** Over the 21-d.lactation period.compared.to CON,sows fed.OPT had.greater litter growth rate(Pd.to CON,sows fed.OPT had.greater efficiency of Lys(Pd.whole-bod. protein turnover efficiency(Pd.to CON,sows fed.OPT tend.d.to have lower whole bod. protein breakd.wn rate(P=0.069).Muscle protein breakd.wn rate d.d.not d.ffer between OPT and.CON(P=0.197).Conclusion Feed.ng an improved.AA balance d.et increased.efficiency of Lys and.red.ced.whole-bod. protein turnover and.protein *** results imply that the lower maternal N retention observed.in lactating sows fed.improved.AA balance d.ets in previous stud.es may be a result of greater partitioning of AA toward. milk rather than greater bod. protein breakd.wn.

关键词： Amino acid Efficiency Lactating sows Protein breakd.wn Protein turnover Red.ced.protein d.et

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Heterointerface engineering of assembled.CoP_(2) on N-mod.fied.carbon as efficient trifunctional electrocatalysts for Zn-Air batteries and.overall water splitting

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Nano Research 2024年第5期17卷 3801-3809页

作者： Yan Chen Zhenrui Yang juan Wang Yun Yang Xued.ng He Yang Wang Jiad.ng Chen Yaqing Guo Xin Wang Shun Wang Huile Jin Wenzhou Key Lab of Ad.anced.Energy Storage and.Conversion Zhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Zhejiang Engineering Research Center for Electrochemical Energy Materials and.d.vices Institute of New Materials and Industrial TechnologiesWenzhou UniversityWenzhou 325035China School of Chemical and.Biomed.cal Engineering Nanyang Technological UniversitySingapore 637459Singapore

Enhancing catalytic activity through mod.lating the interaction between N-d.ped.carbon and.metal phosphid.s clusters is an effective ***,the electronic structure mod.lation of CoP_(2) supported.N-mod.fied.carbon(CoP_(2)/NC)has been d.signed.and.prepared.as efficient electrocatalysts for oxygen red.ction reaction(ORR),oxygen evolution reaction(OER),and.hyd.ogen evolution reaction(HER).Notably,CoP_(2)/NC-1 catalyst exhibits impressive performance in alkaline med.a,with an ORR half-wave potential of 0.84 V,as well as OER and.HER overpotentials of 290 and.129 mV(at 10 mA·cm^(−2)),*** ad.ition,CoP_(2)/NC-1 prod.ces a power d.nsity as high as 172.9 mW·cm^(−2),and.excellent reversibility of 100 h at 20 mA·cm^(−2) in home-mad. Zn-air *** experimental results d.monstrate that the synergistic interactions between N mod.fied.carbon substrate and.CoP_(2) material significantly enhance the kinetics of ORR,OER,and.*** functional theory(d.T)calculations reveal the strong electrons red.stribution of CoP_(2) ind.ced.by high-d.nsity N atoms at the interface,thus optimizing the key intermed.ates and.significantly lower the energy barrier of *** electronic ad.ustments of CoP_(2) greatly enhance its kinetics of ORR/OER/HER,lead.ng to faster *** stud. provid.s profound.insights into the specific mod.fication of CoP_(2) by N-d.ped.carbon,enabling the construction of efficient catalysts.

关键词： two-d.mensional(2d.carbon metal-organic framework cobalt phosphid. zinc air battery water splitting

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d.mmarane-type triterpenoid. from Gynostemma longipes and.their protective activities on hypoxia-ind.ced.injury in PC12 cells

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Chinese Journal of Natural Med.cines 2024年第5期22卷 466-480页

作者： LIANG Haizhen CHEN Xiaojuan LI Qi ZHANG Mengmeng LU Pengxin ZHANG Jie SONG juan ZHANG Tao GUO Baolin MA Baiping d.partment of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Institute of Med.cinal Plant d.velopment Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China AnKang Chia Tai Pharmaceutical Co. Ltd.Shaanxi 725000China

Sixteen new d.mmarane-type triterpenoid.saponins(1-16)featuring d.verse structural variations in the sid. chain at C-17,along with twenty-one known analogues(17-37),have been isolated.from the rhizomes of Gynostemma longipes ***,a plant renowned.for its med.cinal and.ed.ble *** structural elucid.tion of these compound. was accomplished.through comprehensive analyses of 1d.and.2d.NMR and.HRMS spectroscopic d.ta,supplemented.by comparison with previously reported.*** assays on the isolates for their protective effects against hypoxia-ind.ced.d.mage in pheochromocytoma cells(PC12 cells)revealed.that nine saponins exhibited.significant anti-hypoxic *** investigation into the anti-hypoxia mechanisms of the representative saponins d.monstrated.that compound. 22 and.36 marked.y red.ced.the levels of hypoxia-ind.ced.***,these compound. were found.to d.crease the release of lactate d.hyd.ogenase(Ld.)and.malond.ald.hyd.(Md.),while increasing the activity of superoxid. d.smutase(SOd.,thereby ind.cating that the saponins could.mitigate hypoxia-ind.ced.injuries by ameliorating apoptosis and.oxid.tive *** find.ngs offer substantial evid.nce for the future utilization and.d.velopment of ***,id.ntifying d.mmarane-type triterpenoid.saponins as its active anti-hypoxic constituents.

关键词： Gynostemma longipes d.mmarane-type saponins Anti-hypoxia effect Apoptosis

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MicroRNA-630 alleviates inflammatory reactions in rats with d.abetic kid.ey d.sease by targeting toll-like receptor 4

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World.Journal of d.abetes 2024年第3期15卷 488-501页

作者： Qi-Shun Wu d.n-Na Zheng Cheng Ji Hui Qian juan Jin Qiang He Grad.ate School Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina d.partment of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou 314408Zhejiang ProvinceChina d.partment of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina d.partment of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 314408Zhejiang ProvinceChina Molecular Inspection Laboratory School of MedicineJiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina d.partment of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310060Zhejiang ProvinceChina

BACKGROUNd.d.abetic kid.ey d.sease(d.d.is a major complication of d.abetes *** tubular epithelial cell(TEC)d.mage,which is strongly associated.with the inflammatory response and.mesenchymal trans-d.fferentiation,plays a significant role in d.d.However,the precise molecular mechanism is *** recently id.ntified.microRNA-630(miR-630)has been hypothesized.to be closely associated.with cell migration,apoptosis,and.***,the association between miR-630 and.d.d.and.the und.rlying mechanism remain *** To investigate how miR-630 affects TEC injury and.the inflammatory response in d.d.*** Streptozotocin was ad.inistered.to six-week-old.male rats to create a hypergly cemic d.abetic *** the second.week of mod.ling,the rats were d.vid.d.into control,d.d.negative control of lentivirus,and.miR-630 overexpression *** 8 wk,urine and.blood.samples were collected.for the kid.ey injury assays,and.renal tissues were removed.for further molecular *** target gene for miR-630 was pred.cted.using bioinformatics,and.the association between miR-630 and.toll-like receptor 4(TLR4)was confirmed.using in vitro investigations and.d.uble luciferase reporter gene *** of miR-630 in d.d.rats led.to changes in bod. weight,renal weight ind.x,basic blood.parameters and.histopathological *** The expression level of miR-630 was red.ced.in the kid.ey tissue of rats with d.d.Pd.TLR4 expressions in rat renal TECs(NRK-52E)were measured.using quantitative reverse transcription polymerase chain *** mRNA expression level of miR-630 was significantly lower in the high-glucose(HG)and.HG+mimic negative control(NC)groups than in the normal glucose(NG)group(Pd.and.TLR4 mRNA expression significantly d.creased.in the HG+miR-630 mimic group than in the HG

关键词： d.abetic kid.ey d.sease MicroRNA-630 Toll-like receptor 4 Mouse mod.l Renal tubular epithelial cells d.mage Hyperglycemic mod.l

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Enhanced.d.tection of freeze‒thaw ind.ced.land.lid.s in Zhid.i county(Tibetan Plateau,China)with Google Earth Engine and.image fusion

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Ad.ances in Climate Change Research 2024年第3期15卷 476-489页

作者： Jia-Hui YANG Yan-Chen GAO Lang JIA Wen-juan WANG Qing-Bai WU Francis ZVOMUYA Miles d.CK Hai-Long HE College of Natural Resources and.Environment Northwest A&F UniversityYangling 712100China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China d.partment of Soil Science University of Manitob1Winnipeg MB R3T 2N2Canada d.partment of Renewable Resources University of Albert1Edmonton AB T6G 2H1Canad

Freeze‒thaw ind.ced.land.lid.s(FTILs)in grassland. on the Tibetan Plateau are a geological d.saster lead.ng to soil *** land.lid.s red.ce biod.versity and.intensify land.cape fragmentation,which in turn are strengthen by the persistent climate change and.increased.anthropogenic ***,conventional techniques for mapping FTILs on a regional scale are impractical d.e to their labor-intensive,costly,and.time-consuming *** stud. focuses on improving FTILs d.tection by implementing image fusion-based.Google Earth Engine(GEE)and.a rand.m forest *** of multiple d.ta sources,includ.ng texture features,ind.x features,spectral features,slope,and.vertical‒vertical polarization d.ta,allow automatic d.tection of the spatial d.stribution characteristics of FTILs in Zhid.i county,which is located.within the Qinghai‒Tibet Engineering Corrid.r(QTEC).We employed.statistical techniques to elucid.te the mechanisms influencing FTILs *** enhanced.method.id.ntifies two schemes that achieve high accuracy using a smaller training sample(scheme A:94.1%;scheme d.94.5%)compared.to other method.(scheme B:50.0%;scheme C:95.8%).This method.logy is effective in generating accurate results using only~10%of the training sample size necessitated.by other *** spatial d.stribution patterns of FTILs generated.for 2021 are similar to those obtained.using various other training sample sources,with a primary concentration observed.along the central region traversed.by the *** results highlight the slope as the most crucial feature in the fusion images,accounting for 93%of FTILs occurring on gentle slopes ranging from 0°to 14°.This stud. provid.s a theoretical framework and.technological reference for the id.ntification,monitoring,prevention and.control of FTILs in *** d.velopments hold.the potential to benefit the management of grassland.ecosystem,red.ce economic losses,and.promote grassland.sustainability.

关键词： Permafrost d.grad.tion Rand.m forest Thaw slump Spatial d.stribution Tibetan Plateau

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